Reflex Effects Research Articles

Thinking Theoretically in Nursing Research-Positionality and Reflexivity in an Interpretative Phenomenological Analysis (IPA) Study.

This paper explores the application of positionality and reflexivity drawing on the experience of a British Minority Ethnic (BME) group senior nurse researching nurses with the same ethnic heritage in an IPA study. It explores how using IPA informed reflexivity and positionality as a researcher who shared the same ethnicity with the research participants. The IPA study allowed for the exploration of Internationally Educated Nurses' (IENs) perspectives on their integration into British healthcare and their navigation of career progression. The central aims of an IPA study are to understand the participant's world, its description, the development of a clear, and open interpretative analysis with a descriptive focus on the social, cultural and theoretical context, and the participant's sense-making of their lived experience. In this paper, we discuss how the lead researcher employed reflexivity, stated his intentionality and positionality in the conduct of the IPA study. This paper discusses some examples of the effects of positionality and reflexivity in the conduct of research by researchers of different racial background, and explicate the influence of personal and professional experiences of a researcher in using reflexivity and positionality to ensure cross-cultural validity and reliability of an IPA research. This paper concludes that appropriate use of reflexivity and positionality in an IPA study may recognise the personal and professional influence of a researcher's experiences on the research process, including their ethnicity.

The change in Baroreflex Regulation of Heart Rhythm after “Dry” Immersion Appears during Orthostasis, but not Lower Body Negative Pressure Test

The ratio of low-frequency (LF, ~0.1 Hz) waves of RR interval duration (RRI) and systolic blood pressure (SAP) reflects the cardiac baroreflex sensitivity (BRS). Gravitational unloading (GU) may alter BRS during the passive orthostatic test (HUT) and lower body negative pressure (LBNP) test. Both effects cause blood redistribution to the lower body, but HUT is accompanied by greater unloading of sinocarotid baroreceptors than LBNP and activation of the vestibulosympathetic reflex but GU effects on BRS in these tests have not been directly compared previously. In this study we tested the hypothesis that the effect of “dry” immersion (DI, on-ground model of GU) on BRS in the same subjects will be more pronounced during HUT than during LBNP, which causes a comparable decrease in stroke volume. Nine healthy men participated in two test sessions (before and after 7-day DI) consisting of five 3-min HUT (65°) and five 3-min LBNP (–35 mmHg) with averaging the parameters in each test. Wavelet analysis was used to determine the amplitude of the RRI and SAP waves in the range of 0.05–0.13 Hz. The amplitude of LF waves of SAP increased in both tests, after DI - more significantly in HUT. The amplitude of LF RRI waves decreased in the two tests; the degree of decrease did not differ between tests and did not change under the influence of DI. The α-coefficient (the ratio of the amplitudes of RRI and SAP LF waves) decreased equally in the two tests before DI, but after DI, the degree of α-coefficient reduction increased in HUT test but did not change in LBNP test. Thus, the effect of DI on BRS is evident in HUT, but not in LBNP, which may be explained by the more pronounced influence of HUT on the mechanisms of neural control of heart rhythm.

Assessment of reflex risks of inhalation exposure to harmful substances among the Murmansk oblast population

This study aimed to assess the individual risks of immediate (reflex) effects of inhalation exposure to nitrogen oxide and nitrogen and sulfur dioxides among the population of the Murmansk Oblast. The study was conducted in seven cities and covered the period of October, November, and December 2021. The considered chemical compounds belong to the third hazard class. Calculations were carried out using mathematical models, linking the penetration values with the actual concentrations of pollutants in the atmospheric air and their maximum permissible one-time concentrations. A table of normal probability distribution was used to convert probits into risks. The calculated risk values were compared with the acceptable values of the maximum risks of immediate action. The acceptable value of nitrogen oxide and dioxide (0.02–0.05) was found to be exceeded in the city of Kovdor in November and December. In the city of Monchegorsk, the acceptable value of sulfur dioxide was exceeded in November.

