Effectiveness Of Module Research Articles

The Effect of Al-Ghazali Therapeutic Consultation Module (KiTA) on Mental Health and Spiritual Intelligence among Students

The Effect of Al-Ghazali Therapeutic Consultation Module (KiTA) on Mental Health and Spiritual Intelligence among Students

The Effect of CBM1 and Linker on the Oxidase, Peroxidase and Monooxygenase Activities of AA9 LPMOs: Insight into Their Correlation with the Nature of Reductants and Crystallinity of Celluloses

This study explores the effect of carbohydrate-binding module 1 (CBM1) and the linker on the function of auxiliary activity 9 (AA9) lytic polysaccharide monooxygenases (LPMOs), with a particular focus on monooxygenase activity, using different crystallinity celluloses and electron donors. The tested C1/C4-oxidizing AA9 LPMOs exhibited higher oxidase and peroxidase activities compared to those of the C4-oxidizing AA9 LPMOs. While the presence of CBM1 promoted cellulose-binding affinity, it reduced the oxidase activity of modular AA9 LPMOs. The effect of CBM1 on peroxidase activity was variable and enzyme-specific. Its influence on monooxygenase activity was linked to the type of reductants and the crystallinity of celluloses. Overall, CBM1 improved the monooxygenase activity on high-, medium-, and low-crystallinity celluloses when ascorbic acid (AscA) was used as the electron donor. CBM1 also facilitated monooxygenase activity on high-crystallinity cellulose, but significantly inhibited monooxygenase activity on low-crystallinity cellulose when cellobiose dehydrogenase (CDH) was the electron donor. Linker truncation of NcLOMO9C enhanced the cellulose-binding affinity but decreased both the oxidase and peroxidase activities. Linker truncation also impacted the monooxygenase activity in both the AscA-AA9 LPMO and AfCDH-AA9 LPMO systems, though its effect was less pronounced compared to that of CBM1. This work provides new insights into the role of the reductant type and cellulose crystallinity in the functionality of CBM1 and the linker in AA9 LPMOs.

Sustained Success: Evaluating the Enduring Effects of Leadership Training on Professional Growth

The focus of this longitudinal study is on the long-term effectiveness of leadership training modules on the professional growth of graduates, with a particular emphasis on the strategic management and leadership training modules in postgraduate management education programmes. The study aims to track a cohort of graduates over five years post-module completion, assessing their leadership skills, career progression, and their impact on organisational performance. The first phase of the study focused on the initial assessment of the ongoing influence of leadership training over time, highlighting the key areas of career progression. Data was collected at multiple time points—immediately post-completion, and at the 1, 2, and 5-year mark. This approach enables a comprehensive analysis of the trajectory of leadership development over time. The study employs quantitative methods, administering the same questionnaire annually to the same cohort of graduates. The consistent data collection allows for a robust comparative analysis across different years, providing insights into how the leadership training modules contribute to individual career progression and organisational outcomes over time. Initial findings revealed that six months after completing the module, 90% of respondents integrated the leadership concepts into their daily activities, with a 75% implementation rate. Additionally, 80% observed noticeable changes in job responsibilities, and 85% reported increased job satisfaction. One-year post-completion, 55% of the initial respondents participated in the study, with 29% engaging in further leadership development programs. All respondents perceived a significant improvement in job performance, and 41% received promotions or career advancement opportunities. Two years after completion, 29% of the original respondents remained employed at the organisation. Among them, 76% attributed their career advancements to the leadership module, and 80% felt confident in leading and managing teams. Additionally, 84% were satisfied with their overall career progression. Five years post-completion, only 13% of respondents remained employed, with 90% rating the module's long-term impact on their leadership abilities and career trajectory as significant. All these respondents had assumed leadership roles and rated their organisation's overall success positively. This research significantly contributes to understanding the sustained impact of leadership education and offers valuable implications for curriculum developers, educators, and organisational leaders, highlighting the importance of continuous investment in leadership development for long-term career and organisational success.

