Effect Of Peppermint Oil Research Articles

Effects of peppermint oil (Mentha piperita L.) on cardiometabolic and other health-related outcomes: a parallel placebo randomized controlled trial

Effects of peppermint oil (Mentha piperita L.) on cardiometabolic and other health-related outcomes: a parallel placebo randomized controlled trial

Effect of peppermint and anise oil and pesticide SIVANTO in the control of Culex pipiens (Diptera:Culicidae) mosquitoes

The study dealt with the effect of peppermint oil and anise oil and the pesticide SIVANTO in the control of C. pipiens mosquitoes, and the concentrations used for peppermint oil and anise oil and pesticide SIVANTO (0.5,1,1.5,2) the lowest killing rate for peppermint oil was 2.6% after 48 hours of treatment, and the highest killing rate was 4.6% after 48 hours Of the treatment, while anise oil had the lowest killing rate of 3.3% after 48 hours of treatment, and the highest killing rate of 4.6% after 48 hours of treatment, and the lowest killing rate of SIVANTO was 8% after 48 hours of treatment, and the highest killing rate of 10% after treatment. 48 hours of treatment compared to the control treatment in which no homicide occurred.

Effect of peppermint oil and its microemulsion on necrotic enteritis in broiler chickens.

Background and Aim:Clostridium perfringens is one of the multiple drug-resistant intestinal pathogens causing necrotic enteritis disease, leading to great economic losses in poultry farms. This study aimed to evaluate the potential use of peppermint oil and its microemulsion (ME) as an alternative to antibiotics to control necrotic enteritis in broiler chickens.Materials and Methods:Peppermint oil ME formulation (15% oil/water) was prepared and characterized by zeta potential, Fourier transform infrared, high-resolution transmission electron microscopy, and liquid chromatography–mass spectrometry (LC-MS/MS). The minimal inhibitory concentrations of the peppermint oil and its ME were investigated. A total of 80 commercial one day old Arbor Acres broiler chickens were randomly assigned to four groups of 20 birds each. The four groups were the negative control, positive control, peppermint oil (0.5 mL/mL water/10 days old), and its ME (0.25 mL/mL water/10 days old) groups. C. perfringens was orally provided at concentration of 1×108 CFU/mL on days 14, 15, and 16. Clinical signs and mortality were observed daily. Growth performance, gross lesions and cecal samples were investigated and examined on days 21, 28, and 35.Results:Peppermint oil ME formulation has a polydispersity index, zeta potential and droplet size of 0.234, −24 mV±4.19, and 29.96±1.56 nm, respectively. LC–MS/MS analysis of oil and ME revealed common presence of phenolic compounds such as rosmorinic (360.31 g/mol), chlorogenic acid (354.31 g/mol), hesperidin (610.56 g/mol), and luteolin 7-O-β-glucuronide (462.1 g/mol). The treated groups with peppermint oil and ME showed lower lesions, mortality and colony-forming units in addition to higher growth performance (p < 0.05) compared to the positive control group.Conclusion:Our study suggests the potential efficacy of peppermint oil and ME in the reduction of necrotic enteritis lesions and C. perfringens count.

125 Mint oils: in vitro anti-inflammatory effects tested in porcine alveolar macrophages

Abstract Essential oils as feed additives are being investigated for promoting health in piglets due to their anti-inflammatory activity. The objective of the study was to measure the in vitro anti-inflammatory effects of peppermint oil and spearmint oil with porcine alveolar macrophages as host immune responses. Briefly, macrophages were harvested from the bronchial lavage of 6 pigs at 6 weeks of age, and then seeded into 24-well plate with at 106 cells/mL. After 24 h incubation at 37oC and 5% CO2, cells were treated with mint oil or lipopolysaccharide (LPS) by randomized complete block design with 12 replicates. The treatments were 2 × 5 factorial arrangement with 2 doses of LPS (0 or 1 μg/mL) and 5 doses of mint oil (0, 25, 50, 100, 200 µg/mL). The supernatants were collected after another 24 h incubation to measure the concentration of tumor necrosis factor alpha (TNF-α) by ELISA assay. Cell viability was also tested by the MTT assay. Data were analyzed using the MIXED procedure of SAS 9.4. Administration of both mint oils and LPS did not impact the PAM cell viability of macrophages. LPS challenge significantly stimulated (P &amp;lt; 0.05) TNF-α secretion from macrophages. In the non-challenge group, peppermint oil reduced (P &amp;lt; 0.05) TNF-α production at 25, 50, and 100 μg/mL, whereas spearmint oil reduced (P &amp;lt; 0.05) TNF-α concentration from 50 to 200 μg/mL. In the LPS challenge group, both mint oils linearly inhibited (P &amp;lt; 0.001) TNF-α secretion from LPS-challenged macrophages with 200 μg/mL as the strongest dose. Results of the current study indicated that both peppermint and spearmint oils had anti-inflammatory activities in vitro. In vivo animal trials will be conducted to evaluate their impacts on animal health and performance.