Adaptive backstepping sliding mode subject-cooperative control for a pediatric lower-limb exoskeleton robot

The passive-assist rehabilitation mode with a fixed desired trajectory neglects the subject’s active involvement and degrades the therapeutic performance in case of partial muscle strength. Therefore, this study proposes a novel subject-cooperative control based on a variable admittance control scheme and a robust trajectory control scheme for a pediatric lower-limb exoskeleton robot. Initially, the system description and dynamic modeling are briefly explained. Thereafter, a neural-fuzzy–based variable admittance control ( nf VAC) is designed to incorporate a realistic subject-exoskeleton interaction and consider the subject’s active participation. Finally, a robust adaptive backstepping sliding mode control with rapid reaching law is used to handle parametric uncertainties and external disturbances. A stepwise selection of Lyapunov functions is utilized to address the stability of the trajectory control. The effectiveness of the proposed adaptive backstepping sliding mode–neural-fuzzy variable admittance control (ABSM- nf VAC) scheme is compared with two contrast control schemes, namely, adaptive backstepping-fixed admittance control (AB-FAC) and adaptive terminal sliding mode-fuzzy variable admittance control (ATSM- f VAC) for the active-assist mode with the effect of sudden reflex. Based on the numerical results, the suggested cooperative controller has demonstrated favorable tracking performance, compliant interaction, and safety aspects during gait training.

Synergistic interaction of guanfacine or dexmedetomidine coadministered with lidocaine for cutaneous analgesia in rats

ABSTRACT Background This study examined the cutaneous analgesic effects of lidocaine co-injected with guanfacine and its comparison with dexmedetomidine. Methods Cutaneous analgesic effects are quantified through the blocking effects of the cutaneous trunci muscle reflex against skin pinpricks in rats. The dose-response curves of guanfacine, dexmedetomidine, and lidocaine were constructed and drug-drug interactions were analyzed by the ED50 isobologram. Results Subcutaneous injections of guanfacine, dexmedetomidine, and lidocaine produced dose-dependently nociceptive/sensory blockade. On the ED50 (50% effective dose) basis, the potency rankings of the drug are dexmedetomidine (0.09 [0.08–0.11] μmol/kg) > guanfacine (3.98 [2.96–5.34] μmol/kg) > lidocaine (25.40 [23.51–27.44] μmol/kg) (p < 0.01). On their equipotent doses (ED25, ED50, and ED75), the duration of sensory blockade induced by guanfacine or dexmedetomidine was longer than lidocaine’s (p < 0.01). Both guanfacine and dexmedetomidine showed synergistic effects with lidocaine. Conclusions We showed that guanfacine elicits dose-dependent cutaneous analgesia when administered subcutaneously. Lidocaine is less potent than guanfacine or dexmedetomidine. Both guanfacine and dexmedetomidine enhance the potency and duration of lidocaine. Better synergistic responses we are getting with guanfacine plus lidocaine.

Measuring the Acoustic Reflex through the Tympanic Membrane

Introduction: The acoustic reflex is the active response of the middle ear to loud sounds, altering the mechanical transfer function of the acoustic energy into the inner ear. Our goal was to observe the effect of the acoustic reflex on the tympanic membrane by identifying a significant nonlinear increase in membrane oscillations. Methods: By using interferometric spectrally encoded endoscopy, we record the membrane oscillations over time in response to a loud, 200-ms-long acoustic stimulus. Results: A gradual reflex activation is measured between approximately 40 and 100 ms, manifested as a linear 42% increase in the umbo oscillation amplitude. Conclusion: The measured oscillations correlate well with those expected from a mechanical model of a damped harmonic oscillator, and the results of this work demonstrate the potential of interferometric spectrally encoded endoscopy to observe unique dynamical processes in the tympanic membrane and in the middle ear.

Ostracism negatively impacts working self‐perceptions of personality

AbstractWe examined if being ostracized (excluded and ignored) changes working self‐perception of personality ─ a core aspect of the self ─ which may contribute to understanding post‐ostracism behaviour. Across three studies (N = 943), using a virtual ball‐toss game (i.e., Cyberball), participants were either ostracized, included or mentally visualized playing the game. Subsequently, participants reported working self‐perceptions of their personality (using two measures of Big Five personality), ostracism's immediate effects (e.g., basic needs) and post‐ostracism behavioural intentions: aggressive temptations and solitude seeking. Across the studies, ostracism in Cyberball negatively impacted working self‐perception of personality: ostracized participants were less conscientious, agreeable, open and extraverted, and more neurotic (negative emotionality), compared to controls. Illustrating that altered working self‐perceptions are important to consider, ostracism's increase of aggressive temptations was mediated by agreeableness, even when accounting for ostracism's immediate (reflexive) effects. Additionally, ostracism's increase in solitude seeking was mediated by extraversion. Ultimately, these aversive self‐perceptions may create difficulties in socially connecting with others.