Design, techno-economic evaluation, and experimental testing of grid connected rooftop solar photovoltaic systems for commercial buildings

This study aims to investigate the potential of rooftop solar photovoltaic systems for commercial buildings. Helio-Scope software is utilized to perform simulations to determine the ideal rooftop area for photovoltaic panels. The efficiency of photovoltaic systems is impacted by the shading effects of photovoltaic modules installed in parallel rows. To enhance energy output, the optimal distance between rows is determined, and it is found that 5-feet inter-row spacing provides the best results. The simulation results indicate that with 5-feet inter-row spacing, photovoltaic system has an energy generation of 371.6 MWh, specific yield of 1508.0 kWh/kWp, performance ratio of 82.1%, solar access rate of 98.9%, total solar resource fraction of 96.3% and a total irradiance of 1655.9 kWh/m2. The annual nameplate energy is 425.1 MWh, output energy at irradiance levels is 423.1 MWh, optimal DC output is 378.5 MWh, inverter output is 373.5 MWh, and total energy delivered to the national power grid is 371.6 MWh. The average daily DC inverter input power is 158881.5110 W and the average daily AC inverter output power is 152231.6311 W, showing an inverter efficiency of approximately 95.93%. Moreover, detailed testing of the installed PV system is performed on-site to make sure that equipment’s performance guarantees are achieved, the system is properly installed and its configuration is suitable for commercial operations. The maximum daily output energy generation of an installed photovoltaic (PV) system is 1.33 MWh, and its average energy generation is 1.09 MWh. The voltage of all strings is within the rated range of the inverter, with a maximum voltage of 835 V and a minimum of 698 V, as tested by PV string open-circuit voltage. The inverter efficiency test is also performed, with a maximum efficiency of 98.83% and fill factors ranging from 81.37% to 82.34%. The payback period of a photovoltaic system is 4.22 years and LCOE is 0.0229$/kWh. PV system saved 215569.818 metric tons of CO2 in the first year and a total of approximately 5068976.99 metric tons in 25 years.

A cost-effective load side management solution based on power line carrier communication i-PLCC.

Conventional power systems are almost at the verge of their existence and are quickly being replaced by modern, especially smarter alternatives. Rapid and wide deployment of Load side management, which is a smarter and modern way to ensure efficient and economical use of power, is a classic example. However, there are several challenges which need to be addressed before it can be realized as a commercially viable solution. Suitable communication method, called "Home Area Networks", is a mandatory requirement which should be cost effective, robust and with ability to simultaneously handle large number of devices. Due to various inherent issues, communication protocols commonly used now-a-days, are not fully capable to address the requirements of HANs. Power Line Carrier Communications (PLCC) can be a suitable and efficient alternative of quick realization of HANs. In this paper, various aspects of PLCC have been analyzed for use in HANs. Modulation methods, materials, physical parameters and effect of noise have been analyzed. The paper evaluates performance and effectiveness of FSK modulation with aluminum transmission medium for PLC within a residential environment, focusing on the tradeoffs between distance, transmission medium diameter, and type of transmission medium, and cable gauge, which can degrade the performance of PLCC. A novel simulation model has been presented incorporating RLCG (Resistance, Inductance, Capacitance, and Conductance) tools and additive white Gaussian noise (AWGN). Performance parameter have been comprehensively analyzed of implementation using aluminum as a communication medium. This paper discusses cost effectiveness of PLCC by replacing copper by aluminum as the transmission medium. The study reveals that aluminum cables must be twice the size of copper cable in order to achieve same communication distances. Higher carrier frequencies in FSK modulation increase noise susceptibility, consequently reducing achievable communication distances. Cables with smaller diameters results in lower transmission ranges. These results highlight the trade-offs involved in implementing FSK for in-home PLCC (iPLCC). The study highlights how crucial it is to take these trade-offs into account while developing and refining FSK-based iPLCC systems for use in smart homes.

