Cell Efficiency Research Articles

The Multifaceted Applications of Origami

Origami, a traditional Japanese art of paper folding, has evolved from art to the area of study with broad applications across various fields. The paper comprises the applications of origami in engineering, medicine and design. Applications like miura-ori foldings for telescopes , origami-inspired designs for stents and solutions for solar cell efficiency have helped various fields excel in their new findings. With growing popularity, come challenges which is what this paper deals with- Applications and challenges.

Overview of Recent Solar Photovoltaic Cooling System Approach

In recent years, research communities have shown significant interest in solar energy systems and their cooling. While using cells to generate power, cooling systems are often used for solar cells (SCs) to enhance their efficiency and lifespan. However, during this conversion process, they can generate heat. This heat can affect the performance of solar cells in both advantageous and detrimental ways. Cooling cells and coordinating their use are vital to energy efficiency and longevity, which can help save energy, reduce energy costs, and achieve global emission targets. The primary objective of this review is to provide a thorough and comparative analysis of recent developments in solar cell cooling. In addition, the research discussed here reviews and compares various cooling systems that can be used to improve cell performance, including active cooling and passive cooling. The outcomes reveal that phase-change materials (PCMs) help address critical economic goals, such as reducing the cost of PV degradation, while enhancing the lifespan of solar cells and improving their efficiency, reliability, and quality. Active PCMs offer precise control, while passive PCMs are simpler and more efficient in terms of energy use, but they offer less control over temperature. Moreover, an innovative review of advanced cooling methods is presented, highlighting their potential to improve the efficiency of solar cells.

Increase the efficiency of lead sulfide colloidal quantum dots solar cells by incorporating In2O3 and NiO interlayers

Substantial advancements have been made in PbS colloidal quantum dot solar cells (CQDSCs) by focusing on device architecture, manipulating band alignment, and refining the surface chemistry of colloidal quantum dots (CQDs). Nevertheless, creating an incredibly stable and efficient solar cell remains a challenging problem for researchers in this field. This study reveals that the efficiency of PbS CQDSCs can be improved by incorporating ultrathin In2O3 (between ITO electrode & indium-doped zinc oxide ETL) and NiO (between PbS-EDT HTL and Au electrode) nanocrystalline interlayers. The enhanced power conversion efficiency (PCE), which increases from 11.5 % to 13.6 %, is attributed to the improved surface smoothness and well-matched energy bandgap. Furthermore, following a heating period of 90 min at a temperature of 80 °C and 50 days of storage in the air, the solar cells containing these interlayers retained 98 % and 99 % of their initial efficiency, respectively. In distinction, the control device without these interlayers maintained only 85 % and 91 % of their initial efficiency under identical testing environments.

Optimizing efficiency in CHTS-based solar cells through controlling tin content of (Zn, Sn)O buffer layer and integration of SnS as back surface field layer: a numerical approach

Optimizing efficiency in CHTS-based solar cells through controlling tin content of (Zn, Sn)O buffer layer and integration of SnS as back surface field layer: a numerical approach

Enhancing Multi-Junction Solar Cell Performance: Advanced Predictive Modeling and Cutting-Edge CIGS Integration Techniques

Historically, multi-junction solar cells have evolved to capture a broader spectrum of sunlight, significantly enhancing efficiency beyond conventional solar technologies. In this study, we utilized Silvaco TCAD tools to optimize a five-junction solar cell composed of AlInP, AlGaInP, AlGaInAs, GaInP, GaAs, InGaAs, and Ge, drawing on advancements documented in the literature. Our research focused on optimizing these cells through sophisticated statistical modeling and material innovation, particularly examining the relationship between layer thickness and electrical yield under one sun illumination. Employing III-V tandem solar cells, renowned for their superior efficiency in converting sunlight to electricity, we applied advanced statistical models to a reference solar cell configured with predefined layer thicknesses. Our analysis revealed significant positive correlations between layer thickness and electrical performance, with correlation coefficients (R2 values) impressively ranging from 0.86 to 0.96 across different regions. This detailed statistical insight led to an improvement in overall cell efficiency to 44.2. A key innovation in our approach was replacing the traditional germanium (Ge) substrate with Copper Indium Gallium Selenide (CIGS), known for its adjustable bandgap and superior absorption of long-wavelength photons. This strategic modification not only broadened the absorption spectrum but also elevated the overall cell efficiency to 47%. Additionally, the optimization process involved simulations using predictive profilers and Silvaco Atlas tools, which systematically assessed various configurations for their spectral absorption and current–voltage characteristics, further enhancing the cell’s performance. These findings underscore the critical role of precise material engineering and sophisticated statistical analyses in advancing solar cell technology, setting new efficiency benchmarks, and driving further developments in the field.

