Effluent Flow Rate Research Articles

Evaluation of Effluent Quality Trends Before and After Filtration Through the Composite Filter from Shirere Wastewater Treatment Plant to River Isiukhu in Kakamega County, Kenya

The current stabilization ponds as wastewater treatment practices in urban areas have proven insufficient with continued discharge of untreated wastes into water bodies. Their challenge comes from inappropriate system selection and maintenance, improper design, construction mistakes, physical damage and hydraulic overload. Appropriate infrastructural technologies for waste removal that can be adopted in the drainage channels of effluents into water bodies are scarce. This study incorporates a reactor based composite filter of pumice and sand as an innovative approach for removing residual waste in effluents discharged from Shirere Wastewater Treatment Plant into River Isiukhu, Kakamega Municipality. The objective of the study was to evaluate the trend of effluent quality from Shirere wastewater treatment plant upto river Isiukhu before and after installation of composite granular filter. Effluents, drinking water from Shirere WWTP, Shikoye stream, River Isiukhu and protected spring along Shikoye stream, were collected using presterilized water sampling containers for microbial quality analysis at MMUST and KACWASCO laboratories. The measurements were carried out using UV-VIS spectrophotometer at 752 nanometer wavelengths. Research design was experimental. The average reduction of COD in the mid-season of June to August was 42.2 ±4.6%, being the highest. Concomitantly, the BOD removal by the filter in the season of June to August was19.6±7% and 15.6 ±3.5% for September to November. The average rate of TSS removal in June to August was 19.3±4.5% followed by 16.6±3.8% in September to November and 11.6±7% in March to May. The average rate of Nitrate removal in June to August was 41.8±7.6% followed by 30.0±2.2% for March to May and 25±8.6% for September to November. Phosphates had an average rate of removal in June to August at 31.9±2.7% followed by 20.6±4.8% for September to November and 20.0 ±4.3% for March to May. Specifically, for the first season of March – May 2021 at 200 mm filtration depth were carried out at effluent flow rate of 0.0032 and volume, 0.234 Concentrations of most parameters were above NEMA standards, like COD was 322mg/l yet maximum should be 100 mg/l. Therefore, it was concluded that silica pumice composite filter performance was achieved by big variations in the concentrations of COD, BOD, TSS, Phosphates and Nitrates at Shirere WWTP after filtration which was attributed to effective removing capacity. The effluent concentrations from sampling sites S1-S3 and S5-S7 were found to be above the NEEMA standards implying the high risk of using Isiukhu water and catchment area. Thus, this study recommended that, the composite filter reduced concentrations of all the parameters (COD, BOD, TSS, PO3, NO3) significantly from Shirere WWTP along Shikoye stream up to the confluence of river Isiukhu. Most of the parameters after filtration were ranging within the required standards of NEMA. The requisite measure of adopting new technology of composite filtration should be sustained.

Edoxaban pharmacokinetics during in vitro continuous renal replacement therapy

BackgroundTo evaluate the clearance of edoxaban during modeled in vitro continuous renal replacement therapy (CRRT), assess protein binding and circuit adsorption, and provide initial dosing recommendations.MethodsEdoxaban was added to the CRRT circuit and serial pre-filter bovine blood samples were collected along with post-filter blood and effluent samples. All experiments were performed in duplicate using continuous veno-venous hemofiltration (CVVH) and hemodialysis (CVVHD) modes, with varying filter types, flow rates, and point of CVVH replacement fluid dilution. Concentrations of edoxaban and urea were quantified via liquid chromatography-tandem mass spectrometry. Plasma pharmacokinetic parameters for edoxaban were estimated via noncompartmental analysis. Two and three-way analysis of variance (ANOVA) models were built to assess the effects of mode, filter type, flow rate, and point of dilution on CLCRRT. Linear regression was utilized to provide dosing estimations across CRRT effluent flow rates from 0.5 to 5 L/h. Optimal edoxaban doses were suggested using CLCRRT and population non-renal clearance (CLNR) to estimate total clearance and match the systemic AUC associated with efficacy in the treatment of venous thromboembolism.ResultsEdoxaban clearance from the CRRT circuit occurred primarily via hemofilter adsorption to the HF1400 and M150 filters at 74% and 65%, respectively, while mean percent protein binding was 41%. Multivariate analyses confirmed the lack of influence of CRRT mode, filter type, and point of dilution on the CLCRRT of edoxaban allowing dosing recommendations to be made based on effluent flow rate. Edoxaban doses of 30-45 mg once daily were estimated to achieve target the AUC threshold for flow rates from 0.5 to 5 L/h.ConclusionFor CRRT flow rates most employed in clinical practice, an edoxaban dose of 45 mg once daily is predicted to achieve target systemic exposure thresholds for venous thromboembolism treatment. The safety and efficacy of this proposed dosing warrants further investigation in clinical studies.

