Effects Of Different Delivery Methods Research Articles

Effects of Different Delivery Methods on The Functional Status of The Postpartum Pelvic Floor and Guidance on Pelvic Floor Rehabilitation Training

Objective: This study is to investigate the effects of normal and cesarean delivery on the pelvic floor function of pregnant women in the early postpartum period. Methods: 277 pregnant women who delivered in our hospital were divided into two groups: normal delivery and cesarean delivery, and pelvic floor muscle function testing was performed at 42 d after delivery to compare the functional status of the pelvic floor in the two groups. Results: The overall score of the cesarean delivery group was higher than that of the normal delivery group; among the indicators, the incidence of abnormal pelvic floor muscles in the pre and post resting stages was higher in the cesarean delivery group than in the normal delivery group, and the incidence of abnormalities in the fast and slow muscle stages and the endurance test stage was lower than that in the normal delivery group, and the differences were statistically significant (p<0.05). Conclusion: Although cesarean delivery could reduce the incidence of early pelvic floor muscle abnormalities, postoperative pelvic floor muscle function and life would still be affected to a certain extent, and early instruction of pelvic floor rehabilitation training for pregnant women was beneficial to the recovery of pelvic floor function.

Short-term effects of delivery methods on postpartum pelvic floor function in primiparas: a retrospective study.

The present study sought to investigate the short-term effects of different delivery methods on postpartum pelvic floor function in Chinese primiparas. Primiparous women who delivered a full-term, cephalic, singleton infant at our hospital between January 1, 2018 and August 15, 2019 were recruited into this study. All women underwent pelvic floor function screening at 6-8 weeks postpartum. Tests included postpartum Pelvic Organ Prolapse Quantification (POP-Q) score, incidence of urinary incontinence, pelvic floor muscle (PFM) strength, and Pelvic Floor Distress Inventory Questionnaire-Short Form 20 (PFDI-20) score. A total of 284 postpartum women were recruited into the study. Of the participants, 147 had undergone vaginal delivery, 37 had undergone intrapartum cesarean delivery (ICD), and 100 had undergone elective cesarean delivery (ECD). Points Aa, Ba, Ap, and Bp showed a greater degree of prolapse in the vaginal delivery group than in the ECD group (P≤0.05). UI was less prevalent in ECD group relative to the vaginal delivery group (P≤0.05). Tonic PFM contraction was weaker in the vaginal delivery group than in the ECD and ICD groups (P≤0.05). Significant differences were also observed between the vaginal delivery group and the ECD group with respect to PFDI-20 scores (P≤0.05). Compared with vaginal delivery, ECD was strongly linked to a lower risk of pelvic organ prolapse (POP) and UI, stronger tonic PFM strength, and lower PFDI-20 scores. ECD confers relatively better protection against pelvic floor dysfunction (PFD) than does ICD.

Differential effects of different delivery methods on progression to severe postpartum hemorrhage between Chinese nulliparous and multiparous women: a retrospective cohort study

BackgroundDelivery methods are associated with postpartum hemorrhage (PPH) both in nulliparous and multiparous women. However, few studies have examined the difference in this association between nulliparous and multiparous women. This study aimed to explore the difference of maternal and neonatal characteristics and delivery methods between Chinese nulliparous and multiparous women, and then examine the differential effects of different delivery methods on PPH between these two-type women.MethodsTotally 151,333 medical records of women who gave birth between April 2013 to May 2016 were obtained from the electronic health records (EHR) in a northern province, China. The severity of PPH was estimated and classified into blood loss at the level of < 900 ml, 900–1500 ml, 1500–2100 ml, and > 2100 ml. Neonatal and maternal characteristics related to PPH were derived from the same database. Multiple ordinal logistic regression was used to estimate associations.ResultsMedical comorbidities, placenta previa and accreta were higher in the nulliparous group and the episiotomy rate was higher in the multiparous group. Compared with spontaneous vaginal delivery (SVD), the adjusted odds (aOR) for progression to severe PPH due to the forceps-assisted delivery was much higher in multiparous women (aOR: 9.32; 95% CI: 3.66–23.71) than in nulliparous women (aOR: 1.70; 95% CI: 0.91–3.18). The (aOR) for progression to severe PPH due to cesarean section (CS) compared to SVD was twice as high in the multiparous women (aOR: 4.32; 95% CI: 3.03–6.14) as in the nulliparous women (aOR: 2.04; 95% CI: 1.40–2.97). However, the (aOR) for progression to severe PPH due to episiotomy compared to SVD between multiparous (aOR: 1.24; 95% CI: 0.96–1.62) and nulliparous women (aOR: 1.55; 95% CI: 0.92–2.60) was not significantly different. The (aOR) for progression to severe PPH due to vacuum-assisted delivery compared to SVD in multiparous women (aOR: 2.41; 95% CI: 0.36–16.29) was not significantly different from the nulliparous women (aOR: 1.05; 95% CI: 0.40–2.73).ConclusionsForceps-assisted delivery and CS methods were found to increase the risk of severity of the PPH. The adverse effects were even greater for multiparous women. Episiotomy and the vacuum-assisted delivery, and SVD were similar to the risk of progression to severe PPH in either nulliparous or multiparous women. Our findings have implications for the obstetric decision on the choice of delivery methods, maternal and neonatal health care, and obstetric quality control.

