Egg Consumption Research Articles

Association between dietary diversity and lipid indices among Indian Kho-Kho players

Purpose Dietary diversity (DD) is a proxy indicator of nutrient adequacy and has been propagated as a health beneficial component of dietary behavior. This study aims to understand DD and its association with lipid indices among Indian Kho-Kho players. Design/methodology/approach In all, 50 Indian Kho-Kho players aged between 16 years and 31 years belonging to different regions of India were recruited. Dietary diversity score (DDS; food groups/day) and food variety score (FVS; number of food items/day) were considered to assess the DD. The United Nations Food and Agricultural Organization food frequency questionnaire was used as a tool. Serum total cholesterol (TC), triglycerides (TG), LDL, VLDL and HDL were measured. Findings The DDS and FVS showed that athletes were consuming approximately 7 of 9 food groups (Mean ± SD: 6.5 ± 1.3) and 27 varieties of foods (Mean ± SD:27.0 ± 8.6) from 9 food groups per day. This study could not find significant differences for DDS and FVS among athletes belonging to different regions. FVSs of organ meat, eggs and spices and condiments were significantly positively associated with TG (p < 0.036, p < 0.020 and p < 0.001) and VLDL (p < 0.054, p < 0.021 and p < 0.001). LDL was inversely significantly associated with FVS of cereals, white root and tubers (p < 0.032). Research limitations/implications DDS and FVS were not associated with lipid indices among Kho-Kho players. However, individual FVS of organ meat, eggs and spices and condiments may increase TG and VLDL. Optimum consumption of cereals and root tubers may help to maintain LDL levels among Kho-Kho players. Originality/value It was found that daily consumption of organ meat and eggs may increase TG and VLDL, and optimum consumption of cereals and white roots and tubers may help to maintain LDL. High energy and fat foods may act as mediators along with spices and condiments in increasing TG and VLDL.

Association between whole egg consumption and cognitive function in older adults: Birjand longitudinal aging study

OBJECTIVE: Egg consumption could reduce the chance of cognitive decline. We aimed to assess this possible protective effect using data from the Birjand longitudinal aging study (BLAS). METHODS: In this cross-sectional study, the association between number of whole eggs consumed per week and cognitive impairment was assessed on 1352 participants in the context of the first wave of BLAS conducted on September 2018 to April 2019. Six Item Cognitive Impairment Test (6-CIT), Mini-Mental State Examination (MMSE), Verbal Fluency Test (VFT) and abbreviated mental test (AMT) questionnaires were used to assess the cognitive function. Analyses have been conducted using multiple logistic regression. RESULTS: Participants ate an average of 2.4 eggs per week. Older adults with moderate and high egg consumption (2–3 eggs/week and ≥4 eggs/week, respectively) performed better at 6-CIT (OR: 0.61, 95% CI: 0.46; 0.80; and 0.58, 95% CI: 0.41; 0.82), AMT (0.67, 95% CI: 0.52; 0.87; and 0.56, 95% CI: 0.39; 0.80) and all 4 cognitive tests combined (0.47, 95% CI: 0.30; 0.73; and 0.44, 95% CI: 0.24; 0.78). VFT was not associated, and MMSE score was only associated with high egg intake (0.53, 95% CI: 0.38; 0.74). High egg intake was more protective of cognitive decline (≥40%) than the moderate intake (30–40%). The significance of most associations disappeared after adjustment for confounders and covariates. CONCLUSIONS: In summary, the findings of this study suggest a potential inverse relationship, displaying an ascending trend, between weekly egg consumption and cognitive function among elderly Iranians.

Occurrence of Salmonella spp. in flocks of laying hens in different housing systems in eastern Croatia from 2020 to 2023

