ABSTRACT Objective In this study, we investigated the advantages of attention allocation and spatial orientation among video game players (VGPs) and non-video game players (NVGPs) and explored the performance differences between the two groups in flight simulations. Method Thirty candidates from a Chinese university were categorised as VGPs and NVGPs before participating in all tests. Results The comparison of flight performance and eye movement indicators between the two groups showed that the flight performance of VGPs was significantly better than that of NVGPs. We then found that an attention shift task and group factors predicted flight performance during take-off, while spatial orientation and tracking tasks have direct and indirect effects on cruise task performance, respectively. Eye movement indicators can directly predict flight performance to a certain extent. Conclusion We believe that the transfer effect of game experience in simulated flight tasks assisted VGPs in using top-down processing strategies in the flight process, and in better allocating cognitive resources. KEY POINTS What is already known about this topic: The advantages of attention allocation and spatial orientation among video game players (VGPs) and non-video game players (NVGPs). This difference not only caused by gaming experience, but also comes from the interaction of gaming experience and individual differences. The VGPs perform better on simulated flight mission. We speculated that gaming practice had assisted VGPs in using top-down processing strategies in the flight process, and in better allocating cognitive resources. VGPs did not depend solely on low-level cognitive abilities to finish tasks, but rather could rapidly understand the relevant situation and task in order to choose a proper attention allocation strategy, that visual search patterns must be adapted according to different situations, as opposed to reliance on a single parallel or sequence search. What this topic adds: The promotional effects of gaming experience occurred in high-level cognitive processing, but this effect was also observed in low-level ability tests. The key to promoting and maintaining excellent long-term performance are comprehensive cognitive skills, advanced cognitive skills, the establishment of mental models, and adaptive top-down processing strategies. The aviation training system design should not stop at elemental training to improve general cognitive abilities, but should be a comprehensive ability-training game in order to improve training efficiency for pilots. In order to establish a cognitive ability video game training system for pilots in the future, further exploration is needed to understand whether the transfer effect would occur in real world flight missions.