Efficacy Of High-intensity Laser Therapy Research Articles

Efficacy of High-intensity laser therapy in patients with temporomandibular joint disorders: A systematic review and meta-analysis.

This study aimed to assess the effects of High-intensity laser therapy (HILT) on individuals suffering from temporomandibular joint disorders (TMDs). A search was conducted across six electronic databases for randomized controlled trials (RCTs) focusing on HILT for TMDs: PubMed, Scopus, Web of Science, ScienceDirect, EBSCOhost, Cochrane Library, the PEDro database and Google Scholar (last updated on July 18, 2024). Eligible studies were chosen by independent reviewers, and their quality was assessed with the Cochrane risk of bias tool (RoB). The main outcome was pain intensity (VAS), with secondary outcomes including mouth opening (mm), disability (JFLS-20), and quality of life (OHIP-14). A meta-analysis was conducted to assess the pooled effect by calculating mean differences (MD) for these variables (95% confidence level). The heterogeneity of the meta-analyses was explored using the I2 statistic. Three studies met the selection criteria and were included in the meta-analysis. The main RoB was the blinding of participant and treaters. Statistically significant differences (p < 0.05) in favor of HILT were observed for VAS and maximum mouth opening. The pooled effect showed an MD of -14.8mm (95% CI:-27.1,-2.5) for pain intensity and 3.7mm (95% CI:0.9,6.5) for mouth opening, changes that were assessed as clinically important. According to GRADE, the evidence was rated as important, and the certainty was moderate due to the heterogeneity between studies. A sensitivity analysis was not performed to address heterogeneity, primarily due to the limited availability of RCTs. HILT has been found effective in short-term pain relief and improvement of jaw opening in TMDs, potentially enhancing quality of life by facilitating activities such as chewing, jaw mobility, and communication. However, further research is needed to confirm its long-term effectiveness. Combining HILT with interventions such as occlusal splints or therapeutic exercises could potentially enhance its effects, leveraging the existing evidence supporting these treatments. It is important to note that the high RoB associated with the lack of blinding of participants and treaters may influence data collection, compromising the internal validity of findings in some studies.

The efficacy of high-intensity laser therapy in wound healing: a narrative review.

The efficacy of high-intensity laser therapy in wound healing: a narrative review.

Effect of High-Intensity Laser Therapy on Carpal Tunnel Syndrome Patients: A Systematic Review and Meta-analysis.

To provide a strong foundation for the use of high-intensity laser therapy in carpel tunnel syndrome, we conducted a systematic review and meta-analysis to investigate the outcomes of short- and long-term follow-up studies. This is a systematic review and meta-analysis. Sample sizes of included studies ranged from 16 to 98 patients ( N = 308). Overall, a significant difference between the treatment and control groups were found across majority of the measures. Studies using a 4-wk follow-up period, however, only found significantly greater benefits for high-intensity laser therapy in visual analog scale compared with placebo ( P = 0.0191), transcutaneous electrical nerve stimulation ( P = 0.0026), and low-intensity laser therapy 20 J/cm 2 ( P < 0.0002), and exercise ( P < 0.0001). For improvement in visual analog scale score over a long treatment period, high-intensity laser therapy was also preferred over control group ( P < 0.0071). Insufficient evidence exists to determine effect of high-intensity laser therapy on nerve conduction examinations. The only statistically significant differences observed in examinations were in relation to sensory nerve action potential ( P = 0.0083) and sensory nerve conduction velocity ( P = 0.0468). Moderate evidence exists regarding efficacy of high-intensity laser therapy compared with placebo, high-intensity laser therapy + wrist splint, and exercise in a short period of follow-up time but evidence on long-term follow-up is limited.

The efficacy of high-intensity laser therapy in low back pain: A critical appraisal.

The current narrative review was planned to identify the most likely factors that influence the diversity of the findings among clinical studies that investigate the use of high-intensity laser therapy in treating low-back pain. It also planned to provide recommendations with respect to the methodological drawbacks identified in literature. An extensive literature search of clinical and randomised, controlled trials was conducted using Embase, MEDLINE, Cinahl databases and the Cochrane Controlled Trial Register as well as a search by hand. The search yielded only six studies that could be critically reviewed. This limited number of studies exhibited different treatment approaches, parameters, blinding procedures, symptom durations, irradiated areas and testing occasions. The studies assessing the efficacy of high-intensity laser therapy in treating low-back pain showed controversial findings, which may be due to diversity in treatment parameters, approaches, symptom duration, blinding and / or randomisation procedures and testing occasions.