Human Salmonella infections are often associated with the consumption of infected eggs and egg products. Therefore, knowing the prevalence of Salmonella spp. in flocks of laying hens and the factors that influence the occurrence of Salmonella on farms is of the utmost importance. Since 2012, housing laying hens in conventional cages has been prohibited in the European Union, and hens may only be kept in enriched cages or alternative housing systems. The prohibition of conventional cages has improved the welfare of laying hens, but has raised issues concerning the detrimental consequences for the spread and occurrence of infectious diseases in hen flocks. The aim of this study was to analyse the occurrence of Salmonella spp. in laying hen flocks in eastern Croatia in the period from 2020 to 2023, and to determine whether housing systems have an impact on occurrence. During this period, a total of 1534 samples of laying hen faeces from 191 flocks (106 flocks housed in enriched cages and 85 flocks in housing systems with closed outdoor runs) were tested at the Diagnostics Laboratory of the Croatian Veterinary Institute, Veterinary Department Vinkovci, as part of implementation of the National Salmonellosis Control Programme and official sampling in the Republic of Croatia for the presence of Salmonella spp. Isolation, identification and serotyping of Salmonella was conducted in accordance with the standard HRN EN ISO 6579-1:2017/A1:2020 method. Salmonella spp. was confirmed in the faeces of seven laying hen flocks (6.60%) housed in enriched cages, and 11 flocks (12.94%) of laying hens in housing systems with outdoor runs. The research results showed that there was no significant difference in the total occurrence of Salmonella between flocks of laying hens housed in housing systems with outdoor runs and those in enriched cages. The highest percentage of positive flocks was found in 2020 in 11.11% of flocks of laying hens housed in enriched cages and 18.18% of flocks of laying hens kept in housing systems with outdoor runs. When observed by county over the four-year study period, the percentage of positive flocks was significantly higher (P<0.05) in Brod-Posavina County in comparison with Osijek-Baranja County and Vukovar-Srijem County. The research results suggest that there is small possibility that transitioning from enriched cage systems to alternative housing systems, with strict biosecurity measure implementation, would increase Salmonella infections in laying hen flocks.

Evaluation of Complementary Feeding Indicators Among Children Aged 6–23 Months According to the Health Literacy Status of Their Mothers

Background/Objectives: Infant and young child feeding (IYCF) practices directly affect child health, development, and survival, especially under 2 years of age and ultimately affect adult life well-being. As the primary caregivers of the children, mothers with higher health literacy may better perceive the benefits of optimal complementary feeding practices, leading to improved health outcomes for their children. In this study, we aimed to assess complementary feeding practices among children aged 6–23 months in Turkey according to 2021 World Health Organization IYCF indicators [minimum dietary diversity (MDD); minimum meal frequency (MMF); minimum acceptable diet (MAD); egg and/or flesh food consumption (EFF); sweet beverage consumption (SwB); unhealthy food consumption (UFC); zero vegetable or fruit consumption (ZVF); and bottle feeding (BoF)] and investigate their associations with sociodemographic characteristics and mothers’ health literacy. Methods: With a descriptive study design, we reached 572 mothers of children aged 6–23 months from five regions of Turkey. We used the Turkey Health Literacy Scale-32 (TSOY-32) to assess mothers’ health literacy. Results: While maternal and child age are significantly associated with more complementary feeding practices, specifically MDD, MAD, and EFF, having multiple children has negative impacts on several complementary feeding indicators, including MDD, MMF, MAD, UFC, and ZVF. The only indicator associated with mothers’ TSOY-32 scores was zero fruit and vegetable consumption. Conclusion: Raising awareness among mothers about the importance of complementary feeding practices and identification of vulnerable groups will guide practitioners and policymakers to improve child health and nutrition.

Effects of fortified eggs and time-restricted eating on cardiometabolic health: The prosperity trial

