The delicate control of effluent quality in wastewater engineering becomes imperative for fulfilling its role in protecting the ecological environment and promoting the water recycling. In this paper, an adaptive multivariable self-healing control strategy for the wastewater treatment process (WWTP) operating under complicated environments and facing abnormal conditions. The control goal is to meet the strict effluent standards of the WWTP and to optimize the abnormal conditions by analyzing the process operating status in the event of sudden sensor failures. Therein, a new residual-triggered threshold decision method is designed and integrated into a dynamical detection mechanism to identify such sensor failures. After locating the failures, a multivariable self-healing control scheme incorporating failure compensation information is activated to guarantee the process output tracking and improve the self-recovery capability of faulty performance in the WWTP. Extensive experiments are carried out on a standardized wastewater treatment platform, and the regulation results on the key component concentrations indicate that the proposed control scheme can ensure excellent control performance and reduce the impact of sensor failures.