Contribution of Adsorption and Hematocrit Levels to Ganciclovir Clearance in an in Vitro Continuous Hemodiafiltration Model.

Estimation of the continuous hemodiafiltration (CHDF) clearance (CLCHDF) of ganciclovir (GCV) is crucial for achieving efficient treatment outcomes. Here, we aimed to clarify the contribution of diafiltration, adsorption, and hematocrit level to the CLCHDF of GCV in an in vitro CHDF model using three membranes: polyacrylonitrile and sodium methallyl sulfonate copolymer coated with polyethylenimine (AN69ST); polymethylmethacrylate (PMMA); and polysulfone (PS). In vitro CHDF was performed with effluent flow rates (Qe) of 800, 1500, and 3000 mL/h. The initial GCV concentration was 10 µg/mL while that of human serum albumin (HSA) was 0 or 5 g/dL. The CLCHDF, diafiltration rates, and adsorption rates were calculated. The whole blood-to-plasma ratio (R) of GCV for a hematocrit of 0.1 to 0.5 was determined using blood samples with 0.5 to 100 µg/mL of GCV. The in vitro CHDF experiment using AN69ST, PMMA, and PS membranes showed that the total CLCHDF values were almost the same as the Qe and not influenced by the HSA concentration. The diafiltration rate exceeded 88.1 ± 2.8% while the adsorption rate was lower than 9.4 ± 9.4% in all conditions. The R value was 1.89 ± 0.11 and was similar at all hematocrit levels and GCV concentrations. In conclusion, diafiltration mainly contributes to the CLCHDF of GCV, rather than adsorption. Hematocrit levels might not affect the relationship between the plasma and blood CLCHDF of GCV, and the CLCHDF of GCV can be estimated from the Qe and R, at least in vitro.

Energy-saving analysis of desalination equipment based on a machine-learning sequence modeling

Abstract To control water quality and seawater desalination dosage, modeling the coagulation process of saltwater is crucial. With a focus on the features of seawater coagulation with a long lag, a machine-learning sequence-based modeling approach is suggested. The link between influent and effluent turbidities, flow rates, flocculant and coagulant dosages, and other parameters is modeled using structured units such as a gate recurrent unit encoder and a linear network decoder. The model’s validity is confirmed by numerical experiments based on real operating data, which also offer a solid foundation for managing flocculant and coagulant assistance reduction.

Removal of methylene blue and Congo red from the wastewater in a jet loop reactor using ozone and activated carbon

The textile industry consumes a large amount of fresh water, resulting in colored effluent due to the incomplete fixation of certain dyes. Traditional textile wastewater treatment such as coagulation-flocculation, membrane filtration, thermal separation and electrochemical processes are expensive and pose significant environmental challenges. To address these issues an alternative technique for decolorizing textile effluent using a modified sparged loop reactor was proposed in this study. The jet loop reactor basically a multiphase reactor was utilized to treat textile wastewater with ozone. In this study, the textile wastewater containing water-soluble basic dyes such as Methylene blue and Congo red was simulated at a concentration of 50 ppm and the color removal efficiency of the reactor was analyzed. The effect of process parameters such as effluent flow rate (0.2– 0.4 Liter/min), sparger openings (2−4), adsorbent weight (0.5 – 1.5 g) and ozone dosage time (10–30 min) on the decolorization efficiency of the reactor were examined and optimized using Response Surface Methodology. In this study, a maximum color removal of 93 % and 85 % for Congo red dye and Methylene blue dye simulated wastewater was achieved. A correlation was developed using Response Surface Methodology-Box Behnken Design and the developed model was successfully interpreted with experimental values. Based on our results, we believe that it is possible to replace the energy-intensive thermal separation process with jet loop sparged reactor to treat the textile effluent. As a sustainable process, loop reactor may result in a huge reduction of freshwater consumption.

