Efficacy Of Disease Management Research Articles

Assessing the Impact of Integrated Dogwood Disease Management Practices on Labor Needs and Production Costs in Tennessee Nurseries

Early and accurate detection of diseases, and implementation of efficient disease management practices are crucial to reducing the economic impact associated with plant disease outbreaks. Based on survey responses from dogwood nursery growers in Tennessee, USA, scouting was identified as an important disease management practice adopted by a majority of growers for disease management in field-grown, container-grown, and pot-in-pot production systems. Our results show a significant positive correlation between disease severity and scouting frequency for dogwood plants grown in container and pot-in-pot production systems. Our efficiency measure is a self-rated efficacy scale perceived by the nursery growers about their existing disease management system in nursery plants. A significant positive correlation was found between the efficacy of disease management and the number of workers involved in scouting and a negative association between the worker hours spent in scouting and the grower's experience/exposure to other disease detection methods. The majority of nursery growers followed a set spray schedule between May and October, with applications scheduled every other week. In addition, our results showed significant positive correlations between efficacy and spray-related factors, such as disease severity and worker hours spent in spraying; efficacy of disease management and spraying frequency in field-grown dogwoods; and foliar spray costs and efficacy of disease management. We estimated ≈$379/acre per year average costs for dogwood disease management, which the growers find to be one of the major components of the dogwood production budget. Moving to automated systems of disease scouting and management has the potential to reduce the cost of these labor-intensive disease management practices of dogwood production.

Lesson from nature: Zataria multiflora nanostructured lipid carrier topical gel formulation against Candida-associated onychomycosis, a randomized double-blind placebo-controlled clinical trial

PurposeThe increasing resistance to onychomycosis treatment globally is a major concern as it results in treatment failures. This research aimed to investigate the effectiveness of incorporating nanostructured lipid carriers (NLCs) in a gel formulation for treating mild to moderate Candida-associated onychomycosis using Zataria multiflora (Zt) essential oils. MethodsThe characteristics of Zataria multiflora-loaded nanostructured lipid carriers (Zt-NLCs) were validated using a carbopol gel (1 % w/w). In vitro tests were conducted using CLSI M60 standards to evaluate the susceptibility of ten commonly encountered dermatophyte species to antifungal agents. A clinical study was conducted involving 40 volunteers randomly assigned to two groups: one receiving the Zt-NLCs gel and the other receiving a placebo, using a double-blind, placebo-controlled design. The objective was to assess clinical manifestations and mycological findings after topical application for 2 and 4 weeks. The causative agents' species were identified using a PCR-RFLP method. ResultsThe preparation of Zt-NLCs gel resulted in a uniform suspension of spherical nanoparticles with favourable characteristics and no cytotoxic effects. Zt-NLCs demonstrated significant inhibitory effects on fungal growth and effectively improved clinical and mycological criteria in comparison to the placebo group (p < 0.005), even after 2 weeks of treatment. The C. albicans complex was recognized as the predominant species isolated from the patients using PCR-RFLP. ConclusionThe administration of Zt-NLCs gel for two weeks showed significant efficacy in disease management, as reported by both dermatologists and mycologists and therefore shows its potential use as a treatment against Candidal onychomycosis.

Antibody-drug conjugates transform the outcome of individuals with low-HER2-expression advanced breast cancer.

Antibody-drug conjugates (ADCs)-a groundbreaking class of agents for targeted oncological therapies-consist of monoclonal antibodies with strong antigenic specificity coupled with highly active cytotoxic agents (also referred to as "payloads"). Over the past 2 decades, breast cancer research has evolved into a focal point for the research and development of ADCs, leading to several recent landmark publications. These advancements are ushering in a transformative era in breast cancer treatment and redefining conventional classifications by introducing a prospective subtype termed "HER2-low." The latest iterations of ADCs have demonstrated enhanced efficacy in disease management through the optimization of various factors, notably the incorporation of the bystander effect. These conjugates are no longer limited to the oncogenic driver human epidermal growth factor receptor 2 (HER2). Other antigens, including human epidermal growth factor receptor 3 (HER3), trophoblast cell surface antigen 2 (Trop-2), zinc transporter ZIP6 (LIV-1), and folate receptor α (FRα), have recently emerged as intriguing tumor cell surface nondriver gene targets for ADCs, each with one or more specific ADCs that showed encouraging results in the breast cancer field. This article reviews recent advances in the application of ADCs in the treatment of HER2-low breast cancer. Additionally, this review explores the underlying factors contributing to the impact of target selection on ADC efficacy to provide new insights for optimizing the clinical application of ADCs in individuals with low HER2 expression in advanced breast cancer.