Effects of contralateral noise on envelope-following responses, auditory-nerve compound action potentials, and otoacoustic emissions measured simultaneously.

This study assessed whether the effects of contralateral acoustic stimulation (CAS) are consistent with eliciting the medial olivocochlear (MOC) reflex for measurements sensitive to outer hair cell (otoacoustic emissions, OAEs), auditory-nerve (AN; compound action potential, CAP), and brainstem/cortical (envelope-following response, EFR) function. The effects of CAS were evaluated for simultaneous measurement of OAEs, CAPs, and EFRs in participants with normal hearing. Clicks were presented at 40 or 98 Hz in three ipsilateral noise conditions (no noise, 45 dB SPL, and 55 dB SPL). For the no noise condition, CAS suppressed or enhanced EFR amplitudes for 40- and 98-Hz clicks, respectively, while CAS had no significant effect on CAP amplitudes. A follow-up experiment using slower rates (4.4-22.2 Hz) assessed whether this insignificant CAS effect on CAPs was from ipsilateral MOC stimulation or AN adaptation; however, CAS effects remained insignificant despite favorable signal-to-noise ratios. CAS-related enhancements of EFR and CAP amplitudes in ipsilateral noise were not observed, contrary to the anti-masking effect of the MOC reflex. EFR and OAE suppression from CAS were not significantly correlated. Thus, the effects of CAS on EFRs may not be solely mediated by the MOC reflex and may be partially mediated by higher auditory centers.

Spinal manipulation techniques in the treatment of arterial hypertension. (A literature review)

There is a long-observed relationship between the pathology of the spine and arterial hypertension. There are a number of explanations for this, including one based on reflex effects and obstruction of blood flow to the cerebral vasodilatory centre localized in the rhomboid fossa projection. Obstruction can be absolute and relative, preventing the increase of blood flow during stress, when the brain turns on additional energy demand (phenomenon of «selfish brain»). In conditions of insufficient blood supply anaerobic metabolism is included, requiring in the future, the addition of anaerobic glycolysis products. This leads to the persistence of an elevated level of AD and is part of the theory of centralized compensation of aerobic-anaerobic balance (theoretical aerobic-anaerobic energy concept, TAAEBC). The existing methods of manual manipulation and physical action on the spine, mainly the atlantoacral section of the cervical spine, have, according to existing publications, varying degrees of effectiveness. The modern approach to treatment of arterial hypertension and correction of metabolic disorders by A. Shishonin is promising. It is based on the TAAEBC concept and assumes a system approach and long-term effect through a consistent three-step manual and physical interventions aimed at restoring, retaining and long-term support of the vertebral blood flow.

Robotic exoskeleton embodiment in post-stroke hemiparetic patients: an experimental study about the integration of the assistance provided by the REFLEX knee exoskeleton

Hemiparetic gait is the most common motor-disorder after stroke and, in spite of rehabilitation efforts, it is persistent in 50% of community dwelling stroke-survivors. Robotic exoskeletons have been proposed as assistive devices to support impaired joints. An example of these devices is the REFLEX knee exoskeleton, which assists the gait of hemiparetic subjects and whose action seems to be properly embodied by stroke survivors, who were able to adapt the motion of their non-assisted limbs and, therefore, reduce their compensation mechanisms. This paper presents an experimental validation carried out to deepen into the effects of REFLEX’s assistance in hemiparetic subjects. Special attention was paid to the effect produced in the muscular activity as a metric to evaluate the embodiment of this technology. Significant differences were obtained at the subject level due to the assistance; however, the high dispersion of the measured outcomes avoided extracting global effects at the group level. These results highlight the need of individually tailoring the action of the robot to the individual needs of each patient to maximize the beneficial outcomes. Extra research effort should be done to elucidate the neural mechanisms involved in the embodiment of external devices by stroke survivors.

