Global Effects Research Articles

Reported impact of creativity in the Wakakosha ('You're Worth It') internal stigma intervention for young people living with HIV in Harare, Zimbabwe.

Internal stigma (negative judgements towards oneself) continues to be a barrier to HIV treatment, management and care, and has global public health consequences. People living with HIV (PLHIV) who report internal stigma are less likely to seek care, adhere to treatment and can experience increased depression and lower quality of life. The Wakakosha ('You're Worth It') programme sought to reduce internal stigma among young PLHIV using inquiry-based stress reduction (IBSR), a cognitive and awareness-based methodology. This sub-study focused on creativity, exploring how it promotes young PLHIV's well-being. We analysed individual interviews (n = 14), focus groups (n = 3), poems (n = 5), songs (n = 2) and self-compassion letters (n = 38) and 23 activity journals from November 2021 to March 2022, utilising inductive thematic analysis to identify themes across the data. Creativity saturated the Wakakosha intervention through modalities such as drawing, colouring, body mapping, music and letter writing. These engaged participants and gave them a space in which to shift their internal stigmatising beliefs, and helped them in multiple ways including: facilitating emotional regulation, self-acceptance, self-compassion, self-worth and body positivity. Creativity also enhanced participants' self-image and allowed them to see their own abilities. Music improved the therapeutic environment by helping participants focus, emote, retain messages and connect within the group setting. Letters to self/others allowed participants to let go of stigma towards themselves and the circumstances of their infection. Tools such as drawing and body mapping assisted participants with emotional recognition and expression. This sub-study provided insight into the potential of creativity, when integrated into an IBSR intervention, in counteracting internal stigma. Ongoing replication is needed to continue to evolve best practices for internal stigma interventions. Future work should use more structured and specific interviews with participants regarding their creative processes.

A meso–micro atmospheric perturbation model for wind farm blockage

As wind farms continue to grow in size, mesoscale effects such as blockage and gravity waves become increasingly important. Allaerts & Meyers (J. Fluid Mech., vol. 862, 2019, pp. 990–1028) proposed an atmospheric perturbation model (APM) that can simulate the interaction of wind farms and the atmospheric boundary layer while keeping computational costs low. The model resolves the mesoscale flow, and couples to a wake model to estimate the turbine inflow velocities at the microscale. This study presents a new way of coupling the mesoscale APM to a wake model, based on matching the velocity between the models throughout the farm. This method performs well, but requires good estimates of the turbine-level velocity fields by the wake model. Additionally, we investigate the mesoscale effects of a large wind farm, and find that aside from the turbine forces and increased turbulence levels, the dispersive stresses due to subgrid flow heterogeneity also play an important role at the entrance of the farm, and contribute to the global blockage effect. By using the wake model coupling, we can explicitly incorporate these stresses in the model. The resulting APM is validated using 27 prior large-eddy simulations of a large wind farm under different atmospheric conditions. The APM and large-eddy simulation results are compared on both mesoscale and turbine scale, and on turbine power output. The APM captures the overall effects that gravity waves have on wind farm power production, and significantly outperforms standard wake models.

Exploring Differing Perspectives on Sustainability and Corresponding Strategies in German Automotive Companies

In addition to acute crises dominating the societal discourse, such as the global consequences of the COVID-19 pandemic and the Russian invasion of Ukraine, the world continues to face the ongoing challenge of limiting climate change and achieving a sustainable transformation. Yet, in public discourse, the widely used terms “sustainability” and “transformation” are not clearly defined, and the understanding varies greatly depending on the industry and the stakeholders considered. One important transformation arena lies within the German automotive industry, as it is one of the country’s biggest industrial sectors by revenue and the number of employees. In addition, the German automotive industry is currently going through a transition period due to the switch to electric drivetrains as the main propulsion technology opposed to combustion engines. Therefore, the following paper identifies the differing understandings of sustainability and according actions in the German automotive industry. Moreover, possible conflicts and prioritizations along the economic, ecological, and social dimensions of sustainability are presented based on an expert interview study. To do so, a structuring qualitative content analysis in combination with a descriptive approach was used focusing on the differing perspectives on sustainability of both the interviewees and their companies. The gathered data then allows to compare the aggregated individual and corporate sustainability perspectives in the German automotive industry, as well as comparing the sustainability perspectives of the interviewees and their respective companies case by case. The results suggest that there is a considerable discrepancy between individual and corporate understandings of sustainability. These differences can mainly be attributed to the companies’ economically driven views in contrast to the individuals’, mostly ecologically driven sustainability perspective. Moreover, several barriers and conflicts, rooted in the prioritization of economic gains, can be traced back to conflicts in the supplier pyramid. The identification of common transformation goals and measures among companies is necessary to enable a collaborative, sustainable transformation in the German automotive industry, which benefits all societal stakeholders in or attached to this sector.