BackgroundGiven the increasing interest in dietary interventions to improve cardiovascular health, this trial assessed the impact of fortified eggs (FE) versus non-egg supplemented diet and time-restricted eating (TRE) versus usual care diet on cardiovascular biomarkers. MethodsThe study was a unblinded, 2-by-2 factorial design, which randomized patients, with either a prior cardiovascular event or two cardiovascular risk factors, to FE or a non-egg supplemented diet and TRE or usual care diet. Patients randomized to FE were instructed to consume at least 12 FE/week (with eggs provided); those on a non-egg supplemented diet restricted egg consumption to <2 eggs/week. TRE participants were instructed to consume all calories within an 8-hour window daily and fasted for the remaining 16 hours. Patients randomized to usual diet were advised to maintain current dietary habits. Follow-up was performed in-person at 1 and 4 months, and telephone calls at 2 and 3 months. Co-primary endpoints were 4-month LDL- and HDL-cholesterol. Secondary endpoints included additional lipids, cardiometabolic- and inflammatory biomarkers and micronutrient levels at 4-months. ResultsOverall, 140 patients were randomized with median (25th, 75th percentiles) age 66 (58, 73) years; 72 (51%) women, 38 (27%) Black, and 33 (24%) with diabetes mellitus. The difference in least squares (LS) means from baseline to 4-months for HDL and LDL levels revealed no significant clinical difference between FE vs. non-egg supplemented diet (HDL: -0.64 mg/dL [95% CI: -3.86, 2.58]; LDL: -3.14 mg/dL [-10.81, 4.52]) and TRE vs. usual care diet (HDL: 1.51 mg/dL [-1.65, 4.68]; LDL 1.17 mg/dL [-6.36, 8.70]). Pre-specified subgroups revealed a non-significant HDL increase and LDL decrease with FE in patients ≥65 years. ConclusionsThese data did not demonstrate clinically relevant differences in changes in LDL and HDL levels over 4 months with FE and TRE compared with non-egg supplemented diet and usual care diet, respectively, providing evidence that adverse short-term lipid and biomarker changes did not occur with FE consumption. Trial RegistrationClinicalTrials.gov Identifier: NCT04673721.

GEOGRAPHICALLY WEIGHTED MACHINE LEARNING MODEL FOR ADDRESSING SPATIAL HETEROGENEITY OF PUBLIC HEALTH DEVELOPMENT INDEX IN JAVA ISLAND

Random Forest (RF) machine learning models have emerged as a prominent algorithm, addressing problems arising from the sole use of decision trees, such as overfitting and instability. However, conventional RF has global coverage that may need to capture spatial variations better. Based on the analysis of the level of public health development, the relationship between the level of health development and risk factors can vary spatially. We use a modified RF algorithm called Geographically Weighted Random Forest (GW-RF) to address this challenge. GW-RF, as a tree-based non-parametric machine learning model, can help explore and visualize relationships between the Public Health Development Index (PHDI) as response variables and factors that are indicators at the district level. GW-RF output is compared with global output, which is RF in 2018 using the percentage of the population with access to clean/decent water (X1), consumption of eggs and milk per capita per week (X2), number of healthcare facilities per 1000 people (X3), number of doctors per 1000 people (X4), pure participation rate ratio female/male (X5), percentage of households that have hand washing facilities with soap and water (X6) as independent variables. Our results show that the non-parametric GW-RF model shows high potential for explaining spatial heterogeneity and predicting PHDI versus a global model when including six major risk factors. However, some of these predictions mean little. Findings of spatial heterogeneity using GW-RF show the need to consider local factors in approaches to increasing PHDI values. Spatial analysis of PHDI provides valuable information for determining geographic targets for areas whose PHDI values need to be improved.

Association between dietary factors and breast cancer risk: a matched case-control study in Vietnam

BackgroundThe role of diet in breast cancer prevention is controversial and limited in low-middle-income countries (LMICs). This study aimed to investigate the association between different dietary factors and breast cancer risk in Vietnamese women.MethodsThree hundred seventy newly histologically confirmed breast cancer cases and 370 controls matched by 5-year age from September 2019 to March 2020 in Ho Chi Minh City were recorded dietary intake using a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (95% CI) were evaluated using conditional logistic regression and adjusted with potential confounders.ResultsCompared to the lowest quartile of intake, we found that the highest intake of vegetables, fruit, soybean products, coffee, and egg significantly decreased breast cancer risk, including dark green vegetables (OR 0.46, 95% CI 0.27-0.78, ptrend=0.022), legumes (OR 0.19, 95% CI 0.08-0.44, ptrend <0.001), starchy vegetables (OR 0.37, 95% CI 0.21-0.66, ptrend=0.003), other vegetables (OR 0.46, 95% CI 0.28-0.77, ptrend=0.106), fruits (OR 0.44, 95% CI 0.26-0.74, ptrend <0.001), soybean product (OR 0.45, 95% CI 0.24-0.86, ptrend=0.311), coffee (OR 0.47, 95% CI 0.23-0.95, ptrend 0.004), and egg (OR 0.4, 95% CI 0.23-0.71, ptrend=0.002).ConclusionGreater consumption of vegetables, fruit, soybean products, coffee, and eggs is associated with a lower risk of breast cancer. This study provides evidence of breast cancer prevention by increasing the intake of these dietary groups, especially in LMICs.

