Effect Of Vitamin Supplementation Research Articles

6683 The Interrelationship of Baseline Vitamin K and Vitamin D Status on Incident Fractures: Results from the VITamin D and OmegA-3 TriaL (VITAL)

Abstract Disclosure: S.H. Chou: None. S.L. Booth: None. D. Ratnarajah: None. N. Cook: None. G. Kotler: None. X. Fu: None. J. Buring: None. J.E. Manson: None. M.S. LeBoff: None. Vitamin D and vitamin K have interdependent roles in bone metabolism. We recently reported that, in the VITamin D and OmegA-3 TriaL (VITAL), daily supplemental vitamin D (2000 IU/d) vs. placebo did not reduce fracture risk in 25,871 U.S. men (aged ≥50) and women (aged ≥55).[1] While vitamin D stimulates transcription and translation of osteocalcin (OC) and matrix Gla protein (MGP), vitamin K is needed to carboxylate and activate these proteins. Older adults tend to have low vitamin K intakes, and low vitamin K status may attenuate effects of vitamin D on bone. In this VITAL ancillary study, we tested in a case-cohort sample of 1,162 participants with fractures and an age-sex-matched subcohort size of 2,652, whether baseline low vitamin K status, alone or in combination with lower 25(OH) vitamin D level, predicts incident total, non-vertebral, and hip fractures. The mean (±SD) age of participants was 68.3±7.2 years, 61.5% were female, and 81.7% was Non-Hispanic White. Fractures were reported on annual questionnaires and adjudicated through medical record review. To assess vitamin K function, percent undercarboxylated OC (%ucOC) and dephosphorylated undercarboxylated MGP ([dp]ucMGP) were measured in fasting baseline blood samples, with %ucOC calculated from measures of ucOC and total OC. Higher levels of %ucOC and (dp)ucMGP indicate lower vitamin K status. Serum 25(OH)D was measured by LC-MS/MS and vitamin K biomarkers by sandwich ELISAs (IDS-iSYS Multi-Discipline Automated System). Participants with incident fracture had higher baseline vitamin K status, as assessed by (dp)ucMGP levels, but this was not corroborated by %ucOC. Compared to participants with low baseline vitamin K status and baseline 25(OH) vitamin D levels below the median (30.0 ng/mL), participants with higher baseline vitamin K and D status had a similar incidence of total and non-vertebral fractures. For the 91 hip fracture cases, baseline status of vitamin K and D did not predict hip fracture incidence. In this ancillary study, low vitamin K status by (dp)ucMGP and %ucOC, alone or in combination with baseline 25(OH) vitamin D levels below the median, was not associated with increased fracture incidence. Ongoing analyses are assessing whether phylloquinone levels as another vitamin K biomarker predict incident fracture risk. Furthermore, we have also previously shown that the effects of supplemental vitamin D on total and hip fractures were not modified by baseline vitamin K status in VITAL, the largest randomized controlled trial of supplemental vitamin D vs. placebo on fractures. From our findings in VITAL, higher vitamin K status does not protect against fractures. 1. LeBoff MS, et al. NEJM. 2022. Presentation: 6/1/2024

9275 The Interrelationship of Baseline Vitamin K and Vitamin D Status on Incident Fractures: Results from the VITamin D and OmegA-3 TriaL (VITAL)

