Health Effects Research Articles

Health issues and management practices of pesticide exposure in Ethiopia, East Africa

Pesticides are commonly used in agriculture for pest control, but their improper usage and handling can lead to high farmer exposures, negative health effects, and pollution of water bodies. The purpose of this study was to investigate farmer’s perceptions of the effects of pesticide runoff on water bodies, and to describe their self-reported knowledge of appropriate pesticide use, methods of application, sources of information, and related health issues and management strategies in Ethiopia. Data were collected via structured questionnaire, which was administered as an in-person interview to 582 farmers who cultivated vegetables. To assess unsafe pesticide handling practices, researchers observed the storage of pesticides and the condition of personal protective equipment and asked farmers about their pesticide disposal methods. The study found that nearly 87.97% of farmers reported mixing pesticides using a stick or their bare hands. Most respondents (88.83%) mixed pesticides to spray just on their farmland, and some (10.14%) were near water sources. It revealed that farmers have a low level of awareness about the risks and effects associated with pesticides and do not follow safe practices. Out of the farmers who had utilized pesticides, 55.67% reported encountering health issues associated with pesticide exposure. To reduce exposure and health risks, the study suggests implementing comprehensive interventions, such as integrated pest management, safety training, and alternative control methods.

Subchronic Exposure to Low-Level Lanthanum, Cerium, and Yttrium Mixtures Altered Cell Cycle and Increased Oxidative Stress Pathways in Human LO-2 Hepatocytes but Did Not Cause Malignant Transformation.

Human exposures to rare earth elements are increasing with expanded use in aerospace, precision instruments, and new energy batteries, materials, and fertilizers. Individually these elements have low toxicity, although few investigations have examined the health effects of longer-term mixture exposures. We used the LO-2 cell line to examine the effects of graded exposures to lanthanum, cerium, and yttrium (LCY) mixtures at 1-, 100-, and 1000-fold their human background levels (0.31 μg/L La, 0.25 μg/L Ce, and 0.12 μg/L Y) on cell cycle, oxidative stress, and nuclear factor erythroid-2-related factor (NRF2) pathway biomarkers, assessing responses every 10 passages up to 100 passages. Cell migration, concanavalin A, malignant transformation, and tumorigenesis in nude mice were also examined. Mixed LCY exposures activated oxidative stress and the NRF2 pathway by the 30th passage and increased the proportion of cells in the S phase and cell cycle-specific biomarkers by the 40th passage. LCY exposures did not cause malignant transformation of hepatocytes or induced tumorigenesis in nude mice but enhanced cell proliferation, migration, and agglutination. Importantly, LCY mixtures with longer-term exposure activated the NRF2 pathway and altered the hepatocyte cell cycle at doses far below those used in previous toxicological studies. The consequences of LCY mixtures for public health merit further study.

The 1,7-malaria reactive community-based testing and response (1,7-mRCTR) approach in Tanzania: a cost-effectiveness analysis

BackgroundReactive case detection (RACD) for malaria control has been found effective in low transmission settings, but its impact and cost-effectiveness in moderate-to-high transmission settings are unknown. We conducted an economic evaluation alongside an empirical trial of a modified RACD strategy (1,7-mRCTR) in three moderate-to-high malaria transmission districts in Tanzania.MethodsThe costs and cost savings associated with the intervention relative to passive case detection alone were estimated in the study sites of Kilwa, Kibiti, and Rufiji districts in Tanzania from 2019–2021. Empirical cost data were collected using household surveys. The incremental costs of the intervention were calculated from under a societal perspective. Costs are reported in 2022 US dollars.Trial data and malaria registers from health facilities were used to calculate the number of malaria cases detected. We simulated unobserved and distal health effects of the intervention to assess cost-effectiveness in terms of incremental cost-effectiveness ratios (ICERs).Propagated uncertainty was assessed via second-order Monte Carlo simulation, including bootstrapping of empirical data distributions. Incremental costs per disability-adjusted life year (DALY) averted were compared to a willingness-to-pay threshold based on estimated opportunity costs of healthcare spending in Tanzania.ResultsThe programmatic cost of the 1,7-mRCTR intervention was 5327 United States Dollars (USD) per 1000 population. The combination of reactive and passive case detection in the intervention arm resulted in an additional 445 malaria cases detected per 1000 compared to passive detection alone, yielding an incremental cost per additional case detected of 12.0 USD. Based on modelling results, for every percentage point decline in malaria prevalence, the intervention averted 95.2 cases and 0.04 deaths per 1000 population. On average, the 1,7-mRCTR intervention averted 19.1 DALYs per 1000 population. Compared to passive malaria detection, the ICERs for the 1,7-mRCTR intervention were 7.3 USD per case averted, 16,884 USD per death averted, and 163 USD per DALY averted.ConclusionsOur analysis demonstrates that the 1,7-mRCTR intervention appears to be cost-effective under a willingness-to-pay threshold of 417 USD per DALY averted, showing that modified RACD strategies can provide value for money in moderate-to-high transmission settings.Graphical

