Effects Of Zinc Methionine Research Articles

The effects of Zinc-Methionine on glucose metabolism and insulin resistance during late pregnancy in ewes

This study investigated the effects of dietary supplements of Zinc-Methionine (Zn-Met) on the zinc concentration of the blood and indices such as insulin resistance and glucose tolerance in late-pregnancy ewes to provide a practical solution to prevent metabolic diseases associated with energy status. In this research, 18 Makouei pregnant ewes were selected and randomized into 3 experimental groups: Group 1: Basal diet containing 10.3 mg Zn/kgDM and no zinc supplementation = CTR (Control); Group 2: Basal diet supplemented with low-dose zinc equivalent to the pregnancy requirements (30 mg Zn/kgDM) = LZN; Group 3: Basal diet supplemented with high-dose zinc (300 mg Zn/kgDM) = HZN. Blood samples for insulin resistance and glucose tolerance indices were collected according to standard methods. The results of this study indicated that supplementation of high-dose Zn-Met decreased (P < 0.05) blood glucose and tended (P < 0.1) to reduce the beta-hydroxybutyrate (BHB) concentrations. After intravenous injection of glucose and insulin, none of the glucose tolerance and insulin resistance indices were significant among groups (P > 0.05). However, the intravenous glucose tolerance test (IGTT) showed that the area under the curve (AUC) of serum glucose in the HZN group was numerically lower than that of the LZN and CTR groups. Furthermore, the numerically higher clearance rate (CR) of glucose and more negative glucose AUC following intravenous administration of insulin in Zinc-supplemented groups suggested that the ewes had greater insulin response than control group. The results showed a decrease in blood glucose concentration due to higher zinc intake after insulin injection and supported the evidence for improving insulin sensitivity. In addition, our results showed that ewes receiving zinc supplementation experienced a more favorable state of BHB or NEFA values. In conclusion, Zn-Met supplementation was found to have promising effects in improving energy metabolism in late pregnant ewes. However, further studies are needed to understand the mechanisms involved in regulating lipolysis and energy metabolism.

The Effects of Zinc Methionine on Reproductive and Thyroid Hormones in Rats with Polycystic Ovarian Syndrome.

Background:Polycystic ovarian syndrome (PCOS) is an endocrine disorder in fertile women, which seems to be adversely affected by associated thyroid dysfunction. Zinc methionine (ZM) has positive effects on PCOS, but its concerted effects on PCOS and thyroid function have not been investigated. We evaluated the effects of ZM on reproductive and thyroid hormones and the number of follicles in rats with PCOS.Materials and Methods:This study was conducted on 45 female rats, using sesame oil as control; PCOS animals administered with 0, 25, 75, and 175 mg/kg BW of ZM. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid function were investigated. Premature follicles (PMF), primary follicles (PF), preantral follicles (PAF), antral follicles (AF), corpus luteum (CL), and cystic follicles (CF) were assessed.Results:PCOS decreased the concentrations of FSH and free T4, but increased the levels of LH, TSH, and LH/FSH ratio (ALL P < 0.05). ZM at a dose of 75 and 175 mg increased the level of FSH, free T4, and decreased LH, TSH, and LH/FSH ratio (ALL P < 0.05). Induction of PCOS decreased PMF, PF, PAF, AF, and CL, but increased CF (P < 0.05). PCOS treated groups (75 and 175 mg/kg) increased these follicle numbers and decreased CF compared to ZM 25 mg/kg and PCOS groups (Both P < 0.05).Conclusions:Although the induction of PCOS had a negative effect on reproductive and thyroid hormones and follicle numbers, ZM treatment (75 and 175 mg/kg) overcame the negative effects. A high dosage of ZM can alleviate the hormonal and cysts disturbances occurring in PCOS.

Effect of Zinc Methionine on Some of the Productive Traits of Broilers

The trial was designed to evaluate the addition of zinc methionine to the diet on some productive and carcasses performance of broiler, the study was conducted in the poultry field, Animal Production Department, Agriculture Faculty, Al-Muthanna University, from 1/4/2018 to 15/5/2018. A total of 400 broiler, one day, unsexed Ross308 strain were randomly distributed to four treatments (100 chick/treatment), each treatment included four replicates (25 chick per replicate), The chickens were reared in four-floor batteries with a measuring 2 x 1.5 meters per floor. The treatments of the experiment were as follows: First treatment (T1): a control treatment, zinc methionine was added at levels 400, 500 and 600 g per ton of feed for T2, T3 and T4 treatments respectively. The results showed that the T4 resulted in a significant improvement (p≤0.05) in body weight, body gain, feed consumption, feed conversion and mortality compare with other treatments.

