Efficacy Of Peppermint Oil Research Articles

Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome.

Irritable bowel syndrome (IBS) is one of the most common disorders of gut-brain interaction, with a complex pathophysiology. Antispasmodics are prescribed as first-line therapy because of their action on gut dysmotility. In this regard, peppermint oil also has antispasmodic properties. To update our previous meta-analysis to assess efficacy and safety of peppermint oil, particularly as recent studies have cast doubt on its role in the treatment of IBS METHODS: We searched the medical literature up to 2nd April 2022 to identify randomised controlled trials (RCTs) of peppermint oil in IBS. Efficacy and safety were judged using dichotomous assessments of effect on global IBS symptoms or abdominal pain, and occurrence of any adverse event or of gastro-oesophageal reflux. Data were pooled using a random effects model, with efficacy and safety reported as pooled relative risks (RRs) with 95% confidence intervals (CIs). We identified 10 eligible RCTs (1030 patients). Peppermint oil was more efficacious than placebo for global IBS symptoms (RR of not improving=0.65; 95% CI 0.43-0.98, number needed to treat [NNT]=4; 95% CI 2.5-71), and abdominal pain (RR of abdominal pain not improving=0.76; 95% CI 0.62-0.93, NNT=7; 95% CI 4-24). Adverse event rates were significantly higher with peppermint oil (RR of any adverse event=1.57; 95% CI 1.04-2.37). Peppermint oil was superior to placebo for the treatment of IBS, but adverse events were more frequent, and quality of evidence was very low. Adequately powered RCTs of peppermint oil as first-line treatment for IBS are needed.

Recent meta-analysis on the efficacy of peppermint oil in irritable bowel syndrome

The meta-analysis demonstrated that peppermint oil is an effective and safe medicinal agent for treating the symptoms of irritable bowel syndrome. In seven clinical studies, peppermint oil was clearly superior to placebo in terms of the improvement in general symptoms of irritable bowel syndrome. In relation to side effects, no statistically significant difference was detectable between peppermint oil and placebo.

Recent meta-analysis on the efficacy of peppermint oil in irritable bowel syndrome

The meta-analysis demonstrated that peppermint oil is an effective and safe medicinal agent for treating the symptoms of irritable bowel syndrome. In seven clinical studies, peppermint oil was clearly superior to placebo in terms of the improvement in general symptoms of irritable bowel syndrome. In relation to side effects, no statistically significant difference was detectable between peppermint oil and placebo.

Using Essential Oils to Decrease Potato Tubers Sprouting, Rotting and Insect Infestations during Storage at Ambient Temperature

Two storage experiments were carried out at El-Mansoura Horticultural Research Station, Dakahalia Governorate, Egypt, during four months of storage in summer seasons of 2013 and 2014 for studying the effect of seven treatments, i.e,. natural essential oils and selecron on storability and quality of potato tubers and reduction percentages in the infestations potato tubers moth (PTM) under Nawwala condition. These treatments such as ; clove oil, garlic oil, lemonion oil, eucalyptus oil, peppermint oil, basil oil, mixture of these oils and selecron. The obtained results revealed that all storage treatments expect, selecron and control gave different significantly in all studied characters. Using peppermint and clove oils recorded the lowest significant values of sprouting percentage, sprout weight, sprout length and weight of loss percentage in both seasons. The highest values of dry matter %, starch% and vitamin C were recorded with peppermint oil, but the lowest sugar percentage was obtained by using the same treatment during two seasons. Results indicated that the effects of essential oils and selecron under storage in Nawwala conditions on Phthorimaea operculla (Zell.) (PTM), after four months of storage, the tubers infestation in control were (48- 48.67%), while the mean reduction percentages of infestation ranged between (94.10- 98.86% and 93.23- 96.84) during two seasons of 2013/2014 respectively. Peppermint oil, eucalyptus oil, clove oil and mixture oils gave highest mean reduction percentages of infestation such as selecron. Generally, the obtained data indicated that all used oils offered the highest protection. Also, the results in laboratory showed that the effects of oil treatments on larvae PTM recorded significantly variation according to the type of oil and time of exposure which showed fatal action on the larvae of PTM. The efficacy of Peppermint oil, Eucalyptus oil, clover oil and Mixer oils were the best. The percent of mortality ranged between (76.14 and 100%) compared with selecron. Also, all oils were used effected inhibitor action on adults. The inhibition of egg laying and reduction percentages ranged between were (47.54 %and 95.02 %) of peppermint oil and galaric oils, respectively. This study recommends that it can be sprayed peppermint oil concentration at (2 cm 3 / L / ton) three times during the storage of potato tubers in Nawwala for (4 months) in order to reduce the proportion of sprouting and weight loss and rotting and get a higher percentage of dry matter, starch and less injuries Pferashh (PTM) in tubers. Finally, it could be recommended with peppermint oil, eucalyptus oil, clove oil and mixer oils were the best during storage to obtain the best characters storage and quality. These natural treatments are very safe and potent in improving storability and greatly decreasing PTM insect infection during storage conditions in Nawwala on potato tubers.