Research and Design of an Active Light Source System for UAVs Based on Light Intensity Matching Model

The saliency feature is a key factor in achieving vision-based tracking for multi-UAV control. However, due to the complex and variable environments encountered during multi-UAV operations—such as changes in lighting conditions and scale variations—the UAV’s visual features may degrade, especially under high-speed movement, ultimately resulting in failure of the vision tracking task and reducing the stability and robustness of swarm flight. Therefore, this paper proposes an adaptive active light source system based on light intensity matching to address the issue of visual feature loss caused by environmental light intensity and scale variations in multi-UAV collaborative navigation. The system consists of three components: an environment sensing and control module, a variable active light source module, and a light source power module. This paper first designs the overall framework of the active light source system, detailing the functions of each module and their collaborative working principles. Furthermore, optimization experiments are conducted on the variable active light source module. By comparing the recognition effects of the variable active light source module under different parameters, the best configuration is selected. In addition, to improve the robustness of the active light source system under different lighting conditions, this paper also constructs a light source color matching model based on light intensity matching. By collecting and comparing visible light images of different color light sources under various intensities and constructing the light intensity matching model using the comprehensive peak signal-to-noise ratio parameter, the model is optimized to ensure the best vision tracking performance under different lighting conditions. Finally, to validate the effectiveness of the proposed active light source system, quantitative and qualitative recognition comparison experiments were conducted in eight different scenarios with UAVs equipped with active light sources. The experimental results show that the UAV equipped with an active light source has improved the recall of yoloV7 and RT-DETR recognition algorithms by 30% and 29.6%, the mAP50 by 21% and 19.5%, and the recognition accuracy by 13.1% and 13.6, respectively. Qualitative experiments also demonstrated that the active light source effectively improved the recognition success rate under low lighting conditions. Extensive qualitative and quantitative experiments confirm that the UAV active light source system based on light intensity matching proposed in this paper effectively enhances the effectiveness and robustness of vision-based tracking for multi-UAVs, particularly in complex and variable environments. This research provides an efficient and computationally effective solution for vision-based multi-UAV systems, further enhancing the visual tracking capabilities of multi-UAVs under complex conditions.

The Efficiency of a Video-Assisted Instructional Module in Enhancing Staff Nurses' Understanding of Surgical Foot Surgery Practice

The study aimed to evaluate the effectiveness of a Video-Assisted Teaching Module (VATM) in enhancing knowledge on the practice of surgical fomentation for patients with diabetic foot among staff nurses at Vinayaka Mission Kirupananda Variyar Medical College Hospital, Salem. The objectives included assessing pre-existing knowledge, evaluating VATM’s effectiveness, and analysing demographic variables' impact. A pre-experimental research design was employed, with 48 staff nurses selected using purposive sampling. Data was collected using a closed-ended questionnaire before and after the VATM intervention. The pre-test mean score was 12.73 (42%), and the post-test mean score increased to 19.19 (64%), demonstrating the VATM’s effectiveness with a 22% improvement. The highest effectiveness (26%) was in the "surgical fomentation" domain, while the "articles required" domain showed the lowest effectiveness (17%). Data analysis revealed significant improvement in knowledge post-intervention, with no significant association between knowledge scores and demographic variables such as age, gender, or educational background. The study concludes that VATM is an effective tool for improving nurses' knowledge on surgical fomentation, supporting better care for diabetic foot patients. The results emphasize the need for ongoing educational interventions to enhance nursing practices.

Perception towards personal enrichment competency modules and interprofessional collaboration readiness among students

To evaluate the correlation between perception towards Personal enrichment competency (PEC) modules effectiveness and interprofessional collaboration readiness among students. A cross-sectional study design was used. Two different variables were used to measure the perception towards PEC modules and the readiness for interprofessional collaboration; this was done using the readiness for interprofessional learning scale (RIPLS). A convenience sampling method was used. The respondent was drawn from current medical, health science and pharmacy undergraduate students from the first year to the fifth year in a private University in Malaysia. A Spearman's rank-order correlation test was run to determine the statistical relationship between both variables.The scores for the perception towards PEC modules (inclusive of overall scores, content structure, practicum and assessment) and readiness towards IP learning (comprised of teamwork and collaboration, negative professional identity, positive professional identity and roles and/or responsibilities) showed above average score (4.04 ± 0.92 and 3.77± 0.81 respectively) among students of various healthcare programs. There was a strong, positive correlation between PEC module effectiveness and IP collaboration readiness, which was statistically significant (r = 0.713, p < 0.001). There was an effective PEC delivery among undergraduates in medical school, pharmacy school and faculty of health sciences. Undergraduates in medical school, pharmacy school and faculty of health sciences were shown to be ready for interprofessional collaboration when entering professional careers. Interprofessional learning should be incorporated into the curriculum such as in the PEC modules for all medical, health science and pharmacy programs, which may nurture students to become more competent healthcare givers and appreciate each professional role.

