Nowadays, the efficiency of multiagent systems in wireless sensor networks prompts the researchers to use these emerging mobile software packets in different simulated approaches or real-world applications. Heterogeneous and distributed wireless sensor networks could be integrated with the multiagent systems to map the real-world challenges into the artificial intelligence world. The multiagent systems have been applied from simulated approaches like object detection/tracking, healthcare, control/assistant, and security systems to real-world applications, including medical/human-care systems and unmanned aerial vehicles. Furthermore, the integration of wireless sensor networks with multiagent systems have emerged novel application, which is known as mobile robots. However, the extensive use of mobile agents in wireless sensor networks has posed different challenges for researchers, including security, resource, and timing limitation. In this work, we review recent simulated approaches and real-world applications of multiagent systems in wireless sensor networks, in which a set of common factors about the things that have been studied are extracted and compared to analyze the performance of mobile agent–based systems in the wireless sensor networks, as well. This analysis provides new research directions about multiagent systems in wireless sensor networks for interested researchers. Finally, a novel framework for dealing with the challenges of multiagent-based applications in the wireless sensor networks which have been mentioned is suggested.