Population Pharmacokinetic Modeling of Unbound Meropenem in Patients Undergoing Continuous Renal Replacement Therapy: An Observational Cohort Study.

The most effective dosing strategy of meropenem for patients undergoing continuous renal replacement therapy (CRRT) remains uncertain. This study aimed to analyze the population pharmacokinetics (popPKs) of unbound meropenem and establish an appropriate dosing approach. This prospective study involved 19 patients for the development of a popPK model and an additional 10 for its validation. Ethical approval was obtained. The clearance of unbound meropenem was influenced by the sequential organ failure assessment (SOFA) score [=2.22 × (SOFA score/12)^1.88] and the effluent flow rate from the CRRT device, with an interindividual variability of 44.5%. The volume of distribution was affected by the simplified acute physiology score II [=23.1 × (simplified acute physiology score II/52)^1.54]. Monte Carlo simulations suggested meropenem doses ranging from 1.0 to 3.0 g/d using continuous infusion to achieve a target time above the 4 times of minimum inhibitory concentration of the unbound form (% f T >4×MIC ) of 100% for definitive therapy. For empirical therapy, a dose of 1.0 g/d using continuous infusion was recommended to target % f T >MIC of 100%. This study developed a popPK model for unbound meropenem in patients undergoing CRRT and formulated dosing guidelines. UMIN000024321.

A New Dosing Frontier: Retrospective Assessment of Effluent Flow Rates and Residual Renal Function Among Critically Ill Patients Receiving Continuous Renal Replacement Therapy.

In 2020, cefiderocol became the first Food and Drug Administration-approved medication with continuous renal replacement therapy (CRRT) dosing recommendations based on effluent flow rates (QE). We aimed to evaluate the magnitude and frequency of factors that may influence these recommendations, that is, QE intrapatient variability and residual renal function. Retrospective observational cohort study. ICUs within Hartford Hospital (890-bed, acute-care hospital) in Connecticut from 2017 to 2023. Adult ICU patients receiving CRRT for greater than 72 hours. CRRT settings including QE and urine output (UOP) were extracted from the time of CRRT initiation (0 hr) and trends were assessed. To assess the impact on antibiotic dosing, cefiderocol doses were assigned to 0 hour, 24 hours, 48 hours, and 72 hours QE values per product label, and the proportion of antibiotic dose changes required as a result of changes in inpatient's QE was evaluated. Among the 380 ICU patients receiving CRRT for greater than 72 hours, the median (interquartile range) 0 hour QE was 2.96 (2.35-3.29) L/hr. Approximately 9 QE values were documented per patient per 24-hour window. QE changes of greater than 0.75 L/hr were observed in 21.6% of patients over the first 24 hours and in 7.9% (24-48 hr) and 5.8% (48-72 hr) of patients. Approximately 40% of patients had UOP greater than 500 mL at 24 hours post-CRRT initiation. Due to QE changes within 24 hours of CRRT initiation, a potential cefiderocol dose adjustment would have been warranted in 38% of patients (increase of 21.3%; decrease of 16.6%). QE changes were less common after 24 hours, warranting cefiderocol dose adjustments in less than 15% of patients. Results highlight the temporal and variable dynamics of QE and prevalence of residual renal function. Data also demonstrate a risk of antibiotic under-dosing in the first 24 hours of CRRT initiation due to increases in QE. For antibiotics with QE-based dosing recommendations, empiric dose escalation may be warranted in the first 24 hours of CRRT initiation.