Clinical Efficacy of High-Intensity Laser Therapy on Lateral Epicondylitis Patients: A Systematic Review and Meta-analysis.

Recently, high-intensity laser therapy has been used in the therapeutic protocols for pain management. We aimed to evaluate the clinical efficacy of high-intensity laser therapy versus other different modalities for improving lateral epicondylitis symptoms. We conducted a systematic review and meta-analysis on prospective randomized controlled trials from PubMed, Embase, Scopus, Web of Science, and Science Direct until June 2021 using relevant key words. We analyzed the data using Review Manager software (RevMan 5.4). Six randomized controlled trials with 344 patients were included. There is low-quality evidence that high-intensity laser therapy generates a small reduction on pain intensity compared with a control group either during activity (mean difference = -0.98, 95% confidence interval = -1.6 to -0.35, P = 0.002) or during rest (mean difference = -0.98, 95% confidence interval = -1.68 to -0.09, P = 0.03). In addition, there is low-quality evidence that high-intensity laser therapy provides small improvements in quality of life (physical component) compared with control (mean difference = 9.76, 95% confidence interval = 2.69 to 16.83, P < 0.0001). High-intensity laser therapy is an effective therapeutic modality to reduce pain and improve quality of life (36-item short form health survey physical component) in patients experiencing persistent symptoms of lateral epicondylitis. However, grip strength, hand function, and quality of life (36-item short form health survey) did not show significant differences between high-intensity laser therapy and other therapies.

Efficacy of high-intensity laser therapy on mechanically induced sciatic nerve injury in Wister rats

Background: Traumatic nerve injury (TNI) is a common source of motor disability. Early application of low-level laser therapy promotes the regeneration of nerves in TNI with a lack of evidence of high-intensity laser therapy (HILT) on nerve regeneration. Aim: The purpose of the study was to evaluate the efficacy of HILT in the treatment of mechanically induced sciatic nerve injury in Wister rats.

The effectiveness of high-intensity laser therapy in the treatment of post-stroke patients with hemiplegic shoulder pain: a prospective randomized controlled study.

To evaluate clinical and ultrasonographic efficacy of high-intensity laser therapy (HILT) in patients with hemiplegic shoulder pain (HSP) accompanied by partial thickness rotator cuff tear (PTRCT). The study was designed as a prospective, randomized, controlled trial. Patients with HSP accompanied by PTRCT (n = 44) were randomly assigned to HILT and control groups. Both groups were treated with a multidisciplinary stroke rehabilitation and a therapeutic exercise program to the affected shoulder supervised by physiotherapists. In addition, HILT group received 3 sessions of the intervention per week for 3 weeks. Primary outcome measure was visual analogue scale (VAS) for pain. Secondary outcome measures were range of motion (ROM) of the shoulder joint, Shoulder Pain and Disability Index (SPADI), Brunnstrom Recovery Stage (BRS), Modified Ashworth Scale (MAS), Nottingham Health Profile (NHP), Functional Independence Measure (FIM), and ultrasonographic PTRCT size. Participants were assessed at pre- and post-treatment. A total of 41 patients completed the study. A statistically significant improvement was observed in VAS, ROM, FIM, SPADI, NHP, and PTRCT parameters in HILT group at post-treatment compared to pre-treatment (all P < 0.05). However, control group indicated significant improvement only in VAS, ROM, and SPADI parameters (all P < 0.05). When differences in clinical parameters at pre- and post-treatment assessment were compared between two groups, change in VAS, FIM, BRS, SPADI, NHP, and PTRCT in HILT group was significantly better than control group (all P < 0.05). HILT combined with therapeutic exercise seems to be clinically and ultrasonographically more effective in the treatment of patients with HSP accompanied by PTRCT than therapeutic exercise alone in the short term. Further studies are needed with long-term follow-up. CinicalTrials.gov Identifier: NCT04669405.

Efficacy of high-intensity laser therapy in patients with adhesive capsulitis: a sham-controlled randomized controlled trial.

