Effects Of Low Magnesium Research Articles

Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian.

The relationship between sleep and micronutrients, including magnesium, is implicated in its regulation. The effects of low magnesium and other micronutrients on sleep disruption and telomere loss are not well understood. The present study was carried out in 172 healthy elderly subjects from South Australia. Plasma micronutrients including magnesium were measured. Each participant provided information about their sleep hours (<7 h or ≥7 h). Lymphocyte telomere length (TL) was measured by real-time qPCR assay. Plasma magnesium level was significantly low in subjects who sleep less than 7 h (p = 0.0002). TL was significantly shorter in people who are low in magnesium and sleep less than 7 h (p = 0.01). Plasma homocysteine (Hcy) is negatively associated with magnesium (r = -0.299; p < 0.0001). There is a significant interaction effect of magnesium and Hcy on sleep duration (p = 0.04) and TL (p = 0.003). Our results suggest that inadequate magnesium levels have an adverse impact on sleep and telomere attrition rate in cognitively normal elderly people, and this may be exacerbated by low levels of vitamin B12 and folate that elevate Hcy concentration.

Effects of low magnesium and an arbuscular mycorrhizal fungus on the growth, magnesium distribution and photosynthesis of two citrus cultivars

The effects of the arbuscular mycorrhizal (AM) fungus, Glomus versiforme, on plant growth, magnesium (Mg) concentration and distribution, and photosynthesis in the ‘Newhall’ (Citrus sinensis Osbeck cv. Newhall) navel orange and ‘Ponkan’ (Citrus reticulate Blanco cv. Ponkan) tangerine grafted on the rootstock trifoliate orange (Poncirus trifoliata L. Raf.) were studied in potted cultures under Mg-poor and Mg-rich conditions. The low soil Mg inhibited the ‘Newhall’ seedlings growth more than that of ‘Ponkan’. This was accompanied by greater decreases of Mg concentrations and CO2 assimilation rate in the basal leaves, and lower soluble sugar concentrations in the roots of ‘Newhall’. AM inoculation improved the growth, the Mg concentrations in various plant parts, and the photosynthesis of the two cultivars, especially the ‘Newhall’ seedlings under the Mg-poor condition. These results suggest that G. versiforme has the potential to enhance growth and Mg distribution in ‘Newhall’ seedlings grown in low Mg soil in a greenhouse.

Low serum magnesium and cardiovascular mortality in chronic heart failure: A propensity-matched study

Background Low serum magnesium levels may cause fatal ventricular arrhythmias. However, their long-term effects on mortality and morbidity in chronic heart failure patients are relatively unknown. Methods We studied 1569 chronic systolic and diastolic heart failure patients with normal sinus rhythm who participated in the Digitalis Investigation Group trial and had serum magnesium data available at one month. Of these, 741 patients had normal (> 2 mEq/L) and 828 had low (≤ 2 mEq/L) serum magnesium levels. Propensity scores for having low serum magnesium levels were calculated for each patient using a non-parsimonious multivariable logistic regression model, and were used to match 560 (76%) low-magnesium patients with 560 normal-magnesium patients. Effects of low-magnesium on mortality and hospitalization during a mean follow-up of 36 months were assessed using matched Cox regression analyses. Results All-cause mortality occurred in 156 (rate, 915/10,000 person-years) normal- magnesium and 171 (rate, 1034/10,000 person-years) low-magnesium patients, respectively, during 1704 and 1653 years of follow-up (hazard ratio, 1.23; 95% confidence interval, 0.97–1.57; p = 0.089). Cardiovascular mortality occurred in 110 (rate, 646/10,000 person-years) normal-magnesium and 133 (rate, 805/10,000 person-years) low-magnesium patients (hazard ratio, 1.38, 95% confidence interval, 1.04–1.83, p = 0.024). Hazard ratios and 95% confidence intervals for all-cause and cardiovascular hospitalizations were respectively 1.18 (0.99–1.42; p = 0.068) and 1.14 (0.94–1.39; p = 0.182). Conclusions In a propensity-matched population of ambulatory chronic heart failure patients who were balanced in all measured baseline covariates, serum magnesium level 2 mEq/L or less was associated with increased cardiovascular mortality, but had no association with cardiovascular hospitalization.

NMDA-receptor-independent effects of low magnesium: involvement of adenosine

Perfusion of hippocampal slices with magnesium-free media elicits epileptiform activity attributable partly to the activity of N-methyl- D-aspartate (NMDA) receptors, but recent reports have documented an NMDA-independent enhancement of orthodromic potentials by moderate reductions in magnesium concentration. The present experiments indicate that this enhancement is comparable with that produced by perfusion with an adenosine antagonist, 8-phenyltheophylline, and that superfusion with this compound or adenosine deaminase precludes any enhancement of potential size in low magnesium solutions. The low magnesium enhancement is probably attributable to the recently described magnesium dependency of presynaptic inhibition by adenosine.