Quantitative attribution of industrial agglomeration patterns in Africa: global, local drivers and indirect effects

ABSTRACT Finding appropriate measures to drive industrial agglomeration is particularly urgent for Africa, which has been facing a decline in industrial production activities. Therefore, this study contributed by developing a multi-level spatial analysis framework that explored the global driving mechanisms and local heterogeneity of industrial agglomeration in Africa through various critical factors. The findings are as follows: (1) From 2009 to 2019, the industry in Africa has always been highly concentrated in a few countries, but the degree of agglomeration has been declining, with some countries in the East and West African regions showing a significant increase in the level of industrial agglomeration and a high potential for development. (2) Industrial agglomeration in African countries was driven by several factors, of which GDP per capita, highway network density, and electricity supply were the strongest and most consistent drivers. The impact strength of factors varied considerably across regions. (3) The drivers didn’t act independently and directly on the dependent variable, but were the product of synergy after the interaction between the two factors. Synergies between access to electricity and GDP per capita and other factors dominated the pattern of industrial agglomeration in Africa.

The role of mitochondrial transfer in the suppression of CD8+ T cell responses by Mesenchymal stem cells

Background. CD8+ Cytotoxic T lymphocytes play a key role in the pathogenesis of autoimmune diseases and clinical conditions such as graft versus host disease and graft rejection. Mesenchymal Stromal Cells (MSCs) are multipotent cells with tissue repair and immunomodulatory capabilities. Since they are able to suppress multiple pathogenic immune responses, MSCs have been proposed as a cellular therapy for the treatment of immune-mediated diseases. However, the mechanisms underlying their immunosuppressive properties are not yet fully understood. MSCs have the remarkable ability to sense tissue injury and inflammation and respond by donating their own mitochondria to neighboring cells. Whether mitochondrial transfer has any role in the repression of CD8+ responses is unknown.Methods and results. We have utilized CD8+ T cells from Clone 4 TCR transgenic mice that differentiate into effector cells upon activation in vitro and in vivo to address this question. Allogeneic bone marrow derived MSCs, co-cultured with activated Clone 4 CD8+ T cells, decreased their expansion, the production of the effector cytokine IFNγ and their diabetogenic potential in vivo. Notably, we found that during this interaction leading to suppression, MSCs transferred mitochondria to CD8+ T cells as evidenced by FACS and confocal microscopy. Transfer of MSC mitochondria to Clone 4 CD8+ T cells also resulted in decreased expansion and production of IFNγ upon activation. These effects overlapped and were additive with those of prostaglandin E2 secreted by MSCs. Furthermore, preventing mitochondrial transfer in co-cultures diminished the ability of MSCs to inhibit IFNγ production. Finally, we demonstrated that both MSCs and MSC mitochondria downregulated T-bet and Eomes expression, key transcription factors for CTL differentiation, on activated CD8+ T cells.Conclusion. In this report we showed that MSCs are able to interact with CD8+ T cells and transfer them their mitochondria. Mitochondrial transfer contributed to the global suppressive effect of MSCs on CD8+ T cell activation by downregulating T-bet and Eomes expression resulting in impaired IFNγ production of activated CD8+ T cells.

Cross-Sectional Associations Between Expectancies for Cannabis use and Pain in an Emerging Adult Sample.