Abstract Disclosure: S.H. Chou: None. S.L. Booth: None. D. Ratnarajah: None. N. Cook: None. G. Kotler: None. X. Fu: None. J. Buring: None. J.E. Manson: None. M.S. LeBoff: None. Vitamin D and vitamin K have interdependent roles in bone metabolism. We recently reported that, in the VITamin D and OmegA-3 TriaL (VITAL), daily supplemental vitamin D (2000 IU/d) vs. placebo did not reduce fracture risk in 25,871 U.S. men (aged ≥50) and women (aged ≥55).[1] While vitamin D stimulates transcription and translation of osteocalcin (OC) and matrix Gla protein (MGP), vitamin K is needed to carboxylate and activate these proteins. Older adults tend to have low vitamin K intakes, and low vitamin K status may attenuate effects of vitamin D on bone. In this VITAL ancillary study, we tested in a case-cohort sample of 1,162 participants with fractures and an age-sex-matched subcohort size of 2,652, whether baseline low vitamin K status, alone or in combination with lower 25(OH) vitamin D level, predicts incident total, non-vertebral, and hip fractures. The mean (±SD) age of participants was 68.3±7.2 years, 61.5% were female, and 81.7% was Non-Hispanic White. Fractures were reported on annual questionnaires and adjudicated through medical record review. To assess vitamin K function, percent undercarboxylated OC (%ucOC) and dephosphorylated undercarboxylated MGP ([dp]ucMGP) were measured in fasting baseline blood samples, with %ucOC calculated from measures of ucOC and total OC. Higher levels of %ucOC and (dp)ucMGP indicate lower vitamin K status. Serum 25(OH)D was measured by LC-MS/MS and vitamin K biomarkers by sandwich ELISAs (IDS-iSYS Multi-Discipline Automated System). Participants with incident fracture had higher baseline vitamin K status, as assessed by (dp)ucMGP levels, but this was not corroborated by %ucOC. Compared to participants with low baseline vitamin K status and baseline 25(OH) vitamin D levels below the median (30.0 ng/mL), participants with higher baseline vitamin K and D status had a similar incidence of total and non-vertebral fractures. For the 91 hip fracture cases, baseline status of vitamin K and D did not predict hip fracture incidence. In this ancillary study, low vitamin K status by (dp)ucMGP and %ucOC, alone or in combination with baseline 25(OH) vitamin D levels below the median, was not associated with increased fracture incidence. Ongoing analyses are assessing whether phylloquinone levels as another vitamin K biomarker predict incident fracture risk. Furthermore, we have also previously shown that the effects of supplemental vitamin D on total and hip fractures were not modified by baseline vitamin K status in VITAL, the largest randomized controlled trial of supplemental vitamin D vs. placebo on fractures. From our findings in VITAL, higher vitamin K status does not protect against fractures. 1. LeBoff MS, et al. NEJM. 2022. Presentation: 6/1/2024

Effect of vitamin supplementation and exposure-free break on hematological, Biochemical, and pathological parameters in male Wistar rats exposed to quinalphos

ABSTRACT Background: India is a land of agriculture, where the economy is based on cash crop cultivation. The wide and chronic use of pesticides for agriculture, domestic, and industrial purposes without protective measures has led to subsequent adverse health effects and further evaluation. It has become a major concern of public health due to its usage throughout the year among pesticide industrial workers, distributors and retail shopkeepers, agricultural field workers, and sprayers. Among the different types of pesticides (organochlorines, organophosphorus, carbamates, and pyrethroid compounds) used, quinalphos is the most common organophosphorus compound used in South India. These compounds were known to produce oxidative damage in the liver, kidney, bone marrow, brain, and intestine. Nonenzymatic antioxidants like vitamin C and E were found to alleviate the oxidative damage imposed by these pesticides. Thus, the present study aims to evaluate the effect of oral supplementation of vitamin E and vitamin C in comparison to exposure-free days on complete blood count, antioxidant enzymes, liver enzymes, and histopathological changes in the liver following exposure of male Wistar rats to quinalphos. Materials and Methods: This experimental study was done at XXXX after getting scientific and ethical committee clearance. A total of 24 adult male Wistar rats were divided randomly into four groups, with six in each group. Group A consists of animals not exposed to quinalphos for 60 days (control group), group B exposed to quinalphos for 60 days, group C exposed to quinalphos orally only for the first 30 days with exposure-free days for the next 30 days, and group D exposed to quinalphos orally for 60 days along with vitamin E and vitamin C oral supplementation. During exposure, quinalphos was administered at the dose of 3 mg/kg/day mixed with drinking water through oral gavage. Animals were sacrificed at the end of 60 days. Blood was collected by direct cardiac puncture, and the liver tissue was used for histopathological investigation. Data were analyzed with one-way ANOVA and post hoc Turkey’s test for intergroup comparison using SPSS 21.0 software. Results: RBC count (P = 0.011), Hb % (P = 0.000), and hematocrit (P = 0.000) were significantly reduced, whereas WBC count (P = 0.005) and neutrophil % (P = 0.001) significantly increased in the quinalphos-exposed group (group B) compared to other three groups. Liver enzymes, SGPT (P = 0.028) and SGOT (P = 0.343), were elevated, and the antioxidants catalase (P = 0.000) and glutathione peroxidase (P = 0.000) were significantly reduced in the quinalphos-exposed group when compared to the control and exposure free group. Histopathology of the liver showed diffuse necrosis of the hepatocytes with central venous congestion in quinalphos-exposed (group B) compared to the other three groups. The exposure-free group (group C) has shown better histopathological changes when compared to quinalphos exposure with (group D) and without (group B) vitamin C and E supplementation group. Conclusion: Quinalphos exposure orally results in anemia, leucocytosis with neutrophilia, liver damage, and oxidative stress. As evidenced by liver histopathology and altered antioxidant enzymes in the supplementation group compared to the group with exposure-free days, the toxic effects of quinalphos were less during exposure-free days. Thus, people occupationally exposed to quinalphos can alleviate the ill effects by having exposure-free days as interval breaks to remove the toxic accumulation of organophosphorus compounds.