Análise da eficácia do óleo de hortelã pimenta (Mentha piperita L.) na síndrome do intestino irritável: revisão baseada em evidência

Objective: To evaluate the efficacy of peppermint oil (Mentha piperita L.) on individuals diagnosed with irritable bowel syndrome (IBS) regarding symptom improvement and quality of life enhancement. Methods: Literature search was conducted according to evidence based on methodology review at Trip database, National Guideline Clearinghouse, Guidelines finder, Cochrane Library, Dare, Bandolier and Medline, as well as using the MeSH index terms “Irritable bowel syndrome” and “peppermint oil”. We selected practice guidelines, systematic reviews, meta-analysis and randomized controlled trials that evaluated peppermint oil (PO) efficacy in improving symptoms and/or quality of life when compared to placebo or other approved therapy for IBS. Results and Discussion: A total of eight articles were selected including five practice guidelines and three systematic reviews/ meta-analysis. Existing evidence suggests that there are enough data to support the use of peppermint oil in IBS for overall symptomatic relief, especially when abdominal pain is the dominant symptom, when compared to placebo (with an odds ratio of 2.7; CI 95%, 1.6 to 4.8 and NNT of 3). There is also evidence regarding overall quality of life improvement when using PO compared to placebo (p<0.001). Conclusion: So far, evidence suggests that PO should be considered for IBS patients, especially in the presence of abdominal pain (Strength of recommendation B). However, more high methodological quality studies that evaluate long-term efficacy and security of PO are needed.

Bioefficacy of Mentha piperita essential oil against dengue fever mosquito Aedes aegypti L

Objective To assess the larvicidal and repellent potential of the essential oil extracted from the leaves of peppermint plant, Mentha piperita ( M. piperita) against the larval and adult stages of Aedes aegypti ( Ae. Aegypti). Methods The larvicidal potential of peppermint oil was evaluated against early fourth instar larvae of Ae. aegypti using WHO protocol. The mortality counts were made after 24 and 48 h, and LC 50 and LC 90 values were calculated. The efficacy of peppermint oil as mosquito repellent was assessed using the human-bait technique. The measured area of one arm of a human volunteer was applied with the oil and the other arm was applied with ethanol. The mosquito bites on both the arms were recorded for 3 min after every 15 min. The experiment continued for 3 h and the percent protection was calculated. Results The essential oil extracted from M. piperita possessed excellent larvicidal efficiency against dengue vector. The bioassays showed an LC 50 and LC 90 value of 111.9 and 295.18 ppm, respectively after 24 h of exposure. The toxicity of the oil increased 11.8% when the larvae were exposed to the oil for 48 h. The remarkable repellent properties of M. piperita essential oil were established against adults Ae. aegypti. The application of oil resulted in 100% protection till 150 min. After next 30 min, only 1-2 bites were recorded as compared with 8-9 bites on the control arm. Conclusions The peppermint essential oil is proved to be efficient larvicide and repellent against dengue vector. Further studies are needed to identify the possible role of oil as adulticide, oviposition deterrent and ovicidal agent. The isolation of active ingredient from the oil could help in formulating strategies for mosquito control.

