Efficacy Of Ropivacaine Research Articles

Pharmacological Insights of Ropivacaine and Clinical Applications: A Narrative Review.

This review focuses on ropivacaine, a long-acting amide local anaesthetic, detailing its pharmacology and clinical applications. The article highlights its applications in providing analgesia, prolonging pain relief, and improving recovery outcomes in surgical settings. Ropivacaine is particularly effective for epidural labor analgesia in obstetrics, promoting stable hemodynamics and rapid onset when used with adjuvants. Its prolonged anesthetic effects reduce the need for postoperative opioids in peripheral nerve blocks. Intrathecal administration may enhance functional recovery and postoperative analgesia in various surgical procedures. While effective in treating acute pain, its role in chronic pain management remains unclear, indicating a need for further research. The review underscores the versatility and efficacy of ropivacaine in acute pain management and the importance of exploring its potential in chronic pain treatment.

Efficacy of Ropivacaine in Conjunction with Dexmedetomidine on Postoperative Pain Relief and Sleep Quality in Laparoscopic Cholecystectomy

Efficacy of Ropivacaine in Conjunction with Dexmedetomidine on Postoperative Pain Relief and Sleep Quality in Laparoscopic Cholecystectomy

The Efficacy of Ropivacaine 0.5% in Transversus Abdominis Plane Block to Relieve the Postoperative Pain of Female Laparoscopic Surgery Grade II.

Background:The aim of this study was determination of the effect of the transversus abdominis plane block (TAP block) with ropivacaine 0.5% in relieving postoperative pain after laparoscopic gynecologic surgery.Materials and Methods:The population of the double-blinded clinical trial study included 200 women candidates for elective laparoscopic gynecologic surgery who referred to Al-Zahra and Beheshti hospitals in Isfahan during 2016–2018. In the TAP block group in addition to standard general anesthesia, an anesthetic drug Ropivacaine (Naropin, 0.5%) was injected at a dose of 0.5 mg/kg between transverse abdominal muscle and internal oblique muscle facia. And in control group just received standard general anesthesia. Hence, the severity of pain and nausea and vomiting is recorded at the time of recovery, at 30 min, 2, 4, 6, 12, and 48 h after the surgery.Results:The results of this study showed that in all periods of time (30 min, 2, 4, 6, 12, 24, 36, and 48 h after the surgery), mean pain score in TAP block group was lower than control group (P < 0.001). Hence that, in the 48 h after the surgery, the pain score in the TAP block group with a mean of 0.46 ± 0.50 was significantly lower than the control group with a mean of 1.06 ± 0.68 (P < 0.001). Nausea and vomiting between the two groups were no significant differences. There was no decrease in narcotic use or length of stay among those who received the TAP block.Conclusions:TAP block with ropivacaine 0.5% had a significant role in reducing postoperative pain of laparoscopic surgery.

Comparative study on efficacy of ropivacaine and bupivacaine for supraclavicular brachial plexus

Supraclavicular brachial plexus block is a very popular mode of anaesthesia for various upper limb surgeries, due to its effectiveness in terms of cost, performance, margin of safety and good post-operative analgesia. The study was a prospective randomized, double blind control study conducted on 60 patients aged 20 to 60 years, undergoing elective upper limb surgeries under supraclavicular brachial plexus block. Onset of sensory block between the two groups shows that onset of block is earlier in group B (Ropivacaine) with mean value of 11.93 min compared to group A(Bupivacaine) with a mean value of 14.33 min and is statistically significant. Onset of motor block is higher in Group A with mean value of 19.7 min compared to group B which has a mean value of 14.9 min and is statistically significant. Comparison of duration of block between the two groups shows that duration of sensory block is longer in group A with a mean value of 446.43 min compared to group B with a mean value of 420.37 min and is statistically significant. Duration of motor block is longer in group A with a mean value 406.97 min and is statistically significant.

Comparative analysis on efficacy of ropivacaine and bupivacaine for supraclavicular brachial plexus block: Randomized study

Comparative analysis on efficacy of ropivacaine and bupivacaine for supraclavicular brachial plexus block: Randomized study

Local Wound Infiltration with Ropivacaine for Postoperative Pain Control in Caesarean Section.