Boosting the Efficiency of Perovskite/Organic Tandem Solar Cells via Enhanced Near-Infrared Absorption and Minimized Energy Losses.

The compatibility of perovskite and organic photovoltaic materials in solution processing provides a significant advantage in the fabrication of high-efficiency perovskite/organic tandem solar cells. However, additional recombination losses can occur during exciton dissociation in organic materials, leading to energy losses in the near-infrared region of tandem devices. Consequently, a ternary organic rear subcell is designed containing two narrow-bandgap non-fullerene acceptors to enhance the absorption of near-infrared light. Simultaneously, a unique diffusion-controlled growth technique is adopted to optimize the morphology of the ternary active layer, thereby improving exciton dissociation efficiency. This innovation not only broadens the absorption range of near-infrared light but also facilitates the generation and effective dissociation of excitons. Owing to these technological improvements, the power conversion efficiency (PCE) of organic solar cells increased to 19.2%. Furthermore, a wide-bandgap perovskite front subcell is integrated with a narrow-bandgap organic rear subcell to develop a perovskite/organic tandem solar cell. Owing to the reduction in near-infrared energy loss, the PCE of this tandem device significantly improved, reaching 24.5%.

Effect of a Polypropylene Separator with a Thin Electrospun Ceramic/Polymer Coating on the Thermal and Electrochemical Properties of Lithium-Ion Batteries

Lithium-ion batteries (LIBs) are well known for their energy efficiency and environmental benefits. However, increasing their energy density compromises their safety. This study introduces a novel ceramic-coated separator to enhance the performance and safety of LIBs. Electrospinning was used to apply a coating consisting of an alumina (Al2O3) ceramic and polyacrylic acid (PAA) binder to a polypropylene (PP) separator to significantly improve the mechanical properties of the PP separator and, ultimately, the electrochemical properties of the battery cell. Tests with 2032-coin cells showed that the efficiency of cells containing separators coated with 0.5 g PAA/Al2O3 was approximately 10.2% higher at high current rates (C-rates) compared to cells with the bare PP separator. Open circuit voltage (OCV) tests revealed superior thermal safety, with bare PP separators maintaining stability for 453 s, whereas the cells equipped with PP separators coated with 4 g PAA/Al2O3 remained stable for 937 s. The elongation increased from 88.3% (bare PP separator) to 129.1% (PP separator coated with 4 g PAA/Al2O3), and thermal shrinkage decreased from 58.2% to 34.9%. These findings suggest that ceramic/PAA-coated separators significantly contribute to enhancing the thermal safety and capacity retention of high-energy-density LIBs.

Estimation of power conversion efficiency up to 12% of nanocomposites of catechin and carboxylated graphene quantum dots doped/functionalised with boron as photosensitizers in DSSC applications

ABSTRACT The power conversion efficiency (PCE) of dye-sensitised solar cells (DSSCs) measures their solar energy conversion performance. With PCEs below 15%, significant energy loss occurs, leading researchers to seek improvements to reduce fossil fuel dependence and enhance DSSCs as an alternative energy source. However, predicting PCE theoretically is challenging due to its dependence on various parameters. In this work, the improved normal model was used to predict the PCE accurately using DFT and TD-DFT of four nanocomposites consisting of catechin natural compound attached to carboxylated graphene quantum dots (GQD) that have been further doped at the centre/edge and decorated with a boronic group. The nanocomposites have been adsorbed on a TiO2 cluster for PCE estimation. This is the first attempt of using decorated GQD with boronic groups in a DSSC and estimating its PCE. The results show that the PCE of catechin improved from 0.077% to the range of 3.96% – 12.61% (B1-CG-C@TiO2 – B2-CG-C@TiO2). This was due to the improved short-circuit current density ( J sc ) and fill factor (FF) of all the nanocomposites and the improved open-circuit voltage ( V oc ) of all nanocomposites except B1-CG-C@TiO2 in comparison to catechin. This means all the designed nanocomposites are more promising candidates than catechin. Highlights Adsorption at carboxyl group is the most stable site among hydroxyl and GQD base. The improved normal model gives accurate V oc results. All designed nanocomposites exhibited higher PCEs than isolated catechin. Edged doping exhibited the highest V oc , high J sc , and highest PCE of 12.61%.