Dose–responses of zinc–methionine supplements on growth, blood metabolites and gastrointestinal development in sheep

The effects of zinc-methionine (Zn-Met) supplementation on growth, blood metabolites and gastrointestinal development were investigated in two experiments with sheep. The objective of Experiment 1 was to determine the effects of Zn-Met supplementation on hormones and metabolites involved in growth and energy balance regulation, while Experiment 2 aimed to determine the effects of Zn-Met on feed intake, body weight, gastrointestinal development and liver glycogen concentration in lamb. The animals were assigned to groups with different concentrations of dietary Zn-Met (0, 0.4, 0.8 and 1.2g/day) in both experiments. In Experiment 1, feeding different doses of Zn-Met increased plasma insulin-like growth factor 1 (IGF-1) concentration, but it linearly decreased plasma growth hormone (GH). No differences were observed in blood cortisol, insulin and glucose concentrations among the treatments. In Experiment 2, addition of Zn-Met to the diets did not lead to changes in the body weights of the lambs. Both average daily gain and dry matter intake (DMI) increased linearly with increasing concentrations of dietary Zn-Met. Lambs receiving Zn-Met showed higher liver glycogen concentrations than the control. While significant increases were observed in the villus height and crypt depth in the duodenum and jejunum as a result of Zn-Met supplementation, no change was detected in blood glucose concentrations (p>0.05). Our findings suggest that dietary Zn-Met may improve growth, energy balance and gastrointestinal development in sheep.

Effect of Zinc Methionine or Zinc Sulfate Supplementation on Milk Production and Composition of Milk in Lactating Dairy Cows

Eighteen lactating dairy cows were used to compare the effects of organic and inorganic Zn supplements on milk production and chemical composition of milk. Animals received three diets in a randomized block design: basal diet with no supplemental Zn (control, 42 mg Zn/kg), basal diet plus 500 mg Zn/kg of dry matter (DM) as zinc sulfate monohydrate (ZnS) and basal diet plus 500 mg Zn/kg of DM as zinc methionine (ZnM). Results showed that milk and fat-corrected milk yield in dairy cows were not significantly affected by Zn source although a numerical increase was observed. The percentages of protein, lactose, fat, solid nonfat, total solid, and density of milk were not significantly different between treatments. However, dairy cows that received ZnM tended to produce more milk and fat-corrected milk with a lower somatic cell count as compared to controls. The zinc concentration in milk in the ZnM and ZnS groups was higher (P < 0.05) than in milk from the control group, but there were no significant differences between ZnS and ZnM groups.

Effects of Zinc-methionine and Feed Restriction on Performance, Immunocompetence and Gut Content Osmolarity of Broilers Challenged with a Mixed Coccidial Infection

Effects of Zinc-methionine and Feed Restriction on Performance, Immunocompetence and Gut Content Osmolarity of Broilers Challenged with a Mixed Coccidial Infection

Effects of zinc-methionine on performance of Angora goats

Effects of supplementation with zinc-methionine (Zn-Met), a source of potentially rumen protected methionine and zinc (Zinpro 40, Edina, MN), on mohair growth, BW gain and blood metabolites were investigated in Angora goats. Forty yearling Angora goats (20 wethers and 20 doelings) were offered a basal diet (11.2% CP, 22 ppm Zn, 2.3 Mcal/kg DM) at 4% BW of DM for 120 days. The treatments (1–5) were: 1, 3 and 5 g/day of Zn-Met, 150 mg/day of zinc oxide and control (no supplementation). Supplementation of the diet with Zn-Met (1, 3 and 5 g/day of Zn-Met) increased ( P < 0.07) ADG (65.5 versus 55.9 g/day for control). ADG for goats receiving ZnO was lower ( P < 0.04) than for goats receiving a similar amount of Zn from 3 g/d Zn-Met (50.5 versus 62.9 g/day), although Zn-Met inclusion in the diet numerically ( P = 0.13) increased clean mohair production, which also changed quadratically ( P < 0.09) as Zn-Met level increased (1.59, 1.51, 1.62, 1.60 and 1.59 kg in 120 days) for treatments 1, 2, 3, 4 and 5, respectively. Supplementation of the diet with Zn-Met increased ( P < 0.03) plasma Zn concentration (0.92 versus 0.72 mg/l for control); there were no differences in plasma Zn concentration between goats receiving the ZnO supplement and goats receiving a similar amount of Zn from Zn-Met (0.87 versus 0.92 mg/l; P > 0.56). Plasma methionine concentration was not affected by Zn-Met supplementation ( P > 0.53). In summary, supplementation of a Zn-adequate diet with Zn-Met increased ADG by yearling Angora goats regardless of level of Zn-Met added. Supplementation of 1 g Zn-Met may have positive effect on ADG and mohair growth when diet contains about 20 ppm Zn.

