Effects Of Virgin Coconut Oil Research Articles

Effectiveness of Virgin Coconut Oil (VCO) Topically to The Formation Granulations of Grade I and II Pressure wound (Decubitus)

Effectiveness of Virgin Coconut Oil (VCO) Topically to The Formation Granulations of Grade I and II Pressure wound (Decubitus)

Virgin Coconut Oil Supplementation Ameliorates Diabetes and Atrazine-Induced Inflammation in Male Wistar Rats

We assessed the ameliorative effect of Virgin Coconut Oil (VCO) following atrazine-induced inflammation in rats. Adult male Wistar rats weighing 180 - 200 g body weight were separated into two major experimental groups. 35 rats in the test group were divided into five groups of 7 rats: Group 1,2 and 3 received 10 ml/kg body weight of distilled water, 10 ml/kg VCO and 123 mg/kg Atrazine (ATZ) respectively, group 4 was diabetic control and group 5 was diabetic group treated with 10 ml/kg of VCO for 2 weeks, after which the animals were sacrificed, and blood collected for analysis. 35 rats for the recovery group were also divided into 5 groups of 7 rats; group 1 and 2 received 10 ml/kg body weight of distilled water and 10 ml/kg of VCO; group 3,4 and 5 received 123 mg/kg of ATZ for 2 weeks. After the first 2 weeks, group 1,2,3 continued the initial treatment while the rats in group 4 and 5 were administered 10 ml/kg of VCO and 10 ml/kg of distilled water respectively. After 2 weeks all the animals were sacrificed and blood collected for analysis. C-reactive protein (CRP) and interleukin 6 (IL-6) were significantly (p<0.05) raised in VCO control, atrazine and diabetic untreated group when compared to normal control. Following recovery, CRP and IL-6 were significantly lowered in the VCO treated group when compared to ATZ group. ATZ toxicity resulted in increase in inflammatory markers but the withdrawal of ATZ significantly reversed some of these derangements; with more pronounced effect following VCO administration.

Pathway analysis of the effect of virgin coconut oil on suppressing colonic mucosal inflammation and clinical symptoms in ulcerative colitis

Pathway analysis of the effect of virgin coconut oil on suppressing colonic mucosal inflammation and clinical symptoms in ulcerative colitis

The Effect of Virgin Coconut Oil on TNFα and Cytochrome P450 Aromatase Levels in Obese Female White Rats (Rattus norvegicus) Induced with a High-Fat Diet

Background: The high level of various proinflammatory cytokines due to adipocyte hypertrophy such as TNFα in obesity increases cytochrome-P450-aromatase, further inducing increased estrogen production, hypersecretion of Luteinizing Hormone and decreased Follicle Stimulating Hormone, resulting in impaired folliculogenesis, and chronic anovulation. Virgin Coconut Oil is rich in Medium Chain Fatty Acid and phytochemicals as anti-inflammatory. Aim: The aim of this study was to determine the effect of VCO on reducing TNFα and cytochrome-P450-aromatase levels in obese female white rats. Methods: Post test only control group, 24 rats were divided into 3 groups, namely: negative control group (K-), positive control group (K+), and treatment group (P). The K+ and P groups were induced using a high-fat diet for 10 weeks, then the P group was given VCO in weeks 7-10. On the first day of week 11, blood was taken from the orbital vein of the eyes of all rats for TNFα levels. Both examinations used ELISA kits. Data analysis used Shapiro Wilks normality test. The value of p>0.05, followed by hypothesis testing using one-way annova and post hoc Bonferroni. Results: Mean TNFα in the K- group: 141.71±8.87, K+ group: 15.09±19.30, P group: 162,09±13,57. Mean cytochrome-P450-aromatase levels in the K- group: 9.00±0.77, K+ group: 12.22±1.69, P group: 10.58±0.97. The mean levels of one way ANOVA analysis showed that the administration of VCO can significantly reduce TNFα levels (p=0.001) and significantly reduce Cytochrome-P450-aromatase levels (p=0.001). Conclusion: VCO administration can reduce TNFα levels and cytochorme-P450-aromatase levels in obese female white rats. Keywords: TNFα, cytochrome-P450-aromatase, infertility, obesity