Laboratory assessment of predation and fecundity of Laricobius species (Coleoptera: Derodontidae), predators of hemlock woolly adelgid

ABSTRACT The hemlock woolly adelgid (HWA), Adelges tsugae (Hemiptera: Adelgidae), is native to the Pacific Northwest and Asia and is an invasive insect in the eastern United States causing widespread decline in health and increased mortality of native eastern and Carolina hemlock. Laboratory experiments conducted at ambient field temperatures were done to determine the adult and larval feeding totals on HWA and fecundity of the introduced predators Laricobius nigrinus and L. osakensis, and the native L. rubidus (Coleoptera: Derodontidae). During the 22-week period when Laricobius spp. adults are active in Virginia, from early November until late March the total mean ( x ¯ ± SE) of HWA eggs, nymphs, and adults were projected to be consumed per L. nigrinus (33.8 ± 4.0), L. osakensis (33.2 ± 4.0), and L. rubidus (16.4 ± 2.5) adults. Laricobius osakensis (102.1 ± 13.7) and L. nigrinus (72.0 ± 10.5), oviposited a similar number of eggs while L. rubidus (24.5 ± 5.2) oviposited a lower number of eggs. Mean larval consumption of HWA progrediens eggs was: L. nigrinus (169.6 ± 7.1), L. osakensis (140.1 ± 8.7), and L. rubidus (135.8 ± 12.8). The mean egg production of HWA was 74.5 ± 2.2. Based on predation and fecundity totals, L. osakensis was predicted to have a greater impact in reducing the number of HWA progrediens eggs than L. nigrinus and L. rubidus.

Association between Egg Consumption and Dementia in Chinese Adults.

The association between egg consumption and dementia is unclear. We carried out a population-based case-control study in China to determine the independent association of egg consumption with dementia. We randomly recruited 233 participants with dementia and 233 without dementia from the community health service clinics and the dementia management system in Guangzhou, China to examine their dietary intakes over the past two years and other risk factors for chronic diseases. Egg consumption was categorised by frequency as Non-consuming/<monthly, Monthly, Weekly, Daily or ≥Twice a day. Participants with dementia, compared to controls, were more likely to consume eggs at Monthly (15.5% vs. 8.6%) but less likely to consume at Daily (28.3% vs. 41.6%). The age-adjusted odds ratio (OR) of dementia was 1.76 (95% CI 1.10-2.84) in participants who consumed eggs Weekly and 4.34 (2.16-8.72) in Monthly consumption compared to Daily. However, no significant associations were found for those Non-consuming/<monthly 1.35 (0.71-2.56) and ≥Twice a day 3.49 (0.83-14.67). After further adjustments, including gender, education, family income, smoking, alcohol consumption, dietary intakes (including red meats, poultry, fish, vegetables and fruits), cardiovascular disease and other co-morbidities, the corresponding ORs were 2.10 (1.10-4.02), 4.82 (1.90-12.27), 0.73 (0.29-1.88) and 4.16 (0.80-21.63), respectively. Among participants who consumed eggs Monthly, Weekly or Daily, an inverse association between egg consumption and dementia was observed; the multiple adjusted OR of dementia was 0.48 (0.30-0.76) per average increment in egg consumption. Compared to Monthly consumption, the OR for Weekly consumption was 0.44 (0.18-1.08) and 0.22 (0.08-0.59) for Daily consumption. This study suggests that Daily egg consumption could help reduce the risk of dementia, while uncertainties regarding the association of non-consuming/<monthly or ≥Twice a day consumption with dementia warrant further research.