Adhesive capsulitis is an idiopathic condition characterized by painful shoulder stiffness, impairs quality of life, and causes disability. The purpose of the study is to evaluate the effects of high-intensity laser therapy (HILT) on pain, disability, and quality of life in patients with adhesive capsulitis. The study was designed as a prospective, double-blinded, and sham-controlled randomized trial. Thirty-six patients diagnosed with adhesive capsulitis were randomized into HILT plus therapeutic exercises, sham-laser plus therapeutic exercises, and control-therapeutic exercises only groups. All groups received 25min of exercises to the shoulder joint supervised by a physiotherapist. Patients in both the HILT and the sham-laser group were blinded to their group randomization. The interventions were performed five times a week for 3weeks (a total of 15 sessions). The primary outcome measure was the visual analogue scale for pain (Visual Analog Scale for pain (VAS)-pain). The secondary outcome measures were shoulder pain and disability index (SPADI), short-form health survey-36 (SF-36), and range of motion (ROM) of the shoulder joint. Assessments were performed at pre-intervention, post-intervention, and 12-week follow-up by an investigator who was blinded. Thirty-one participants completed the study. HILT plus therapeutic exercises showed significant differences in VAS-pain, SPADI-pain, and SF-36 (subgroups of energy/fatigue, pain, and general health) scores (all P < 0.05). All groups provided comparable improvements in SPADI-disability and ROM of shoulder joint after the interventions and during the follow-up (all P < 0.05). Fifteen sessions of HILT are superior to improve pain and quality of life but not superior in terms of disability or function in patients with adhesive capsulitis. Clinical trial registration number: The study was registered at the US National Institutes of Health ( ClinicalTrials.gov ) (NCT03929276) and available at https://clinicaltrials.gov/ct2/show/NCT03929276?term=tu%C4%9Fba+atan&draw=2&rank=3.

Efficacy of high-intensity laser therapy on arthropathy of the hands in patients with systemic lupus erythematosus: a double-blinded, randomized controlled trial

Objective: To determine the efficacy of high-intensity laser therapy (HILT) on arthropathy of the hands in patients with systemic lupus erythematosus. Design: A double-blinded randomized, controlled study. Setting: Outpatient setting Participants: Fifty patients, 30–50-years-old, suffering from arthropathy of the hands were randomly assigned either into the experimental group, received HILT plus the routine physical therapy program or the control group, received sham HILT plus the same routine physical therapy program. Intervention: All treatment interventions were applied at a frequency of three sessions per week for eight weeks. Outcome measures: Handgrip strength, joints swelling counts, joints tenderness counts, visual analog scale (VAS) were measured before and after eight-weeks of interventions. Results: There were statistically significant differences in handgrip strength, joint swelling count, joint tenderness count and VAS in favor of the study group (P < 0.05). After eight-weeks of intervention, the mean (SD) for handgrip strength, joint swelling counts, joint tenderness count, and pain score was 28.34 ± 8.3 kg, 4.4 ± 2.18, 5 ± 2.1, and 35.6 ± 13.87 mm in the study group, and 22.96 ± 8.76 kg, 7.36 ± 2.14, 9.08 ± 1.63, and 58.8 ± 10.54 mm in the control group, respectively. The MD (95%CI) for handgrip strength, joint swelling counts, joint tenderness count, and pain score was 5.38(0.53,10.23) kg, −2.96(−4.19, −1.73), −4.08(−5.15, −3.01), and −23.2(−30.2, −16.2) mm between groups, respectively. Conclusions: Adding HILT to the routine physical therapy program might be more effective than routine physical therapy program alone in improving handgrip strength, decreasing joint swelling counts, joint tenderness counts, and pain in patients with arthropathy of the hands.

The effect of high-intensity versus low-level laser therapy in the management of plantar fasciitis: randomized participant blind controlled trial

Objectives: To evaluate and compare the efficacy of high-intensity laser therapy (HILT) and low-level laser therapy (LLLT) for plantar fasciitis. Design: A participant blind randomized controlled trial with parallel group design and an active comparator with follow-up at four weeks. Settings: Outpatient, University hospital. Subjects: Unilateral plantar fasciitis participants (n = 102) were randomly assigned into two groups. Recruitment period was from January 2017 to April 2019. Interventions: Interventions included eight sessions of laser therapy over three weeks and single session of patient education. The HILT group (n = 51) received HILT and the LLLT group (n = 51) received LLLT. Main measures: Primary outcomes: visual analogue scale; secondary outcomes: pressure algometry, sonography of plantar fascia thickness (time frame: baseline to three-week and four-week follow-up) and numeric rating scale (0%–100%) for opinion of participants on effect of treatment (time frame: three weeks). Data presented: mean (SD) or n (%). Results: There was no statistically significant difference between the groups according to visual analogue scale (pain in general reduction in three weeks: 2.57(3.45) vs. 2.88(3.28) cm), pressure algometry (pain threshold difference between healthy and affected heel reduction in three weeks: 1.80(6.39) vs. 1.77(2.85) kg) and sonography measurements (plantar fascia thickness difference between healthy and affected heel reduction in three weeks: 0.19(0.56) vs. 0.30(0.57) mm). There was a statistically significant difference between the groups in participants’ opinion in favor to HILT group (efficacy of treatment better than 50%: 26(51%) vs. 37(73%)). Conclusion: No statistically significant difference between groups was observed.