Different effects of vitamin supplementation on arsenic bioaccessibility in contaminated soils using multiple in vitro methods and their relevant mechanisms

Exposure to arsenic (As) induces adverse effects on human health. Vitamins B1, B6, and C, as indispensable micronutrients for humans, have been proven to influence the metabolism and toxicity of ingested As. To determine the effect of vitamins on health risks associated with soil exposure, As bioaccessibility in 14 soil samples using four in vitro methods of IVG, PBET, SBRC, and UBM was measured with the addition of vitamins B1, B6, and C. With vitamins B1 and B6 addition, the gastric As bioaccessibility in 14 soil samples was reduced by 1.14–3.52 and 1.14–5.02 fold, respectively, and instead an increase in the intestinal bioaccessibility was presented in some cases. Vitamin C supplementation yielded higher As bioaccessibility in the gastric (1.13–13.02 fold) and small intestinal (1.21–33.35 fold) phases, respectively. As evidenced by the X-ray absorption near-edge spectroscopy (XANES) and Fourier transform infrared spectroscopy (FTIR) analysis, arsenic dissolution was promoted by Fe-As and hindered by the formation of Al-As fractions. Soil As dissolution in the simulated gastrointestinal tract was strongly influenced by soil minerals and ingested vitamins, due to the chelation of arsenic with vitamins and soil minerals such as Fe (hydr)oxides, and Fe(III) reductive dissolution to enhance As release by vitamin C as an iron reducer. These findings will expand the knowledge of health risks of exposure to As-contaminated soils and nutritional interventions aiming at the mitigation of As toxicity.

The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials.

This review aims to evaluate the efficacy of any vitamin administration(s) in preventing and managing COVID-19 and/or long-COVID. Databases were searched up to May 2023 to identify randomized clinical trials comparing data on the effects of vitamin supplementation(s) versus placebo or standard of care on the two conditions of interest. Inverse-variance random-effects meta-analyses were conducted to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs) for all-cause mortality between supplemented and non-supplemented individuals. Overall, 37 articles were included: two regarded COVID-19 and long-COVID prevention and 35 records the COVID-19 management. The effects of vitamin D in preventing COVID-19 and long-COVID were contrasting. Similarly, no conclusion could be drawn on the efficacy of multivitamins, vitamin A, and vitamin B in COVID-19 management. A few positive findings were reported in some vitamin C trials but results were inconsistent in most outcomes, excluding all-cause mortality (RR = 0.84; 95% CI: 0.72-0.97). Vitamin D results were mixed in most aspects, including mortality, in which benefits were observed in regular administrations only (RR = 0.67; 95% CI: 0.49-0.91). Despite some benefits, results were mostly contradictory. Variety in recruitment and treatment protocols might explain this heterogeneity. Better-designed studies are needed to clarify these vitamins' potential effects against SARS-CoV-2.

Abstract TP239: Vitamin D and Post-Stroke Depression: A Systematic Review and Meta-Analysis

Objective: Low vitamin D levels have often been associated with depression as well as worsen stroke outcomes. With post-stroke depression (PSD) being an important factor contributing to poor recovery and rehabilitation and thereby poor functional outcomes, this study was undertaken to explore the role of vitamin D deficiency in PSD and their correlation with stroke prognosis and outcomes. Methods: A systematic search of eligible studies from PubMed, MEDLINE, Cochrane CENTRAL, and Google Scholar were identified. Selected studies were those that met the inclusion criteria. Statistical analysis was conducted using Review Manager 5.4.1. A random-effects model was used to pool the data when heterogeneity was seen and so,results were reported in the standard mean differences within their corresponding 95% confidence interval. Results: Our analysis showed statistically significant clinical depression in the Vitamin D deficient group on the BDIII (SMD= 6.90 [3.32, 10.48]; p= 0.0002) and PHQ-9 (SMD= 3.20 [1.84, 4.56]; p< 0.00001) scales. Of the seven studies, four showed significantly poorer prognosis in PSD patients with respect to NIHSS (SMD=1.54; [0.34, 2.74]; p< 0.0001) and MMSE (SMD= -2.53 [3.79, 1.27]; p< 0.0001). Conclusion: This study shows a significant association between serum Vitamin D levels and PSD. Further studies are needed to explore causal relationships and the effect of vitamin supplementation on stroke prognosis and outcomes in relation to PSD