BackgroundThe rate of the caesarean section has been on a progressive rise ever since its association with improved fetal prognosis was established. This study was conducted to assess the effect of local wound infiltration with ropivacaine on the postoperative analgesia requirement and pain scores in caesarean section patients.MethodsThis was a prospective single-blinded randomized control trial conducted at the Department of Obstetrics and Gynecology, KRL Hospital, Islamabad, Pakistan over a duration of six months from January 2018 to June 2018. All the women aged 19 to 40 years, who underwent elective caesarean sections under spinal anesthesia, with American Society of Anesthesiologists (ASA) score II, were included in the study and randomized into two groups. The primary outcome studied was the efficacy of ropivacaine in controlling postoperative wound pain compared to no local analgesic. Pain severity was assessed using the visual analog scale (VAS) which was explained to the patient beforehand and which comprised a range of score from zero (no pain) to 10 (worst pain imaginable). Initially, paracetamol 1 g intravenous (IV) was given every six hours, over 24 hours. If pain did not settle on this, ketoprofen 3 mg/kg IV was given every eight hours, and in case of further analgesic demand by the patient, nalbuphine 10 mg was given IV, if necessary. The data was collected on a specific questionnaire and analyzed on the Statistical Package for Social Sciences (SPSS Inc., Chicago, IL) version 23.0. A p-value of less than 0.05 was considered significant.ResultsA total of 100 patients were randomized into two groups. Pain scores were significantly reduced in the ropivacaine group at four, six, and 12 hours after surgery. The percentage of patients who requested the multiple doses of IV paracetamol, ketoprofen, and nalbuphine, was significantly lowered in the ropivacaine group as compared to the placebo group (p<0.001).ConclusionsLocal infiltration with ropivacaine during caesarean section significantly reduces the postoperative analgesic requirement and visual analog scores, reducing the incidence of side effects.

Efficacy of Ropivacaine and Bupivacaine on Postoperative Analgesia through Epidural Route in Spine Surgeries- A Comparative Clinical Study

Efficacy of Ropivacaine and Bupivacaine on Postoperative Analgesia through Epidural Route in Spine Surgeries- A Comparative Clinical Study

To compare the efficacy of ropivacaine with fentanyl v/s levobupivacaine with fentanyl in post-operative epidural analgesia in lower limb and lower abdominal surgeries

Aims: To compare the efficacy of ropivacaine V/S levobuivacaine with fenatnyl as adjuvant for post operative analgesia in below umbilicus surgeries under combined spinal and epidural anaesthesia. Settings and Design: A prospective randomized double blind study was planned on 60 ASA grade I and II patients, admitted for elective surgeries. Materials and Methods: Patients were randomly divided into two Groups, Group I (n=30) received ropivacaine 0.1% (10ml of 0.2% ropivacaine) with 2µgm/ml of fentanyl (0.8 ml of fentanyl) & 9.2 ml of normal saline making a total volume of 20 ml, Group II (n=30) received 0.1% levobuivacaine (4 ml of 0.5% levobuivacaine) with 2µgm / ml of fentanyl (0.8 ml of fentanyl) & 15.2 ml of normal saline making a total volume of 20 ml. In both the groups, VAS score at different intervals of time, onset and duration of sensory block, and hemodynamic parameters and complications were assessed. Statistical Analysis Used: Data was expressed as either mean + standard deviation or numbers and percentages and analyses were performed using “Microsoft Excel 2007” for windows. The parameters were analyzed using Student’s Paired and Unpaired t-test. Results: The average duration of sensory block was 276±30.80 and 259±20.95 min for Group I and Group II respectively which were comparable for both Groups (p >0.05). The hemodynamic changes and complications have no significant differences between two groups, (p > 0.05). Conclusions: The combination of ropivacaine and levobupivacine with fentanyl as common adjuvant is equipotent for post-operative epidural anesthesia. Keywords: Ropivacaine, Levobupivacaine, Fentanyl, Epidural.

Comparison of the efficacy of ropivacaine and ropivacaine with dexmeditomidine in post tonsilectomy pain relief after peritonsillar infiltration- A prospective randomized double blind study