Efficacy of high-intensity laser therapy in subacromial impingement syndrome: a three-month follow-up controlled clinical trial

Objectives: To evaluate the effectiveness of high-intensity laser therapy on shoulder pain and function in subacromial impingement syndrome. Design: Clinical controlled trial with alternate allocation. Setting: Hospital Department of Rehabilitation. Subjects: A total of 46 participants with subacromial impingement syndrome. Intervention: Participants were sequence allocated to an intervention group (high-intensity laser therapy + exercise therapy) and control group (sham-laser + exercise therapy) and received 15 sessions (five days a week during three weeks). Main measures: Patiens were evaluated at baseline, after 15 sessions, and at one month and at three months after completing the intervention. The main outcome variables were pain and functionality as measured by visual analogue scale; pressure pain threshold; Shoulder Pain and Disability Index; Constant-Murley Score; and QuickDASH. Secondary outcomes were number of sessions at discharge and drug use. Results: A total of 21 patients in high-intensity laser therapy group (56.7 ± 8.9 years) and 22 patients in sham-laser group (61.3 ± 8.9 years) concluded the study. Visual analogue scale (cm) at baseline, one-month, and three-months were 6.2 ± 0.5, 3 ± 2.6, and 2.6 ± 2.4 for the control group and 5.4 ± 1.5, 3.6 ± 1.3, and 1.8 ± 1.7 for experimental group, respectively. Shoulder Pain and Disability Index (points) at baseline, one-month, and three-monts were 51.8 ± 16.1, 16.3 ± 16.1, and 13.6 ± 17.1 in the control group and 41.8 ± 20.6, 20.5 ± 19.7, 11 ± 14.5 in experimental group, respectively. No differences were found between groups (P > 0.05). Conclusion: The effect of high-intensity laser therapy plus exercise is not higher than exercise alone to reduce pain and improve functionality in patients with subacromial syndrome.

Efficacy of High-Intensity Laser Therapy in Treating Knee Osteoarthritis: A First Systematic Review.

The aim of this study was to evaluate the efficacy of high-intensity laser therapy (HILT) in the treatment of knee osteoarthritis (OA). Due to increased number of randomized controlled trials evaluating efficiency of HILT in patients with knee OA, there was a need to present them in the form of systematic review. The search includes the databases as well as a manual search until August, 2017. The quality of the selected articles was determined in accordance with the revised guidelines of the CONSORT statement. Six studies were included. Laser fluence ranged from 0.51 to 120 J/cm2 for one treatment. The total energy transmitted during one treatment ranged from 1250 to 3000 J. All the selected studies found HILT to be beneficial in treatment of knee OA. HILT seems to be efficient in reducing pain and for providing functional improvements in patients with knee OA.

Efficacy of High-Intensity Laser Therapy and Silicone Insole in Plantar Fasciitis

Efficacy of High-Intensity Laser Therapy and Silicone Insole in Plantar Fasciitis

Efficacy of high-intensity laser therapy in the treatment of chronic neck pain: a randomized double-blind placebo-control trial.

The aim of the study was to investigate the effect of high-intensity laser therapy (HILT) in treatment of patients with chronic neck pain (CNP) on cervical range of motion (ROM), pain, and functional activity. Sixty male patients participated in this study with mean (SD) age of 35.47 (4.18) years. Patients were randomly assigned into two groups and treated with HILT plus exercise (HILT + EX) and placebo laser plus exercise (PL + EX) in groups 1 and 2, respectively. The outcomes measured were cervical ROM, pain level by visual analog scale (VAS), and functional activity by neck disability index (NDI) score. Statistical analyses were performed to compare the differences between baseline and post-treatment. The level of statistical significance was set as p < 0.05. Cervical ROM significantly increased after 6 weeks of treatment in all groups. VAS and NDI results showed significant decrease post-treatment in both groups. HILT + EX effectively increased cervical ROM and decreased VAS and NDI scores after 6 weeks of treatment compared to PL + EX. HILT + EX is an effective physical therapy modality for patients with CNP compared to PL + EX therapy. The combination of HILT + EX effectively increased cervical ROM, functional activity, and reduced pain after 6 weeks of treatment.