Effects of supplemental vitamin A on reproduction and antioxidative status of aged laying hens, and growth, blood indices and immunity of their offspring

The purpose of this investigation was to evaluate the impacts of vitamin A (VA) supplementation in feed at levels of 0 (control), 2,000, 4,000, 6,000, and 8,000 IU VA/kg diet on the reproductive efficiency and antioxidative properties of aged Sinai laying hens at 52 wk of age (n = 300 females and 30 males) in 6 replicates (10 females + 1 male/replicate). As well as blood biochemical indicators, carcass characteristics, growth performance, immunity, and the antioxidative status of their chicks. Results showed that diets supplemented with 2,000 or 6,000 IU/kg of VA increased fertility rate and decreased early embryonic mortality (P < 0.05). Increasing VA from 4,000 to 6,000 IU/kg significantly boosted hatchability rates. All VA levels significantly enhanced glutathione peroxidase (GPx) and reduced malondialdehyde (MDA) and late embryonic mortality. In the shell gland, dietary supplementation of 6,000 or 8,000 IU/kg of VA enhanced actions of GPx actions, catalase (CAT), and superoxide dismutase (SOD). In hatched chicks, all VA levels boosted (P < 0.05) hemoglobin, red blood cell count, and serum concentration of total proteins and IgA while decreasing eosinophils percentage and aspartate aminotransferase activity (AST) concentration. Dietary VA supplementations from 4,000 to 8,000 IU/kg improved lymphocytes, serum total antioxidant capacity (TAC), SOD, and IgM, while decreasing heterophils, heterophils/lymphocytes ratio, and creatinine in hatched chicks. Serum triglyceride concentration was reduced by adding 6,000 or 8,000 IU/kg of VA, while globulin and high-density lipoprotein concentrations were heightened only by 8,000 IU/kg of VA. It could be concluded that the dietary supplementation of VA (6,000 IU/kg) improved reproductive efficiency and antioxidative status in the liver and the shell gland of aged laying hens and improved hemato-biochemicals parameters, antioxidative status, and immunity of their offspring.

The Effects of Supplemental Vitamin C in Mandibular Fracture Patients: A Randomized Clinical Trial

Vitamin C is an oxidative stress mediator and essential cofactor in wound healing. The objective of this study was to investigate the clinical and biochemical effects of vitamin C supplementation on outcomes in patients undergoing mandibular fracture repair. We also aimed to evaluate the effects of sociodemographic, fracture, and treatment characteristics on post-operative clinical outcomes in these patients. The investigators conducted a double-blind, placebo-controlled, randomized clinical trial at Two Metropolitan, Level 1 Trauma Centers to prospectively evaluate the effects of vitamin C vs. placebo in a mandibular fracture population stratified by smoking and fracture status (open vs. closed). The study was conducted at two safety-net hospitals, enrolling a cohort of heavily underserved patients. Forty-five subjects were evaluated. We found decreased overall post-operative complications, decreased wound infection, and some improved bone healing outcomes in the vitamin C group compared to placebo, however, none of these outcomes reached statistical significance. Vitamin C intervention showed a signal of improved clinical and biological wound healing which was not statistically significant. Additionally, significant associations between patient characteristics and post-operative outcomes were identified. Older subjects and those with co-existent trauma were more likely to have increased healthcare utilization, and increased time from injury to surgery was significantly associated with frank infection. Prescription of additional opioids outside of standard practice was significantly associated with a need for additional wound care, increased emergency room visits, and any post-operative complication. Further investigation is needed to evaluate these findings in a larger study population, yet Vitamin C remains a low-risk, inexpensive potential means to improve wound healing outcomes after acute facial trauma.

Effect of vitamin supplementation on polycystic ovary syndrome and key pathways implicated in its development: A Mendelian randomization study.

