BackgroundPleural empyema can be subdivided into 3 stages: exudative, multiloculated, and organizing. In the absence of clear septation, antibiotics plus simple drainage of pleural fluid is often sufficient treatment, whereas clear septation often requires more invasive treatment. Aim of studyTo evaluate the safety and efficacy of medical thoracoscopy in the management of loculated thoracic empyema. MethodsThis study was conducted at chest department, Al-Azhar Faculty of medicine Al-Housein University Hospital in the period from October 2015 to August 2016. On 30 patients, 22 males and 8 females with age ranging between 20 and 74years (mean age 48.3±15.5years). Diagnosed as loculated thoracic empyema (27 patients) or empyema failed to respond to medical treatment or chest tube drainage (3 patients) were undergo medical thoracoscopy. ResultsA total of 30 patients with loculated empyema were managed by medical thoracoscopy. Histopathological finding of study sample were (Non-specific inflammation 23.3%, Suppurative exudative reaction 16.7%, Tuberculous caseating granuloma 23.3%, Lymphocytic Inflammation 6.7%, fibrino purulent inflammation 13.3%, adenocarcinoma 3.3, Pleural fibrosis and thickening 10% and Pleural calcification, ossification, pleurisy 3.3%). Medical thoracoscopy was considered successful without further intervention in 26 of 30 patients (86.7%), 3 patients (10%) clinically improved but lung did not expanded and referred for thoracic surgery for decortication and 1 patient (3.3%) need for surgery to fistula closure. ConclusionsOur study confirms that loculated pleural empyema could safely and successfully be treated by medical thoracoscopy.