Pain and cannabis use are highly prevalent among emerging adults but research regarding how pain is associated with cannabis-related expectancies is limited. Emerging adults who reported past three-month cannabis use (N = 173) were recruited through an online sampling platform. Participants completed the Graded Chronic Pain Scale, Cannabis Use Disorders Identification Test - Revised, and Marijuana Effect Expectancy Questionnaire. Multiple linear regressions indicated that pain intensity and disability were associated with hazardous cannabis use and expectancies for global negative effects (ps < .001). Sex did not moderate any of these relationships (ps > .14). Findings suggest that emerging adults who experience pain report greater hazardous cannabis use and may expect more negative effects of cannabis use. Researchers and clinicians should consider assessing pain in the context of cannabis studies and interventions.

Global limited effects of the conversion of multiple ecosystem types to tree and shrub plantations on soil base cation concentration and exchangeable capacity

Global limited effects of the conversion of multiple ecosystem types to tree and shrub plantations on soil base cation concentration and exchangeable capacity

Cannabidiol Treatment for Adult Patients with Drug-Resistant Epilepsies: A Real-World Study in a Tertiary Center.

Around 30% of patients with epilepsy show drug-resistant epilepsy (DRE). While cannabidiol has demonstrated efficacy as an adjunctive treatment in Dravet syndrome (DS), Lennox-Gastaut Syndrome (LGS), and epilepsy related to tuberous sclerosis complex (TSC), its more global effectiveness in adult patients with DRE apart from these three specific contexts needs to be clarified. We conducted a retrospective study at the epilepsy unit of Pitié Salpêtrière Hospital. Patients initiating pharmaceutical cannabidiol treatment and followed for at least 1 year were included. Patients were categorized into "authorized" (LGS, DS, or TSC) and "off-label" groups. Cannabidiol effectiveness and tolerance were compared between groups, and characteristics of responders (patients with >50% reduction in seizure frequency) in the off-label group were examined. Ninety-one patients, followed by a median duration of 24 months, were included. A total of 35.2% of the patients were in the authorized group. No significant differences were observed in responder rates between groups (31.3% vs. 35.6%, p =0.85) and retention rates at 1 year (75.0% vs. 74.6%, p =0.97). Sleepiness was more commonly reported in the authorized group (50.0% vs. 22.0%, p =0.01), with no other significant differences. Among off-label patients (n = 59), clobazam co-prescription was more prevalent in responders (71.4% vs. 28.9%, p =0.002). Our findings suggest that cannabidiol may benefit all adult patients with DRE, particularly those already receiving clobazam. Randomized controlled trials are warranted in off-label patients to validate these observational findings.

The Impact of Russia – Ukraine War on Global Economy

The invasion of Ukraine by Russia contributed to a notable rise in global prices of food and crude oil petroleum. The surge in the global food price index following the invasion was fueled by supply chain disruptions. In general, the incursion resulted in a continuous increase in inflation in both belligerent and non-belligerent nations. The following study shows how economic sanctions and regional conflict lead to an international energy crisis. Despite mediating countries like Turkey, it had a disastrous impact not only on geopolitical stability but also on economic development within and outside of Europe. The study used to assess the impact of Russia's invasion of Ukraine on global trade and business. This paper investigates the global economic growth and consequences of the Russia-Ukraine war over a four month period from December 2021 to March 2022. Russia invaded Ukraine on the 24th of February 2022.

The Impact of the Russian-Ukrainian War on the Global Economy

The most unexpected thing happened just as the globe was beginning to recover from the COVID - 19 pandemic and there was hope for the economy to be rebuilt. The Russian invasion of Ukraine on February 24, 2022, was seen by the entire globe. The day of the invasion saw a decline in stock values. Not just the economy of Russia and Ukraine suffered during the initial months of the invasion, many other nations also suffered greatly because of the conflict. Food prices increased dramatically worldwide because of the conflict between these two nations. The cost of food increased as well as there was an increase in the price of crude oil. Thus, resulting in Global inflation. Numerous European nations placed harsh sanctions on Russia to lessen the impact of the conflict. However, this did not create much of an impact since These sanctions had a serious impact on both the European nations and the nations that were not involved in the conflict. This resulted in a serious inflation issue that affected both combatant and noncombatant nations worldwide. This paper focuses on the global economic effect of the Russia and Ukraine war and how the actions of one country can create a serious impact on the globe.