Introducing dental practice management in the undergraduate curriculum through an interprofessional module: experience from an Indian dental school

IntroductionThis study aimed to evaluate the effectiveness of a dental practice management education module developed through interprofessional collaboration.Materials and methodsA dental practice management module was developed through need assessment, literature review, and interprofessional collaboration. The IP team included dental practitioners, dental educators, business expert, lawyer, bioethicist, engineer, and architects. Thirty interns were included in the study. Participants were assessed through pre-and post-test. Evaluation of the program was carried out by obtaining feedback from the students and dental practitioners who were invited to attend the program. The pre-and post-test results were compared by paired student t-test. p-value of <0.01 was considered significant. The content of the feedback forms was subjected to qualitative and descriptive analysis.ResultsThrough the process of module preparation, pertinent competencies were identified and included in the program. There was a statistically significant increase in knowledge among students with respect to the domains included, as shown in the pre-post-test comparisons. The feedback obtained was positive. IP collaboration in module design and implementation was considered an important factor for dental practice management.ConclusionPractice management education can be made effective through IP collaborations.

Development of a science, environment, technology, and society-based learning module to foster critical thinking in elementary students

This study aims to develop a science, environment, technology, and society (SETS)-based learning module to enhance critical thinking skills among elementary school students. Employing a research and development (RD) approach adapting the Borg and Gall model, this module is designed to enrich the learning process of natural and social sciences (IPAS). The research sample involved elementary school students from selected schools, utilizing quantitative methods to measure the module's effectiveness. Validation results showed high scores in content, media, language, and pedagogy, indicating a highly valid module. Practicality tests revealed high practicality from both learners' and educators' perspectives, with average scores above 90. The findings indicate a significant increase in students' critical thinking abilities post-module learning, as measured by pre-test and post-test instruments. Implications of these findings suggest that integrating SETS concepts into IPAS learning can be an effective strategy in enhancing elementary students' critical thinking skills. These findings also offer insights for educational practitioners in designing more interactive and environmentally relevant learning materials.

Evaluating the Impact of a Game (Inner Dragon) on User Engagement Within a Leading Smartphone App for Smoking Cessation: Randomized Controlled Trial.

Smartphone apps are a convenient, low-cost approach to delivering smoking cessation support to large numbers of individuals. Yet, the apps are susceptible to low rates of user engagement and retention. This study aims to test the effects of a new game module (called Inner Dragon) integrated into Smoke Free (23 Limited), a leading smoking cessation app with established efficacy. The primary outcomes measured user engagement with the app. A 2-arm, parallel-group, randomized controlled trial was conducted in the United States with an 8-week follow-up. Adult individuals who smoked ≥1 cigarettes daily and planned to quit smoking within 7 days were recruited and randomized (N=500), with equal allocation. Both groups received free access to the original Smoke Free app with "core" features of its smoking cessation program (eg, a diary and craving log). The treated group received additional access to the integrated Inner Dragon game that incorporated several game mechanics designed to increase user engagement. User engagement outcomes were the number of unique app sessions, average minutes per session, days with a session, and program adherence. Self-reported and verified smoking abstinence and app satisfaction were also assessed. The main analysis estimated the intention-to-treat effect of access to Inner Dragon on each outcome. Further analyses assessed effect modification by participant characteristics and the association of intensity of game use with program adherence and abstinence. Overall, user engagement was greater for treated versus control participants: they had 5.3 more sessions of Smoke Free (mean 29.6, SD 36.5 sessions vs mean 24.3, SD 37.9 sessions; P=.06), 0.8 more minutes per session (mean 6.9, SD 5.4 min vs mean 6.1, SD 5.2 min; P=.047), and 3.4 more days with a session (mean 14.3, SD 15.3 days vs mean 11.9, SD 14.3 days; P=.03). Program adherence, based on the number of times core features of the original Smoke Free app were used, was higher for treated versus control participants (mean 29.4, SD 41.3 times vs mean 22.6, SD 35.6 times; P=.03). Self-reported 7-day and 30-day point-prevalence abstinence and verified 7-day point-prevalence abstinence at 8 weeks did not significantly differ by study group. The mean repeated 1-day prevalence of quitting was higher among the treated group versus the control group (mean 17.3%, SD 25.6 vs mean 12.4%, SD 21.3; P=.01). App satisfaction and the motivation to (stay) quit did not differ by study group. Higher intensity of game use was associated with increased program adherence and self-reported abstinence. Findings suggest that the Inner Dragon game increased user engagement and program adherence. Additional refinements to the game design may clarify whether the game increases abstinence rates. Overall, it is feasible to deploy games and gamification to enhance user engagement in existing smoking cessation interventions. ClinicalTrials.gov NCT05227027; https://clinicaltrials.gov/study/NCT05227027.