Effect of Peppermint Oil among Sleep Apnea Individuals

Sleep disturbance or disruption is common among patients within the age limit 25-45. They often feel tired during the day time. During wakefulness which also causes sleep problems. Sleep disturbance associated with the sense of well-being, health, emotion regulation, and productivity, memory and cognitive functions. The main aim of this study is to prove the impact of peppermint oil on sleep apnea. The sample size of this study was 25 individuals and they were selected randomly. The peppermint oil is taken in a few amounts and massaged in the forehead while before sleeping. They were instructed to apply 2-3drops of oil on their forehead or spray on the pillow before going to bed. This has to be followed for 30 days. The sleeping hours and sleeping disturbances were recorded before and after using oil inhalation. Before the use of peppermint oil the sleeping hours was an average of 6.4±0.82 and after the use of peppermint oil the sleeping hours increased to an average of 7.1±1.03. Before the use of peppermint oil Sleep disturbances were of average 3.3±1.02 and after the use of peppermint oil the sleeping disturbances have been decreased to an average of 2.1±0.92. Data was collected and analysed using statistics. Peppermint oil has an effect on sleep apnea and it helps to overcome. From this study, it can be seen that a positive perception has been obtained towards the population.

A full factorial experimental design to study the effect of flavoring agents on the mechanical properties of curcumin chewing gum tablets with high solids content

Objective: Developing chewing gum tablets (CGTs) with high drug loads is a challenge due to the loss of mastication properties. We postulated that poor mastication properties of such gums could be improved by adjusting the concentration of liquid flavors to serve as plasticizers and consequently increase the flexibility of the elastomer in the gum base. To test this hypothesis, the objective of this work was to evaluate the effects of flavor type and concentration, and storage conditions on the textural properties of CGTs loaded with 20% curcumin (CUR) by weight.Methods: CGTs were made by directly compressing Health in Gum® base with CUR. The resultant CGTs were characterized by single and two bites textural tests to measure their yield strength, post-bite failure rate, and compressibility.Results: Flavor concentration (X2) had a significant impact on the masticatory properties of the chewing gums, which could be ascribed to the plasticizing effect of peppermint oil. Addition of liquid flavors and storage at low temperature (X4) produced CGTs with the desirable properties of low yield strength (Y1) and post-bite structural failure rate (Y2), and high compressibility (Y3). The effect of flavors however was negated at high temperatures, especially when flavored gums were stored for extended time at 50 °C. Flavor type (X1) on the other hand had no effect on the masticatory properties of the chewing gums.Conclusions: This study concluded that it is feasible to formulate CGTs with high solids content without negatively impacting their mechanical properties by controlling the concentration of liquid flavors.