A comparative Study of the Effects of Virgin Coconut Oil and Vitamin D on Alzheimer’s Disease Induced by Aluminium Chloride in Male Albino Rats Hippocampus

A comparative Study of the Effects of Virgin Coconut Oil and Vitamin D on Alzheimer’s Disease Induced by Aluminium Chloride in Male Albino Rats Hippocampus

Effectiveness of Ginger and Virgin Coconut Oil on the Cure of Otomycosis in Infected Chicken of Aspergillus sp.

Background: Otomycosis refers to a subacute or prolonged fungal infection occurring in the outer ear canal, leading to inflammation. Ginger has been known as its antifungal agents which comprises powerful bioactive elements such as phenolic compounds and terpenes. The antimicrobial effect of virgin coconut oil (VCO) stems from the presence of monolaurin, a derivative of lauric acid, which operates by compromising the lipid constituents of microorganisms’ cell membranes. Methods: This experimental animal study is to evaluate the effectiveness of ginger extract and VCO in cases of otomycosis. We used chickens aged 2–3 years that divided into 5 groups. Group 1 as the positive control group was given ointment (imidazole), Group 2 was given 2% ginger extract, Group 3 was given 2% VCO extract, Group 4 was given a combination of ginger extract and 2% VCO, and Group 5 was the negative control group which was not given any treatment. Results: We found statistically significant difference result in hyphae growth inhibition of sample which given ginger extract compared to positive and negative control with P = 0.002 and P < 0.001, respectively. Furthermore, VCO treatment also showed a significant difference compared to negative and positive controls with both P < 0.0001. Nonetheless, combination of ginger extract and VCO treatment achieved the best result to inhibit fungal development. Conclusion: A combination of ginger extract and VCO at a concentration of 2% demonstrates greater potency in restraining the growth of Aspergillus flavus, which is responsible for causing otomycosis in chickens, compared to using either extract alone.

Effectiveness of Virgin Coconut Oil in Treating Dry Eyes

Effectiveness of Virgin Coconut Oil in Treating Dry Eyes

Effect of Virgin Coconut Oil on Cognition of Mild‐to‐moderate Alzheimer’s Disease Patients with APOE ε4 Allele

AbstractBackgroundVirgin coconut oil (VCO) is an excellent source of medium chain fatty acids and thus, a potential natural ketogenic agent that can be used to substitute glucose in Alzheimer’s disease (AD) brain, in which the glucose metabolism is compromised. High content of polyphenols in VCO will also support to reduce inflammation and oxidative stress associated with AD. The aims of this double‐blind placebo‐controlled trial were to investigate the effect of VCO on cognition in mild‐to‐moderate AD patients and the association of apolipoprotein E (APOE) ε4 genotype on the outcome.MethodStudy participants were 120 mild‐to‐moderate AD patients [Mini‐Mental State Examination (MMSE) score = 15‐25, age ≥65 years], randomly allocated to either treatment or control groups and orally fed 30 mL/ day of VCO as the treatment and a same amount of canola oil as the placebo for 24 weeks. Cognition was assessed by MMSE, Montreal Cognitive Assessment (MOCA), and executive clock drawing task (CLOX) at the baseline and at the end of the intervention. APOE genotyping was conducted at the baseline. Fasting lipid profile and glycated hemoglobin (HbA1C) levels were analyzed at the baseline and at the end of the intervention.ResultThere was no significant difference in the post‐intervention changes of cognitive assessment scores, lipid profile and HbA1C levels between the treatment and control groups. The MMSE scores of the APOE ε4 carriers in the treatment group was improved compared to the non‐carriers (change of MMSE = 2.37, p = 0.021), whereas there was no difference in the control group. In both treatment and control groups, the lipid parameters were not compromised during the intervention.ConclusionOral supplementation of 30 mL/day of VCO for 24 weeks did not improve cognition of mild‐to‐moderate AD patients compared to canola oil. However, VCO improved the MMSE scores of APOE ε4 carriers compared to non‐carriers. Consumption of VCO was safe as it did not compromise lipid parameters.

