Aim: To synthesize the existing literature and determine the efficacy of occupational therapy intervention, startingin the neonatal intensive care unit (NICU), on the motor, cognitive, and behavioural outcomes of Indian infantsborn pre-term.Method: Databases were searched for randomized controlled trials, quasi-randomized controlled trials, pre andpost studies etc of occupational therapy early intervention for infants with a gestational age of less than 37 weeks,initiated in the NICU and delivered by a therapist or parent with therapist support. Quality was evaluated usingthe Cochrane standardized risk of bias assessment tool. Recommendations were made using the Grading ofRecommendations, Assessment, Development and Evaluations approach.Results: Ten studies met the inclusion criteria. Studies were categorized into four intervention categories: (1)nesting, positioning and diaper sizing; (2) multi-sensory stimulation; (3) KMC (skin to skin care) (4) oral-motorintervention. Risk of bias varied from low to high or was unclear.Interpretation: Preliminary support indicates that occupational therapy improves motor and cognitive outcomesin the short-term and possibly long-term. Occupational therapy intervention programmes for pre-term infantshave a positive influence on cognitive and motor outcomes during infancy. A great deal of heterogeneity betweenstudies was due to the variety of early developmental intervention programmes tested and to gestational agesof included pre-term infants; thus, comparisons of intervention programmes were limited. Further research isneeded to determine which early developmental interventions are most effective in improving cognitive andmotor outcomes, and to discern the longer-term effects of these programmes.