Adherence to 24-hour movement guidelines among rural middle-aged and older adults in South Africa: prevalence, antecedents, and consequences on mental health outcomes

ABSTRACT Objective The purpose of this study was to look into the prevalence, correlates, and mental health effects of middle-aged and older adults in South Africa meeting the 24-hour movement guidelines (HMG). Methods We analyzed data (N = 5059, aged 40 years and older) from A Longitudinal Study of an INDEPTH Community in South Africa, Health and Ageing in Africa (HAALSI, conducted in 2014/2015). Measures included demographics, activity limitations, depressive symptoms, posttraumatic stress disorder (PTSD), loneliness, happiness, and self-reported 24-HMG defined as follows: 150 minutes or more of physical activity per week; 480 minutes or less of sedentary time; 180 minutes or less of screen time; 7-9 hours of sleep for those aged 40–64; and 7-8 hours of sleep for those aged 65 and over. The relationship between self-rated mental health (e.g. measured using the CES-D 8-item version) and meeting the 24-HMG number was investigated using logistic regression models. Results The percentages of participants who adhered to none, one, and two movement guidelines were 10.9%, 29.7%, and 37.9%, respectively, whereas only 21.5% of participants met all three 24-HMG. Participants who were older, were South African, and had functional disabilities were less likely to meet all three 24-HMG. In adjusted analysis, compared with meeting all 3 24-HMG, all participants and male participants who met fewer 24-HMG were more likely to report depressive symptoms, PTSD and less likely to report happiness, and all participants, male and female participants who met fewer 24-HMG were more likely to report loneliness. Conclusions This is the first study to look at the prevalence, correlates, and relationships between 24-HMG adherence and mental health outcomes among older adults in Africa. The results highlight how critical it is to encourage senior citizens in South Africa to engage in healthy movement behaviors. Future mental health interventions for older adults should focus on improving their overall movement behaviors while taking demographic differences into account.

Identifying and Prioritizing Hazardous Chemicals in Construction Metal Structure Coating Systems: A Roadmap for Data-Driven Disease Prevention.

Occupational exposure as a painter was classified by the International Agency for Research on Cancer (IARC)as a Group 1 carcinogen (carcinogenic to humans) in 1989. Chemical agents responsible for cancers and other illnesses among industrial painters are not well-documented. The goal of this systematic review and synthesis was to document the chemistries of metal structure coating systems, summarize data gaps on occupational exposures and health effects among painters, and identify and prioritize hazardous chemicals to guide future exposure and occupational health studies, and ultimately disease prevention efforts. We reviewed coating products approved by the Northeast Protective Coating Committee (NEPCOAT) for use in steel bridges in New England, with a special focus on Part B of these reactive chemical systems, and related literature on exposures and health effects. From the review of safety datasheets (SDS), we identified 61 unique CAS numbers belonging to different Part B chemical groups of isocyanate- and epoxy-based formulations, including amine hardeners, solvents, nanomaterials, and other additives. The list of identified ingredients contained 14 potent sensitizers, two IARC Group 1 known carcinogens, and 7 IARC Group 2B possible carcinogens. Cancers of the lungs, urinary bladder, liver, kidneys, and gastrointestinal system, allergic contact dermatitis, lung fibrosis, and asthma were some possible disease endpoints. Existing occupational exposure studies focused on solvent exposures, while exposure and biomonitoring studies of amine hardeners and other ingredients of concern in these formulations are lacking. The list of chemicals of concern identified here, including sensitizers and carcinogens, can serve as a basis for analytical method development and field exposure assessment studies. A national multi-pronged strategy to reduce chemical exposures and health risks among construction painters is warranted, including research on exposure monitoring and reduction efforts, longitudinal epidemiological studies, and product reformulation.