An electro-thermal finite element method (FEM) model for local hotspot kinetics in Cu(In, Ga)Se2 thin-film solar modules

Partial shading can significantly impair the efficiency of thin-film solar cells. When exposed to partial shading, cells within the array tend to become reverse biased, leading to thermal runaway events and the emergence of hotspots. In Cu(In,Ga)Se2 (CIGS) solar cells such hotspots are also associated with so-called worm-like defects. Both theoretical and experimental studies have shown that in CIGS, a positive-feedback loop leads to instability and thermal runaway events. However, we observe an inconsistency between published simulation results and recently published experimental work. In a recent experimental study, it was shown that under certain conditions, a hotspot develops within 1ms, showing signs of melting of the CIGS in an area with a 5μm radius. However, in published simulation results, the time for such high temperatures to develop is in the order of seconds, a discrepancy of three orders of magnitude. In this work, we argue that this discrepancy is explained by the size of the seed defect, demonstrating that the origin of these experimentally observed, fast-developing hotspots is likely microscopic defects. To this end, we developed an electro-thermal finite element model, with very high temporal and spatial resolution. We demonstrate that, assuming a seed defect with a 10nm radius, we can reproduce the experimental results with respect to the size of the defect and the time it took to develop.

Alder-Ene Reaction-Mediated Suppression of Tin(II) Oxidation for Efficient Tin-Lead Perovskite Solar Cells.

Despite numerous studies have reported the inhibition of tin (II) oxidation in mixed tin-lead halide perovskite, there remains a dearth of mechanistic information regarding how tin (II) undergoes oxidation in the precursor solution, particularly in terms of the involvement of DMSO. We here take advantage of density functional theory (DFT) to uncover that SnI2 can coordinate with DMSO and react with singlet oxygen, resulting in the generation of Sn (IV). Moreover, our DFT simulations reveal that benzaldehyde oxime (BZHO) competes with SnI2 in reacting with oxygen through the Alder-ene reaction, hence effectively restraining the oxidation of tin (II), which is further verified by several experimental characterizations. Besides, the introduction of BZHO has also regulated the crystallization of the perovskite film and modified the electronic structure of the perovskite surface. As a result, the perovskite solar cells with the addition of BZHO demonstrate superior performance and operational stability, retaining 82% of the initial PCE under continuous 1-sun illumination for 800 hours. Furthermore, the efficiency of all-perovskite tandem solar cells treated with BZHO reached 26.76%. Therefore, this work presents a promising strategy for designing high-performance and stable all-perovskite tandem solar cells.

Tyrosinase-Woven Melanin Nets for Melanoma Therapy through Targeted Mitochondrial Tethering and Enhanced Photothermal Treatment.

Manipulating intracellular biological processes and organelles has emerged as a pivotal strategy to influence cellular physiological functions. Mitochondria, recognized as the powerhouse of cells, play a crucial role in tumorigenesis and progression. Inspired by the Nature's tyrosinase-catalyzed melanin formation within melanoma cells, here an approach is developed using a polysaccharide dually-functionalized with tyrosine and triphenylphosphine (TPP) for targeted mitochondria cross-linking in melanoma cells. This technique intricately weaves melanin nets within the cells, serving as a tether for the mitochondria and effectively decelerating tumor metabolism through nanoparticle-net transformation. Tyrosinase acts as the "needle", while the functionalized polysaccharide serves as the "string" successfully constructing nets within the cell. Furthermore, the tyrosinase-catalyzed cross-linking of tyrosine not only facilitates the production of artificial melanin but also enhances the photothermal conversion efficiency of melanoma cells, leading to decrease of the tumor growth. This study unveils a non-drug method for regulating organelle physiological activity and introduces photothermal treatment. This work not only sheds light on the manipulation of cellular functions but also holds promise for advancing cancer therapeutic strategies.

