Effects Of Inorganic Selenium Research Articles

Effect of Inorganic Selenium on Blood Biochemistry under Dexamethasone Induced Stress in Broiler Chicken

Effect of Inorganic Selenium on Blood Biochemistry under Dexamethasone Induced Stress in Broiler Chicken

Accumulation of selenium in a Chinese cabbage of a grade Pak-choi in the course of cultivation

Most agricultural areas of Russia have soils poor in mineral selenium, causing higher oncology risks for population of such areas. The way to control malignancy incidence is selenium fortification of soils and plants. This can be achieved by agrochemical enrichment of cultivated plants with nutritive substrates containing essential minerals and trace elements. The current study aimed to assay the effect of inorganic selenium on the rate of Chinese pakchoi cabbage biomass gain for the development of agrochemical techniques for introducing selenium. The optimal selenium introduction technique would demonstrate the best balance of biomass gain rate and selenium ion accumulation in organic matter. Selenium ion accumulation dynamic was assessed during controlled growth of plants in soils enriched with nutritive substrate containing inorganic selenium (potassium selenite). The amount of selenium in plants was determined by spectroscopy. Mathematical functions describing the selenium uptake dynamic of controlled grown plants have been found, including derivatives of these functions that led to obtaining the numerical values of the respective uptake rates. It has been found that agricultural techniques that involve introduction of selenium at intermediate and late stages of cultivation are optimal for plant growth dynamic, as introducing selenium at early stages of cultivation has a negative impact on biomass uptake rates. Additionally, introducing potassium selenite to the nutritive substrate at 1.0 mg×dm–3 proved to be more effective than introducing potassium selenite at 0.5 mg×dm–3 as the former dosage led to a better plant growth dynamic.

The increase of immunity and disease resistance of the giant freshwater prawn, Macrobrachium rosenbergii by feeding with selenium enriched-diet

The effects of inorganic selenium (Se) (sodium selenate, SSe) and organic selenium (seleno- l-methionine, MSe) supplementation on the immune response, antioxidant status, and disease resistance of the giant freshwater prawn, Macrobrachium rosenbergii, were studied. Five experimental diets, including a control diet (without Se enrichment), 0.5 mg (kg diet) −1 of MSe, 1 mg (kg diet) −1 of MSe, 0.5 mg (kg diet) −1 of SSe, and 1 mg (kg diet) −1 of SSe, were used. After 75 days of culture, prawn fed the Se-enriched diets had lower mortality compared to that of prawn fed the control diet after being challenged by the pathogen, Debaryomyces hansenii. No significant differences in the total hemocyte count, superoxide dismutase activity, or clearance efficiency of prawn were recorded among the control and treated groups. Significantly increased phenoloxidase and phagocytic activities in prawn fed the Se-enriched diets were found compared to the controls. Respiratory bursts of prawn fed both forms of 1 mg Se (kg diet) −1 significantly increased compared to control prawns. For the antioxidant status analysis, glutathione peroxidase, glutathione reductase, and glutathione s-transferase of prawn fed the SSe-enriched diet at 1 mg (kg diet) −1 were significantly increased. The results indicated that the cheaper selenium, SSe is recommended to be added in prawn feed at the concentration of 0.5 mg resulting in 1.5 mg SSe (kg diet) −1 increased prawn immunity and disease resistance against the pathogen, D. hansenii.

