Efficient Catalyst For One-pot Research Articles

CrCl3•6H2O As an Environmentally Friendly and Efficient Catalyst for One-Pot, Synthesis of 2-oxo- and 2-thio-1,2,3,4-Tetrahydropyrimidines Under Solvent-Free Conditions

A one-pot, simple, and eco-friendly synthesis of 2-oxo- and 2-thio-1,2,3,4-tetrahydropyrimidines using a Biginelli condensation between β-keto esters (methyl or ethyl acetoacetate), aromatic benzaldehydes, and urea or thiourea in the presence of CrCl 3 ·6H 2 O as an environmentally friendly and mild catalyst under solvent-free conditions has been performed. Based on reaction of benzaldehyde (1.0 mmol), ethyl acetoacetate (1.0 mmol), and urea (1.5 mmol), as well as 15 mol% of CrCl 3 ·6H 2 O catalyst, the 82% yield was reached within 30 minute reaction time. The advantages of this methodology are solvent-free conditions, ease of handling, one-pot nature, low-cost, environmental friendliness, simple purification of products, and short reaction time. Normal 0 false false false EN-US X-NONE AR-SA

Hexamethylenetetramine as an Efficient Catalyst for One-Pot, Three Component Synthesis of 2-Amino-4H-Pyran Derivatives

Hexamethylenetetramine has been found to be an efficient catalyst for the preparation of 2-amino-4H-pyran derivatives in ethanol. The products were obtained with very good yields.

Meglumine: A Novel and Efficient Catalyst for One-Pot, Three-Component Combinatorial Synthesis of Functionalized 2-Amino-4H-pyrans

An efficient one-pot synthesis of functionalized 2-amino-4H-pyrans by a meglumine-catalyzed three-component reaction has been developed. A broad range of substrates including aromatic and heteroaromatic aldehydes, isatin derivatives, and acenaphthenequinone are condensed with enolizable C-H activated compounds and alkylmalonates to give the desired products in high to excellent yields. This methodology provides an alternative approach for rapid access to construct a diversity-oriented library of 4H-pyrans.

Sodium Dihydrogen Phosphate as an Efficient Catalyst for One-Pot, Three-Component Synthesis of α-Aminophosphonates Under Solvent-Free Conditions at Room Temperature

A simple, efficient, and general method has been developed for the one-pot, three-component synthesis of α-aminophosphonates from a condensation reaction of trimethyl phosphite, aldehydes, and amines in the presence of sodium dihydrogen phosphate under solvent-free conditions. Thus, α-aminophosphonates were synthesized relatively quickly in good yields at room temperature.

Trifluoroacetic Acid as an Efficient Catalyst for One-Pot, Four-Component Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Under Microwave-Assisted, Solvent-Free Conditions

An efficient method for synthesis of various tetrasubstituted imidazoles, using trifluoroacetic acid (TFA) as a catalytic support, by four-component condensation of benzil, aldehydes, amines, and ammonium acetate under microwave-irradiated, solvent-free conditions is described.