Effectiveness of virgin coconut oil (VCO) in increasing immunity in Stunting Toddlers

Stunted toddlers experience chronic malnutrition, which causes a decrease in their immune system, resulting in a higher risk of developing acute and chronic infectious diseases as well as recurrent infections and suffering death. Giving VCO to stunted toddlers aims to improve metabolic function to increase immunity, optimize growth and development, and improve the quality of health status of little toddlers. This research aims to determine the effectiveness of VCO in increasing the immunity of stunted toddlers. This research used a Quasi-Experimental method with 32 stunted toddlers as respondents. The instrument used was a questionnaire given pre-and post-intervention. Data analysis used the Paired t-test. The research results showed that most respondents' immunity level was poor before administering VCO (62.5%). In contrast, after administering VCO, the immunity level of most of the respondents was sufficient (46.9%), with a p-value = 0.01, which means that the administration of VCO has proven effective in increasing immunity in toddlers. It is recommended that the public include VCO as a functional nutrition in therapy for stunting toddlers.

Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum-induced neurotoxicity in an in vitro Alzheimer's disease model.

Alzheimer's disease (AD) is a progressive neurological disorder that affects various cognitive functions, behavior, and personality. AD is thought to be caused by a combination of genetic and environmental factors, including exposure to aluminum (Al). Virgin coconut oil (VCO) may have potential as a natural neuroprotectant against AD. Aim of this study was to determine neuroprotective effects of VCO on Al-induced neurotoxicity in an in vitro AD model. SH-SY5Y cells were initially cultured in normal growth medium and then differentiated by reducing fetal bovine serum content and adding retinoic acid (RA). Later, brain-derived neurotrophic factor (BDNF) was added along with RA. The differentiation process was completed on the seventh day. Study groups (n = 3) were designed as control group, VCO group, Al group, Al-VCO group, Alzheimer model (AD) group, AD + Al-exposed group (AD+Al), AD + VCO applied group (AD + VCO) and AD + Al-exposed + VCO applied group (AD + Al + VCO). Specific markers of AD (hyperphosphorylated Tau protein, amyloid beta 1-40 peptide, and amyloid precursor protein) were measured in all groups. In addition, oxidative stress parameters (total antioxidant capacity, lipid peroxidase, protein carbonyl, and reactive oxygen species) and neurotransmitter-related parameters (dopamine, dopamine transporter acetylcholine, and synuclein alpha levels, acetylcholinesterase activity) were measured comparatively in the study groups. VCO reduced amyloid beta and hyperphosphorylated Tau protein levels in the study groups. In addition, oxidative stress levels decreased, and neurotransmitter parameters improved with VCO. Our study shows that VCO may have potential therapeutic effects in Alzheimer's disease and further experiments are needed to determine its efficacy.

Ameliorating Effects of Virgin Coconut Oil (VCO) on Nicotine Dependence and Quality of Life in Smokers.

Safer and effective alternatives to manage nicotine dependence are still required. Preliminary studies have shown the potential of virgin coconut oil (VCO) to be used in dependence treatment. To assess the VCO effect administered for 14 days on nicotine dependence and quality of life. Forty smoking subjects participated in an open-label, single-center, pre/post-intervention study, and were required to take 15 ml VCO twice daily for 14 days. They were evaluated with the Fagerstrom Test for Nicotine Dependence (FTND) for nicotine dependence intensity and EuroQolvisual analogue scales (EQ VAS) for quality of life. The VCO regimen improved FTND (0.53 points decrease, p<0.05) and EQ-VAS (5.85 points increase p<0.01) scores. Adverse events were all mild. Results of the present study suggest that VCO has the potential to be a safe and effective adjunct therapy for the management of nicotine dependence.