Cognition and depression among the elderly might be associated with egg consumption

Cognition and depression among the elderly might be associated with egg consumption

The impact of egg consumption on lipid profiles in hypercholesterolemia patients; a randomized controlled trial, crossover design

The impact of egg consumption on lipid profiles in hypercholesterolemia patients; a randomized controlled trial, crossover design

Heavy metal contamination in eggs on poultry farms and ecological risk assessment around a gold mine area in northern Thailand

The aim of this study was to analyze and compare the Hg, Pb, Cd, and Mn levels in egg feed, soil, and water among laying hens, laying ducks, and free-grazing duck farms in contaminated and uncontaminated areas. This study revealed that the Hg concentration in the eggs of free-grazing ducks was significantly greater than that in the eggs of laying hens and ducks in both contaminated and uncontaminated areas. However, the Pb and Mn levels in the eggs of laying ducks and free-grazing ducks were significantly greater than those in the eggs of laying hens in the contaminated area. Unfortunately, the Hg, Pb, Cd, and Mn concentrations in the feed, soil, and water from these three farms in both areas were not significantly different (P > 0.05). Hg and Cd were confirmed to be enriched in the egg albumin fraction, while Pb and Mn were found mainly in the egg yolk. However, egg consumption from free-grazing duck farms was the riskiest to Hg, Pb, and Mn contamination in the contaminated area. Additionally, the ecological risk factor (ER) in the soil revealed that all the farms were at considerable to high environmental risk for Cd except for Hg and Pb. Although the potential ecological risk index (RI) indicated a moderate risk for all farms in both contaminated and uncontaminated areas, these results were not consistent with our hypothesis. Therefore, the information gained in this study could be useful for setting up mitigation strategies and making decisions about public health concerns related to health hazards, especially for ecological risk assessments of heavy metal contamination.

Women Veterans' Stroke Risk Factors: Identified Prevention Methods and Knowledge Gaps.

Stroke is a significant health burden for veterans and the fifth leading cause of death for women. Compared to civilian women, women veterans have significant multimorbid physical and mental health conditions contributing to their stroke risk. This scoping review aimed to synthesize evidence on the stroke risk factors specific to U.S. women veterans and identify any association between risk factors and a delay in prevention and treatment for women veterans. This study was approved by the organizational Institutional Review Board. The search strategy was run across 6 databases: MEDLINE and EMBASE via Ovid, Scopus, Web of Science, Cochrane Library, and ClinicalTrials.gov. A total of 1218 records were uploaded to Covidence for screening. Criteria for included studies were peer-reviewed primary research articles written in English about women veterans and cardiovascular disease and stroke risk factors. No restrictions were placed on publication date. Fourteen articles met the inclusion criteria. Cohorts were 30 years and older. Data originated from national and individual Veterans Affairs studies. Women veterans starting at age 30 have a steadily increasing positive curvilinear association with stroke risk, indicating a need to screen earlier than the recommended age of 45 years. Stroke incidence was higher in veterans with post-traumatic stress disorder, insomnia, restless leg syndrome, traumatic brain injury, constipation with laxative use, egg consumption (2-4 eggs/wk), frailty, and systemic sclerosis. When comparing White veterans and civilian counterparts, Black veterans had a higher incidence of stroke. Ten studies addressed prevention methods. The clinicians should screen and treat women veterans for post-traumatic stress disorder and constipation and consider alternative treatment methods for constipation. Empirical literature on this matter is lacking. Examining and understanding the differences in sex, gender, and veteran status, and their association with stroke risk, is warranted. Screening women veterans for post-traumatic stress disorder and for stroke early, at 30 years of age, is recommended.

Dietary eggs, egg nutrients, polygenic score for body mass index, “Western pattern” diet, and weight change, a prospective analysis in the Women's health initiative

Background & AimsEggs contain nutrients which could help enrich the diets of postmenopausal women. Egg consumption and elevated body weight have been associated with elevated risk of serious chronic disease. It is possible that elevated body weight mediates between egg consumption and serious chronic disease. However, few studies exist on the link between egg consumption and body weight in post-menopausal women, and none of them accounted for genetic weight gain predispositions. Our objective was to examine associations between egg consumption, body weight, and genetic predisposition for an elevated Body Mass Index (BMI), in postmenopausal women. MethodsWe analyzed data from 4,439 healthy Women’s Health Initiative participants of European descent during a 6-year follow up using multivariable generalized linear mixed models to prospectively evaluate egg and egg-nutrient intake (measured by a food frequency questionnaire) against body weight and a BMI polygenic score (PGS-BMI) derived from GWAS meta-analysis effect-allele frequencies. ResultsWe found a positive prospective association between change in egg intake and body weight during the 6-year follow up. For instance, at year 3, women whose intake had increased by 2.0 eggs/week had gained 0.70 kg (95%CI: 0.34, 1.07, p=.0002) more than women whose intake had decreased by 2.4 eggs/week, p-linear <.0001. Cholesterol-intake and choline-intake, but not betaine-intake, showed similar significant associations. Exploratory analysis revealed that: 1) women only demonstrated these significant associations if they exhibited higher intakes of “Western-pattern” foods including processed and red meats, French fries, sweets and deserts, sugar-sweetened beverages, fried foods, and dietary fat, and energy; and 2) there was a significant positive prospective association between PGS-BMI and body-weight change, but only in the top quintile of egg-intake change. ConclusionsWe found significant positive prospective associations between weight change and changes in egg intake, cholesterol intake, and choline intake among healthy postmenopausal women of European ancestry in the Women’s Health Initiative. Exploratory analyses revealed that: 1) these significant associations only obtained among women who ate large amounts of “Western-pattern” foods; and 2) women with a higher genetic susceptibility for an elevated BMI gained more weight only if they increased their egg intake considerably. Our results require confirmation.

