A simple numerical approach is developed to predict the wear and friction of piston ring pack and cylinder liner during the break-in period and under transient speed conditions. In the model, a solution of mixed lubrications using the load-shearing concept is presented based on the selected elastic-plastic equations of asperity contacts in conjunction with well-established elastohydrodynamic equations. The model takes shear-thinning, thermal effects in elastohydrodynamic lubrication (EHL) and lubricant starvation effects into account. Modified Archard’s wear coefficient to describe the piston ring against cylinder liner wear is introduced. The approach is valid for the calculations of the asperity pressure at low values of the ratio of oil film thickness to combined roughness of the interacting surfaces, that is, less than 0.5. Applications are discussed, including association of piston side thrust force on wear and friction characteristics of piston ring/cylinder bore, gas blowby through the ring pack on the cylinder liner wear, a strong coating dependence for the piston ring wear, and wear distribution across the stroke under engine operating conditions. A good agreement between the experimental and analytical data indicates that the proposed model can be used to predict the wear and friction of the piston ring pack sliding against cylinder liner.