Efficacy Of Statins In Treatment Research Articles

Effect of atorvastatin on dyslipidemia and carotid intima-media thickness in children with refractory nephrotic syndrome: a randomized controlled trial.

Dyslipidemia is an important cardiovascular risk factor in steroid-resistant nephrotic syndrome (SRNS). Efficacy of statins for treatment of hyperlipidemia in children with SRNS is unclear. This prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial enrolled 30 patients with SRNS, aged 5-18years, with serum low-density lipoprotein cholesterol (LDL-C) levels between 130 and 300mg/dl, to receive a fixed dose of atorvastatin (n= 15, 10mg/d) or placebo (n= 15) by block randomization in a 1:1 ratio. Primary outcome was change in serum LDL-C at 12months. Change in levels of other lipid fractions, carotid intima-media thickness (cIMT), flow-mediated dilation (FMD) of the brachial artery, and adverse events were also evaluated. At the end of 12months, atorvastatin was not superior to placebo in reducing plasma LDL-C levels, median percentage reduction 15.8% and 9.5% respectively, in atorvastatin and placebo arms (n = 14 in each; P = 0.40). Apolipoprotein B levels significantly declined with atorvastatin in modified intention-to-treat analysis (P = 0.01) but not in the per-protocol analysis. There was no significant effect on other lipid fractions, cIMT and FMD. Adverse events were similar between groups. Change in serum albumin was negatively associated with change in serum LDL-C, very low-density lipoprotein cholesterol, total cholesterol, triglyceride, and apolipoprotein B (P < 0.001), irrespective of receiving atorvastatin, age, gender, body mass index, and serum creatinine. Atorvastatin, administered at a fixed daily dose of 10mg, was not beneficial in lowering lipid levels in children with SRNS; rise in serum albumin was associated with improvement in dyslipidemia.

The beneficial effects of statins and autoimmune diseases

Statins, HMG-CoA reductase inhibitors, are widely used for the treatment of hypercholesterolemia and the prevention of cardiovascular diseases. Recent experimental and clinical studies evaluated the effect of statins on immune and inflammatory cells, and the efficacy of statins in treatment of immune diseases. This review discusses the roles of statins in the treatment of immune and inflammatory diseases.