Introduction: Post operative pain relief is desired goal after tonsillectomy, infiltration of local anesthetic with or without adjuvant can reduce post tonsillectomy pain. Objective: To compare the postoperative analgesic efficacy and side-effects of peritonsillar-infiltration of ropivacaine with or without dexmeditomidine. Materials and Methods: Sixty patients aged 4-14 years posted for tonsillectomy under GA were randomly assigned in two groups of 30 each. In group R: Inj. ropivacaine (0.5%) 0.2ml/kg and in group RD: Inj.ropivacaine (0.5%) 0.2 ml/kg + Inj. dexmeditomidine 1mcg/kg were infiltrated in peritonsillar fossa post tonsillectomy. Patient were monitored for post-operative pain using VAS score, CHEOPS score and Wong baker pain rating scale at 30 minute, 1hr, 2hr, 4hr, 10 hr, 16hr and 24hr, pain on deglutination, time to first analgesic requirement, total dose of analgesics requirement in 24 hr postoperatively, amount of bleeding and parent’s satisfaction score. Results: VAS score, CHEOPS and Wong baker pain rating scale were comparable in both the groups at 30 min, 1hr, 2hr (P >0.05) but it was significantly low in group RD as compared to group R at 4hr, 10hr, 16hr and 24hr (P Conclusion: We concluded, peritonsillar infiltration of ropivacaine with or without dexmeditomidine is effective method for post-tonsillectomy pain relief. Addition of dexmeditomidine was found to prolong duration, decrease analgesic requirement and improve parent’s satisfaction score. Keywords: Tonsillectomy, Visual analog score, CHEOPS, Wong baker pain rating scale, Ropivacaine and dexmeditomidine.

Use of combined wound and intraperitoneal ropivacaine instillation in laparoscopic cholecystectomy for postoperative pain management: A prospective randomized study at a referral center in Northeast India

Background: Although laparoscopic cholecystectomy(LC) causes less postoperative pain than conventional laparotomy, still patients often suffer from considerable pain during early postoperative hours. In this study, efficacy of ropivacaine was studied in post-operative pain relief through peripheral local administration in patients undergoing LC. Aims and Objectives: The primary aim of the study is to evaluate the effect of intraperitoneal and local wound instillation of 0.75% Ropivacaine on post operative pain relief and duration of post-operative hospital stay in LC patients. Materials and Methods: This Prospective randomized Double blind clinical study was performed for 2 years on 190 patients. The primary endpoints of the study for the postoperative pain assessment were Visual Analog Scale (VAS) scores at 6 and 24 hours after LC and the amount of analgesics required in the postoperative period. These variables were compared between intervention and control groups. Results: The VAS score for pain abdomen in the intervention group (ropivacaine group) was significantly less, compared to the placebo group at 6 (P Conclusion: This study concludes that the combined intraperitoneal and local wound instillation of ropivacaine has a significant effect on the postoperative pain management in LC.

Efficacy of ropivacaine alone and ropivacaine with dexamethasone in supraclavicular brachial plexus block - A comparative study in north Karnataka population

Efficacy of ropivacaine alone and ropivacaine with dexamethasone in supraclavicular brachial plexus block - A comparative study in north Karnataka population

To Study and Compare Efficacy of Ropivacaine and Bupivacaine for Caudal Analgesia in Paediatric Patients

To Study and Compare Efficacy of Ropivacaine and Bupivacaine for Caudal Analgesia in Paediatric Patients

Comparative Effectiveness of Anesthetics Subtenon Injection in Phacoemulsification of Cataracts

Purpose. Currently cataract surgery is a high-tech procedure that is usually performed on an outpatient basis under local anesthesia. To perform anesthesia, novocaine, lidocaine, bupivokaine, and others are used. The recently published articles suggest a ropivacaine as a new anesthetic in ophthalmology. In connection with this, the purpose of the present paper was to study the efficacy of ropivacaine in subtenon anesthesia with Phaco.Patients and methods.We have examined 318 patients (318 eyes) with age-related cataracts, which have been operated by Phaco on the “Infinity” (“Alcon”) device using standard methods. During the operation, 156 patients have been under subtenon anesthesia by administering 1.5 ml of ropivacaine solution (0.75 mg/ml). 162 patients underwent subtenon anesthesia with 1.5 ml of a 1% solution of lidocaine. The distribution of patients by groups was carried out using a random number generator. Results.144 patients did not feel pain during the operation. Among them, most patients were anesthetized with ropivacaine (68%). Only 32% of patients operated with lidocaine anesthesia did not feel pain (p &lt; 0.05). Ropivacaine anesthesia had pain intensity averaged 2.1 ± 1.6 points, median 2 points (1–2), lidocaine –3.1 ± 1.5 points, median 3 points (2–4) (U = 4,714, p &lt; 0.001). The risk of pain syndrome when using lidocaine in comparison with ropivacaine is twice as high. We have found that the intensity of pain during Phaco surgery did not have gender and age differences. There was no dependence of the pain syndrome on the predominant type of cataract — cortical (n = 181) or nuclear (137) ((χ2 = 1.066, p = 0.302), as well as the cataract stage.