Application of Ultra Fine Bubbles for Deoxygenation of Produced Water and Tap Water via Nitrogen Purging Scheme

In this study, we present our findings from examining a gas lift tower for produced and tap water de-oxygenation, applying the nitrogen purging at an ultra-fine bubble scale (18 μm average size). The experiments were conducted for produced water samples grafted with polyacrylamide concentration 300 ppm with a measured bulk viscosity of 5 mPa.s. Upon applying a series of experimental sets, 0 ppm DO was attained in all examined operational schemes (semi batch and once through) within various time limits, depending on the water level in the column. Considering the zero DO level as an objective function, the results showed an improvement of 5.7–14 folds in reaching the 0 ppm DO upon experimenting with the ultra-fine bubble purging in different schemes, compared with of the results obtained from the ordinary bubble size (mm scale). The results show that DO reached < 10 ppb within 23 minutes with nitrogen flowrate 3 L/min while DO reaching < 10 ppb within 28 minutes with nitrogen flowrate 5 L/min. Furthermore, implementing the ultra-fine bubble nitrogen purging was successful in running the de-oxygenation tower in a full continuous mode at a balanced inlet/outlet water flow rate. This has been done after reaching stability in the column operation (lasting around 1 hour for 422 L of examined water sample). The stable fine bubbles cloud in the column was quite efficient in treating water influent stream to be exited directly at 0 ppm DO within the same effluent flow rate. The treatment efficiency has shown an increase with increasing water level in the column, resulting in a denser layer/cloud of fine bubbles. This result suggests a unique approach/solution for the complete removal of DO from produced water, which is accounted effective to be adopted industrially

Investigation of Carbonate Matrix Damage and Remediation Methods for Preformed Particle Gel Conformance Control Treatments

Summary Preformed particle gels (PPGs) have been widely applied to control excessive water production in mature oil fields with fractures or fracture-like features, especially in sandstones, but with limited attention to carbonates. However, a vital concern arises regarding the potential damage of PPGs on the adjacent matrix that might promote negative results. This paper comprehensively evaluates PPGs’ potential damage to the carbonate matrix and seeks design optimization solutions. Filtration tests were applied to compare PPGs’ penetration into the matrix under different sets of conditions. The filtration regimes were defined by filtration curves, and the gel damage on the matrix was determined by permeability measurement results. Experiments were conducted to investigate the efficiency of an oxidizer as a remediation method to remove the damage. The qualitative description of gel particles’ invasion and plugging behavior in the carbonate matrix was presented based on the analysis of filtration test results and permeability measurements. The results show that the swollen gel filtration curves can be divided into three regions: prior-filter-cake, filter-cake-building, and stable stages according to the gel particles’ response to the injection pressure and effluent flow rates. PPGs can form cakes on the rock surface to prevent particles’ further penetration into the carbonate matrix, and the penetration was only limited to less than a few millimeters. The smallest gel particles (50–70 US mesh size) were more likely to form external and internal filter cakes at higher pressure values (700 psi) and result in more damage to the matrix. To restore the matrix permeability after filtration tests, oxidizer soaking proved to be a reliable solution. In all, the results indicated that unintentional matrix permeability damage induced by gel injection is generally unavoidable but conditionally treatable.

Utilization of phosphogypsum in phenol removal from coking wastewater

The paper presents the results of the application of raw phosphogypsum as an adsorbent for the preliminary treatment of coke-chemical wastewater with an initial concentration of phenol 395 mg/L. Studies in batch mode have proved that phenol removal is promoted by increasing the adsorbent dose and effluent temperature, the optimal phosphogypsum dose was found to be 5 g/L. The adsorption kinetics follows a pseudo-first-order model, the maximum adsorption capacity of phosphogypsum reaches 85 mg/g, which provides purification from phenol at the level of 85–90%. The process is spontaneous and endothermic. In column mode, at an effluent flow rate of 3 mL/min and the height of the fixed bed of 15 mm adsorbent dynamic capacity reached 124 mg/g. The obtained data indicate that raw phosphogypsum, available in huge quantities in the dumps of phosphoric acid plants, can be effectively used for the pretreatment of phenolic wastewater before biological treatment.

