Efficient Synthesis Of Nitriles Research Articles

An Efficient Synthesis of Nitriles from Aldoximes in the Presence of Trifluoromethanesulfonic Anhydride in Mild Conditions

A new and convenient protocol has been proposed for the transformation of aldoximes to nitriles using trifluoromethanesulfonic anhydride and triethylamine. The proposed method allows a range of aldoximes, including aromatic, heterocyclic, aliphatic, and cycloaliphatic aldoximes, to be converted to the corresponding nitriles in good to excellent yields.

A Novel and Efficient Synthesis of Nitriles from Aldehydes under Solvent‐Free Microwave Irradiation Conditions.

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A Novel and Efficient Synthesis of Nitriles from Aldehydes under Solvent-free Microwave Irradiation Conditions

Thus considerable efforts have been directedtowards developing efficient methods for the conversion ofaldehydes into corresponding nitriles. Among the numerousmethods to prepare nitriles, the dehydration of aldoximeshas been served as one of the most useful method. Conven-tional methods for the dehydration of aldoximes include theuse of reagent systems such as alumina/methanesulfonylchloride,

ZnO/CH3COCl: A New and Highly Efficient Catalyst for Dehydration of Aldoximes into Nitriles under Solvent‐Free Condition.

A rapid and efficient synthesis of nitriles via dehydration from the corresponding aldoximes has been carried out in the presence of ZnO/CH 3 COCl as catalyst under solvent free conditions in 83-95% yields. The zinc oxide (ZnO) powder can be re-used upto three times after simple washing with CH 2 Cl 2 .

ZnO/CH3COCl: A New and Highly Efficient Catalyst for Dehydration of Aldoximes into Nitriles Under Solvent-Free Condition

A rapid and efficient synthesis of nitriles via dehydration from the corresponding aldoximes has been carried out in the presence of ZnO/CH 3 COCl as catalyst under solvent free conditions in 83-95% yields. The zinc oxide (ZnO) powder can be re-used upto three times after simple washing with CH 2 Cl 2 .

Synthesis of Nitriles from Aldoximes Using Silica Gel as Catalyst under Microwave Irradiation.

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Synthesis of Nitriles from Aldoximes Using Silica Gel as Catalyst Under Microwave Irradiation

A rapid and efficient synthesis of nitriles via dehydration from the corresponding aldoximes has been carried out in the presence of Silica gel as catalyst under microwave irradiation in 83–95% yield.

ChemInform Abstract: TrocCl Mediated Efficient Synthesis of Nitriles from Primary Amides.

Abstract In order to establish a rapid conversion method of primary amides to nitriles, various types of carboxamides were treated with 2,2,2-trichloroethyl chloroformate and Et3N, as a dehydrating agent to obtain the desired nitriles in 82–95% yields.

TrocCl Mediated Efficient Synthesis of Nitriles from Primary Amides

In order to establish a rapid conversion method of primary amides to nitriles, various types of carboxamides were treated with 2,2,2-trichloroethyl chloroformate and Et3N, as a dehydrating agent to obtain the desired nitriles in 82–95% yields.

An efficient synthesis of nitriles from aldoximes

An efficient synthesis of nitriles from aldoximes