Boosting Microbial Fuel Cell Efficiency via Ultrasonic Pretreatment of Water Hyacinth Biomass

Boosting Microbial Fuel Cell Efficiency via Ultrasonic Pretreatment of Water Hyacinth Biomass

Design and numerical investigation of Cs2SnI6 vacancy-ordered double perovskite solar cell

Perovskite solar cells (PSCs) represent an emerging technology in solar photovoltaics due to their outstanding optical and electrical characteristics. The urgency of lead-free solar materials has increased due to the environmental concerns. In light of these considerations, Cs2SnI6, a high-performance tin-based double perovskite, holds the potential to be a key absorber material in promoting the cell efficiency. In this paper, a device design of lead-free Cs2SnI6-based PSC is proposed based on an n-i-p planar structure. Through a comprehensive analysis by simulation using SCAPS-1D, the impacts of electron transport layer materials (SnO2, TiO2, CdS, GO, MZO) and hole transport layer materials (MoO3, Cu2O, CuI, Spiro-OMeTAD) with varying thicknesses as well as the donor density, acceptor density and the absorber thickness have been examined. Additionally, an examination is conducted on the performance metrics of PSCs, encompassing Voc, Jsc, FF, and PCE, while taking into consideration the influences of temperature, Rseries, and Rshunt. The results show that the optimized FTO/SnO2/Cs2SnI6/MoO3/Au device presents the highest PCE of 22.60 % at 300 K temperature, together with a visible quantum efficiency of 99.49 %. The appropriate thicknesses of the ETL, HTL, and absorber layer for achieving the optimal performances are 50 nm, 200 nm, and 450 nm, respectively. Also, the donor density and acceptor density for the best efficiency are both at 1018 cm−3. The values of Rseries, and Rshunt are 2 Ω cm2 and 6000 Ω cm2, respectively. This investigation demonstrates that the proposed vacancy-ordered double perovskite Cs2SnI6 solar cell is promising for photovoltaic devices due to the highlighted characteristics and optical parameters.

Elimination of physiological senescent cutaneous cells in a novel p16-dependent senolytic mouse model impacts lipid metabolism in skin aging.

The evidence of the correlation between cellular senescence and aging has increased in research with animal models. These models have been intentionally generated to target and regulate cellular senescent cells with the promoter activity of p16Ink4a or p19Arf, genes that are highly expressed in aging cells. However, the senolytic efficiency in various organs and cells from these models represents unexpected variation and diversity in some cases. We have generated a novel knock-in model, p16tdT-hDTR mice, which possess tdTomato and human diphtheria toxin receptor (hDTR) downstream of Cdkn2a, an endogenous p16Ink4a gene. We successfully demonstrated that p16-derived tdTomato and hDTR expressions are observed in these mouse embryo fibroblasts and following treatment with diphtheria toxin (DT) eliminates those cells. Furthermore, we demonstrated the efficacy of eliminating p16-positive cells in vivo, and also observed a tendency to decrease their cutaneous SA-β-gal activity after subcutaneous DT injection into p16tdT-hDTR mice. In particular, comprehensive gene expression analysis in skin revealed that upregulated genes related to lipid metabolisms with aging exhibited remarkable expressions under the senolysis. These results clearly unveiled p16-positive senescent cells contribute to age-related changes in skin.

Enhancement of photovoltaic parameters of thermally stable graphene/LaVO3 semitransparent solar cell by employing interfacial graphene quantum dots.

Semitransparent solar cells are attracting attention not only for their visual effects but also for their ability to effectively utilize solar energy. Here, we demonstrate a translucent solar cell composed of bis(trifluoromethane sulfonyl)-amide (TFSA)-doped graphene (Gr), graphene quantum dots (GQDs), and LaVO3. By introducing a GQDs intermediate layer at the TFSA-Gr/LaVO3 interface, we can improve efficiency by preventing carrier recombination and promoting charge collection/separation in the device. As a result, the efficiency of the GQDs-based solar cell was 4.35%, which was higher than the 3.52% of the device without GQDs. Furthermore, the average visible transmittance of the device is 28%, making it suitable for translucent solar cells. The Al reflective mirror-based system improved the power conversion efficiency (PCE) by approximately 7% compared to a device without a mirror. Additionally, the thermal stability of the device remains at 90% even after 2000 h under an environment with a temperature of 60°C and 40% relative humidity. These results suggest that TFSA-Gr/GQDs/LaVO3-based cells have a high potential for practical use as a next-generation translucent solar energy power source.

Enhanced Performance and Stability of Perovskite Solar Cells Through Surface Modification with Benzocaine Hydrochloride.