Association between whole egg consumption and depression among older adults: Birjand Longitudinal Aging Study (BLAS)

BACKGROUND: Egg consumption may be associated with the risk of depression. OBJECTIVES: We aimed to assess this possible relationship in the context of the Birjand longitudinal aging study (BLAS). METHODS: In this cross-sectional study PHQ-9 was used to assess depression in a total of 1364 adults above 60 years of age, participating in the first stage of BLAS between September 2018 to April 2019. Socio-demographic information, anthropometric indices, and number of whole eggs consumed per week were assessed. Depression was assessed across the egg consumption groups: low (≤1 eggs/week), moderate (≥2 to ≤3 eggs/week), and high (≥4 eggs/week), and the association was investigated using logistic regression. RESULTS: Mean egg intake in the studied population was 2.4 eggs/week. In the crude model and after adjustment for age and sex, moderate and high egg consumption were both associated with lower risk of depression in older adults (P≤0.05). Adjustment for more confounding variables revealed that only moderate egg consumption protected against depression, while high egg consumers were still at risk of depression. CONCLUSION: Both moderate and high egg intake had reverse association with depression, and reduced the odds of depression among the elderly to approximately 30–40%. Future longitudinal studies could better confirm this association.

Demand and Nutrient Elasticities of Egg Consumption: Evidence from Saudi Arabia

Demand and Nutrient Elasticities of Egg Consumption: Evidence from Saudi Arabia

Historically Polluted Area Increases Human Exposure Risks to Polychlorinated Naphthalenes through Waterfowl Egg Consumption

Historically Polluted Area Increases Human Exposure Risks to Polychlorinated Naphthalenes through Waterfowl Egg Consumption

Comprehensive risk assessment of lead concentrations in chicken, quail, and duck egg albumen and yolk using Monte Carlo simulations

This study conducted a comparative analysis of the concentration of the lead (Pb) in the albumen and yolk of eggs from domesticated chicken, quail, and duck, with a concurrent assessment of the potential carcinogenic and non-carcinogenic risks associated with the consumption of eggs sourced from Türkiye. A total of 78 poultry egg samples were gathered from breeding farms and farmers' markets situated in Şanlıurfa province. Lead concentrations were assessed through inductively coupled plasma optical emission spectrometry (ICP-OES). Human health risk assessment adheres to the guidelines set forth by the United States Environmental Protection Agency (US EPA), which primarily emphasizes estimated daily intake (EDI), international lifetime cancer risk (ILCR), target hazard quotient (THQ), and Monte Carlo simulation (MCS) as a probabilistic approach. One-way analysis of variance (ANOVA) was employed to compare Pb concentrations within egg yolks and albumens, as well as among various types of eggs. The levels of Pb found in the albumen of chicken, quail, and duck eggs were measured to be 0.31 ± 0.11, 0.43 ± 0.11, and 0.47 ± 0.16 μg kg−1, respectively. The concentrations of Pb in the yolks of chicken, quail, and duck eggs were found to be 0.54 ± 0.19, 0.28 ± 0.11, and 0.69 ± 0.21 μg kg−1, respectively. These concentrations were below the maximum permitted levels set by the FAO/WHO. The results indicated that Pb content in all tested eggs was safe for consumption, with exposure levels significantly below Joint FAO/WHO Expert Committee on Food Additives (JECFA) risk thresholds. The THQ values were less than one, indicating no non-carcinogenic risk. In addition, this study provides accurate and reliable data for policy makers to improve food safety measures and reduce potential public health risks.