Effect of Virgin Coconut Oil (VCO) on Cardiometabolic Parameters in Patients with Dyslipidemia: A Randomized, Add-on Placebo-Controlled Clinical Trial

Objective Statin monotherapy for dyslipidemia is limited by adverse effects and limited effectiveness in certain subgroups like metabolic syndrome. Add-on therapy with an agent with a known safety profile may improve clinical outcomes, and virgin coconut oil (VCO) may be the candidate agent for improving the cardiometabolic profile. The present study was conducted to evaluate the effect of add-on VCO with atorvastatin in dyslipidemia in adults. Methods A randomized, double-blind clinical trial was conducted on 150 patients with dyslipidemia who were randomized into control and test groups. The control group received atorvastatin monotherapy, whereas the test group received add-on VCO with atorvastatin for 8 weeks. At baseline, demographic, clinical, and biochemical parameters were assessed and repeated after 8 weeks of therapy. The main outcome measures were lipid profile, cardiovascular risk indices, 10-year cardiovascular risk, body fat compositions, and thiobarbituric acid reactive substances (TBARS). Results The increase in HDL in the test group was significantly greater than in the control group (MD: 2.76; 95%CI: 2.43–3.08; p < 0.001). The changes in the atherogenic index (p = 0.003), coronary risk index (p < 0.001), cardiovascular risk index (p = 0.001), and TBARS (p < 0.001) were significantly greater in the test group. The decrease in LDL, total cholesterol and lipoprotein(a), were significantly higher in the control group. There were no significant differences between the groups with respect to the changes in triglyceride, VLDL, and 10-year cardiovascular risk. Conclusions Add-on VCO (1000 mg/day) with atorvastatin (10 mg/day) can achieve a better clinical outcome in patients with dyslipidemia by increasing HDL and improving oxidative stress cardiovascular risk indices.

Restoration of Germinal Epithelium with Usage of Antioxidant Oils in Phenytoin Induced Testicular Toxicity: A Comparative Study in Rats

Objective: To evaluate antioxidant effect of Virgin Coconut Oil (VCO) and Corn Oil (CO) on germinal thickness (GT) in rats induced with phenytoin toxicity. Study design and setting: An Experimental Longitudinal study was done at AL-Tibri Medical College and Hospital Isra University Karachi Campus. Methodology: 28 male albino rats were selected and were divided into 4 groups each consisting of 7 rats. Group A received normal saline solution only, Group B received 10mg/kg/body weight of Phenytoin, Group C received VCO+ Phenytoin, and Group D received CO+ Phenytoin. Animals were euthanized on the 4th, 5th, &amp; 6th week and tissue sample was acollected for measuring GT using stage micrometer. Data was analyzed using SPSS 20.0. All values were expressed as mean ± S.D., groups compared using One way ANOVA followed by Post hoc Tukey’s test with p- value &lt;0.05. Results: on 4th, 5th, &amp; 6th week significant difference in germinal thickness was seen in Group A comparing it against the phenytoin group B (P-value: &lt;0.001, &lt;0.001, &amp; 0.001). On 4th, 5th, &amp; 6th week significant difference in GT was seen in Group C (VCO + Phenytoin) comparing it against the phenytoin group B (P-value: &lt;0.001, &lt;0.001, &amp;&lt; 0.001). No significant difference in germinal thickness was seen on 4th, 5th, &amp; 6th week was seen when Group D (CO + Phenytoin) was compared to Group B (p-value: 0.551, 0.954, &amp; 0.931). Conclusion: Virgin Coconut Oil can reduce the negative effect caused by phenytoin induced toxicity by preventing thinning of the germinal layer.