How do exchange rates affect environmental quality?

AbstractExchange rates are integral to explaining the environmental consequences of globalization because they govern the prices of imported inputs and the price competitiveness of exports and, consequently, firms' input use decisions, production levels and emissions. We study how exchange rates, foreign input sourcing and export orientation determine environmental outcomes across countries and industries in both theoretical and empirical contexts. For industries that rely intensively on imported intermediate inputs, a stronger domestic currency leads to higher emission intensities (emissions per unit of output), while the reverse holds for industries that export intensively. Our results thus show that exchange rates have implications for the environment that have heretofore remained unexplored.

Integrated models for concurrent disorders from a Public Mental Health lens: a Systematic Review

Abstract Concurrent disorders (COD), historically defined by the World Health Organization as the simultaneous presence of a psychoactive substance use disorder and another psychiatric disorder within the same individual, pose a significant challenge to public mental health. In today’s global landscape of mental health services, the prevalence of COD is on the rise, underscoring the need for an integrated approach to management. This review aims to provide an overview of existing global models and the evaluation approaches. This systematic review examined research evidence in PubMed, Scopus and Web of Science up to 2023 regarding integrated management systems for COD. Following PRISMA guidelines, we included articles describing specific models and evaluating the effectiveness of integrated versus non-integrated approaches. Quality assessment was conducted using the appropriate scales. Out of 7700 screened articles, 18 were included, all of fair or good quality. A diverse array of patient care models, programs, and interventions addressing comorbidities between mental health and substance use disorders emerged. The majority of studies focused on clinical outcomes, particularly alcohol and drug dependence, with global mental health consequences also under examination. Psychodiagnostics and social outcomes were also considered in a significant portion of the research, shedding light on health services utilization patterns. The integrated model for concurrent disorders in psychiatry stands as an effective approach, yet its implementation encounters challenges. This study showcases successful integration examples, providing valuable insights for policymakers and healthcare professionals to enhance existing models or develop new ones, particularly within European healthcare reforms like Italy’s restructuring of primary care, where they could serve as a criterion for the setting and organization of community houses. Key messages • COD, involving both substance use and psychiatric disorders, present a significant challenge to public mental health. Rising prevalence underscores the need for integrated management approaches. • Insights from successful integration examples offer valuable guidance for healthcare professionals and policymakers, particularly within healthcare reforms like Italy’s restructuring of primary care.

Placebo-controlled efficacy of 17 anti-anginal drugs and percutaneous coronary intervention for first-line treatment of stable angina: systematic review &amp; meta-analysis of 5153 patients from 53 trials