Effect of reflex mediated core stabilization and system-based task-oriented approach on motor function and motor ability in children with developmental delay: protocol for a comparative study

Background When a child doesn’t meet the developmental milestones at the same rate as peers their own age, it is considered to be a developmental delay. Its severity can be divided into three categories: minimal (functional age &lt; 33% of chronological age), intermediate (34-66% of chronological age), and severe (functional age &gt; 66% of chronological age), and has several impairments including motor, speech, and learning. In motor impairment, there is a significant delay in fine and gross motor skills, including stiff muscles, loose trunk and limbs, limited movement in the legs and an inability to bear weight on feet and/or legs. To avoid long-term disability, early detection and intervention are essential. This study will aim to identify the effect of a reflex-mediated core stabilization and a system-based task-oriented approach on motor function and motor ability in children with developmental delay. Methods A total of 54 children with developmental delay who meet the eligibility criteria will be chosen for the prospective experimental design trial and will be assigned into two groups. Group A will undergo reflex-mediated core stabilization along with conventional therapy, while Group B will undergo a system-based task-oriented approach along with conventional therapy. The session will extend for 60 minutes each day, six days per week for six weeks. Gross Motor Function Measure version 88 (GMFM-88), Gross Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS) as outcomes will be assessed at baseline, after two weeks, four weeks, and after completion of the entire treatment protocol. Conclusions The data will be compiled and analyzed to compare the effectiveness of the interventions. Registration Clinical Trials Registry India (CTRI/2023/08/055998, registered on 01/08/23).

Deep inspiration electrocardiogram test: physiologic mechanisms and diagnostic capabilities

The article reflects modern concepts about the effect of deep inspiration and breath holding on the heart functioning and the reflection of these processes at ECGs. Positional changes of Q waves, primarily in leads III and aVF, and their possible differences from pathological Q waves are described. Reflex and humoral effects of deep inspiration and breath holding on heart functions such as contractility, automatism and conductivity are considered. Examples of rhythm and conduction disturbances that rarely occur during breath holding are illutrated on ECGs. A recommended variant of the implementation of the deep inspiration ECG test using computer ECG systems is described, which implements continuous ECG recording on free breathing, during inspiration and while holding the breath. This version of the test does not change the operators’ complexity and time of ECG registration.

Exploring the expansion of British Practical Theology: an enquiry using c/Critical i/Intersubjectivity, conversation, and autoethnography as a methodological approach

ABSTRACT Can I, as a Brown British Muslim Woman, belong in British Practical Theology? Deploying conversational and autoethnographic methods, and using Courtney Goto’s c/Critical i/Intersubjectivity approach, I reflect on an eight-year doctoral journey. Unexpected insights and deeper awareness into the challenges encountering those engaging in intercultural bridge building are generated. First, I describe the research context and include a relevant précis of my background. Second, I summarise Goto’s c/Critical i/Intersubjectivity approach and emphasise some key ethical considerations in its use. Third, I advocate for bringing dimensions of ‘power, privilege and oppression’ [Goto 2018, 98] into the reflexive work of Practical Theology. Finally, I present a case study deploying c/Critical i/Intersubjectivity by British Practical Theologians and demonstrate the mutual reflexive effect of conversation and autoethnography as methodological approaches. The paper concludes by drawing attention to the enhanced personal and relational awareness created by engaging with those who appear to be different to ourselves. I propose that c/Critical i/Intersubjectivity influences and deepens individual and collective understanding of humanity, and creates space for mutual presence and engagement despite obvious and hidden differences. A call is made for Practical Theologians to undertake intercultural and interreligious exchange with the aim of getting to know one another.

The Dark Side Effect of Entrepreneurial Resilience Diversity on Pivoting: The Role of Team Reflexivity.

Resilience is widely recognized as a form of psychological capital that helps entrepreneurs cope with challenges in the face of adversity by actively adjusting business strategies. Prior research has investigated the effect of resilience on pivoting, which is an important entrepreneurial decision to forgo the original business opportunity and exploit new opportunities. Despite the increasing empirical evidence on the effect of resilience on strategic changes and the pivot, the literature may have overstated the benefits of entrepreneurial resilience while neglecting its potential dark sides. Hence, the current study focuses on the structure of resilience within an entrepreneurial team and introduces the concept of resilience diversity. Drawing from sensemaking theory, we develop a research framework that investigates the dark-side effects of resilience diversity on team reflexivity and pivoting and the moderating effect of environmental hostility. Empirical results from a two-wave survey of 112 entrepreneurial teams in China reveal that resilience diversity negatively affects pivoting by impairing the quality of team reflexivity. Moreover, the mediating effect of team reflexivity is strengthened in hostile environments. These findings contribute to the literature on entrepreneurial resilience, pivot, and team reflexivity, and provide important practical implications for entrepreneurial teams.