Effectiveness and Acceptability of Asynchronous Digital Health in Asthma Care: Mixed Methods Systematic Review.

Asynchronous digital health (eg, web-based portal, text, and email communication) can overcome practical barriers associated with in-person and remote synchronous (real-time) consultations. However, little is known about the effectiveness and acceptability of asynchronous digital health to support care for individuals with asthma (eg, asthma reviews). We aimed to systematically review the qualitative and quantitative evidence on the role of asynchronous digital health for asthma care. Following Cochrane methodology, we searched 6 databases (January 2001-July 2022; search update: September 2023) for quantitative, qualitative, or mixed methods studies supporting asthma care using asynchronous digital health. Screening and data extraction were duplicated. We assessed the risk of bias in the clinical outcomes of randomized controlled trials included in the meta-analysis using the revised Cochrane risk of bias tool. For the remaining studies, we evaluated the methodological quality using the Downs and Black checklist, critical appraisal skills program, and mixed methods appraisal tool for quantitative, qualitative, and mixed methods studies, respectively. We determined the confidence in the evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) criteria. We conducted a meta-analysis of trial data and a thematic analysis of qualitative data. We included 30 studies (20 quantitative, 6 qualitative, and 4 mixed methods) conducted in 9 countries involving individuals with asthma, their caregivers, and health care professionals. Asynchronous digital consultations linked with other functionalities, compared to usual care, improved asthma control (standardized mean difference 0.32, 95% CI 0.02-0.63; P=.04) and reduced hospitalizations (risk ratio 0.36; 95% CI 0.14-0.94; P=.04). However, there were no significant differences in quality of life (standardized mean difference 0.16; 95% CI -0.12 to 0.43; P=.26) or emergency department visits (risk ratio 0.83; 95% CI 0.33-2.09; P=.69). Patients appreciated the convenience of asynchronous digital health, though health care professionals expressed concerns. Successful implementation necessitated an organizational approach. Integrative synthesis underscored the ease of asking questions, monitoring logs, and medication reminders as key digital functionalities. Despite low confidence in evidence, asynchronous consultation supported by digital functionalities is an effective and convenient option for nonemergency asthma care. This type of consultation, well accepted by individuals with asthma and their caregivers, offers opportunities for those facing challenges with traditional synchronous consultations due to lifestyle or geographic constraints. However, efficient organizational strategies are needed to manage the associated workload. PROSPERO CRD42022344224; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=344224. RR2-10.1371/journal.pone.0281538.

Probabilistic Health Risk Assessment of Heavy Metals in People Living Near the Mine-Closure in Tak Province

Heavy metals including lead (Pb), zinc (Zn), and cadmium (Cd) can damage the kidney, liver, brain, lungs, blood composition, and other vital organs. As a result, their toxicity, especially when contaminated in food, water, and soil, can be harmful to human health. This study evaluated the risk of adverse health effects to residents near closed zinc mines in Tak Province, Thailand. Data was collected from three subdistrict sites and analyzed for probable health risk. Scenario pathways were oral and dermal contact of heavy metals; including Pb, Zn, and Cd, in four age groups with average daily dose and hazard quantification; hazard index (HI); and cancer risk (CR) considered. Results were that carcinogen risk quantification exceeded the recommended limit (CR ≤10-6) in all scenarios, and the hazard index for non-carcinogenic risk was below the acceptable level (HQ ≤1), in which Cd dominated for all categories. These findings suggest that all medias and food products should be appropriately monitored, especially with carcinogenic surveillance, to mitigate health effects on residents.

A Simple Narrative Review of Progress on the Processing and Utilization of Functional Rice

This paper aims to review the research progress on the processing and utilization of functional rice and explore its potential to enhance human health. The research progress in the processing and utilization of colored rice, low-protein rice, high-resistant starch rice, micronutrient-enriched rice, and bioreactor rice was systematically analyzed through a comprehensive literature review. The impact of various processing techniques on the retention of nutritional components in functional rice was also discussed. This study found that functional rice exhibits great potential in terms of nutritional value, health effects, and market demand. However, issues such as the loss of bioactive components during processing, the maintenance of specific agronomic traits, and market acceptance still need to be addressed. The research and development of functional rice are significant for enriching people’s dietary choices and addressing global malnutrition and chronic disease problems. Future efforts should focus on further optimizing processing techniques and utilizing genetic engineering and molecular breeding technologies to enhance the nutritional value and agronomic traits of functional rice, thus meeting market demands and health objectives.