Many epidemiologic investigations have explored the relationship between viatmins and polycystic ovary syndrome (PCOS). However, the effectiveness of vitamin, vitamin-like nutrient, or mineral supplementation in reducing the risk of PCOS remains a subject of debate. To investigate the impact of plasma levels of vitamins A, B12, D, E, and K on PCOS and key pathways implicated in its development, namely, insulin resistance, hyperlipidemia, and obesity, through Mendelian randomization (MR) analysis. Single nucleotide polymorphisms associated with vitamin levels were selected from genome-wide association studies. The primary analysis was performed using the random-effects inverse-variance-weighted approach. Complementary analyses were conducted using the weighted median, MR-Egger, MR-robust adjusted profile score, and MR-PRESSO approaches. The results provided suggestive evidence of a decreased risk of PCOS with genetically predicted higher levels of vitamin E (odds ratio [OR] = 0.118; 95% confidence interval [CI]: 0.071-0.226; P < 0.001) and vitamin B12 (OR = 0.753, 95%CI: 0.568-0.998, P = 0.048). An association was observed between vitamin E levels and insulin resistance (OR = 0.977, 95%CI: 0.976-0.978, P < 0.001). Additionally, genetically predicted higher concentrations of vitamins E, D, and A were suggested to be associated with a decreased risk of hyperlipidemia. Increased vitamins K and B12 levels were linked to a lower obesity risk (OR = 0.917, 95%CI: 0.848-0.992, P = 0.031). The findings of this MR study suggest a causal relationship between increased vitamins A, D, E, K, and B12 levels and a reduced risk of PCOS or primary pathways implicated in its development.

Prevalence of homocysteinemia and effect of vitamin supplementation in retinal vein occlusion

ObjectiveThe objective of this study was to determine the prevalence of homocysteinemia in patients with retinal vein occlusion (RVO). We investigated the association of B complex vitamin (BCV) and multivitamin...

The role of dietary education and vitamin supplementation in the treatment of Allergic Rhinitis

Introduction and purpose &#x0D; Allergic rhinitis (AR) is a widely prevalent condition which affects mainly children. The disease is not as severe as other allergic disorders; however, its symptoms significantly impact the patient's quality of life. The therapeutic options have limited effectiveness and they are burdened with numerous side effects. In addition, AR’s underlying causes are not fully elucidated; thus, there is an urgent need to conduct more large sample studies on this topic.&#x0D; State of knowledge &#x0D; In recent years, research concerning the role of vitamin deficiency in AR pathogenesis gathered pace. Some studies report that children with vitamin A, C and D deficiencies more often suffer from allergic diseases, especially AR and asthma. Furthermore, they are more likely to have severe infections and other disorders caused by immune imbalance. The crucial aspect of vitamins' role in AR is their significant ability to modulate the immune response, especially adaptive, by restoring Th1/Th2 balance. Recent publications reported that vitamin supplementation in AR patients results in an improved clinical course of the disease and restored immune balance. Moreover, vitamins added to the typical treatment improve its effects.&#x0D; Conclusions&#x0D; This review aims to summarize the state of knowledge about the role of vitamin A, C and D deficiency in the pathogenesis of AR. Moreover, we point out the values of education in the field of proper dietary habits among AR patients. In addition, the effects of vitamin supplementation in AR patients are also emphasized.

Effect of Vitamin Supplementation on Egg Production, Egg Quality, and Mortality of Sasso Chickens.

IntroductionEthiopia has a huge poultry population that plays a role in rural development. However, feed shortage is a major problem. Vitamin supplementation in feed formulation is crucial to improve the productivity of poultry. The objective of this study was to evaluate extra doses of vitamin supplements in quality egg production.MethodsThis experimental study was conducted on Sasso Ruby T chickens aged 22 weeks. The experimental and control groups each contained 60 hens. For the study group, extra doses of vitamins were added to the drinking water. Weekly observation was carried out for 3 months for a total of 12 observations. The effect of extra doses of vitamins on layers in terms of mortality, egg production, egg size, egg-specific gravity, and eggshell thickness was analyzed using SPSS 20 with t-tests.ResultsSignificant changes were observed for mortality (P<0.05), with mean mortality of 0.25±0.45 and 0.66±0.65 and general mortality of 5% and 13% in the study and control groups, respectively. Average egg production per week in the study group (279.5±3.80) was significantly (P<0.05) higher than the control group (256±4.81). However, no significant difference (P>0.05) was found for egg size between the groups: study group 59.99±0.92 g and control group 59.34±0.95 g. There was no significant variation (P>0.05) in average egg-specific gravity: study group 1.068±5.33×10−3 and control group 1.061±5.33×10−3. Average eggshell thickness was significantly greater (P<0.05) in the study group(0.36±0.048 mm) than the control group (0.32±0.04 mm).ConclusionWe identified that extra vitamin supplements for layer chickens is very important to increase profitability in the poultry industry by decreasing mortality and increasing egg production.