Incidental learning of faces during threat: No evidence for enhanced physiological responses to former threat identities

Remembering an unfamiliar person and the contextual conditions of that encounter is important for adaptive future behavior, especially in a potentially dangerous situation. Initiating defensive behavior in the presence of former dangerous circumstances can be crucial. Recent studies showed selective electrocortical processing of faces that were previously seen in a threat context compared to a safety context, however, this was not reflected in conscious recognition performance. Here, we investigated whether previously seen threat-faces, that could not be remembered, were capable to activate defensive psychophysiological response systems. During an encoding phase, 50 participants with low to moderate levels of anxiety viewed 40 face pictures with neutral expressions (6 s each), without an explicit learning instruction (incidental learning task). Each half of the faces were presented with contextual background colors that signaled either threat-of-shock or safety. In the recognition phase, all old and additional new faces (total of 60) were presented intermixed without context information. Participants had to decide whether a face was new or had been presented previously in a threatening or a safe context. Results show moderate face recognition independent of context conditions. Startle reflex and skin conductance responses (SCR) were more pronounced for threat compared to safety during encoding. For SCR, this differentiation was enhanced with higher levels of depression and anxiety. There were no differential startle reflex or SCR effects during recognition. From a clinical perspective, these findings do not support the notion that perceptual biases and physiological arousal directly relate to threat-associated identity recognition deficits in healthy and clinical participants with anxiety and trauma-related disorders.

Wi-Flex

In this paper, we are interested in startle reflex detection with WiFi signals. We propose that two parameters related to the received signal bandwidth, maximum normalized bandwidth and bandwidth-intense duration, can successfully detect reflexes and robustly differentiate them from non-reflex events, even from those that involve intense body motions (e.g., certain exercises). In order to confirm this, we need a massive RF reflex dataset which would be prohibitively laborious to collect. On the other hand, there are many available reflex/non-reflex videos online. We then propose an efficient way of translating the content of a video to the bandwidth of the corresponding received RF signal that would have been measured if there was a link near the event in the video, by drawing analogies between our problem and the classic bandwidth modeling work of J. Carson in the context of analog FM radios (Carson's Rule). This then allows us to translate online reflex/non-reflex videos to an instant large RF bandwidth dataset, and characterize optimum 2D reflex/non-reflex decision regions accordingly, to be used during real operation with WiFi. We extensively test our approach with 203 reflex events, 322 non-reflex events (including 142 intense body motion events), over four areas (including several through-wall ones), and with 15 participants, achieving a correct reflex detection rate of 90.15% and a false alarm rate of 2.49% (all events are natural). While the paper is extensively tested with startle reflexes, it is also applicable to sport-type reflexes, and is thus tested with sport-related reflexes as well. We further show reflex detection with multiple people simultaneously engaged in a series of activities. Optimality of the proposed design is also demonstrated experimentally. Finally, we conduct experiments to show the potential of our approach for providing cost-effective and quantifiable metrics in sports, by quantifying a goalkeeper's reaction. Overall, our results confirm a fast, robust, and cost-effective reflex detection system, without collecting any RF training data, or training a neural network.

Increasing Eye Injuries Following Exposure to Laser Beams, the Silent Epidemic

Increasing Eye Injuries Following Exposure to Laser Beams, the Silent Epidemic

Comparison between rood inhibitory approach and bobath reflex inhibiting patterns to improve gross motor function and reduce spasticity in hemiplegic children of encephalitis

Objectives: To compare the effects of Rood Inhibitory approach and Bobath Reflex Inhibiting pattern to improve Gross motor Function and reduce spasticity in Hemiplegic Children of Encephalitis. Methods: A randomized clinical trial was conducted comprising of 22 patients recruited from different clinics of Faisalabad. Participants from both genders, in age range from 08-12 years were recruited and randomly allocated into two groups. Treatment group A received Rood inhibitory approach and treatment group B received Bobath Reflex inhibiting pattern. Measurement of Modified Ashworth scale were recorded at pre-treatment and weekly for 4 weeks, while (GMFM-88 and GMFM- 66) was assessed at baseline and at end of 4th week. SPSS version 22 was used to analyze the data. Result: Mean age in Group A was 10.00+1.673 years and in Group B was 9.82+1.537 years. Total 11 were male and 11 were female. There was significant improvement in mean MAS score at 2nd week, 3rd week and 4th week post treatment readings (p value &lt; 0.05). There was significant improvement in mean (GMFM-88 and GMFM- 66) at 4th week post treatment readings (p value &lt; 0.05).