Protective effect of virgin coconut oil against doxorubicin-mediated hepatotoxicity in rats

Protective effect of virgin coconut oil against doxorubicin-mediated hepatotoxicity in rats

Effectiveness of Virgin Coconut Oil (VCO) on Changes in Weight and Height among Under-five Children with Stunting

Virgin Coconut Oil (VCO) is a type of vegetable oil that can facilitate the food digestion and nutrients absorption processes. VCO contains plus minus 10percent unsaturated fatty acids and plus minus 90percent saturated fatty acids. Besides fat, VCO also contains micronutrients. Administering VCO to under-five children with stunting aims to improve metabolic function so as to increase immunity, optimize growth and development and quality of child health status. This study aims to determine the effectiveness of Virgin Coconut Oil (VCO) on changes in body weight and height among under-five children with stunting. This was a Quasi-Experimental study with a Non Equivalent Control Group design. The samples involved 32 under-five children with stunting. The intervention by administering VCO at a dose of 1 X 5 ml before eating in the morning was conducted for 30 days. Data were analyzed using paired t-test. The results of the study found that administration of VCO was not proven to be effective in significantly increasing body weight (p equals 0.693) and height (p equals 0.548) among under-five children with stunting (p more than 0.05).

The Effect of Virgin Coconut Oil (VCO) on Malondialdehyde, Glutathione Peroxidase, and Cortisol Hormone Levels

Vigorous physical activity is a physical movement that produces excessive free radicals due to leakage of electrons from the mitochondrial transport system. The body's antioxidant system is reduced due to the inability of the body's defenses to reduce the production of free radicals resulting in oxidative stress, so it requires a supply of antioxidants from outside the body such as Virgin Coconut Oil (VCO). The purpose of this study is to determine the effect of VCO administration on malondialdehyde levels, glutathione peroxidase levels and cortisol hormone levels in male Wistar rats subjected to strenuous physical activity. The research method uses an experimental with posttest only control group design. The experimental subjects were 24 male Wistar rats which were randomly divided into 4 groups (K1, K2, K3, and K4). The administration of VCO at dose of 25 mL and 50 mL are based of human weight 70 kg and the conversion dose in mice (BB = 200 g) resulted in 0.45 mL/200 g BW/day and 0.9 mL/200 g BW / day which is made into a 1 mL solution and given orally for 28 days. K3 and K4 groups were given strenuous physical activity and given VCO at a dose of 0.45 and 0.9 mL/200 g BW/day. The measurement of malondialdehyde levels using the TBARS method. The glutathione peroxidase (GPx) and the cortisol hormone using ELISA method at PSPG UGM in June 2022. The lowest average levels of MDA and GPx were in the K1 group. One-Way Anova test result showed that the levels of malondialdehyde, glutathione peroxidase, and the cortisol hormone in the K3 and K4 groups had significant differences with K2 group (p &lt; 0.05). The administration of VCO at doses of 0.45 mL/200 g BW/day and 0.9 mL/200 g BW/day could affect the levels of malondialdehyde, glutathione peroxidase, and the hormone cortisol in male Wistar rats subjected to strenuous physical activity.

The Effect of Virgin Coconut Oil (VCO) on Malondialdehyde, Glutathione Peroxidase, and Cortisol Hormone Levels

The Effect of Virgin Coconut Oil (VCO) on Malondialdehyde, Glutathione Peroxidase, and Cortisol Hormone Levels

Anti-inflammatory and nephroprotective influence of virgin coconut oil on gentamicin‐induced nephrotoxicity in non-diabetic and streptozotocin-induced diabetic rats