Effect of Peppermint Oil On Postoperative Urinary Retention

Effect of Peppermint Oil On Postoperative Urinary Retention

Effect of Peppermint Oil on the Storage Quality of White Button Mushrooms (Agaricus bisporus)

White button mushrooms (Agaricus bisporus) were treated with 5 μl L−1, 10 μl L−1, 20 μl L−1, and 50 μl L−1 peppermint oil and then stored at 4 °C for 8 days to investigate with respect to browning and postharvest qualities. It was found that 20 μl L−1 peppermint oil treatment could provide the best effect on inhibiting browning of fruit bodies. Our results indicated 20 μl L−1 peppermint oil fumigation restrains browning development and alleviated membrane lipid peroxidation, as reflected by lower electrolyte leakage (17.42%), malondialdehyde (MDA) content (21.95%), and weight loss (1.69%) compared with those of the control mushrooms at 8 days, respectively. In addition, the 20 μl L−1 peppermint oil fumigation had 1.49-fold and 1.24-fold higher phenolics and flavonoids accumulation respectively than those in control and retained high levels of soluble protein and total sugar at the end of the storage time. Furthermore, peppermint oil treatment significantly improved the antioxidant system, which increased the activity of superoxide dismutase (SOD) and phenylalnine ammonia lyase (PAL), and inhibited the activity of polyphenol oxidase (PPO) and peroxidase (POD), as well as regulated the relative expression levels of genes encoding polyphenol oxidase (AbPPO1, AbPPO2, AbPPO5, AbPPO6) and phenylalanine ammonia lyase (AbPAL1, AbPAL2) during the storage period. These findings suggest that peppermint oil fumigation is a promising method to control browning and improve the quality of button mushrooms.

PEMBERIAN AROMATERAPI MINYAK PEPPERMINT SECARA INHALASI BERPENGARUH TERHADAP PENURUNAN MUAL MUNTAH PADA IBU HAMIL DI PMB LINDA SILALAHI PANCUR BATU TAHUN 2019

Feelings of nausea and vomiting are one of the discomforts that are often found in pregnancy and which usually occur early in pregnancy. The handling of vomiting and nausea can be done through non-pharmacological therapy in the form of peppermint oil inhaled aromatherapy that is noninstructive, non-invasive, inexpensive, effective and has no side effects. This study aims to determine the effect of peppermint oil inhaled aromatherapy on decreasing the nausea and vomiting in pregnant women at the private clinic of Linda Silalahi Pancur Batu. This research is a pre-experimental study designed with one group pretest posttest designs examining 15 pregnant women as samples obtained through purposive sampling techniques. Then the data were analyzed by the Wilcoxon Sign Rank Test and based on the results of the study it was found that before the inhalation of the peppermint oil aromatherapy, majority of the pregnant women experienced moderate nausea, 12 people (80%), but after the aromatherapy majority of pregnant women did not experience nausea vomiting, 12 people (80%). It was also found that differences in the mean scores of nausea and vomiting of pregnant women before and after inhalation of peppermint oil aromatherapy were 6.13. Through the Wilcoxon Sign Rank Test obtained p value of 0.001, which means that there is an effect aromatherapy to decrease nausea and vomiting in pregnant women at private clinic of Linda Silalahi Pancur Batu. Pregnant women who experience nausea and vomiting can use peppermint oil inhaled aromatherapy to reduce the use of pharmacological therapy.

The Effects of Peppermint Oil on Post-Operative Urinary Retention

Background: As a primarily postoperative unit, postoperative urinary retention is a common complication. Standard nursing interventions like running water and getting the patient up to the restroom, were not always successful which frequently led to the patient needing to be catheterized. A patient’s mother reported as a Labor and Delivery nurse she had successfully used peppermint oil in postpartum moms. A literature review did not reveal any Evidence Based nursing interventions to treat postoperative urinary retention. Peppermint oil was a nursing intervention in textbooks on postpartum care, with no evidence to support this indication for use. Due to a lack of evidence, a research project was started. Research Question: Does the use of peppermint oil in postoperative pediatric patients result in a reduced need for cauterization when experiencing urinary retention? Methods: The subject must be postoperative, continent, between the ages of 3 and 17, and experiencing urinary retention. A peppermint oil infused patch is placed on the patient for the patient to inhale while attempting to void. After one hour the patch is removed and physician is notified if no void. Results: Over 13 months 23 patients were enrolled. Of those, 15 were able to void within one hour of patch placement. Three patients voided after the patch was removed. A total of five patients required catheterization. A total of 22% of the study patients were catheterized after the use of peppermint oil. The retrospective chart search was performed to determine the control group. The search found 13 patients that met the research criteria. Of those 13, seven required catheterization which equates to a 54%. Conclusion: Even though there was a 32% decrease in the need for catheterization after the implementation of peppermint oil, the data did not prove to be statistically significant (p value of 0.07) due to the small sample size of both the study population and the retrospective chart search. Peppermint oil is now available to any patients meeting criteria for urinary retention. View a PDF of this Poster Presentation