Current development of inverted p-i-n perovskite solar cells (PSCs), with nickel oxide as the hole transport layer, is progressing toward lower net costs, higher efficiencies, and superior stabilities. Unfortunately, the high density of defect-based traps on the surface of perovskite films significantly limits the photoelectric conversion efficiency and operational stability of perovskite solar cells. Finding cost-effective interface modifiers is crucial for the further commercial development of p-i-n PSCs. In the present work, we report a passivation strategy using a multifunctional molecule, benzocaine hydrochloride (BHC), which is shown to reduce defect density and enhance the photovoltaic performance and stability of the resultant p-i-n PSCs. It has been revealed that BHC strongly interacts with perovskite precursor components and triggers the evolution of the perovskite absorber film morphology and enables improved surface energy level alignment, thus promoting charge carrier transport and extraction. These properties are beneficial for improving open-circuit voltage (VOC) and fill factor (FF). Our results show that the photoelectric conversion efficiency (PCE) of p-i-n PSCs with nickel oxide as the hole transport layer increased from an initial 20.0% to 22.1% after being passivated with BHC, and these passivated devices also exhibited improved stability. DFT calculations reveal the unusual ability of the BHC passivant to improve band alignment while also preventing the accumulation of holes at the interface. In this work, the advantages of BHC passivation are demonstrated by linking theoretical calculations with optical and electrical characterizations.

Construction of a Bifunctional Nanoelectrode for Intracellular Natural Product Delivery and Monitoring Anticancer Efficiency in Single Cells.

Natural products play a significant role in new drug discovery and anticancer therapy, making the evaluation of their anticancer efficiency crucial for clinical application. However, delivering natural products to single cells and in situ monitoring of induced signaling molecule fluctuation to evaluate anticancer efficiency remain significant challenges. Hence, we proposed a universal and straightforward strategy to construct a bifunctional nanoelectrode that integrates drug loading and monitoring of signal molecule fluctuations at the single-cell level. Platinum (Pt) nanoparticles/reduced graphene oxide (rGO) composites were first electrochemically deposited on the carbon fiber nanoelectrode (CFNE@Pt/rGO) to serve as electrocatalytic materials for the monitoring of natural-product-induced reactive oxygen species (ROS) generation. The GO/natural product complex, formed by π-π stacking and hydrophobic interactions, was further electrochemically reduced on the surface of CFNE@Pt/rGO to enable the CFNE drug-loading function. Using this bifunctional functional nanoelectrode, a series of natural products (such as capsaicin, curcumin, and chrysin) were delivered into single cancer cells, and their anticancer efficiency was evaluated by measuring ROS generation. The results showed that intracellular ROS production induced by chrysin was 1.5-fold greater than that of curcumin and 2.1-fold greater than that of capsaicin. This work proposes an effective tool to evaluate the anticancer efficiency of various natural products. Additionally, this nanotool can be expanded to monitor the fluctuation of other biomolecules (such as RNS, GSH, NADH, etc.) by replacing Pt nanoparticles with other electrocatalytic materials, which is significant for comprehensively exploring the anticancer efficiency of new drugs and for the clinical treatment of various diseases.

Achieving Closed-Loop Recycling of a Semi-Conjugated Polymer through Incorporation of Ester Linkers.

Design strategies to achieve degradation and ideally closed-loop recycling of organic semiconductors have attracted great interest in order to minimize the electronic waste (E-waste). In this work, three ester-incorporated monomers were synthesized by the names of Thiophene-Ester-Ethylene-Thiophene (TEET), Thiophene-Ester-Methylene-Thiophene (TEMT), and Thiophene-Ester-Thiophene (TET), which were co-polymerized via Stille polycondensation with a benzodithiophene (BnDT) pi-conjugated unit to yield a series of ester-incorporated polymers: PBnDT-TEET, PBnDT-TEMT, and PBnDT-TET. While the ester-only linker can maintain some extended conjugation in PBnDT-TET, the other two ester linkers having conjugation breaking units result in isolated conjugated segments in PBnDT-TEET and PBnDT-TEMT, evidenced by UV-Vis and CV results. This yields an improved photovoltaic performance of PBnDT-TET compared to PBnDT-TEET. While all three polymers can degrade under methanolysis, the alternating co-polymer PBnDT-TEET demonstrates the highest recyclability potential with a single dimethyl ester-functionalized product with an excellent 92% isolated yield, which can then be repolymerized to obtain the repolymerized PBnDT-TEET with a 36% yield. This work provides a framework towards achieving recyclable organic semiconductors to reduce E-waste. Although the incorporation of ester linkers allowed for closed-loop recycling, the low solar cell efficiency of PBnDT-TEET highlights the significant challenges in achieving both recycling and high device performance.

