The application method of Electric Submersible Pump increases the oil recovery factor Y at 05-1A block, the Nam Con Son basin, which is affected by many factors such as energy regime, fluid regime, fractures, etc. All these factors are based on the simulation model from Prosper simulation software. The process starts from the appropriate PVT data, exploitation data, selecting necessary parameters, designing wells, and predicting exploitation to find the best case for the Electric Submersible Pump exploitation plan. The results showed that if oil is only exploited by natural energy, it will not be effective, so it is possible to equip a Electric submersible pump system with 2 exploitation wells for the most efficient exploitation. The Electric Submersible Pump is applied and effective in the case of wells with high WTC and low GOR.