Warburgia Ugandensis: A Review of Compounds and Bioactivity

Warburgia species (Canellaceae) are traditionally used to treat a wide range of illnesses including stomach ache, diarrhea, abdominal pains, toothache, oral thrush, venereal diseases, cold and cough, fever, muscle pains, weak joints, skin diseases, malaria, parasitic infections and snake bite. Therapeutic properties of medicinal plants have been linked to the secondary metabolites which are biosynthesized by the plants. The aim of this study was to review the bioactivities and chemical composition of Warburgia ugandensis. The findings from this study show that extracts from the plant have antifungal, antibacterial, antiulcer, insect antifeedant, molluscicidal, antimycobacterial, antileishmanial and anti-plasmoidal effects. The most investigated part of W. ugandensis is the stem bark (22 articles) followed by leaves (15), root bark (6), seeds (2) and fruits (2). All parts the plant have important bioactivities. Sixty nine compounds have been reported from the plant including sesquiterpenes (43), flavonoids (15), lignanamides, and macrocyclic glycosides (10) and fatty acid (1) some of which have demonstrated different bioactivities. The drimane sesquiterpenes are the main class of sesquiterpenes in the plant. The Further investigation of the not well studied parts of the plant such as the flowers and fruits is recommended to determine their chemical composition and efficacy in disease management.

Establishing a Virtual Home Assessment Program: from Concept to Implementation as a Result of the COVID-19 Pandemic.

Environmental home assessments have traditionally been performed in-person at the homes of Children's Mercy Kansas City patients. The COVID-19 pandemic brought many challenges to the way patients interact with their healthcare providers, including home visiting programs. Reaching out to patients with high-risk asthma and immunocompromised health was still needed, despite the pandemic. This project's purpose was to develop a virtual (telemedicine) healthy home assessment protocol that would continue to meet patients' needs during the isolation resulting from the pandemic. This is a newly developing approach to performing home environmental assessments with limited published research. Research on the effective use of telemedicine as an alternative to in-person clinic visits has shown that for some health conditions telemedicine represents a useful technique to engage with patients and caregivers. For some conditions, like pediatric asthma, it provides a similar level of efficacy in disease management while providing a more efficient form of interaction. This article describes the development and delivery process, timelines of caregiver interaction, and guidelines for performing virtual home assessments. It summarizes the challenges and benefits of using a virtual process for delivering home assessment services for asthma and allergy patients. Overall, caregivers indicated they found the use of virtual technology had significant benefits for them including their personal comfort and the time efficiency gained by using virtual visits to interact with Healthy Homes Program staff.

Synergistic effects of arbuscular mycorrhizal fungi associated to plant growth-promoting rhizobacteria in suppression of soil-borne Fusarium wilt of date palm

