This study explores the health consequences of prolonged sitting by introducing a standing chair and examining the effects of seat tilt angles on comfort. Using synchronized pressure distribution testing and surface electromyographic (sEMG) signal analysis, we assessed pressure and sEMG responses at tilt angles of 0°, 20°, and 40° during tasks such as computer work, writing, and ironing. Initial measurements with body pressure distribution sensors targeted the buttocks and feet, while surface electromyographic equipment captured signals from the bilateral lumbar erector spinae, vastus lateralis, and gastrocnemius muscles. MATLAB processing facilitated the analysis of integrated electromyographic values and mean power frequencies, elucidating the effects of tilt angles on comfort. Our research findings indicate that a 20° tilt angle significantly enhances comfort during computer and writing tasks and noticeably increases the comfort of the erector spinae muscles during ironing. Conversely, a 0° tilt angle is more beneficial for the vastus lateralis and gastrocnemius muscles. These results underscore the importance of selecting appropriate tilt angles to improve comfort across various tasks. Furthermore, integrating pressure sensors and surface electromyographic signals enables a comprehensive evaluation of chair ergonomic quality, offering valuable insights for chair design optimization.