Phase-insensitive amplifiers (PIAs), as a class of important quantum devices, have found significant applications in the subtle manipulation of multiple quantum correlation and multipartite quantum entanglement. Gain is a very important parameter for quantifying the performance of a PIA. Its absolute value can be defined as the ratio of the output light beam power to the input light beam power, while its estimation precision has not been extensively investigated yet. Therefore, in this work, we theoretically study the estimation precision from the vacuum two-mode squeezed state (TMSS), the estimation precision of the coherent state, and the bright TMSS scenario, which has the following two advantages: it has more probe photons than the vacuum TMSS and higher estimation precision than the coherent state. The advantage in terms of estimation precision of the bright TMSS compared with the coherent state is researched. We first simulate the effect of noise from another PIA with gain M on the estimation precision of the bright TMSS, and we find that a scheme in which the PIA is placed in the auxiliary light beam path is more robust than two other schemes. Then, a fictitious beam splitter with transmission T is used to simulate the noise effects of propagation loss and imperfect detection, and the results show that a scheme in which the fictitious beam splitter is placed before the original PIA in the probe light beam path is the most robust. Finally, optimal intensity difference measurement is confirmed to be an accessible experimental technique to saturate estimation precision of the bright TMSS. Therefore, our present study opens a new avenue for quantum metrology based on PIAs.