Efficacy Of Rectal Misoprostol Research Articles

A Comparative Study Between Preoperative Rectal Misoprostol and Intraoperative Intrauterine Administration in the Reduction of Blood Loss During and After Cesarean Delivery: A Randomized Controlled Trial

(Int J Gynaecol Obstet. 2021;153:113–118. doi: 10.1002/ijgo.13426) Cesarean delivery (CD) rates are on the rise worldwide, increasing the risk for postpartum hemorrhage (PPH; blood loss over 1000 mL). Though oxytocin is the recommended drug of choice to combat PPH, there are potential adverse side effects to using it. A combination of misoprostol and oxytocin has been shown to reduce operative and postoperative blood loss compared with oxytocin alone, and misoprostol has other beneficial factors such as low cost, availability, and thermal stability. This study aims to determine the safety and efficacy of rectal misoprostol before CD compared with intrauterine misoprostol during CD in reducing intraoperative and postoperative blood loss.

Efficacy of Rectal Misoprostol in Active Management of Third Stage of Labour in Comparison with Oxytocin

Background Third stage of labour is defined as the time from delivery the baby to complete delivery of the placenta and its attached membranes Most common complications of the third stage of labour are postpartum hemorrhage (PPH). Active management of third stage of labour (AMTL) prevents PPH. Misoprostol is a prostaglandin E1 analogue has been suggested as an alternative of the routine prophylactic oxytocic agents in AMTL. Rectal route had been chosen because it avoids gastrointestinal side effects Objectives: To asses effectiveness of (400 mcg) rectally administered misoprostol tablet in the AMTL in comparison with standard oxytocin regimen Patients and Methods In prospective case-control study, 100 women were randomized, 50 patients received either 400mcg misoprostol tablets rectally (study medication) the other 50 received 10 IU oxytocin in 500 ml Ringer lactate solution IV. As a method of AMTL. Patient with risk factor for PPH had been excluded. A comparison between the two groups in their amount of blood loss, drop in hemoglobin level from admission to 24 hr. after delivery, duration of third stage of labour and any side effects appear done Results Maximum amount of blood loss in both groups of the study was 440 ml, so we had no case of PPH. There was no stastically significant difference in mean blood loss, mean difference in Hb level (gm/dl) on admission and 24 hours after delivery, and duration of third stage of labour found between study groups [p values= 0.138, 0.227, 0.08 respectively]. More shivering occurs in cases but the difference was not significant. Conclusions: Misoprostol in a dose of 400 mcg rectally shows promising results, it seems safe and effective drug that can be used in the management of third stage of labour.

Compare the Efficacy of Rectal Misoprostol with Intravenous Oxytocin in Managing the third Stage of Labour

Compare the Efficacy of Rectal Misoprostol with Intravenous Oxytocin in Managing the third Stage of Labour

English

There are various methods have been described for preoperative cervical priming prior to vacuum aspiration (VA) in first trimester pregnancy termination, to facilitate cervical dilatation and shorten the abortion procedure. Recently, misoprostol has been globally the most investigated drug for medical abortion. Misoprostol is affordable, is easily stored at room temperature, and possesses a shelf life of several years. In our prospective interventional comparative study misoprostol (800µg) administered per vaginally was compared tomisoprostol (800µg) administered per rectally for first trimester termination of pregnancy and were observed for spontaneous expulsion of products of conception. The complete abortion rate was 62.86% in vaginal group in contrast to 20% in rectal group which was statically significant and majority of cases in rectal group had incomplete abortions. In vaginal group, patients with < 8 weeks gestational age aborted completely comparable to the patients with gestational age 8-12 weeks while in rectal group, patients< 8 weeks gestational age had aborted completely in contrast to the patients with gestational age 8-12 weeks which was significant statistically and hence the efficacy of rectal misoprostol was

Rectal misoprostol vs. vaginal misoprostol for first trimester termination of pregnancy

There are various methods have been described for preoperative cervical priming prior to vacuum aspiration (VA) in first trimester pregnancy termination, to facilitate cervical dilatation and shorten the abortion procedure. Recently, misoprostol has been globally the most investigated drug for medical abortion. Misoprostol is affordable, is easily stored at room temperature, and possesses a shelf life of several years. In our prospective interventional comparative study misoprostol (800µg) administered per vaginally was compared tomisoprostol (800µg) administered per rectally for first trimester termination of pregnancy and were observed for spontaneous expulsion of products of conception. The complete abortion rate was 62.86% in vaginal group in contrast to 20% in rectal group which was statically significant and majority of cases in rectal group had incomplete abortions. In vaginal group, patients with < 8 weeks gestational age aborted completely comparable to the patients with gestational age 8-12 weeks while in rectal group, patients< 8 weeks gestational age had aborted completely in contrast to the patients with gestational age 8-12 weeks which was significant statistically and hence the efficacy of rectal misoprostol was