Gentamicin is an effective antibiotic against severe infections, but a major downside is its nephrotoxic effects. Virgin coconut oil has potential antidiabetic effects, but there has been no study on its potential role in gentamicin‐induced nephrotoxicity in streptozotocin -induced diabetic rats. Thus, the aim of the current study is to explore the anti‐inflammatory and nephroprotective effects of virgin coconut oil on non-diabetic and streptozotocin-induced diabetic rats. A total of 48 adult male Sprague-Dawley rats were randomly divided into eight groups (n=6), including non-diabetic groups (groups 1-4) and streptozotocin-induced diabetic groups (groups 5-8). Groups 1 and 5 received a normal diet, groups 2 and 6 were fed a normal diet + gentamicin at 100 mg/kg/day for the last 10 days of the study period, groups 3 and 7 were treated with 10 ml/kg/day of virgin coconut oil for four weeks, and groups 4 and 8 were given gentamicin for the last 10 days of the study period plus virgin coconut oil for four weeks at the same doses mentioned. Gentamicin adminstaration caused oxidative stress, and led to antioxidant defense depression which was confirmed by elevated kidney Malondialdehyde (MDA) (4.53, 5.62) and reduced renal antioxidant enzymes including renal superoxide dismutase (59.82, 45.58), catalase (53.11, 37.3) and glutathione peroxidase (51.41.36.34) in non-diabetic (ND) and diabetic (D) rats, respectively. It also resulted in a significant increase of serum urea (31.72, 50.78), creatinine (2.88, 4.16), cystatin-C (13.75, 17.69), and inflammatory biomarkers interleukin-6 (IL-6) (84.01, 102.73) and tumor necrosis factor-α (TNF-α) (667.05, 853.05) in ND and D rats, respectively. Virgin coconut oil showed protective effects and significantly improved renal function parameters, including serum urea (17.35, 38.9), creatinine (1.69, 2.96) and cystatin-C (14.26, 15.94) for ND and D groups, respectively. Pre- and co-administration of virgin coconut oil exerted a remarkable protective effect against oxidative stress induced by gentamicin in normal and diabetic rats. Pro-inflammatory biomarkers were also improved in groups treated with virgin coconut oil. The results are promising in terms of the use of virgin coconut oil as a dietary agent in attenuating the progression of chronic renal disease, especially in the context of diabetes. Key words: anti‐inflammatory, nephroprotective, virgin coconut oil, gentamicin, streptozotocin, flavonoid, phenol, oxidative stress

Test of Inhibitory Power of Virgin Coconut Oil and Olive Oil From Various Brands Against Staphylococcus aureus Bacteria, and The Review According to Islamic Prespective

Infectious disease is a major public health problem in developed and developing countries. One of the bacteria that can cause infection is Staphylococcus aureus. Along with an increase in bacterial resistance, one of which is caused by the inappropriate use of antibiotics, it reduces the effectiveness and performance of treatment methods. Alternative medicine can use pure coconut oil (virgin coconut oil) which contains lauric acid as an antibacterial and olive oil which contains oleuropein as an antibacterial. Experimental research using the Kirby Bauer diffusion disc method by measuring the diameter of the inhibition zone of Staphylococcus aureus bacteria. The materials tested were various types of pure coconut oil and olive oil on the market with 50%, 75% and 100% inhibition zones. In the inhibition test of virgin coconut oil and olive oil, the bacterial inhibition zone was only found at a concentration of 100%, while at a concentration of 50% and 75% there was no bacterial inhibition of the two tested materials. The conclusion is that there is an effect of virgin coconut oil and olive oil on the inhibition of Staphylococcus aureus bacteria at a concentration of 100%.

Effect of virgin coconut oil on body weight, white fat depots, and biochemical and morphological parameters in mice fed standard or high-fat diets.

This study investigated the effects of virgin coconut oil (VCO) on body weight, white fat depots, and biochemical and morphological parameters in male Swiss mice fed standard (SD) or high-fat (HFD) diets. Thirty-three adult animals were assigned to one of four groups, as follows: SD, SD plus VCO (SDCO), HFD, and HFD plus VCO (HFDCO). VCO had no effects on the Lee index, subcutaneous fat, periepididymal fat, retroperitoneal fat, area under the curve for glucose, or pancreas weight, all of which were increased by HFD. Low-density lipoprotein cholesterol increased in the SDCO group compared with the SD group and decreased in the HFDCO group compared with the HFD group. VCO increased total cholesterol only in the SDCO group compared with the SD group, with no differences between the HFD and HFDCO groups. In conclusion, low-dose VCO supplementation did not improve obesity, had no effects on hepatic or renal function, and had beneficial effects on the lipid profile only in animals fed HFD.