Laser Biostimulation

Photomedicine and Laser SurgeryVol. 31, No. 6 Guest EditorialLaser BiostimulationAdam MesterAdam MesterSearch for more papers by this authorPublished Online:6 Jun 2013https://doi.org/10.1089/pho.2013.9876AboutSectionsView articleView Full TextPDF/EPUB ToolsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetailsCited byShort-Term Efficacy of High-Intensity Laser Therapy in Alleviating Pain in Patients with Knee Osteoarthritis: A Single-Blind Randomised Controlled TrialPain Research and Management, Vol. 2022Medical Applications of Diode Lasers: Pulsed versus Continuous Wave (cw) Regime17 June 2021 | Micromachines, Vol. 12, No. 6Effect of Laser Irradiation on Cell Cycle and Mitosis17 September 2018 | Journal of Lasers in Medical Sciences, Vol. 9, No. 4Low level laser therapy reduces oral leukoplakia lesion size: Results from a preliminary studyOral OncologyShould open excisions and sutured incisions be treated differently? A review and meta-analysis of animal wound models following low-level laser therapy30 March 2018 | Lasers in Medical Science, Vol. 33, No. 6Preconditioning With Low-Level Laser Irradiation Enhances the Therapeutic Potential of Human Adipose-derived Stem Cells in a Mouse Model of Photoaged Skin21 April 2018 | Photochemistry and Photobiology, Vol. 94, No. 4Approach and potentiality of low level laser therapy in veterinary medicineMechanisms and Mitochondrial Redox Signaling in Photobiomodulation19 January 2018 | Photochemistry and Photobiology, Vol. 94, No. 2The influence of experimental conditions on the final result of photoinhibition of Staphylococcus aureusPhotodiagnosis and Photodynamic Therapy, Vol. 19Apoptosis induced by low-level laser in polymorphonuclear cells of acute joint inflammation: comparative analysis of two energy densities5 April 2017 | Lasers in Medical Science, Vol. 32, No. 5Penetration depth of photons in biological tissues from hyperspectral imaging in shortwave infrared in transmission and reflection geometriesJournal of Biomedical Optics, Vol. 21, No. 12The effect of red light irradiation on spermatozoa DNADifferent Photoresponses of Microorganisms: From Bioinhibition to Biostimulation8 January 2016 | Current Microbiology, Vol. 72, No. 4Comparative effects of two different doses of low-level laser therapy on wound healing third-degree burns in rats8 February 2016 | Microscopy Research and Technique, Vol. 79, No. 4Radiation absorption in different kinds of tissue analysis: ex vivo study with supercontinuum laser sourceLight Effect on Water Viscosity: Implication for ATP Biosynthesis8 July 2015 | Scientific Reports, Vol. 5, No. 1A Comparative Study of the Effectiveness of Immediate Versus Delayed Photobiomodulation Therapy in Reducing the Severity of Postoperative Inflammatory Complications2 September 2015 | Photomedicine and Laser Surgery, Vol. 33, No. 9Low-intensity infrared laser effects on zymosan-induced articular inflammatory responseBiophotonic effect of diode laser irradiance on tensile strength of diabetic rats16 October 2014 | Journal of Cosmetic and Laser Therapy, Vol. 17, No. 2Combined Central and Peripheral Stimulation for Treatment of Chronic Tinnitus15 July 2014 | Neurorehabilitation and Neural Repair, Vol. 29, No. 3Adjunctive use of combination of super-pulsed laser and light-emitting diodes phototherapy on nonspecific knee pain: double-blinded randomized placebo-controlled trial21 May 2014 | Lasers in Medical Science, Vol. 29, No. 6Light Pumping Energy Into Blood Mitochondria: A New Trend Against Depression?10 February 2014 | Photomedicine and Laser Surgery, Vol. 32, No. 2The Current Status of LLLT in the Field of Dental and Oral Surgery -In Anticipation of the Recent Trend and the Concept of LLLT-Nippon Laser Igakkaishi, Vol. 34, No. 4The use of physiotherapy tools in medical treatment. The use of heat, light, electric, magnetic, ultrasound and shock wave therapy as well as medical massage in Hungarian medical practiceOrvosi Hetilap, Vol. 154, No. 48 Volume 31Issue 6Jun 2013 InformationCopyright 2013, Mary Ann Liebert, Inc.To cite this article:Adam Mester.Laser Biostimulation.Photomedicine and Laser Surgery.Jun 2013.237-239.http://doi.org/10.1089/pho.2013.9876Published in Volume: 31 Issue 6: June 6, 2013PDF download