Research and thermal comfort analysis of the air conditioning system of the Ferris wheel car based on thermoelectric cooling

To solve the problem of thermal discomfort caused by the lack of cooling facilities on the Ferris wheel and to investigate the effect of the coupling effect of thermoelectric modules on the thermoelectric cooling (TEC) system, this paper proposes a two-module thermoelectric cooling and air-conditioning system that can be applied to the Ferris wheel. Firstly, the experimental platform was established to test the performance parameters of the TEC system and reveal the influence of the thermoelectric module (TEM) coupling effect on the system performance. Then, the thermal environment inside the Ferris wheel was simulated using the CFD method and human thermal comfort was evaluated. The results show that when the voltage of TEM1 and TEM2 is 10 V and 6 V respectively, the thermoelectric cooling and air-conditioning system has the best working performance, and the coefficient of performance (COP) is 0.43. And the human thermal comfort deviation AEQT is 0.29, which is in a comfortable state under the action of the air-conditioning system.

Development of Salt Hydrolysis Module Based on Problem Based Learning Integrated with TPACK to Improve Numeracy Literacy Skills of Phase F SMA Students

This research aims to analyze the validity, practicality and effectiveness of the salt hydrolysis module based on problem based learning integrated with TPACK on students numeracy literacy skills. The development model used is the 4-D model. The module developed was validated by two lecturers and three chemistry teachers. The practicality testing of the module was carried out by three chemistry teachers and 32 SMA students. Testing the effectiveness of the module was carried out using a pre-experimental method with a non-equivalent control group design. The validity test was analyzed using the Aiken's V formula where content and construct validity were obtained respectively 0.91 and 0.92 with the valid category. The practicality test was analyzed using the Aiken's V formula where the practicality scores for teachers and students were obtained respectively 0.94 and 0.86 in the practical category. The module effectiveness test was analyzed using N-Gain where an N-Gain value of 0.76 was obtained in the high category. Based on the results of data analysis, it can be concluded that the salt hydrolysis module based on problem based learning integrated with TPACK developed is valid, practical and effective to improve the numeracy literacy skills of Phase F SMA students.

Integrating Gender-Affirming Care in a Medical Spanish Endocrine System Curriculum.

With a growing Hispanic population in the United States, medical education is adapting to provide the necessary language skills and cultural competence for effective health care. However, the incorporation of gender-affirming care in the context of medical education for Hispanic populations requires further emphasis. This curriculum presented a 3-week medical Spanish endocrine system module designed for first-year medical students. The module aimed to enhance students' ability to communicate effectively with Spanish-speaking patients about endocrine health while integrating principles of gender-affirming care. It included classroom sessions, standardized patient practice, and clinical practice with peer tutors. Pre- and postmodule surveys and assessments were conducted to evaluate the module's effectiveness. Out of 76 participants, 72 completed the postmodule evaluation. Survey results indicated significant increases in confidence levels across various aspects of patient interaction in Spanish, with statistically significant gains observed in all assessed areas. Knowledge test outcomes revealed enhanced proficiency in Spanish terminology related to the endocrine system, with scores increasing from an average of 22.3 premodule to 25.7 postmodule (p = .002), as measured by the paired t test. Additionally, students performed well in the diabetic consultation objective structured clinical examination station, with a high mean score of 86%, surpassing the satisfactory threshold. This curriculum highlights the success of a comprehensive educational approach in expanding medical students' language proficiency and ability to provide gender-affirming care to address health care disparities and improve patient outcomes among diverse populations.

