With an increasing global urban population andassociated health concerns, understanding the effects of urban microclimate and air quality is crucial. This study aims to assess the influence of different types and locations of greenery, along with building heights and wind orientation, on urban canyon microclimate and air quality. Focusing on PM10, PM2.5, and NOx concentrations in a hot-arid district, the research employs simulation-based analysis. Results indicate that stepped buildings with green walls exhibit the highest temperature (18.02°C), while scenarios featuring two rows of deciduous trees showcase the lowest temperature (17.56°C) but higher pollution levels. Notably, scenarios lacking trees exhibit elevated temperatures. The study introduces a novel ventilation design pattern for effective air pollutant removal and proposes a scenario with extensive green coverage on streets, walls, and rooftops, incorporating appropriate planting techniques and plant selection. The findings offer valuable insights for urban designers and architects seeking to create more sustainable and environmentally friendly cities.