Tertiary treatment using ultrafiltration in an existing sewage treatment plant for industrial reuse: a modelling approach using artificial neural network with uncertainty estimation

Abstract Navi Mumbai Municipal Corporation of Maharashtra state, India, unified a tertiary treatment plant (TTP) of 20 × 103 m3/day capacity with ultrafiltration technology in an existing Koparkhairane sewage treatment plant (STP) for producing effluent quality usable for industrial purposes. As prior art, an artificial neural network-genetic algorithm (ANN-GA) along with uncertainty estimation using prediction interval is employed to model secondary treated effluent (STE) flow rate (QT) and other quality parameters such as biochemical oxygen demand, chemical oxygen demand, and total suspended solids (TSS) to conclude the reliability of the range in which the input available to TTP. ANN-GA model provides a coefficient of determination above 0.90 for all STE parameters modelled other than TSS. Inferring that a good quantity and quality of 20 × 103 m3/day STP treated water is currently available, where a decreasing trend of QT is also noticed and highlighted. Further, the Wilcoxon signed-rank test on the quality parameter of effluent TTP for industrial reuse standard infers TSS shows infringement during the initial period but started adhering to standards over time. The research delineates at the outset of exploring water reuse policy in India, emphasizing Maharashtra state, modelling STE using ANN-GA and performance evaluation of TTP.

A novel experimental set-up for generating microbubbles for the removal of inclusions from water and liquid metals

ABSTRACT To enhance steel cleanliness, extensive research has been conducted on bubble flotation techniques for inclusion removal. However, effective removal of nonmetallic inclusions smaller than 50 μm remains a challenge during standard liquid metal processing operations. These tiny inclusions have insufficient rising speeds to enable them to float out to the slag layer on their own. Several studies have demonstrated that the use of 500-μm bubbles would be necessary to facilitate the flotation of sub-50-μm inclusion particles from liquid steel within a tundish. Our approach to generating microbubbles in liquid metals uses liquid shearing flows. This method splits forming bubbles into smaller sizes by applying intense shear stresses. As a result, significantly larger surface areas are created, enhancing the interaction between the microbubbles and the inclusions. To test the effectiveness of this approach, a novel setup comprising submerged nozzles within a liquid metal was designed, manufactured, and operated. This setup allowed for experimentation with different rotational speeds and effluent gas flow rates, thereby determining the bubble sizes produced. Microbubbles within the desired size range (400–600 µm) were successfully generated in a Cerrolow 136 eutectic alloy.

Mucor cells passively immobilized on rose waste phyto-biomass: An eco-friendly hybrid material for the biotreatment of reactive dye contamination

The immobilization of microbial cells on eco-friendly supports is a promising technique to obtain effectively immobilized biomaterials for the biotreatment of aquatic pollution. For the biosorption of reactive dye-contaminated water, a new immobilized biosorbent, rose waste/Mucor plumbeus cells (RWMPC) composite was designed by immobilizing the fungal cells on a process waste of the rose oil industry. Batch and continuous mode biosorption features of RWMPC under different pH, initial dye concentration, contact time, biomaterial dose, and effluent flow rate conditions were examined. Zeta potential measurements, FT-IR, and SEM analysis were used to determine the morphological features of the biomaterial and possible Reactive Blue 49 (RB49)-biomaterial interactions. Kinetic investigations revealed that Ho's pseudo-second-order kinetic model could offer the best data fitting for biosorption, while the Freudlich model best matched the equilibrium data. Immobilized biomaterial displayed a high biosorption capacity of 120.88mg g−1. With an appropriate flow rate and amount of RWMPC packed into the column, dynamic treatment tests demonstrated >90% biosorption efficiency. The breakthrough curve of the RWMPC column adequately fits Chu's simplistic model. Regeneration tests revealed that after ten consecutive cycles, the biosorption yield and recovery efficacy of RWMPC were >65 and 85%, respectively. Zeta potential tests, SEM micrographs, and FT-IR studies also verified the dye uptake. Using synthetic wastewater in a continuous system, RWMPC could remove >90% of RB49. Breakthrough and exhaustion points were identified, and the maximum exhaustion capacity value was computed as 127.6 mg g−1. The results might inspire a fresh approach to the problem of reactive dye contamination in waters.