A Graded Redox Interfacial Modifier for High-Performance Perovskite Solar Cells.

Perovskite solar cells have emerged as a potential competitor to the silicon photovoltaic technology. The most representative perovskite cells employ SnO2 and spiro-OMeTAD as the charge-transport materials. Despite their high efficiencies, perovskite cells with such a configuration show unsatisfactory lifespan, normally attributed to the instability of perovskites and spiro-OMeTAD. Limited attention was paid to the influence of SnO2, an inorganic material, on device stability. Here we show that improving SnO2 with a redox interfacial modifier, cobalt hexammine sulfamate, simultaneously enhances the power-conversion efficiency (PCE) and stability of the perovskite solar cells. Redox reactions between the bivalent cobalt complexes and oxygen lead to the formation of a graded distribution of trivalent and bivalent cobalt complexes across the surface and bulk regions of the SnO2. The trivalent cobalt complex at the top surface of SnO2 raises the concentration of (SO3NH2)- which passivates uncoordinated Pb2+ and relieves tensile stress, facilitating the formation of perovskite with improved crystallinity. Our approach enables perovskite cells with PCEs of up to 24.91%. The devices retained 93.8% of their initial PCEs after 1000 hours of continuous operation under maximum power point tracking. These findings showcase the potential of cobalt complexes as redox interfacial modifiers for high-performance perovskite photovoltaics.

Abstract C046: Targeting wild-type IDH1 sensitizes homologous recombination proficient pancreatic cancer to PARP inhibition

Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in the United States. While Poly (ADP-ribose) polymerase (PARP) inhibitors show promise for PDAC with Homologous Recombination Deficiency (HRD), this mutation is present in less than 10% of cases. Our research focuses on exploiting a vulnerability in the remaining 90% of HR proficient (HRP) tumors. We identified that wild-type isocitrate dehydrogenase 1 (IDH1) plays a critical role in HR repair. By inhibiting IDH1, we discovered suppression of the homologous recombination (HR) pathway, leading to compromised genomic integrity. This renders cancer cells more susceptible to PARP inhibitor therapy, offering a novel therapeutic approach for HRP PDAC. Methods:We assessed the impact of IDH1 inhibition on HR pathway activity using Western blotting to measure HR repair protein levels and HR reporter assays. The effect of IDH1 inhibition (Ivosidenib) combined with PARP inhibition (Olaparib) on in vitro growth inhibition was assessed through drug combination assays. Additionally, we investigated the molecular mechanisms underlying the synergistic effects of the drug combination. To further evaluate the therapeutic potential of IDH1 inhibition in combination with PARP inhibitors, we examined tumor growth in xenograft models of PDAC in athymic nude mice and survival studies were performed in C57BL/6J mice transplanted with orthotopic murine pancreatic cancer. Results:Wild-type IDH1 blockade induces a BRCA-like phenotype by decreasing α-ketoglutarate (αKG) levels and causing histone hypermethylation. This leads to decreased HR repair efficiency in HRP pancreatic cancer cells (MiaPaCa-2 and Panc-1), resulting in a strong synergistic effect when combined with the DNA-damaging agent Olaparib. The combination treatment significantly reduced cell survival in both short and long-term assays. Furthermore, we discovered that these compounds complemented each other in the DNA damage response, leading to increased γ-H2AX (DNA damage marker) and apoptosis. In vivo studies using murine PDAC models demonstrated that the combination of ivosidenib and olaparib synergistically enhanced anti-tumor activity compared to either single agent alone. Conclusion:These data provide novel insight into the mechanisms underlying in the context of HRP cancer susceptibility to a dual treatment approach involving an IDH1 inhibitor and a PARP inhibitor. This approach holds promise for precision medicine in pancreatic cancer treatment, although further pre- clinical studies are needed for validation and refinement. Citation Format: Mehrdad Zarei, Omid Hajihassani, Hallie J. Graor, Soubhi Tahhan, Alexander W. Loftus, Faith Nakazzi, Semmer A. Ali, Parnian Naji, Luke D. Rothermel, Jonothan R. Brody, Jordan M. Winter. Targeting wild-type IDH1 sensitizes homologous recombination proficient pancreatic cancer to PARP inhibition [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research; 2024 Sep 15-18; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl_2):Abstract nr C046.