Impact of digital modules on math achievement by gender and locality

Digital modules typically refer to self-contained units of online learning materials designed for specific topics or learning objectives. The researcher developed digital modules for three specific math units and conducted a three-week experiment in six schools in three districts of Punjab. The purpose of the study was to find the effectiveness of digital modules. The study revealed a statistically significant difference in gain achievement scores and posttest achievement between the experimental and control groups. The t statistic for gain achievement scores was 2.41, indicating a p-value of 0.016, and 2.70 for posttest achievement. This suggests a significant difference in learning outcomes between the two groups.

A randomized controlled educational study to evaluate an e-learning module to teach the physical examination of the temporomandibular joint in juvenile idiopathic arthritis

BackgroundThe aim of the study was to evaluate the effectiveness of a novel e-learning module in teaching the physical exam of the temporomandibular joint (TMJ) in Juvenile idiopathic arthritis (JIA.).MethodsAn e-learning module was developed to convey the TMJ physical examination maneuvers that are considered to be best practice in JIA. Pediatric rheumatology fellows were randomized to two groups. One group received an article describing the physical examination skills while the second group received both the article and module. All participants completed a written pre-test, an in-person objective structured clinical examination (OSCE), a written post-test, and a follow-up survey.ResultsTwenty-two pediatric rheumatology fellows enrolled, with 11 per group. Written test: The two groups improved equally, although there was a trend toward improved defining of maximal incisal opening (MIO) in the module group. OSCE: The mean OSCE score was 11.1 (SD 3.3) in the article group and 13.5 (SD 1.9) in the module group (p = 0.06); significant differences were seen in measuring MIO (p = 0.01), calculating maximal unassisted mouth opening (MUMO; p = 0.01), and assessment of facial symmetry (p = 0.03), all favoring the module. Enjoyment scores in the module group were higher than in the article group (mean 7.7/10 vs. 5.9/10, p = 0.02). The two groups self-reported performing TMJ examinations at comparable rates three months following the intervention.ConclusionsThe study demonstrated that a formalized educational program improved knowledge of the physical exam of the TMJ in JIA. Learners viewing the module were more adept at obtaining quantitative TMJ measurements.

Effect of different PV modules surface energies and surface types on the particle deposition characteristics and PV efficiency

The particle deposition behavior of solar photovoltaic (PV) modules and its effect on PV efficiency were numerically investigated using computational fluid dynamics (CFD) methods. The surface flow field of PV modules using the shear stress transfer (SST) k-ω model with a user-defined function (UDF) for the development of entrance boundaries is predicted. A UDF coupled discrete phase model (DPM) that takes into account wall bounce and hydrophobic properties is used to predict particulate deposition in the flow field. Mesh independence and average pressure coefficients are verified. The effects of particle diameter, boundary type, surface energy and surface type on particle deposition of PV panel and PV efficiency are investigated. The results show that the smaller the surface energy γ, the smaller the particle deposition rate. At dp = 150 μm, γ = 0.001J/m2, it showed that the most significant reduction of 427.3 % in particle deposition rate compared to the trap boundary type, and γ = 0.001J/m2 showed a 210 % reduction in particle deposition rate compared to γ = 0.1J/m2. However, at dp ≤ 50 μm, the change in surface energy has little effect on the deposition rate. The effect of convex PV modules on particle deposition is more obvious at low surface energy (γ ≤ 0.001J/m2) compared to planar. The reduction in PV efficiency caused by particle deposition at different surface energies is predicted using an empirical model of PV output reductions developed by the researcher.

CosGCTFormer: An end-to-end driver state recognition framework

Driver state is critical for safety in mixed traffic environments with automated and human-driven vehicles. Recognizing and monitoring the driver’s state is essential to provide early warnings of abnormal driving performance. This paper proposes a driver state recognition framework called cosGCTFormer for end-to-end recognition of the driver’s emotional state and mental load. First, we employ an inverted residual convolution module to extract local features from physiological signal data. Second, the cosGCT module is introduced to extract global features. This module uses cos attention to address the high computational complexity of the Transformer in calculating attention weights. Additionally, it employs Gated Channel Transformation (GCT) to establish relationships between different channel dimensions, something the Transformer alone cannot do effectively. Finally, a simulated driving experiment was designed to collect data for training and testing the proposed method. Results demonstrate that our framework achieves higher accuracy and a more lightweight design compared to prevalent Convolution neural network-based (CNN-based) and Transformer-based methods. Additionally, the effectiveness of both modules was verified.