Impact of Smokeless Oral Nicotine Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment: A Policy Statement From the American Heart Association.

Smokeless oral nicotine products are addictive, and their use has potential adverse effects on some but not all biomarkers of cardiovascular risk. The use of some types of these products, for instance, is associated with an increased mortality risk in those with ischemic heart or cerebrovascular disease. Similarly, smokeless tobacco has the potential to increase the risk of oral cancer, but the risks depend on the chemical composition of the product. The market of smokeless oral nicotine products has transformed since the last American Heart Association smokeless tobacco policy statement. Several varieties of tobacco-free oral nicotine products-including oral nicotine pouches; nontherapeutic nicotine gums, lozenges, and tablets; and nicotine gummies-have rapidly proliferated. The sales of oral nicotine pouches, in particular, have increased substantially; however, no data are available on their cardiovascular or health risks. In addition, synthetic (compared with tobacco-derived) nicotine has been used in some brands of oral nicotine products, but its cardiovascular and health effects have been inadequately studied. Robust public policy levers are identified to support ending addiction to all commercial tobacco products. Critical components and policy initiatives include clinicians emphasizing the prevention of tobacco product initiation and supporting cessation with established pharmacological and behavioral tobacco dependence treatment therapies as primary goals for achieving an end to commercial tobacco and nicotine addiction.

Pivotal Role of Mass Spectrometry for the Assessment of Exposure to Reactive Chemical Contaminants: From the Exposome to the Adductome.

A large part of the Human chemical exposome is now well characterized, and its health effects has been widely documented, although precise causal links remain difficult to establish. In parallel, genetic factors only were shown to contribute less than 30% to various pathologies. Therefore, environmental factors may represent the predominant cause of chronic diseases. Mass Spectrometry has been established for many years as a main "gold standard" in this field due to its performances both in sensitivity and selectivity. However, some unstable or highly reactive compounds may escape their detection in the biological samples because of their short half-life although some of their stable metabolites, if any, can be used for the exposure assessment. These electrophilic molecules are known to bind covalently to nucleophilic molecules in the body to form what are commonly called adducts. The study of adducts formed with DNA, proteins or with glutathione, nowadays called adductomics, can provide additional toxicologically relevant information in biomonitoring studies. This review describes this particular part of the reactive exposome and the related mass spectrometric methods developed therein. Three dedicated parts of this review are devoted to the contribution of mass spectrometry respectively to the assessment of DNA modifications, protein modifications, and reaction with glutathione.

Sexual dimorphism in the effects of maternal adipose tissue growth hormone receptor deficiency on offspring metabolic health

BackgroundThe global incidence of obesity continues to rise, which increases the prevalence of metabolic diseases. We previously demonstrated the beneficial effect of adipose-specific growth hormone receptor (Ghr) knockout (KO) on metabolic parameters in male mice exposed to high fat diet. Although the effect of the growth hormone (GH) axis on lipid metabolism has been well studied, sexual dimorphism has not been considered. Furthermore, the effects of the GH axis on intergenerational adipose development are understudied. The present study aimed to evaluate whether adipose-specific Ghr knockout is associated with sex-specific differences in metabolic health of female offspring.MethodsGhrflox/flox (LL) mice were crossed with Adipoq-Cre mice to generate adipose-specific Ghr knockout (KO) mice. Physiological phenotype and fertility of female LL and KO mice were measured. Body weight, organ weight, glucose homeostasis, liver and adipose histology, hepatic triglycerides (TG) content, serum TG and low-density lipoprotein cholesterol (LDL-C) levels of female offspring were detected.ResultsWe found an increase in adipocyte size in female KO mice, but no change in glucose tolerance or insulin sensitivity. Adipose-specific Ghr deficiency impairs fertility in female KO mice. Maternal adipose-specific Ghr deficiency had a considerable beneficial effect on glucose metabolism in female offspring. The female offspring of the KO mice were protected against diet-induced obesity and the degree of hepatic steatosis and hyperlipidemia was reduced. The adipocyte size of the KO offspring did not change significantly despite the decrease in fat weight. Furthermore, the phenotypes of the offspring of LL mice fostered by the KO mothers differed from those of offspring remaining in the maternal nest.ConclusionsThe findings of our study suggest that adipose GH axis plays a complex and important role in the intergenerational effects of metabolic health and adipocytes on offspring in a sex-specific manner. Future studies are needed to reveal the mechanisms of these sexually dimorphic phenotypes and the feasibility of providing new interventions for improving offspring metabolic health.