Treatment of oily wastewater by electrocoagulation: Simultaneous optimization of oil removal efficiency and specific energy consumption

Electrocoagulation (EC) is an effective process to treat oily wastewater. However, the optimal conditions required to design a continuous EC reactor are still unclear. In this study, an experimental and statistical investigation was performed on the factors affecting the design of a continuous EC reactor used for the removal of oily contaminants. By employing the response surface methodology (RSM), the oil removal efficiency and specific energy consumption (energy consumption per unit volume of treated wastewater) were modeled as a function of three factors, i.e. the current density (30–80 A/m2), the reactor residence time (10–30 min), and the ratio of the anode surface to the reactor volume (S/V ratio, 15–45 m2/m3). The statistical analysis of the experimental results unveiled the considerable impact of the effluent flow rate on the oil removal efficiency. Maximizing the oil removal efficiency and minimizing specific energy consumption were done simultaneously by combining them into an overall desirability function. The optimization results demonstrated that the energy required to treat a unit volume of the tested wastewater in an EC reactor is halved and the operating costs are reduced by 37 % at the cost of <2 % of the oil removal efficiency (from >99 % to 98 %) only by extending the residence time from about 16 to 28 min. The results of this research can pave the path to the development of an efficient and economical industrial EC unit used for the treatment of oily wastewater.

Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy.

Cefepime is an antibiotic commonly used to treat sepsis and is cleared by renal excretion. Cefepime dosing requires adjustment in patients with decreased kidney function and in those receiving continuous kidney replacement therapy (CKRT). We aimed to characterize cefepime PK in a diverse cohort of critically ill paediatric patients on CKRT. Patients were identified from an ongoing pharmacokinetic/pharmacodynamic (PK/PD) study of beta-lactam antibiotics, and were included if they had received at least two cefepime doses in the ICU and were on CKRT for at least 24 h. PK parameters were estimated using MwPharm++ with Bayesian estimation and a paediatric population PK model. Target attainment was assessed as time of free cefepime concentrations above minimum inhibitory concentration (fT > 1× or 4 × MIC). Seven patients were included in the study (ages 2 to 20 years). CKRT indications included liver failure (n = 1), renal failure (n = 4) and fluid overload (n = 2). Total effluent flow rates ranged from 1833 to 3115 (mean 2603) mL/1.73 m2/h, while clearance was 2.11-3.70 (mean 3.0) L/h/70 kg. Effluent flows were lower, but clearance and fT > MIC were similar to paediatric data published previously. Using Pseudomonas aeruginosa MIC breakpoints, all patients had 100% of dosing interval above MIC, but only one had 100% of dosing interval above 4× MIC. Since most patients failed to attain stringent targets of 100% fT > 4× MIC, model-informed precision dosing may benefit such patients.

Process simulation and techno-economic analysis of olive oil mill wastewater steam reforming

Olive oil production contributes to environmental deterioration, mainly due to the land spreading of the pollutant effluents. One solution to treat these liquid effluents (olive mill wastewater - OMWW) is the steam reforming (OMWWSR) reaction.In this work, the effects of the main parameters that affect the OMWWSR process were studied: composition of the effluent, total pressure, and temperature of the reformer; furthermore, several reactor configurations were simulated: traditional reactor (TR), autothermal reactor (ATR), sorption-enhanced reactor (SER), and sorption-enhanced autothermal reactor (SEATR). All reactor configurations treated an effluent flow rate of approximately 12 tons/h, which equals the quantity of OMWW produced by a big Portuguese olive oil producer company. In addition, energy integration and techno-economic analyses were elaborated to reveal which reactor configuration(s) presented the most attractive results. It was verified that the ATR and SER presented higher performances in terms of H2 production per kmol of OMWW fed and energy consumption per kmol of H2 produced. Finally, it was observed that the ATR achieved a net present value (NPV) that ranged from 7.2 to 9.2 M€ and payback times (PB) which ranged from 3 to 2 years. Regarding the SER configuration, the NPV and PB ranged from 4.7 to 12.2 M€ and 5-2 years, respectively.

Effective utilization of discarded reverse osmosis post-carbon for adsorption of dyes from wastewater