Effect of vitamin supplementation in patients of congestive heart failure deficient in vitamin D: A study at a tertiary care center of North India.

Introduction:Heart Failure is a leading cause of mortality worldwide including India. Most cross sectional studies have demonstrated heart failure is associated with deficiency of essential micronutrients including Vitamin D which may play a important role in pathogenesis of ventricular remodelling in heart failure.Aim:Our study performed aimed to determine the effect of supplementation in patients of Heart Failure presenting with Vitamin D deficiency to our institute on severity of Heart Failure.Design and Method:97 patients of Heart failure coming to our institute were given conventional therapies for Heart Failure along with Vitamin supplementation based on serum Vitamin D levels and followed up for 3 months.Results:Patient of Heart failure having Vitamin D deficiency had significant reduction in cardiac biomarkers (NT-pro BNP levels), improvement in Left ventricular ejection fraction (LVEF) and more favourable reverse remodelling determined by Left ventricular end diastolic and systolic diameter (LVEDD & LVESD) though quality of life determined by WHODAS 2.0 score did not changed following 12 weeks supplementation of High Dose Vitamin D.Conclusion:Recognising and treatment of Vitamin D deficiency may determine long term prognosis in patients of Heart Failure.

The Importance of Vitamins E, A and β-Carotene for the Health and Prosperity of Dairy Calves

Raising healthy and viable calves is the goal of every farmer who wants healthy cows in their breeding, with excellent milk production and reproductive parameters. And it is not just infectious and metabolic diseases that are clinically visible. Even minor nutritional deficiencies and insufficient supplementation of certain important vitamins and mineral elements can affect the calf's future health and prosperity. This mini-review summarizes the latest results on the importance of vitamins E, A and β- carotene, especially for the antioxidant and immune system of calves. It also discusses briefly effects of vitamins on the hematological profile of calves. A necessary precondition for ensuring the optimal concentration of these vitamins in calves is their sufficient supply in colostrum/milk or milk replacer. Interesting results were obtained by works focused on the effect of vitamin supplementation (parenterally or per-orally) in pregnant cows before parturition on vitamin concentrations in colostrum and plasma/serum of their calves. This can also be a way to ensure a sufficient concentration of vitamins for calves.

Biochemical profile of castrated and uncastrated male goats supplemented with vitamin E or not

ABSTRACT The objective of this study was to evaluate the biochemical parameters of goats submitted to castration or not and receiving supplementation with vitamin E or not. A total of 24 goats, uncastrated (12 experimental units) and castrated males (12 experimental units), with average body weight weighing 17.6 kg ± 2.67 kg, were distributed in a completely randomized design in a 2 x 2 factorial arrangement, with two animal conditions (castrated and uncastrated male) and vitamin E supplementation (with and without supplementation), with six replications. There was an effect of treatments (P&lt;0.05) over time for all studied variables. There was an effect of vitamin supplementation (P&lt;0.05) for phosphorus, iron, protein, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALP) and gamma-glutamyltransferase (GGT). Vitamin supplementation increased glucose, creatinine and GTT levels over time, and reduced levels of phosphorus, iron, protein, albumin, AST and ALP. We conclude that vitamin E influenced the biochemical parameters studied, but castration did not change the biochemical profile of goats, regardless of whether they were supplemented with vitamin E or not.

For pregnant women, what are the effects of vitamin supplements for prevention of stillbirth, fetal loss, and perinatal death?

For pregnant women, what are the effects of vitamin supplements for prevention of stillbirth, fetal loss, and perinatal death?

Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.

