Improving the removal efficiency of PM2.5 particles is significant for the limitation of particle emissions from coal-fired power plants. This work reports a multiple electric field electrostatic precipitator (ESP) enhanced by magnetic confinement effect to efficiently remove PM2.5 particle from flue gas. Firstly, the electromagnetic dust removal mechanism of PM2.5 capture in multi-electric field ESPs is revealed, and the theoretical and numerical models of the multifield coupling under the effect of magnetic field are established. Secondly, the potential distribution law under different working voltages and the dust removal performance for PM2.5 are analyzed, and the magnetic field effect under the optimal voltage allocation is numerically simulated. Finally, the best magnetic field introduction position under the optimal voltage allocation is investigated. The numerical results show that the optimal voltage allocation and the best magnetic field position are determined to achieve the full effect of magnetic field to improve the PM2.5 dust removal efficiency in the multi-electric field ESP under the premise of ensuring the decrease of voltage load. The relevant results can provide ideas and references for greatly reducing PM2.5 emissions and voltage power consumption in thermal power plants.