Strategic Insights into Bank Performance: CAMELS Analysis of Indian Banks

The banking sector is a cornerstone of the global economy, driving economic growth, financial sta-bility, and efficient resource allocation. Assessing the financial health and operational effectiveness of banks is crucial for maintaining the stability of the broader financial system. The CAMEL model, a well-established analytical framework, provides a comprehensive approach to evaluating key aspects of bank-ing performance, including Capital Adequacy, Asset Quality, Management Efficiency, Earnings Quality, and Liquidity. This model highlights areas for improvement and ensures a thorough assessment of a bank’s financial soundness. Extensive research has confirmed the model's applicability across various global contexts, including India, Nepal, Pakistan, Saudi Arabia, and Sri Lanka, consistently identifying asset quality, capital adequacy, and earnings as essential drivers of profitability. The model also reveals that private banks generally outperform public banks in most parameters. Moreover, the CAMEL model has proven to be a valuable tool in promoting financial inclusion, particularly through the analysis of Small Finance Banks, and its adaptability to emerging markets further underscores its relevance. Despite its broad applicability, gaps exist in the literature, particularly regarding the model’s adaptation to diverse regulatory environments and market dynamics. Addressing these gaps will enable more customized strategies for financial analysis and risk management, enhancing the resilience of the global banking system. This study aims to contribute to this discourse by exploring the nuanced use of the CAMEL model in assessing the financial performance of banks in varied contexts. The findings aim to offer ac-tionable insights for improving financial performance, managing risks, and fostering sustainable growth in the banking industry.

Brain changes following subchronic exposure to copper oxide nanoparticles: animal experimental data analysis

AbstractThe goal of this study was to assess the health effects of (copper oxide nanparticles) CuO NPs on the brain structure and function in rats. Morphology results showed that the number of axons with the damaged myelin sheath in basal ganglia and the proportion of pathologically altered mitochondria in olfactory bulbs and basal ganglia had increased, while the concentration of myelin basic protein in blood serum remained unchanged. We also have observed the lower body weight gain, signs of hemolytic anemia, an increased platelet count, reduced locomotion and exploratory activity. We propose that the central nervous system and haematopoiesis are the targets for toxicity of CuO NPs administered intranasally during six weeks at the total dose of 0.45 mg/kg body weight.

Frequent Consumption Of Non-Vegetarian Food And Its Impact On Adult Health

The study Frequent Consumption of Non-vegetarian Food and its Impact on the Health of an Adult aims to evaluate the association between the frequency of non-vegetarian consumption and its potential health effects. It uses a descriptive study method, the Chi-Square test, and percentages. Most participants were young females, primarily students, with an overall sample size of 73. Half of them consumed non-veg once a week, while a significant number experienced gastric issues. The key finding was a strong association found between frequent non-veg consumption and heart disease risk. Also found that most of the individuals prefer Physical activity and a balanced diet as a health management strategy.

Analysis of the health effects of multiple social networks on the older adult: the substitution role of labor participation

ObjectivesThis study aims to examine the role of social networks in influencing the physical and mental health of older Chinese adults, investigating both the underlying mechanisms and the associations between social networks, labor force participation, and health outcomes.MethodsUsing data from the 2021 China General Social Survey (CGSS), we analyzed a sample of 1,332 older adults, incorporating demographic and health-related variables. Ordinary least squares (OLS) regression and mediation analysis were conducted to evaluate the effects of social networks on health outcomes, with subgroup analyses by gender and education level. Stata 18.0 and SPSS were employed to perform all statistical analyses.ResultsSocial networks demonstrate a significant positive effect on overall, physical, and mental health at the 1% level, with weak-tie networks exhibiting a more substantial impact on health (β = 0.1146, p < 0.01). In promoting physical health, social networks have a coefficient of 0.1371 (p < 0.001) for females and 0.2128 (p < 0.001) for males. Among individuals with lower education, the coefficient is 0.1561 (p < 0.001), while for those with higher education, it is 0.2184 (p < 0.001). Regarding mental health, social networks yield a coefficient of 0.0747 (p > 0.05) for females and 0.1095 (p < 0.01) for males; for individuals with lower education, the coefficient is 0.0914 (p < 0.01), and for those with higher education, it is 0.0441 (p > 0.05). Media use, subjective wellbeing, and perceived social class are key explanatory mechanisms in the relationship between social networks and health of the older adult. Notably, subjective wellbeing and perceived social class function as chain mediators between social networks and health outcomes. The interaction between social networks and labor participation reveals a significant negative coefficient (β = −0.1864, p < 0.01).ConclusionSocial networks contribute to improved health in older adults, with weak ties playing a particularly significant role, although the effect varies across subgroups. Media use, subjective social class, and wellbeing are important mechanisms linking social networks with older adult health, while labor force participation may serve as a substitute for social networks in health promotion among older adults. This study will inform the improvement of older adults health and the development of labor policies for older adults.