Bifidobacterium-mediated high-intensity focused ultrasound for solid tumor therapy: comparison of two nanoparticle delivery methods

Purpose This study was conducted to prepare a novel tumor-biotargeting high-intensity focused ultrasound (HIFU) synergist for indirectly delivering lipid nanoparticles based on the targeting ability of Bifidobacterium longum to the hypoxic region of solid tumors. The effects of two different delivery methods on the imaging and treatment of solid tumors enhanced by lipid nanoparticles were compared. Methods Biotinylated lipid nanoparticles coated with PFH were prepared, cross-linked with B. longum in vitro using a streptavidin-conjugated B. longum antibody (SBA), and observed and detected by laser confocal microscopy and flow cytometry. Solid tumors were treated with HIFU and PFH/BL-NPs. The effects of different delivery methods on the tumor targeting and efficiency of retention of PFH/BL-NPs were observed using Small animal live imaging and frozen sections from small animals. Results The PFH/BL-NPs prepared in this study showed good biocompatibility and safety. PFH/BL-NPs and B. longum were cross-linked in a cluster-like manner (confocal laser scanning microscope) in vitro, with a cross-linking rate of 84 ± 6.23% (flow cytometry). The delivery of B. longum followed by that of PFH/BL-NPs not only enhanced the ability of PFH/BL-NPs to target solid tumors (small animal live imaging), but also increased the retention time of PFH/BL-NPs in the tumor (frozen slices), enhancing the effect of the HIFU synergist. Conclusion Delivery of B. longum followed by that of PFH/BL-NPs can enhance the imaging of solid tumors and effectively improve the efficiency of HIFU treatment of solid tumors, providing a basis for further clinical work.

The Effects of Different Delivery Methods on the Movement Kinematics of Elite Cricket Batsmen in Repeated Front Foot Drives

The aim of this paper was to examine differences in delivery characteristics and the resulting response exhibited by ten elite cricket batsmen when hitting repeated front foot drives against three different ball delivery methods; a bowling machine, a Sidearm™ ball thrower and a bowler. Synchronous three-dimensional Vicon motion capture technology and high-speed video were used to track batsman, bat and ball motion, and a range of discrete timing and kinematic variables were extracted from the resulting biomechanical model. Results showed significant differences in speed and ball release-to-impact time between the three delivery methods, thus questioning the validity of the bowling machine and Sidearm™ in the way they are currently used as true representations of batting against a real life bowler. Findings from the timing and kinematics of the subjects’ movements suggest a different technical response is also exhibited when facing the different delivery methods; for example batters were found to initiate movement earlier and have a lower maximum bat speed against the bowling machine, but initiate and complete their front foot stride earlier as well as moving their COM further forward in the Sidearm™ trials.

A probiotic lozenge administered medical device and its effect on salivary mutans streptococci and lactobacilli

Previous studies have suggested that lactobacilli-derived probiotics in dairy products may affect oral ecology, but the effects of different delivery methods have received little attention. The aim of the present study was to investigate the effect of the probiotic Lactobacillus reuteri, delivered by a new medical device, on the levels of salivary mutans streptococci and lactobacilli in young women with high Streptococcus mutans counts. This is a randomized, double-blind, placebo-controlled study involving 20 healthy young women (aged 20 years): 10 as subjects and 10 as controls. The study subjects (Group A) sucked the medical device containing the probiotic lozenge with L. reuteri ATCC 55730/L. reuteri ATCC PTA 5289 (1.1 x 10(8) CFU) once daily for 10 days, while the control subjects (Group B) received placebo medical devices without bacteria. Salivary mutans streptococci and lactobacilli were enumerated with chair-side kits at baseline and 1 day after the final ingestion. Salivary S. mutans levels in the probiotic test group were significantly reduced, with statistical significance of reduction (P < 0.05). A short-term daily ingestion of lactobacilli-derived probiotics delivered via medical device containing probiotic lozenge reduced the levels of salivary mutans.