The most extensively farmed mushroom in the world is Agaricus bisporus (Lange) Imbach. WBD, which is predominantly instigated by Mycogone perniciosa, might pose a severe danger to A. bisporus output over the world. Because of the similarity between A. bisporus and M. perniciosa, it was predicted that the current study would choose reliable antimycotic agents that could favorably treat this fungal disease on mushrooms. The antimycotic susceptibility of host and pathogen was investigated in vitro using six different fungicides. The effects of chlorothalonil, carbendazim, thiophanate-methyl, azoxystrobin, difenoconazole, and kresoximmethyl on M. perniciosa, the mycoparasite that origins white button mushroom wet bubble disease, were evaluated in vitro and in vivo. Chlorothalonil and carbendazim were the potent antimycotic agents for reducing M. perniciosa mycelial growth in vitro, with inhibitions of 96.93 percent and 94.15 percent, respectively. Chlorothalonil inhibited the pathogen’s mycelial growth at 25-500 ppm, whereas carbendazim did so at 5 to 100 ppm, with least (16.67 percent) inhibition of A. bisporus mycelium. Difenoconazole, kresoximmethyl and azoxystrobin among other fungicides, were shown to be very repressive to the pathogen (91.81 percent, 83.26 percent and 71.05 percent) with the largest percentage of inhibition (87.77 percent, 84.44 percent and 75.55 percent) of A. bisporus mycelium. Chlorothalonil and carbendazim and thiophanatemethyl continued to handle WBD in field experiments with a smaller impact on mushrooms than other fungicides.