Attenuation of inflammation, oxidative stress and TGF-β1/Smad3 signaling and upregulation of Nrf2/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity

Heavy metals are toxic environmental pollutants with serious health effects on humans and animals. Cadmium (Cd) is known for its serious nephrotoxic effect and its toxicity involves oxidative stress (OS) and inflammation. Diallyl disulfide (DADS), a main constituent of garlic, exhibited cytoprotective and antioxidant activities. This study investigated the effect of DADS on OS, inflammation, and fibrosis induced by Cd in rat kidney, pointing to the involvement of transforming growth factor-β (TGF-β)/Smad3 and nuclear factor erythroid 2–related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling, and peroxisome proliferator-activated receptor gamma (PPARγ). Rats received DADS for 14 days and Cd on day 7 and blood and kidney samples were collected. Cd elevated serum creatinine, urea and uric acid, provoked kidney histopathological alterations and collagen deposition, increased kidney malondialdehyde (MDA) level, and decreased glutathione (GSH) and antioxidant enzymes. Nuclear factor-kappaB (NF-κB) p65, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β, and CD68 were upregulated in Cd-administered rat kidney. DADS prevented kidney injury, mitigated OS, suppressed NF-κB, CD68 and pro-inflammatory mediators, and boosted antioxidants. DADS downregulated TGF-β1, Smad3 phosphorylation and Kelch-like ECH-associated protein-1 (Keap1), and increased Nrf2, HO-1, cytoglobin, and PPARγ. In conclusion, DADS protects the kidney against Cd toxicity by attenuating OS, inflammation, and TGF-β1/Smad3 signaling, and enhancement of Nrf2/HO-1 signaling, antioxidants, and PPARγ.

Identification and analysis of NAC genes related to S-alk(en)yl cysteine sulfoxides (CSOs) biosynthesis in Onion (Allium cepa L.)

The NAC family, a specific type of plant transcription factor, has been identified in various horticultural crops. Nevertheless, the comprehensive bioinformatics and biological function of the NAC family in onion remain unclear. S-alk(en)yl cysteine sulfoxides (CSOs) are crucial for onion flavor quality and health effects. There is a growing interest in studying the mechanism of CSOs synthesis regulation in onions due to the increased realization of their potential value. In this study, sixty members of the NAC family was identified based on transcriptomic data. These transcription factors were distributed on eight chromosomes of onion. Phylogenetic tree showed that AcNAC members were divided into three groups with similar conserved protein motifs. Cis-acting elements analysis showed that the promoter of AcNACs contained a large number of photoresponsive and hormone-responsive elements. The correlation analysis of the expression patterns of transcriptome data selected 18 AcNACs that might regulate the synthesis of CSOs. Two putative NAC transcription factors, AcNAC12 and AcNAC17, were speculated as potential regulators in the biosynthesis of CSOs in onions through the analysis of expression patterns of AcNAC genes across different growth stages and cultivars, as well as Y1H, dual luciferase, GUS staining, and gene suppression experiments. This study aims to provide suggestions and research directions for further investigation of the functions of AcNAC family members and regulatory pathways for CSO biosynthesis.

Trial of an mHealth intervention to improve HIV prophylaxis for female sex workers, United Republic of Tanzania.