The Effect of Zinc Methionine in a Mineral Mixture on Gain and Incidence of Footrot in Steers Grazing Native Grass Pastures

Crossbred steers (266kg avg BW) were allotted to groups and provided either a control mineral mixture or one containing 2.5% zinc methionine while grazing late-spring burned native grass pastures in early summer to determine whether zinc methionine would reduce the incidence of footrot. Four pastures were provided per treatment per year, and the treatments were rotated in each year of a 3-yr study. The steers were weighed individually in early morning at the start of the trial in April and again at the end in late July or early August. The pastures were grazed an average of 93 d. The mineral mixtures were fed in open wooden boxes, and intake was recorded weekly. The steers were checked once each week for signs of footrot. The steers receiving zinc methionine gained faster (1.27 vs 1.23kg; P<.06) and had a lower incidence of footrot (2.45 vs 5.38%; P<.06) than the control group. However, the difference in gain between steers with footrot and nonaffected steers did not account for the total difference in gain. Zinc methionine at 2.5% of the mineral mixture improved steer gains and reduced the incidences of footrot.

Effects of zinc methionine and zinc oxide on performance, blood characteristics, and antibody titer response to viral vaccination in stressed feeder calves

Summary Ninety steers with an average weight of 214 kg were purchased at 2 feeder calf sales and transported 70 to 100 km. On arrival at the feedlot, steers were weighed and identified, blood was withdrawn, and the steers were vaccinated against bovine herpesvirus-1 (bhv-1) and parainfluenza3 (pi3), using a modified live vaccine, and randomly assigned to treatment groups. Treatments were: control (no supplemental zinc); zinc methionine; and zinc oxide. The control diet contained 26 mg of zinc/kg diet, and zinc was added in treatments 2 and 3 to provide 25 mg of supplemental zinc/kg diet. Neutralizing antibody titers were determined on serum samples taken on days 0 and 14 as a measure of the immune response to bhv-1 and pi3 vaccination. Weight gains for the 28-day study were similar across treatments. Dry matter intake tended to be higher in steers fed supplemental zinc from either source, because steers fed zinc methionine and zinc oxide consumed 5.2 and 4.4% more feed, respectively, than controls. Antibody titers against bhv-1 tended to be higher in steers supplemented with zinc methionine on day 14. Differences between treatments were not found for pi3 titers. Mortalities did not occur and morbidity rate was low.

Performance and carcass quality of steers supplemented with zinc oxide or zinc methionine.

Forty-five Angus steers (avg initial wt 330 kg) were individually fed for 112 d to assess the value of supplemental Zn and source on performance and carcass quality. Steers had ad libitum access to a control diet (81 ppm Zn) of 33% whole corn, 33% ground milo, 15% cottonseed hulls and 13% cottonseed meal, or this control diet with 360 mg Zn/d added from either zinc methionine or zinc oxide. Steers were slaughtered on d 114, and carcass composition was determined by specific gravity. Average daily gain and feed efficiency were not affected by dietary treatments. Steers fed zinc methionine had a higher (P less than .05) USDA quality grade than those fed the control and zinc oxide diets. Marbling score was higher (P less than .05) for steers fed zinc methionine than for those fed control and zinc oxide treatments (4.4 vs 4.0 and 4.0, respectively, where 3 = slight, 4 = small, 5 = modest). Steers fed zinc methionine tended to have more (P less than .10) external fat (13 mm) than steers fed the control diet (10 mm); steers supplemented with zinc oxide had intermediate amounts of external fat (11 mm). Steers fed zinc methionine had 10.5 and 12.8% more (P less than .05) kidney, pelvic and heart (KPH) fat than steers fed control or zinc oxide diets, respectively. The effects of zinc methionine on carcass quality grade and marbling score may be due to Zn and (or) methionine. Regardless of the mechanism, the difference represents a potential economic benefit to producers.