Efficacy of peppermint oil as an antispasmodic during endoscopic retrograde cholangiopancreatography

During endoscopic retrograde cholangiopancreatography (ERCP), hyoscine-N-butylbromide (Buscopan) or glucagon is used to inhibit duodenal motility. However, they may cause adverse effects. Peppermint oil has an antispasmodic effect and is used as a less hazardous antispasmodic during colonoscopy and upper gastrointestinal endoscopy. The purpose of the present paper was therefore to investigate peppermint as an antispasmodic for ERCP. Forty patients were enrolled prospectively. They were assigned to four groups according to the peppermint oil concentration and site of administration: group 1, 20 mL of 1.6% solution around duodenal papilla; group 2, 20 mL of 1.6% solution both to the antrum of the stomach and around the duodenal papilla; group 3, 20 mL of 3.2% solution around the duodenal papilla; and group 4, 3.2% solution both to the antrum and around the duodenal papilla. Glucagon or hyoscine-N-butylbromide was added when duodenal peristalsis was not adequately diminished. Sixteen patients undergoing ERCP with glucagon were employed as historical controls. The ERCP was attempted in all except one patient in group 2 who had bleeding from invaded tumor to the duodenum. Peppermint administration equally reduced duodenal motility in the groups. Duodenal movement was none or mild in 69.2% of patients. The ERCP was successfully performed with peppermint alone in 91.4% of patients (37/39). Glucagon or hyoscine-N-butylbromide was needed in one patient each in groups 1 and 4. Serious complications related to peppermint oil did not occur. Inhibitory effect of peppermint appears to be identical to that of glucagon. Duodenal relaxation was obtained with 20 mL of 1.6% peppermint oil solution in the duodenum, but additional administration may be required. Peppermint oil is useful as an antispasmodic agent for ERCP.

Current gut-directed therapies for irritable bowel syndrome

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that can present with a wide array of symptoms that make treatment difficult. Current therapies are directed at relieving symptoms of abdominal pain or discomfort, bloating, constipation, and diarrhea. Pharmacologic agents used to treat IBS-associated pain include myorelaxants, peppermint oil, and peripherally acting opiates. Dicyclomine and hyoscyamine, the two myorelaxants available in the United States, have not been proven effective in reducing abdominal pain in patients with IBS. The efficacy of peppermint oil is debated, but methodological problems with existing studies preclude definitive judgment. Loperamide is ineffective for relief of abdominal pain. For IBS patients with excessive abdominal bloating, a small number of studies suggest that bacterial eradication with gut-directed antibiotics and bacterial reconstitution with nonpathogenic probiotics may reduce flatulence. For constipation-predominant (C-IBS) symptoms, current treatment options include fiber supplementation, polyethylene glycol, and tegaserod. Soluble fibers (ispaghula, calcium polycarbophil, psyllium) are more effective than insoluble fibers (wheat bran, corn fiber) in alleviating global symptoms and relieving constipation, although fiber in general has marginal benefit in treatment of overall IBS symptoms. Polyethylene glycol increases bowel frequency in chronic constipation, but its overall efficacy against IBS is unclear. Tegaserod, a 5-HT(4) agonist, demonstrates superiority over placebo in improving bowel frequency and stool consistency and alleviating abdominal pain and bloating in women with C-IBS. Overall global symptoms are modestly improved with tegaserod when compared with placebo. Additional agents under investigation for C-IBS include the ClC(2) chloride channel opener lubiprostone, mu-opioid receptor antagonist alvimopan, and 5-HT(4) agonist renzapride. For diarrhea-predominant (D-IBS) symptoms, available therapies include loperamide, alosetron, and clonidine. Alosetron, a 5-HT(3) antagonist, is superior to placebo for reducing bowel frequency, improving stool consistency, and relieving abdominal pain in women with D-IBS. However, alosetron is available under a restricted license because of concerns for ischemic colitis and severe constipation necessitating colectomy. Clonidine may be helpful in alleviating global symptoms for D-IBS patients.