Abstract Background Percutaneous coronary intervention (PCI) for stable angina is currently recommended for patients with residual symptoms despite maximal anti-anginal medication. Placebo-controlled data demonstrating efficacy of PCI has recently become available. Purpose We evaluated the placebo-controlled efficacy of anti-anginal agents and PCI, as monotherapies for stable angina. Methods We performed a systematic review and meta-analysis of placebo-controlled randomised controlled trials (RCTs) of anti-anginal agents (17 medications across 7 drug classes [beta-blocker, dihydropyridine (DHP) calcium channel blocker (CCB), non-DHP CCB, ivabradine, nicorandil, nitrates and ranolazine]), and PCI, which reported the placebo-controlled treatment effect on standardised exercise duration in patients with stable angina, who were receiving no background anti-anginal medications. We searched MEDLINE, EMBASE, and Cochrane CENTRAL from database inception to 01 December 2023. Relevant systematic reviews and reference lists were inspected to identify publications which had not been identified in the primary searches. Two independent reviewers extracted the data and assessed the risk of bias of included studies. Intention-to-treat data were used. Meta-analyses were carried out using random-effects methods and reported using the PRISMA guidelines. The primary outcome was mean difference in total exercise time with treatment compared with placebo. A pairwise comparison of all anti-anginal medications and PCI was performed to evaluate their relative placebo-controlled efficacy on total exercise time. Results A total of 52 trials were eligible, evaluating 83 treatment arm comparisons of anti-anginal monotherapy (2408 patients) and placebo (2444 patients). The number of trials per medication class ranged from one (ivabradine) to 19 (non-DHP CCBs). All classes improved exercise time compared to placebo, with mean increment ranging from 22.4 seconds (95% confidence interval, 0.8 to 44.0, p=0.04) for ranolazine, to 76.5 seconds (63.2 to 89.8, p&amp;lt;0.0001) for DHP CCBs (Figure 1). There was substantial heterogeneity in exercise time increment between drug classes (I2 98%, p&amp;lt;0.0001). However, across all classes, there was a clear dose-response relationship (b-coefficient 24.8, 15.8 to 33.9, &amp;lt;0.0001). The only trial which compared PCI (151 patients) to placebo (150 patients) showed a placebo-controlled exercise duration increment of 59.5 seconds (16 to 103, P=0.001). This was comparable to the global mean effect across all anti-anginal medications (59, 39 to 79, P&amp;lt;0.0001). Conclusions Each anti-anginal drug class showed a clear increase in placebo-controlled exercise time, with varying effect sizes between classes. The DHP CCB class showed the largest effect size, and ivabradine and ranolazine showed the smallest. The effect of PCI monotherapy was similar to the mean anti-anginal medication monotherapy effect.Figure 1

Environmental Sustainability Assessment of Cold Storage Panel Production

Today's ever-increasing environmental sustainability concerns have led to a major shift in construction sites and industrial sectors. In this context, the choice of construction materials for important structures such as cold storages plays an important role in terms of both environmental impacts and energy efficiency. The aim of this study is to evaluate the environmental loads of cold storage panels with thicknesses of 80 mm, 100 mm, 120 mm, 150 mm, 180 mm and 200 mm. In order to reveal the production inputs that cause these loads, the environmental effects were examined specifically for the 100 mm thick cold storage panel. Environmental impacts were analyzed using the Life Cycle Assessment (LCA) method in accordance with the ISO 14040/44 methodology as a system boundary "cradle to gate". This study focused on three different environmental impact categories of cold storage panels produced in Türkiye: global warming potential (GWP), cumulative energy demand (CED) and water footprint. In the evaluation of environmental impacts, production inventory information obtained from the panel manufacturer was used. For analyses, Simapro v. 8.5 LCA software was used. Analysis results show that the use of galvanized sheet metal in cold storage panel production is a hot spot in terms of global warming effect. It has been determined that the largest share in the water footprint belongs to polyurethane used as insulation material. Additionally, according to the CED, non-renewable fossil and non-renewable nuclear were determined to be the most affected categories, and the use of galvanized sheet metal and polyurethane were determined to be the most important hot spots in terms of non-renewable and renewable resources. To help improve the environmental performance of the cold storage panel, it is recommended to use bio-based and less environmentally impactful raw materials in production and to measure their environmental impact on a life cycle basis from cradle to grave.

The green product investment policy of carbon emission reduction on a competition duopoly and dual-channel supply chain

Considering the increasing emphasis on sustainable development, global warming effects have received attention for properly managing enterprise activities such as manufacturing, energy utilisation, resource consumption, and carbon emissions. The effect of greenhouse gases generated by carbon emissions is the most significant. This study develops a dual-channel supply chain system that consists of duopoly manufacturers and two common retailers and investigates the effects of the pricing policy, the decision-maker’s mental accounting, and carbon emission reduction investments on the channel members’ decisions. We conduct a numerical experiment, demonstrating that investments in carbon emissions reduction decrease carbon emissions while enhancing market competitiveness and profitability. This is primarily because customers prefer green products and exhibit higher brand loyalty, which makes them willing to pay premium prices for environmentally friendly products. Additionally, the leader-follower model shows the dominant role of leaders in pricing and investment decisions, while the multichannel structure highlights the importance of channel synergy. This study contributes to the field by examining intra- and inter-channel competition issues among leader-follower channel members within a multi-channel structure. This analysis facilitates practical profit-maximisation decision-making.