The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy

The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy

Bacillus subtilis BS-2 and Peppermint Oil as Biocontrol Agents Against Botrytis cinerea

Abstract The purpose of this study was to assess the activity of Bacillus subtilis BS-2 and peppermint oil against Botrytis cinerea. In this study parameters such as the age and the density of the bacterial culture and the incubation temperature were taken into consideration. Furthermore, the cellulolytic activity of the bacterium was determined. The effect of peppermint oil was evaluated at a concentration range of 0.5-4.0 %. The research was conducted with a dual culture plate method. The influence of B. subtilis BS-2 and peppermint oil on the growth of B. cinerea was evaluated based on the growth rate index. It was noted that the bacterial culture occurred at an initial density of OD 560 = 1.0, cultivated at 30 °C for 48 hours demonstrated the strongest antagonistic effect (57.07 % inhibition). Furthermore, it was observed that the highest cellulolytic activity occurred on the bacteria incubated for 48 hours at 37 °C. The effect of mint oil, at the lowest concentration of 0.5-1.0 %, was much weaker on bacterial activity (1.1-12.1 % inhibition). The highest concentration (4.0 %) of mint oil caused the maximum inhibition (31.9 %) of the mycelial growth. B. subtilis BS-2 may be environmental-friendly alternatives for protecting plants against B. cinerea

The Effects of Peppermint Oil on the Ventilatory Threshold of Endurance-Trained and Moderately Active Men

Peppermint oil (mentha piperita) has been shown to have cooling effects in animals and humans, as well as beneficial influences on pulmonary function tests possibly due to bronchodilatory mechanisms. PURPOSE:To determine whether a single supplementation of one milliliter of peppermint oil would raise the ventilatory threshold in endurance-trained and moderately active men. METHODS:Six male participants (3 endurance-trained, 3 moderately active) performed two maximal oxygen consumption (VO2max) tests on a cycle ergometer under randomized, single-blind trials of peppermint oil and placebo. For each exercise test, ventilatory threshold was determined through the ventilatory equivalent method (VE/VO2 and VE/VCO2 vs. time), ventilation method (VE vs. time), and the VCO2 vs. VO2 method to validate the point at which the ventilatory threshold occurred. RESULTS:Supplementation of peppermint oil resulted in the ventilatory threshold occurring at a significantly higher percentage of VO2max compared to placebo (71 ± 2 % of VO2max vs. 65 ± 2 % of VO2max, p < .05). Additionally, VO2max values were not different between the two conditions. CONCLUSIONS:Peppermint oil supplementation may have a positive impact on the ventilatory threshold of both endurance-trained and moderately active men by raising the percentage of VO2max at which the ventilatory threshold occurs. Though further research is needed to determine the mechanism, it appears that the cooling and the smooth muscle relaxing properties of peppermint oil may acutely contribute to improved aerobic performance.

Conjunctival Microbiota and Antibiotic Resistance Pattern in Patients Submitted to Cataract Surgery and Antibacterial Activity of Some Plant Essential Oils