To evaluate the effect of a mobile health (mHealth) intervention on early retention of female sex workers in human immunodeficiency virus (HIV) pre-exposure prophylaxis services in the United Republic of Tanzania. The study involved 783 female sex workers: 470 from Dar es Salaam who were given the Jichunge mHealth application (app) in addition to standard HIV pre-exposure prophylaxis (intervention arm), and 313 from Tanga who received pre-exposure prophylaxis alone (control arm). Participants were recruited using respondent-driven sampling and followed up for 12months. Early retention was defined as attending a pre-exposure prophylaxis follow-up clinic within 28days of an appointment scheduled for 1month after starting treatment. To assess if the Jichunge app led to higher retention, we conducted intention-to-treat and per-protocol analyses using a regression model adjusted by inverse probability weighting. Early retention in HIV pre-exposure prophylaxis care was observed in 27.6% (130/470) of participants in the intervention arm and 20.1% (63/313) in the control arm. In the adjusted, intention-to-treat analysis, early retention was observed in 29.4% in the intervention arm and 17.7% in the control arm (risk difference: 11.8 percentage points; 95% confidence interval: 5.3-18.3). Early retention in HIV pre-exposure prophylaxis care was significantly greater among female sex workers in the United Republic of Tanzania who used the Jichunge app than in those who did not. Nevertheless, more than two thirds of sex workers using the application did not attend follow-up services after 1month, suggesting that additional interventions are needed.

Effects of dental insurance and dental care utilization on oral health-related daily life activities among federally qualified healthcare center patients in the United States.

To assess the association between dental insurance, dental care utilization and oral health-related impact on daily activities among patients visiting Health Resources and Services Administration (HRSA)-funded health centers in the United States. This cross-sectional study examined the 2014 Health Center Patient Survey (HCPS), a survey of patients who received care at US health centers. Logistic regression analyses were conducted to explore the likelihood of the oral health-related impact on daily activities domains such as school/work performance, sleeping, eating/chewing, social and home activities considering sociodemographic, dental insurance, and dental care utilization. Among 7002 total participants, 6890 self-reported oral health-related impact on daily activities. Adults aged 18-44 were 2.6 times more likely to report an overall impact on everyday life activities compared to children and adolescents. After adjusting for sociodemographics, Hispanic patients were less likely to report any oral health-related impacts, while patients visiting rural centres reported higher odds of oral health related impairment. Patients who experienced delays in receiving dental care or were unable to access dental care when needed were 4.5 times more likely to encounter difficulties in their daily activities. This study linked limited dental insurance and care to increased oral health issues impacting daily life, particularly among adults, rural populations, and those facing delay in dental care. This highlights the need for policy reforms and interventions aimed at improving dental care access to mitigate the detrimental effects of poor oral health on daily functions for vulnerable populations.

Improving Food-Related Inhibitory Control Through an mHealth Intervention-A Secondary Outcome Analysis of an RCT.

Experimental studies reveal that deficits in food-related inhibitory control, rather than general impulsiveness, are closely linked to overweight and obesity. To date, the real-world implications remain unknown, and it is unclear whether these results are supported in the clinical field. To examine the effectiveness of a mobile health (mHealth) intervention with cognitive and behavioral therapeutic elements in altering impulsiveness and food-related inhibitory control. Prespecified secondary outcome analysis of a randomized controlled trial. Participants with overweight/obesity (BMI: M=33.35kg/m2, SD=3.79kg/m2, N=213) were randomly assigned to either a 12-week mHealth intervention (n=116) or wait-list control group (n=97). The Barratt-Impulsiveness-Scale (BIS-15) and the Food-Related Inhibitory Control Scale (FRIS) were administered at baseline (T0) following the intervention (T1), at 9 and 15 month post baseline (T2, T3). Multi-level analyses were calculated. Compared to the control group, the intervention group reported higher food-related inhibitory control on several subscales of the FRIS: In Withholding in Social Situations at T1 (95% CI: 0.06-0.46) and T2 (95%CI: 0.09-0.50), Action Cancellation at T1 (95%CI: 0.05-0.45), Resisting despite Craving at T1 (95% CI: 0.07-0.49), Withstanding Rewarding Food at T2 (95%CI: 0.08-0.55) and Action Withholding at T3 (95% CI: 0.01-0.55). No differences were found for trait impulsiveness (T1: 95%CI: -1.91-0.47; T2: 95%CI: -1.65-0.84; T3: 95%CI: -0.88-1.67). Food-related inhibitory control, rather than global measures of impulsiveness, addresses the critical association between inhibitory control and health-conscious dietary choices and can be improved by mHealth intervention. ClinicalTrials.gov identifier: NCT04080193.