A Randomized Controlled Study to Compare the Efficacy of Ropivacaine and Bupivacaine in Spinal Anesthesia in Children

A Randomized Controlled Study to Compare the Efficacy of Ropivacaine and Bupivacaine in Spinal Anesthesia in Children

Compare the efficacy of ropivacaine and bupivacaine with fentanyl for epidural labor analgesia

Background: Attempts have been made to reduce or eliminate the pain associated with labor since ancient time. Obstetrics analgesia reached a new phase with lumbar epidural analgesia. We carried out a randomized study to evaluate and compare the analgesic efficacy of ropivacaine and bupivacaine with fentanyl on mother, on fetus and on the course of labor. Objectives: The aim of the present study was to evaluate and compare the analgesic efficacy of ropivacaine (0.125%) and bupivacaine (0.125%) with fentanyl on mother, fetus and on the course of labor, incidence of instrumental delivery, and the rate of cesarean section. Materials and Methods: Study was conducted in 60 term, primi or second gravida parturients with active phase of labor, with cervical dilatation 3-5 cm, with single fetus, vertex presentation belonging to American Society of Anesthesiology (ASA) Class I or II. The patients were randomly divided into two groups. After negative test dose, loading dose of 10 ml of 0.125% ropivacaine in Group R and 0.125% of bupivacaine in Group B with 2.5 μg/ml fentanyl in both groups was given as an initial dose for analgesia. Top up dose with 5 ml of 0.125% of ropivacaine in Group R and 0.125% bupivacaine in Group B were given when visual analog scale (VAS ≥3). For the second stage of labor 8 ml of 0.125% of ropivacaine in Group R and 0.125% of bupivacaine in Group B with 1.25 μg/ml fentanyl in both groups were given in sitting position to allow perineal analgesia. Results: In this study, we observed that maximum number of patients have developed sensory block up to T8, 50% in Group B and 53.3% in Group R, only 2 patients (6.7%) in Group B developed T6 level, and no patients in Group R. There was no significant difference in mean total dose of bupivacaine and ropivacaine (P > 0.05). In Group R total 22 patients and 3 in Group B developed Grade 0 motor blocked, which was statistically very significant. In Group B, 14 and 2 patients developed Grade 2 and Grade 3 motor blocked, respectively, compared to none of the patients in Group R which was statistically very significant. There was no significant difference in Apgar score and VAS scores between the groups at any time during the first and second stage of labor. Conclusions: Ropivacaine group patients required less number of top-up doses and developed significantly less motor block than bupivacaine group patients. We thus conclude that the combinations of 0.125% of ropivacaine with fentanyl and 0.125% bupivacaine with fentanyl is equally effective in producing excellent labor analgesia ensuring the safety of the mother and fetus.

Efficacy of dexmedetomidine mixed with ropivacaine for epidural anesthesia

Objective To evaluate the efficacy of dexmedetomidine mixed with ropivacaine for epidural anesthesia in the patients. Methods Forty-six patients, of ASA physical status Ⅰ or Ⅱ, aged 36–58 yr, weighing 48–77 kg, scheduled for elective hysterectomy under epidural anesthesia, were randomly divided into 2 groups(n=23 each)according to the random number table: normal saline + ropivacaine group(R group)and dexmedetomidine + ropivacaine group(DR group). Epidural anesthesia was performed at L2, 3 interspace.The catheter was inserted into the epidural space.A mixture of 0.75% ropivacaine 15 ml and dexmedetomidine 1 μg/kg was injected epidurally in DR group.A mixture of 0.75% ropivacaine 15 ml and normal sline 2 ml was injected epidurally in R group.The onset time of sensory block, maximum level of sensory block, and duration of sensory block were recorded.The modified Bromage scale, Ramsay sedation score and intraoperative traction reaction were assessed.The occurrence of dexmedetomidine-related cardiovascular events and respiratory depression, and epidural anesthesia-related adverse events within 2 h after operation was recorded. Results Compared with R group, the onset time of sensory block was significantly shortened, the duration of sensory block was prolonged, the maximum level of sensory block and Ramsay sedation score were increased, the degree of intraoperative traction reactions was lessened, and the incidence of shivering was decreased in DR group(P<0.05). No patients developed dexmedetomidine-related adverse events. Conclusion Epidural dexmedetomidine 1 μg/kg significantly optimize the efficacy of ropivacaine when used for epidural anesthesia in the patients. Key words: Dexmedetomidine; Amides; Anesthesia, epidural

Efficacy of ropivacaine by the concentration of 0.25%, 0.5%, and 0.75% on surgical performance, postoperative analgesia, and patient's satisfaction in inguinal hernioplasty: a randomized controlled trial.