Integration of Personal Safety in Students Training on the Specialty “Civil Safety” at Technical Institutions of Higher Education

Security is considered a legitimate goal of every society. In recent years of the pandemic and then the war in Ukraine, the issue of the security paradigm has become particularly relevant. It prompts a revision of conceptual approaches to the formation of human personal security competencies and especially the mechanisms and ways of ensuring it in society and the state in the present conditions. Therefore, in theory, national and international security concepts are being developed, and more recently, individual, social, and global security. This indicates, among other things, a significant expansion of new dimensions of security when political independence, territorial integrity, and viability of the country, as well as the survival and development of its inhabitants, are at stake. Security in itself should have the status of a fundamental human right. Many publicly discussed security issues are related to technical solutions. Debates are underway not only about society's attitude to security, but also about what research and for what purpose it is conducting or has conducted in this direction. This also applies to the educational environment. The article defines and substantiates the principles of the formation of personal safety of students, provides an essential characteristic of the pedagogical process of formation of personal safety of students, considers the technology of formation of personal safety of students based on the competence approach, reveals the content of the competences of the individual in the sphere of life safety. The purpose of this article is to study the process of forming the personal safety of students in the system of professional education in higher technical institutions of a technical profile. The methodology on which the research is grounded is based on the methodological principles of systematicity and an interdisciplinary approach and includes the use of a complex of general scientific methods, namely explanation, comparison, classification, generalization, and systematization. Based on them, a model of forming students' competencies in the life safety field was built. Within the framework of our research, the following results were achieved: the views of scientists on the issue of the formation of security competencies among students in the new context of the construction of Ukrainian society in conditions of war were summarized; the principles of forming students' personal safety based on the competence approach are substantiated; tasks for the development of students' competencies in the field of life safety are formulated; a structural model of students' competencies and the process of their formation in the field of life safety was built. The conclusions allow us to state that the problem of security is complex and multifaceted, since conflicts, wars or unstable state structures often have not only local significance, but also global consequences due to a closely interconnected and globalized world. The formation of personal safety competencies in students as future specialists is important as a basis for self-preservation, self-development and self-improvement. For this purpose, educational professional programs of technical universities should include fundamental educational disciplines that will ensure the development of worldview principles of life safety and determine generally accepted safety needs and generally recognized safety mechanisms.

Global regulator AdpA directly binds to tunicamycin gene cluster and negatively regulates tunicamycin biosynthesis in Streptomyces clavuligerus.

Since a transcriptional regulator has yet to be identified within the tunicamycin biosynthetic gene cluster in Streptomyces clavuligerus, we conducted a comprehensive investigation by focusing on the possible function of the pleiotropic regulator AdpA on tunicamycin. The genes encoding early steps of tunicamycin biosynthesis were significantly upregulated in S. clavuligerus ΔadpA. At the same time, they were downregulated in adpA overexpressed strain as shown by RNA-sequencing (RNA-seq) and reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) analysis. The tunicamycin gene cluster's co-transcription pattern was understood by reverse transcriptase polymerase chain reaction (RT-PCR). Our Electrophoretic Mobility Shift Assay (EMSA) data clearly showed AdpA's binding to the upstream sequence of the tunA gene, asserting its regulatory control. In addition to its direct negative regulation of tunicamycin biosynthesis, AdpA operates at a global level by orchestrating various regulatory genes in S. clavuligerus, such as wblA, whiB, bldM, arpA, brp, and adsA involved in morphological differentiation and secondary metabolite biosynthesis as depicted in RNA-seq data. This study represents a significant milestone by unveiling the AdpA regulator's pathway-specific and global regulatory effect in S. clavuligerus.