Soil-borne Fusarium wilt represents one of the major problems in the cultivation of the date palm. Arbuscular mycorrhizal fungi (AMF) consortium and plant growth-promoting rhizobacteria (PGPR) consortium were tested to determine the efficacy in disease management of Fusarium wilt. When applied individually, PGPR or AMF consortium reduced disease incidence, disease severity, and mortality rate of date palm seedlings. The combination of these consortia showed the best control efficiency which reflects a significant synergistic effect. The decrease in disease progression was accompanied by a significant promotion of plant immunity through the activation of the phenylpropanoid pathway, which was concreted by enhancement of PAL activity and accumulation of polyphenols and lignin content in date palm roots. In vitro antagonistic tests against Fusarium. oxysporum f. sp. albedinis (Foa) revealed that the bacterial strains of the PGPR consortium inhibited Foa growth, particularly the strain Bacillus cereus strain 263AG5' (60.59%). The evaluation of the mycorrhizal status of date palm roots after 27 weeks following the inoculation with Foa showed that the addition of both consortia was accompanied by a 3-fold increase in the intensity of mycorrhization and the arbuscules and vesicles number and 1.5 times increase in the frequency of mycorrhization. Our results highlight the high synergistic effect between PGPR and AMF consortia in date palm protection against Foa that could be attributed to the association of their antagonistic effect with their strong capacity for stimulation of plant natural defenses which suggests that these PGPR/AMF could be an effective approach to pathogen suppression.

Device therapy for the major complications detection and early treatment of patients with natural and iatrogenic comorbidities admitted to internal medicine wards

Abstract Background Whith advances in devices miniaturization and wireless technologies, wereable “on body” ECG patch devices are unobtrusive and easy to use. Continuous ECG monitoring in the short term is indicated in patients who, due to age, comorbidities and polytherapy, are at greater risk of arrhythmias. Since 2017, a randomized-open label study is being conducted at the admission of acute patients in Internal Medicine Unit for 72 hours with continuous monitoring of vital parameters and the 5 leads-ECG (VP-ECG CM) trace by the mean of a tele-cardiology program. Purpose Objective of this study is to perform a cost-effectiveness evaluation of the VP-ECG CM program in inpatient settings. Methods Data were used in order to evaluate costs, the program effectiveness and the QALY gains using wireless monitoring compared to nurses traditional one. Costs were estimated by mean of the identification, measuring and valorization of the resources uptake. Cost drivers included: time spent by personnel, cost of the device, consumables, medical treatments, diagnostic exams and complications. The perspective of the Italian National Health Service was adopted. The incremental analysis was performed in order to present the cost per complication avoided and the cost per QALY gained. Net monetary benefit was also calculated. Either a deterministic and probabilistic analysis were performed by means of a bootstrap simulation allowing for re-sampling. A cost-effectiveness-acceptability curve was estimated, considering a cost-effectiveness threshold of €35,000/QALY. Results On 143 patients, arrhythmias and acute coronary syndrome were detected 4.3% in the experimental arm and 1.9% in the control arm, whilst 29,5% major complications were detected in the experimental arm vs 43.5% in the control and reduction in the number of sudden deaths (16% control and 9.3% experimental). Time spent by nurses in the control arm (58 minutes/day/patient) was the most relevant cost driver and allowed a saving ranging €54–90/patient. This saving overwhelmed the costs for the equipment whilst the other costs remained unchanged, thus allowing for the VP-ECG CM to be dominant versus the standard of care. One way and multiway sensitivity analyses confirmed the robustness of our results with p-value 0,05 involved in the bootstrap presenting dominance of the VP-ECG CM. Conclusions Notwithstanding the concerns of a loss of control in patient management, telemedicine (digital health infrastructure and driver) could perform healthcare transformation enabling physicians to increase the volume of patients seen, reduce the time to diagnosis, improve efficiency and efficacy of disease management, and reduce unnecessary clinic visits and hospital admissions. The miniaturized technologies can improve patient adherence, and the detection, characterization and monitoring of cardiac arrhythmias – readily digitalized markers and phenotypes of cardiovascular disease. Funding Acknowledgement Type of funding sources: None. Wireless Monitoring Study flowchart

Application of plant-derived bioactive compounds as seed treatments to manage the rice pathogen Fusarium fujikuroi