BackgroundThe purpose of this study was to evaluate the use of different concentrations of ropivacaine in ultrasound-guided regional anesthesia with regard to postoperative analgesic and patient’s satisfaction in elderly patients undergoing inguinal hernioplasty in the People’s Republic of China.MethodsA total of 60 patients (>75 years of age) who scheduled inguinal hernioplasty at the Shenzhen People’s Hospital from December 2013 to March 2015 were randomly assigned to three groups: 0.25% ropivacaine (n=20), 0.5% ropivacaine (n=20), and 0.75% ropivacaine (n=20). Ultrasound-guided regional anesthesia was performed before every surgery. Non-invasive blood pressure and heart rate were recorded before the operation, during the first 5 minutes of the surgical procedure, and 5 minutes after the operation of the patients, and compared between the groups. Incidence of adverse reactions, postoperative Visual Analog Scale score, and analgesic effect were also recorded and analyzed.ResultsThe surgical procedure and anesthesia was performed successfully in all patients. Patients with high-dose ropivacaine (0.5% and 0.75%) in ultrasound-guided regional anesthesia exhibited lower arterial pressure and lower heart rate during the operation when compared to low-dose group. The interquartile range of Visual Analog Scale scores in both group C (0.75% ropivacaine) and group B (0.5% ropivacaine) were significantly lower (P<0.05) than in group A (0.25% ropivacaine). Accordingly, the interquartile range of satisfactory scores in both group C (0.75% ropivacaine) and group B (0.5% ropivacaine) were significantly higher (P<0.05) than in group A (0.25% ropivacaine). More cases in high-dose groups reported abnormal skin sensation; however, it did not negatively affect the satisfaction level of patients.ConclusionThe use of ultrasound-guided regional anesthesia with ropivacaine as an anesthetic in inguinal hernia repair for elderly patients is safe and effective, and ropivacaine is optimally effective at the concentration of 0.5% with least side effects.

Continuous wound infusion of ropivacaine for the control of pain after thoracolumbar spinal surgery: a randomized clinical trial

PurposeA prospective randomized clinical trial was carried out to observe the analgesic efficacy of ropivacaine for postoperative pain following thoracolumbar spinal surgery.MethodsSeventy-one patients with elective posterior thoracolumbar spinal surgery were randomly divided into two groups. Local group received 0.33 % ropivacaine by pump through the wound, and intravenous group received flurbiprofen axetil, pentazocine and palonosetron via intravenous pump. We evaluated the level of pain, the incidence of adverse reactions at 2, 4, 6, 12, 24, 36 and 48 h after operation, and the occurrence of chronic pain 3 months later.ResultsThere were no significant differences in the pain level between the two groups. However, the incidence of nausea, vomiting and chronic pain was significantly lower in the local group.ConclusionsOur results showed that local infusion of ropivacaine achieved similar analgesic effects to intravenous delivery of analgesic drugs, but significantly reduced incidence of nausea, vomiting and chronic pain.

English

English

Study of efficacy, safety and cardiotocographic changes during epidural analgesia with ropivacaine in labour

Background: Epidural analgesia during labour provides effective pain relief along with better maternal and neonatal outcome. Our aim of the study is to check safety and efficacy of Ropivacaine during labour analgesia. We have also compared cardiotocographic changes in labour with versus without epidural analgesia. Material & Methods: 60 Antenatal cases in between 37-41 weeks of pregnancy in active labour were selected for study. They were randomly divided into 2 groups: Study Group (Group-1): Patients who received epidural ropivacaine for pain relief. Control Group (Group-2): No analgesia was given for pain relief. Epidural catheter was inserted in study group. They were observed for degree of pain relief, requirement of analgesia, intrapartum cardiotocographic changes and maternal tolerability and safety in terms of side effects. They were also asked for their satisfaction towards epidural analgesia. Observation & Results: We have observed better intrapartum cardiotocographic findings with epidural analgesia. Degree of pain relief was also significantly better with epidural group. Requirement of Top-up doses and duration of rescue analgesia was better with epidural. No significant maternal or fetal side effects were noted with epidural. Patient satisfaction was definitely better with Epidural analgesia. Conclusion: Ropivacaine in epidural is safe and effective and efficacious with better cardiotocographic findings.