The effectiveness of biotin in therapy alopecia of various origins, pathologies of the skin and nails

Biotin deficiency is caused by inflammatory bowel diseases that impair the absorption of the vitamin, special dietary disorders with the consumption of raw eggs (excess avidin – a vitamin B7 blocker protein), magnesium deficiency, smoking, alcohol, treatment with broad-spectrum antibiotics, sulfonamides, and anticonvulsants. Hypovitaminosis B7 has also been noted in individuals with congenital genetic defects of the biotinidase gene or other genes involved in biotin metabolism. Deficiency of water-soluble vitamin B7 (vitamin H) – manifested by dry skin, seborrheic dermatitis, dermatitis around the eyes, nose, mouth, ears and groin, impaired nail growth, slow healing of skin cuts, atopic dermatitis, striations, splitting, brittle nails and alopecia (diffuse and androgenic form). Alopecia occurs when hair follicles die and leads to hair loss. The human proteome contains 51 proteins involved in biotin metabolism. In particular, D-biotin-dependent carboxylases play an important role in the metabolism of fatty acids, amino acids, carbohydrates, cell division and growth, incl. keratinocytes and hair follicle cells. The molecular mechanisms of the effects of D-biotin on the skin and its appendages may involve various growth factors: regulation of the signaling pathways of growth factors (IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt and beta-catenin) has been shown. Hair follicle stem cells cause the cyclical growth of hair follicles. Growth factors are involved in the activation of stem cell growth by D-biotin; activation of the Wnt/β-catenin signaling cascade leads to the activation of cyclin D1 proteins (initiates DNA synthesis and leads to increased viability of hair follicles. The results of fundamental and clinical studies confirm the prospects of using biotin in dermatology for the treatment of diseases of the skin, hair and nails, incl. alopecia of various origins (androgenic, focal, diffuse). The results of the studies indicated that biotin was well tolerated, and there was no risk of hypervitaminosis even when taking megadoses (hundreds of milligrams).

Asian Low-Carbohydrate Diet with Increased Whole Egg Consumption Improves Metabolic Outcomes in Metabolic Syndrome: A 52-Week Intervention Study

BackgroundThe low-carbohydrate-ketogenic diet, an effective strategy to address metabolic syndrome (MetS) and obesity has raised concerns about high-fat consumption on atherogenic lipoproteins. ObjectiveThe aim of this study was to compare the Asian ketogenic diet (AKD), which incorporates balanced protein and fat intake from Asian foods, with a balanced low-caloric diet (BLC) in individuals diagnosed with MetS. MethodsA 52-wk randomized clinical trial included 3 parallel groups: AKD with increased whole egg intake [egg yolk Asian ketogenic diet (Yolk-AKD, n = 28)], yolk-free ketogenic diet with egg white supplementation [egg white Asian ketogenic diet (White-AKD, n = 26)], and BLC (n = 22). Primary outcomes were anthropometric and metabolic changes. ResultsThe AKD groups achieved significant reductions in weight and waist circumference (P < 0.05). Compared with the BLC group, the AKD groups demonstrated significant improvements in insulin resistance at week 6 and in triglyceride concentrations at weeks 12 (Yolk-AKD) and 35 (White-AKD) (P < 0.05). The AKD groups experienced improvements in hormones associated with insulin sensitivity and appetite, whereas only the Yolk-AKD group had a significant decrease in inflammation-related hormones (P < 0.05). From weeks 35–52, the AKD maintained reductions in anthropometric measurements, blood pressure, improved glucose tolerance, enhanced lipid profiles, and better liver function compared with the BLC. ConclusionsThe AKD proved safe and effective, yielding various metabolic improvements in individuals with MetS compared with the BLC. Emphasizing a low-saturated fat diet while disregarding dietary cholesterol, this approach holds promise for MetS and obesity management. The inclusion of both White-AKD and Yolk-AKD groups allowed for a comprehensive assessment of the AKD's impact, elucidating the differential effects of whole egg consumption on metabolic outcomes. Further studies are warranted.This trial was registered at clinicaltrials.gov as NCT04608136.