Efficacy Of Herbal Extracts Research Articles

Efficacy of Herbal Extracts and Synthetic Solutions as Toothbrush Disinfectants against Streptococcus mutans: A Double-blinded, Randomized, In Vivo Clinical Trial

Efficacy of Herbal Extracts and Synthetic Solutions as Toothbrush Disinfectants against Streptococcus mutans: A Double-blinded, Randomized, In Vivo Clinical Trial

Development and characterization of phytosomes containing aegle marmelos (bael)

Aegle marmelos, commonly known as Bael, is a medicinal plant with a wide range of pharmacological properties. However, its therapeutic potential is often limited by its poor bioavailability due to low water solubility and inefficient absorption. Phytosomes, a novel drug delivery system, have emerged as a promising approach to improving the bioavailability and efficacy of herbal extracts. In this study, we aimed to develop and characterize phytosomes containing Aegle marmelos extract for enhanced therapeutic benefits. The phytosomes were prepared using a solvent evaporation technique, where phospholipids were complexed with the Aegle marmelos extract. The formulation was evaluated using various ratios of phospholipids and extract to achieve maximum entrapment efficiency and drug-loading capacity. The resulting phytosomes were then characterized for their physicochemical properties, including particle size, zeta potential, and morphology using techniques such as dynamic light scattering and transmission electron microscopy. Furthermore, the in vitro release profile of the Aegle marmelos phytosomes was evaluated using a dissolution apparatus to determine their sustained release behavior. The improved dissolution profile indicated prolonged drug release, suggesting enhanced bioavailability and potential for reduced dosing frequency. In conclusion, our study successfully developed and characterized phytosomes containing Aegle marmelos extract, showing improved bioavailability and enhanced cellular uptake. These findings indicate the potential of phytosomes as a promising drug delivery system to optimize the therapeutic benefits of Aegle marmelos and potentially other herbal extracts. Keywords: Phytosomes, extract, evaluation.

Efficacy of Herbal Extracts against Enterococcus faecalis on a Dentinal Biofilm

Efficacy of Herbal Extracts against Enterococcus faecalis on a Dentinal Biofilm

Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury.

Acetaminophen (APAP), which is also known as paracetamol or N-acetyl-p-aminophenol is a safe and potent drug for fever, pain and inflammation when used at its normal therapeutic doses. It is available as over-the-counter drug and used by all the age groups. The overdose results in acute liver failure that often requires liver transplantation. Current clinical therapy for APAP-induced liver toxicity is the administration of N-acetyl-cysteine (NAC), a sulphydryl compound an approved drug which acts by replenishing cellular glutathione (GSH) stores in the liver. Over the past five decades, several studies indicate that the safety and efficacy of herbal extracts or plant derived compounds that are used either as monotherapy or as an adjunct therapy along with conventional medicines for hepatotoxicity have shown favorable responses. Phytochemicals mitigate necrotic cell death and protect against APAP-induced liver toxicityby restoring cellular antioxidant defense system, limiting oxidative stress and subsequently protecting mitochondrial dysfunction and inflammation. Recent experimental evidences indicat that these phytochemicals also regulate differential gene expression to modulate various cellular pathways that are implicated in cellular protection. Therefore, in this review, we highlight the role of the phytochemicals, which are shown to be efficacious in clinically relevant APAP-induced hepatotoxicity experimental models. In this review, we have made comprehensive attempt to delineate the molecular mechanism and the cellular targets that are modulated by the phytochemicals to mediate the cytoprotective effect against APAP-induced hepatotoxicity. In this review, we have also defined the challenges and scope of phytochemicals to be developed as drugs to target APAP-induced hepatotoxicity.

Graminex Pollen: Phenolic Pattern, Colorimetric Analysis and Protective Effects in Immortalized Prostate Cells (PC3) and Rat Prostate Challenged with LPS.

Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents. The efficacy of herbal extracts with antioxidant and anti-inflammatory effects for blunting the burden of inflammation and oxidative stress, with possible improvements in clinical symptoms, is under investigation. Pollen extracts have been previously reported as promising agents in managing clinical symptoms related to prostatitis. The aim of the present work was to evaluate the protective effects of Graminex pollen (GraminexTM, Deshler, OH, USA), a commercially available product based on standardized pollen extracts, in rat prostate specimens, ex vivo. In this context, we studied the putative mechanism of action of pollen on multiple inflammatory pathways, including the reduction of prostaglandin E2 (PGE2), nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), and malondialdehyde (MDA), whose activities were significantly increased by inflammatory stimuli. We characterized by means of chromatographic and colorimetric studies the composition of Graminex pollen to better correlate the activity of pollen on immortalized prostate cells (PC3), and in rat prostate specimens challenged with Escherichia coli lipopolysaccharide (LPS). We found that Graminex pollen was able to reduce radical oxygen species (ROS) production by PC3 cells and MDA, NFκB mRNA, and PGE2 levels, in rat prostate specimens. According to our experimental evidence, Graminex pollen appears to be a promising natural product for the management of the inflammatory components in the prostate.

English

English

Efficacy of Herbal Extracts in Management of Amaranth Leaf Caterpillar

Suitable alternatives are necessary to overcome the residue problems caused by chemical insecticides, especially in short duration crops like amaranth (Amaranthus caudatus L.), where lengthy waiting periods between treatment and harvest are not practical. Field trials were conducted to evaluate the potency of botanicals on the amaranth leaf caterpillar (Hymenia recurvalis Fabricius) during two growing seasons in 2008. The extract from Cleistanthus collinus (Roxb.) Benth. was more efficacious than were extracts of Cleome viscose L.; Gynandropsis pentaphylla DC; Andrographis paniculata Nees., a commercial formulation of neem; and the insecticide endosulfan. Two applications with an extract of C. collinus, with a 7-day application interval, reduced populations of H. recurvalis. In both seasons application with the C. collinus extract was found to provide higher yields (7.60 and 6.72 bundles/m2) and higher cost–benefit ratios (1:1.29 and 1:1.14).