Objective: The objective of this study was to identify the conjunctival microbiota of patients undergoing cataract surgery and evaluate its antibiotic resistance pattern. Also to in-vitro evaluate the antimicrobial effects of some essential oils against multidrug resistant isolates. Methodology: Ocular samples were collected using swabs and polymethyl-metaacrylate (PMMA) intraocular lenses from seventy patients submitted to cataract surgery. Isolation and identification of bacteria was performed using conventional microbiological methods. Antibiotic sensitivity was done by disc diffusion method. The sensitivity of 16 essential oils against isolated bacteria was tested using well diffusion method. Results: Thirty six strains were isolated from patients submitted to cataract surgery. Gram positive microorganisms represent 75% of the isolates with coagulase-negative Staphylococci (CoNS) the most common isolate (47.2%) followed by S.aureus (19.4%), whereas gram negative occurred in 25% of cases, with Moraxella spp. the most frequent Gram negative isolate. Antibiotic sensitivity test revealed that the highest antibiotic resistance was exhibited against ceftazidime (100%) followed by clindamycin (86%), ampicillin (80.5%), erythromycin (72.2%) and tetracycline (69.4%). Gentamycin displayed the best activity (55.5%) followed by chloramphenicol (44.4%) and vancomycin (38.88%). Fifteen essential oils showed antibacterial effect against one or more bacterial strains. The most potent oils were peppermint oil, dill oil, cinnamon oil which showed promising inhibitory activity against most tested bacterial species, whereas cotton, ginger, chamomile, blue green, cod liver and parsley oil were the least active against tested strains. Olive oil failed to inhibit any of the tested strains. In general, St. pneumoniae was the most susceptible organism as it inhibited by ten oils. Conclusion: Our results indicate a promising antibacterial effect of peppermint oil, dill oil and cinnamon oil against conjunctival microorganisms.

A Preclinical Study of Novel Phentolamine Formulation and in Vitro/in Vivo Evaluation

Phentolamine (PT) is a non-selective a-adrenoceptor blocking agent. Oral and intracavernosal PT therapy are effective treatment options for erectile dysfunction. In the present study, a local therapy system of PT preparation was developed, by which its penetration enhancers, safety, stability and in vivo were investigated. The effect of permeation enhancers on in vitro mucosa permeability was assessed using sodium dodecyl sulphate (SDS), azone, propylene glycol (PG), Pharmasolve, Labrasol, Transcutol P, oleic acid, peppermint oil (lipophilicity), peppermint oil (hydrophilic) and their concentrations for absorption enhancement were optimized. The rabbit model was used to evaluate the safety and efficacy. peppermint oil appeared to be the most effective one for enhancing the mucosa permeation of PT than the other enhancers. These enhancements by peppermint oil were statistically significant (p PO (lipophilicity) > azone > Transcutol P ≈ Labrasol > SDS ≈ PG ≈ Pharmasolve ≈ oleic acid. Histological investigations were performed on buccal mucosa and indicated no major morphological changes. The enhancing effect of peppermint oil on the mucosa absorption of PT was evaluated from the mucoadhesive gels in rabbits. Phentolamine local therapy would produce an ideal therapeutic effect on ED.

Effect of Peppermint Oil on Serum Lipid Peroxidation and Hepatic Enzymes after Immobility Stress in Mice

This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic en-zymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. The mice exposed to drink water, 0.9, 27 and 60 mg/kg peppermint oil from the days 1 to 5 for a period of 4 h before and after immobility stress. Serum MDA in-creased in treatment group II, III and IV after immobility stress. There was a significant decrease in ALT in treatment group III and IV after immobility stress. There were also significant decreases in ALP and GGT in treatment group IV af-ter immobility stress. This result may suggest that, MDA level is higher in immobilization stress group than in the un-immobilized animals in serum and this results show that enzyme activities decreased after immobilization stress.

Tu1399 The Effect of Peppermint Oil on Rectal Sensorimotor Function in Health

Tu1399 The Effect of Peppermint Oil on Rectal Sensorimotor Function in Health

Effect of Peppermint Oil on Gastric Accommodation to a Meal, Compliance and Sensitivity to Balloon Distension in Health

Effect of Peppermint Oil on Gastric Accommodation to a Meal, Compliance and Sensitivity to Balloon Distension in Health

Effect of Peppermint Oil on Intragastric Pressure During Fasting and Intragastric Infusion of a Liquid Meal in Health

Effect of Peppermint Oil on Intragastric Pressure During Fasting and Intragastric Infusion of a Liquid Meal in Health

HUMAN BEHAVIORAL AND PHYSIOLOGICAL REACTIONS TO INHALATION OF SWEET ORANGE OIL

HUMAN BEHAVIORAL AND PHYSIOLOGICAL REACTIONS TO INHALATION OF SWEET ORANGE OIL