Heterogenous Origins of Calcium Homeostasis Disorders Arising from Five Heterozygous Calcium-Sensing Receptor Variants.

The human calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis, and most identified CASR variants are associated with hypercalcemic and hypocalcemic disorders. Here we characterized the pharmacological implications of five heterozygous CASR variants from individuals with familial hypocalciuric hypercalcemia 1 [FHH1: Y63C, I81T, Q459R, W818stop] or autosomal dominant hypocalcemia 1 [ADH1: R955stop]. Total and cell surface expression levels of wild-type (WT) and variant CaSRs expressed in human embryonic kidney 293T (HEK293T) cells were determined using ELISA, and the pharmacological properties of the receptors were delineated in two functional assays. The Y63C and I81T variations in the extracellular domain (ECD) of CaSR yielded markedly reduced cell surface expression and Ca2+ responsiveness, while Q459R displayed WT-like expression and functional properties. Truncation of the 7-transmembrane domain (7TMD) in W818stop eliminated cell surface expression, whereas R955stop in the intracellular carboxy-terminal yielded modestly increased surface expression and Ca2+ potency compared with WT CaSR. Interestingly, the effectiveness of positive allosteric modulators (PAMs) at the variants varied. Ca2+-mediated signaling through Y63C and I81T was significantly augmented by 7TMD-binding PAMs (NPS R-568 and Evocalcet) but not by ECD-binding PAMs (Etelcalcetide and Nb4), whereas signaling through Q459R and R955stop were robustly potentiated by all four PAMs. While the molecular phenotypes exhibited by the five CaSR variants concord with the clinical phenotypes in individuals harboring them, CASR variant-induced calcium homeostasis disorders clearly arise from diverse molecular origins, and the effectiveness of calcimimetics in these disorders could differ depending on the specific variants.

Efektivitas Modul dan Film Pendek Check Up Diabetic Foot: Ipswch Touch Test dalam Meningkatkan Pengetahuan dan Ketrampilan Mendeteksi Neuropati Sensori Diabetes Mellitus Tenaga Kesehatan di Kabupaten Bima

Early detection of diabetic neuropathy is very important for patients with type 2 diabetes mellitus because early prevention can reduce morbidity and mortality. One of the examinations to detect diabetic neuropathy is the Ipswich Touch Test (IpTT). The purpose of this study was to determine the Effectiveness of the Diabetic Foot Check Up Module and Short Film: Ipswich Touch Test in Improving Knowledge and Skills in Detecting Sensory Neuropathy of Diabetes Mellitus Health Workers. The research method used was Quasi-experimental with a pre-test and post-test with control group design with a non-parametric Wilcoxon test to analyze knowledge and skills before and after treatment, a total of 60 respondents. A significant test result of 0.0001 was obtained for the intervention group, namely there was a difference in skills before and after treatment in the form of counseling with media in the form of short films, while in the control group a significant test result of 0.0001 was obtained, namely there was a difference in skills before and after treatment in the form of counseling with media in the form of modules with a significance level of 0.05 because p value <0.05. The results of the significant test were obtained at 0.0001 for the intervention group, namely there was a difference in knowledge before and after being given treatment in the form of counseling with media in the form of short films, while in the control group the results of the significant test were obtained at 0.0001, namely there was a difference in knowledge before and after being given treatment in the form of counseling with media in the form of modules with a significance level of 0.05 because the p value <0.05. The conclusion on the results of knowledge in the intervention group before being given intervention in the form of education, modules and short films was that they had good knowledge as much as 50% and after being given education they had good knowledge as much as 90% meaning that there was an increase in knowledge before and after being given intervention, meaning that there was an increase of 40%, while in the intervention group they had good skills 0%, enough 90%, less 10% after being given intervention there was a change to good as much as 83.3% meaning that there was a significant change before being given treatment and after being given treatment.