Vitamin B12 is often used to improve cognitive function, depressive symptoms, and fatigue. In most cases, such complaints are not associated with overt vitamin B12 deficiency or advanced neurological disorders and the effectiveness of vitamin B12 supplementation in such cases is uncertain. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to assess the effects of vitamin B12 alone (B12 alone), in addition to vitamin B12 and folic acid with or without vitamin B6 (B complex) on cognitive function, depressive symptoms, and idiopathic fatigue in patients without advanced neurological disorders or overt vitamin B12 deficiency. Medline, Embase, PsycInfo, Cochrane Library, and Scopus were searched. A total of 16 RCTs with 6276 participants were included. Regarding cognitive function outcomes, we found no evidence for an effect of B12 alone or B complex supplementation on any subdomain of cognitive function outcomes. Further, meta-regression showed no significant associations of treatment effects with any of the potential predictors. We also found no overall effect of vitamin supplementation on measures of depression. Further, only one study reported effects on idiopathic fatigue, and therefore, no analysis was possible. Vitamin B12 supplementation is likely ineffective for improving cognitive function and depressive symptoms in patients without advanced neurological disorders.

Effects of vitamin supplements on clinical cardiovascular outcomes: Time to move on! - A comprehensive review.

Background & aimsVitamin supplementations have increasingly been advertised on media and reported to be widely used by the general public to improve cardiovascular health. Due to the COVID-19 pandemic, people have become more interested in ways to improve and maintain their health. Increased awareness of people on healthy lifestyle is translating into inquisition regarding dietary supplements. Aim: First, focus on the most commonly used vitamin supplements and comprehensively review the evidence for and against recommending them to patients to improve and/or maintain cardiovascular health. Second, illustrate how the interest in studies shifted over time from Vitamin A, E, C, and B to Vitamin D and observational studies led to randomized controlled trials.MethodsA thorough PubMed search with the phrase: “Vitamin supplements and cardiovascular health” was performed. In the present review, focus was maintained on the evidence for the use of vitamin supplements in the prevention of major cardiovascular events and/or the maintenance of cardiovascular health by comprehensively reviewing all previous studies indexed in PubMed. Studies with clinical ‘hard’ end-points were included only.ResultsA total of 87 studies met the inclusion criteria and were reviewed in the present article. High-quality evidence suggesting benefits for the use of vitamin supplements to maintain or improve cardiovascular health in people is minimal to non-existent.ConclusionsVitamin supplementation does not improve clinical cardiovascular outcomes in general population. Counseling on the importance of maintaining a healthy lifestyle with adequate and nutritious food intake seems more appropriate to improve and maintain cardiovascular health.

The role of vitamin A and vitamin D in modulation of the immune response with a focus on innate lymphoid cells.

The immune system with its numerous and complex interactions helps to protect the host from pathogenic microorganisms, and enables cleaning of damaged tissues. It is also associated with constant “monitoring” of the appearance of malignant cells and their elimination that can occur in the human body. Such a role depends on many factors including adequate intake of nutrients, including vitamins. The effect of vitamin supplementation on the modulation of the immune response has always been the focus of numerous studies. Vitamins A and D have been shown to have the greatest immune-modulatory effect. In this review, we discuss and consider the possible roles of vitamins A and D on the immune response through innate and adaptive immune cells, with special focus on the cell population recently characterized as innate lymphoid cells. Recent literature data indicate that vitamin A and its metabolites modulate the balance between Th1 and Th2 immunity. In addition, vitamin D expresses protective effects on the innate immune system and inhibitory effects on adaptive immunity.

Efficacy of Oral Vitamin Supplementation in Inflammatory Rheumatic Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: We aimed to provide a systematic review and meta-analysis of randomized controlled trials assessing the effect of oral vitamin supplementation on symptoms and disease activity in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic arthritis (PsA). Methods: A systematic literature review and meta-analysis of randomized controlled trials including patients with inflammatory rheumatic diseases were performed using MEDLINE, EMBASE and abstracts from recent international rheumatology congresses. Studies were reviewed in accordance with PRISMA guidelines. We analysed clinical outcomes according to each type of vitamin supplementation. Results. The initial search yielded 606 articles. Of these, 13 studies were included in the qualitative synthesis: eight studied vitamin D supplementation, two assessed vitamin E supplementation, two folic acid, and one vitamin K, all of them on RA patients. No studies on SpA or PsA were selected. Oral vitamin supplementations were not associated with a reduction in RA activity (DAS-28 or pain) or RA flares. Conclusions: Despite their beneficial effects, the effects of vitamin supplementation on RA activity, if any, seem to be limited. Evidence on their efficacy on SpA or PsA activity is lacking. However, folic acid supplementation should be suggested to prevent methotrexate-related side effects, and vitamin D should be given to patients with vitamin D deficiency to prevent musculo-skeletal complications.