Rice, as a staple food for more than half of the world's population, plays a crucial role in global food security. However, weed competition poses a significant challenge to rice cultivation, affecting yield and quality. To address this challenge, rice farmers have increasingly turned to chemical herbicides as a cost-effective alternative to labor-intensive manual weeding. This review paper explores the current practices and future directions in herbicide strategies for weed control in rice cultivation, with a specific focus on diverse approaches adopted in various agro-ecological regions, particularly in Pakistan. The paper begins by highlighting the importance of rice cultivation in global agriculture and the economic significance of the crop, emphasizing the need for effective weed management to ensure sustainable production. It discusses the impact of labor shortages and rising labor costs on weed control practices, driving the adoption of chemical herbicides, especially in direct-seeded rice cultivation. Additionally, the review underscores the importance of integrated weed management systems, which combine cultural practices, targeted herbicide applications, and legislative measures to optimize crop productivity while minimizing environmental impact. Furthermore, the paper evaluates the efficacy of different herbicides and their timing of application in managing weeds and maximizing rice yield. It synthesizes findings from recent studies to provide insights into the effectiveness of pre-emergence and post-emergence herbicides, as well as their impact on weed-crop competition and overall crop health. By analyzing the strengths and limitations of existing herbicide strategies, the review identifies opportunities for innovation and improvement in weed management practices. Overall, this review paper offers a comprehensive overview of herbicide strategies for weed control in rice cultivation, highlighting the need for sustainable and integrated approaches to address weed challenges while ensuring food security and environmental sustainability in rice-producing regions.