Effect of a giant meteorite impact on Paleoarchean surface environments and life

Large meteorite impacts must have strongly affected the habitability of the early Earth. Rocks of the Archean Eon record at least 16 major impact events, involving bolides larger than 10 km in diameter. These impacts probably had severe, albeit temporary, consequences for surface environments. However, their effect on early life is not well understood. Here, we analyze the sedimentology, petrography, and carbon isotope geochemistry of sedimentary rocks across the S2 impact event (37 to 58 km carbonaceous chondrite) forming part of the 3.26 Ga Fig Tree Group, South Africa, to evaluate its environmental effects and biological consequences. The impact initiated 1) a giant tsunami that mixed Fe2+-rich deep waters into the Fe2+-poor shallow waters and washed debris into coastal areas, 2) heating that caused partial evaporation of surface ocean waters and likely a short-term increase in weathering and erosion on land, and 3) injection of P from vaporization of the S2 bolide. Strata immediately above the S2 impact event contain abundant siderites, which are associated with organic matter and exhibit light and variable δ13Ccarb values. This is consistent with microbial iron cycling in the wake of the impact event. Thus, the S2 impact likely had regional, if not global, positive and negative effects on life. The tsunami, atmospheric heating, and darkness would likely have decimated phototrophic microbes in the shallow water column. However, the biosphere likely recovered rapidly, and, in the medium term, the increase in nutrients and iron likely facilitated microbial blooms, especially of iron-cycling microbes.

The Impact of Globalization on World Nations: A Study on Protection, Welfare, and Producer Gain

This paper examines the effects of globalization on nations, focusing on economic, social, and cultural dimensions. It analyzes the roles of protectionism and globalization in shaping consumer welfare and producer earnings through qualitative methods and the Customs Union theory framework. The study discusses the benefits and drawbacks of globalization in the context of World Trade Organization (WTO) regulations. The findings indicate that globalization has intensified financial flows between countries, which can exacerbate economic crises. Countries with abundant human resources can capitalize on the international division of labor to specialize in high-value sectors, while those with limited resources risk falling behind in the digital landscape. This division of labor fosters specialization and improves production efficiency through targeted education. However, multinational corporations often impede cost-effective production in developing nations, underscoring the necessity to restructure research and development to facilitate technology adoption in underdeveloped areas. This restructuring can help close the technological gap and encourage equitable participation in the global economy. Jel code Classification: D6: Welfare economics, Fo1 Global outlook, F40: General F4: Macroeconomics aspects of international trade and finance

The impact of climate change anxiety on premenstrual syndrome: A cross-sectional study.

Climate change is thought to have possible effects on changes in the menstruation process, which covers an important period of time in women's lives. Our study aimed to determine the impact of climate change anxiety on premenstrual syndrome (PMS) in women of reproductive age. This is a cross-sectional study. The research was conducted online using various digital platforms between December 2023 and February 2024. This study was conducted on 456 women of reproductive age. The Personal Information Form, PMS Scale and Eco-Anxiety Scale were used for the data collection. The level of statistical significance was set at p < 0.05. The prevalence of PMS was 44.7%. The average score for the Eco-Anxiety Scale was 27.28 ± 6.44. A significant majority of participants (81.4%) stated that climate change would affect women's health, and 81.1% thought that they were affected by climate change. The Eco-Anxiety Scale scores were higher in women with PMS (p < 0.05). The results of the binary logistic regression analysis showed that being affected by climate change (odds ratio [OR] = 2.109, 95% confidence interval [CI] = 1.045-4.259, p = 0.035), age at menarche (OR = 1.249, 95% Cl = 1.073-1.453, p = 0.004) and Eco-Anxiety Scale scores were significant predictors of PMS (OR = 0.828, 95% Cl = 0.791-0.867, p < 0.001). The results of our study showed that women with PMS had higher Eco-Anxiety Scale scores. Given the global effects of climate change, it is important to investigate its effects as a risk factor for the emergence of PMS. Furthermore, women's healthcare providers play an important and beneficial role in adapting to a changing climate; these efforts will have long-term impacts.