The Effects of Team Reflexivity and Gender-Role Attitudes on Female Nurses

Taiwan has significantly fewer senior nursing personnel than many other countries, which can be attributed in part to the prevalence of interpersonal stress and same-sex conflicts that often arise in female-dominated workplaces such as nursing. This study explored how team reflexivity and gender-role attitudes influence the stay intent of female nursing personnel using a cross-sectional design. Results showed group-level team reflexivity has more positive impact on nurses’ stay intent via team-based self-esteem than individual perceived team reflexivity, but traditional gender-role attitudes weaken this impact. Our findings indicate mutual understanding and trust is crucial for nursing teams to function effectively.

Cardiovascular Effects of the Exercise Pressor Reflex and Carotid Chemoreflex Interaction in Patients with Heart Failure with Reduced Ejection Fraction

Background: The interaction of the exercise pressor reflex (EPR) and the carotid chemoreflex (CR) affects circulatory control during physical activity in health. It has been shown that patients with heart failure with reduced ejection fraction (HFrEF) have an abnormal cardiovascular response to EPR or CR activation, which contributes to impaired limb blood flow during exercise. However, the impact of the reflex interaction in HFrEF is unclear. Purpose: To evaluate the interaction between EPR and CR in HFrEF. Method: Five patients with HFrEF and 6 control subjects (Ctrl) completed two experimental sessions. In session 1, participants performed dynamic single-leg knee-extension at 60% of peak power output for 4 min while breathing room air (normoxia; NormC: SaO2~96%, PaO2~81 mmHg, PaCO2~33 mmHg, arterial pH~7.43) and pure O2 (hyperoxia; HyperC: SaO2~100%, PaO2~408 mmHg, PaCO2~35 mmHg, arterial pH~7.40). In session 2, following lumbar intrathecal fentanyl administration to attenuate group III/IV leg muscle afferent feedback, participants repeated the same exercise under normoxic and hyperoxic conditions (NormF and HyperF). Mean arterial pressure (MAP, radial artery catheter), heart rate (HR, 12-lead ECG), stroke volume (SV, finger photoplethysmography), cardiac output (CO), systemic vascular conductance (SVC), femoral blood flow of the working leg (LBF, Doppler ultrasound), and leg vascular conductance (LVC) were continuously quantified during exercise. Results: EPR activation (i.e., ΔHyperC-HyperF) in HFrEF resulted in no changes in MAP and HR, but significantly decreased SV (~10 mL), CO (~1 L min−1), SVC (~9 mL min−1 mmHg−1), LBF (~0.4 L min−1) and LVC (~4 mL min−1 mmHg−1). In contrast, EPR activation in Ctrl significantly increased MAP (~10 mmHg) and decreased LVC (~3 mL min−1 mmHg−1), but did not affect HR, SV, CO, SVC and LBF ( p≥0.20). CR activation in HFrEF (i.e., ΔNormF-HyperF) had no effects on any of the cardiovascular variables ( p≥0.12). CR activation in Ctrl significantly increased HR (~3 beats min−1) and SVC (~3 mL min−1 mmHg−1), but had no effects on MAP, SV, CO, LBF and LVC ( p≥0.10). During EPR:CR co-activation (i.e., ΔNormC-HyperF) in HFrEF, the observed responses were not significantly different from the sum of the responses evoked by each reflex individually. In Ctrl, MAP during EPR:CR co-activation was greater than the summated response (16±7 vs. 10±9 mmHg; p&lt;0.01) and SV and SVC were significantly lower than the summated responses; there were no differences between the observed and summated responses of other parameters. Conclusion: Our findings indicate that during exercise in healthy older adults, EPR and CR interact to synergistically augment MAP by constricting vessels in non-active tissue/organs, which may facilitate blood flow to the exercising limb. The circulatory consequences of the reflex interaction appear to be altered in HFrEF and contribute to the impaired limb blood flow characterizing this population during exercise. National Heart, Lung, and Blood Institute (HL-116579), U.S. Veterans Affairs Rehabilitation Research and Development (E3343-R) This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.