Biosynthesis of selenium-containing polysaccharides with antioxidant activity in liquid culture of Hericium erinaceum

The effects of inorganic selenium (sodium selenite) and Selol containing selenitetriglycerides synthesized from sunflower oil on mycelial growth and selenium-containing extracellular (EPS) and intracellular (IPS) polysaccharides production were examined in shake flask cultures of Hericium erinaceum. Unlike sodium selenite which inhibited mycelial growth, Selol increased in biomass production in a dose-dependent manner. Selol also dramatically enhanced EPS formation to 2.25 g/L which is 2.5–fold higher than in the control. Selenium content in EPS and IPS obtained from Selol-enriched medium reached a maximum of 4.89 and 4.69 mg/g, respectively. The in vitro antioxidant activities of polysaccharides were evaluated by reducing power, inhibition of lipid peroxidation, and 1,1-diphenyl-dipicrylhydrazyl radicals scavenging assays. The selenium-containing EPS showed an excellent antioxidant activity correlated well with increasing concentrations. The results suggested that selenium-containing EPS from H. erinaceum submerged culture should be explored as a novel selenium source in dietary supplements, with potent antioxidant properties.

Comparative effects of selenite and selenite on the glutathione-related enzymes activity in pig blood platelets

The effects of inorganic selenium (Se) compounds (sodium selenite and selenate) on the activities of glutathione-related enzymes (glutathione peroxidase, glutathione-S-transferase [GST] and glutathione reductase [GR]) in pig blood platelets were investigated in vitro. GST activity in blood platelets treated with 10(-4)M of selenite was reduced to 50%, whereas no decrease GST activity was observed after the treatment of platelets with the same dose of selenate. In platelets incubated with physiological doses (10(-7) and 10(-6)M) of Se compounds, the activity of glutathione peroxidase (GSH-Px) was enhanced (about 20%). GR activity after the exposure of platelets to tested Se compounds was unaffected.

Selenium status and the effect of organic and inorganic selenium supplementation in a group of elderly people in Denmark.

The selenium status of 57 elderly people (> or = 65 years) has been investigated on the basis of selenium concentration in serum, whole blood and erythrocytes and on the basis of the activity of the selenium-dependent enzyme glutathione peroxidase (GSH-px) in erythrocytes and plasma. Thirty-six elderly subjects participated in a 4-month trial of supplementation: 12 subjects were supplemented with 125 micrograms organic selenium, 12 subjects were supplemented with 125 micrograms inorganic selenium and 12 subjects participated as controls. The results showed that the selenium status of the elderly people was not significantly lower than that of younger people (p > 0.05). The effect of organic and inorganic selenium on the activity of GSH-px in plasma and erythrocytes showed a nearly identical increase (25-35%) during the period of supplementation. The effect of inorganic selenium supplementation caused a 30% increase in selenium concentration in plasma and erythrocytes which stabilized after 4 weeks. The effect of organic selenium supplementation on selenium concentration in plasma and erythrocytes showed an increase of up to 100% and 120% during the period of supplementation.

Selenium‐iron interaction in young women with low selenium status

The effect of inorganic selenium (Se) supplementation on iron status and iron supplementation on selenium status was investigated in Finnish female students (=33). The students were divided into three groups and supplemented daily for four weeks either with 150 μg Se as sodium selenate, or 120 mg Fe as ferrous sulfate, or 120 mg Fe as ferrous sulfate and 150 μg Se as sodium selenate. Plasma selenium level was used as an indicator of body selenium status. Haematocrit and serum ferritin concentrations were measured to determine the changes in body iron status. The initial plasma selenium level of all subjects was 74.7 ± 2.9 ng/ml (mean ± SEM). The increase in the plasma Se level in the group receiving sodium selenate was significantly higher (P<0.05) than in the group having both sodium selenate and ferrous sulphate. The plasma selenium level in the group receiving ferrous sulphate decreased from 76.0 ± 2.8 ng/ml to 67.8 ± 2.3 (P<0.05) during the supplementation period, but returned to the initial level four weeks after the end of iron supplementation. The data indicate that the supplementary iron affected adversely the body selenium status of these subjects. On the other hand, Se supplementation had no effect on body iron status as indicated by the serum ferritin and haematocrit levels. It was also shown that there was no obvious interaction between the normal levels of selenium and iron in the body, since no correlations were found between plasma selenium and serum ferritin (r = 0.30, P>0.05) in the beginning of the study.