In this study, the deployment of post Reverse Osmosis (RO)-carbon as a adsorbent for dye removal from water has been investigated. The post RO-carbon was thermally activated (RO900), and the material thus obtained exhibited high surface area viz. 753 m2/g. In the batch system, the efficient Methylene Blue (MB) and Methyl Orange (MO) removal was obtained by using 0.08 g and 0.13 g/50 mL adsorbent dosage respectively. Moreover, 420 min was the optimized equilibration time for both the dyes. The maximum adsorption capacities of RO900 for MB and MO dyes were 223.29 and 158.14 mg/g, respectively. The comparatively higher MB adsorption was attributed to the electrostatic attraction between adsorbent and MB. The thermodynamic findings revealed the process as spontaneous, endothermic, and accompanied by entropy increment. Additionally, simulated effluent was treated, and >99% dye removal efficiency was achieved. To mimic an industrial perspective, MB adsorption onto RO900 was also carried out in continuous mode. The initial dye concentration and effluent flow rate were among the process parameters that were optimized using the continuous mode of operation. Further, the experimental data of continuous mode was fitted with Clark, Yan, and Yoon-Nelson models. Py-GC/MS investigation revealed that dye-loaded adsorbents could be pyrolyzed to produce valuable chemicals. The cost and low toxicity associated benefits of discarded RO-carbon over other adsorbents reveal the significance of the present study.

Transdermal Detection of MB-102 and Correlation to Meropenem Pharmacokinetics During Continuous Renal Replacement Therapy: In Vivo Results.

Critically ill patients undergoing continuous renal replacement therapy (CRRT) have medical conditions requiring extensive pharmacotherapy. Continuous renal replacement therapy impacts drug disposition. Few data exist regarding drug dosing requirements with contemporary CRRT modalities and effluent rates. The practical limitations of pharmacokinetic studies requiring numerous plasma and effluent samples, and lack of generalizability of observations from specific CRRT prescriptions, highlight gaps in bedside assessment of CRRT drug elimination and individualized dosing needs. We employed a porcine model using transdermal fluorescence detection of the glomerular filtration rate fluorescent tracer agent MB-102, with the aim to assess the relationship between systemic exposure of MB-102 and meropenem during CRRT. Animals underwent bilateral nephrectomies and received intravenous bolus doses of MB-102 and meropenem. Once MB-102 equilibrated in the animal, CRRT was initiated. Continuous renal replacement therapy prescriptions comprised four combinations of blood pump (low versus high) and effluent (low versus high) flow rates. Changes in transdermal detected MB-102 clearance occurred immediately with a change in CRRT rates. Blood side meropenem clearance mirrored transdermal MB-102 clearance (r2: 0.95-0.97, p value all <0.001). We suggest transdermal MB-102 clearance provides real-time personalized assessment of drug elimination and could optimize prescription of drugs for critically ill patients requiring CRRT.

Design of Optimized RP-HPLC Method for Quantitative Analysis of Bisoprolol Fumarate in Bulk and Pharmaceutical Dosage Form

In this study an effective method was developed to assay Bisoprolol fumarate in tablets dosage form. The chromatographic separation was achieved on Reprosil pure basic C18 analytical column. A mixture of acetonitrile + Potassium dihydrogen phosphate buffer (0.050 mol L-1) (30:70 V/V), pH 3.5 was used as the mobile phase, effluent flow rate monitored at 1.0 mL/min, and UV detection at 233 nm. In forced degradation studies, the effects of acid, base, oxidation, UV light and temperature which were investigated showed no interference in the peak of drug. The proposed method was validated in terms of specificity, linearity, robustness, precision and accuracy. The method was linear at concentrations ranging from 5µg/mL to 17.5µmg/mL, precise (intra- and inter-day relative standard deviations R.S.D. &lt; 2 %), (r2 = 0.9995).

Cefepime Dosing in a Critically Ill Neonate Receiving Continuous Renal Replacement Therapy With the Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM).

We report on a former 27-week gestational age infant who was placed on the Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM) at 4 months post-menstrual age while receiving cefepime treatment for an Enterobacter cloacae bacteremia and persistent peritonitis secondary to an infected peritoneal dialysis catheter. Using therapeutic drug monitoring while assessing the clearance of cefepime on continuous renal replacement therapy (CRRT), we were able to successfully treat this patient's infection while also minimizing the risk of side effects from this medication. Current literature supports dosing in adult patients on all modalities of CRRT with effluent flow rates of 20 to 25 mL/kg/hr; however, pharmacokinetic data on cefepime dosing in pediatric CRRT are scant. This case report describes the successful dosing strategy used for this patient while on various rates of continuous veno-venous hemodialysis with CARPEDIEM. Therapeutic drug monitoring of cefepime should be considered in critically ill pediatric patients on CARPEDIEM receiving CRRT.