Plant essential oils (EO) possess antifungal properties due to the presence of terpenoids and phenolics capable of damaging microbial cell membranes. The compounds present in EO could represent a valid alternative to synthetic fungicides in rice crop protection, especially in Europe, where the available plant protection products are increasingly scarce, particularly for managing seed-borne fungal pathogens like Fusarium fujikuroi Nirenberg, the causal agent of bakanae disease. Bakanae is a major concern in Europe for seed producers, which often fail to comply with the strict regulatory limits on the presence of the pathogen in the field, resulting in the rejection of the seed crop from marketing and economic losses. The present work was aimed at studying 1) the in vitro effect of EO derived compounds against F. fujikuroi and 2) their efficacy in disease management under field conditions applied as seed treatments. Results confirmed the in vitro antifungal activity of tested compounds: specifically, thymol (0.025% vol/vol), terpinen-4-ol (0.1%), and eugenol (0.05%) showed strong antifungal activity against all the tested F. fujikuroi strains. Two-years, two-locations open field trials showed that seeds treated with thymol (20%) and eugenol (5%) significantly reduced bakanae incidence compared to untreated control, without any phytotoxicity effect on rice seed. The efficacy of these two compounds in managing the disease without affecting germination rates was comparable to the commercially available prochloraz and triticonazole formulation, considered as the positive control. Our results suggest that thymol and eugenol could be used as alternative fungicides in innovative formulations for seed dressing, with the advantage of being compliant with the European IPM framework and organic farming legislation.

The Significance of the Mediterranean Diet in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review.

Non-alcoholic fatty liver disease (NAFLD) is the accumulation of intrahepatic fat occurring in the absence of alcohol abuse. The fatty changes in the liver are often the beginning of sequelae of complications, potentially causing steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. The Mediterranean diet is not only a way of eating but is considered a lifestyle and primarily consists of a plant-based diet, with olive oil as the primary lipid. In this study, we reviewed the effectiveness of the Mediterranean diet on NAFLD and its efficacy in disease management. This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) 2009 guidelines. The PubMed database was used to gather articles, using the following terms individually and in combination, “Mediterranean diet,” “non-alcoholic fatty liver disease,” “insulin resistance,” “metabolic syndrome,” “omega-3-fatty acids.” A quality appraisal was completed to include 14 articles in this systematic review. The studies discuss the correlation between the Mediterranean diet and its role in preventing and treating NAFLD. Olive oil is the major monounsaturated fatty acid, whereas nuts, seeds, and fish consist largely of polyunsaturated fatty acids, both of which are essential components of the Mediterranean diet. The plant-based diet, having sufficient amounts of vegetables, legumes, and fruits, provides its anti-oxidant and anti-inflammatory effects, playing a fundamental role in preventing oxidative stress damage. Olive oil polyphenols increase apoptosis and cell cycle arrest. They also decrease proliferation and angiogenesis, all of which prevent neoplasia. Adapting the Mediterranean lifestyle has shown promising effects in NAFLD, reducing overall mortality and morbidity.

The fit between stress appraisal and dyadic coping in understanding perceived coping effectiveness for adolescents with type 1 diabetes.

This study examined whether perceived coping effectiveness (PCE) was associated with better diabetes management and was higher when adolescents' dyadic coping was matched to shared stress appraisals. There were 252 adolescents with Type 1 diabetes who completed stress and coping interviews where they appraised mothers' and fathers' involvement in stress ownership (mine, indirectly shared, directly shared with parent), in coping (uninvolved, supportive, collaborative, or controlling), and rated their effectiveness in coping. Adolescents completed assessments of depressive symptoms (Children's Depression Inventory), self-care behaviors (Self-Care Inventory), and efficacy of disease management (Diabetes Self-Efficacy). Glycosylated hemoglobin levels were obtained from medical records. Higher PCE was associated with fewer depressive symptoms, self-care behaviors, and efficacy across age and, more strongly for older adolescents' metabolic control. Appraisals of support or collaboration from parents were more frequent when stressors were appraised as shared. PCE was enhanced when dyadic coping with mothers (but not fathers) was consistent with stress appraisals (e.g., shared stressors together with collaborative coping). Stress and coping is embedded within a relational context and this context is useful in understanding the coping effectiveness of adolescents.