Effect Of Chlorhexidine Gel Research Articles

The effects of chlorhexidine gel and tranexamic acid application after tooth extraction on the risk of alveolar osteitis formation: a double blind clinical study.

Alveolar osteitis(AO), one of the most common complications occurring in 1-10% of cases following tooth extraction, occurs due to the disruption of clot formation in the extraction socket. This study aims to evaluate the effect of using absorbable gelatin sponge, chlorhexidine gel, and tranexamic acid agents on the development of AO following extraction. Between March and October 2023, the teeth of 98 healthy patients (average age: 38, range: 19-62) with extraction indications were extracted at Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery. 113 extraction sockets(85 molars and 28 premolars) were randomly treated with absorbable gelatin sponge(AGS), chlorhexidine gel with AGS, and tranexamic acid with AGS. Pain and edema levels were recorded using visual analog scale(VAS) ranging from 0 to 10 by the patients. Additionally, presence of halitosis, trismus and exposed bone was noted on forms on 3rd and 7th days (recorded as present or absent). The study prospectively aimed to prevent AO using 3 different dental agents in the extraction sockets. Statistical analyses of the study were conducted using the SPSS software package. Alveolitis was observed in 12 out of 113 tooth extractions(%10.6). Pain and edema scores significantly decreased in absorbable gelatin sponge group on the 7th day (p < 0.05). Pain score on the 7th day in chlorhexidine group and age, edema score on the 7th day in tranexamic acid group, were found to be significantly higher (p < 0.05). Incidence of AO, can be reduced by placing agents in the extraction socket, preventing post-extraction pain experienced by patients. NCT06435832.

Effect of chlorhexidine gel on the prevention of alveolar osteitis and post‐operative pain following transalveolar extraction of impacted mandibular third molars: A randomized study

AbstractObjectiveThis study aimed to compare the efficacy of 0.2% chlorhexidine gel with warm saline mouth rinse (WSMR) in the prevention of alveolar osteitis (AO) following transalveolar impacted mandibular third molar (IMTM) extraction after accounting for surgical operative confounding factors.Materials and MethodsWe conducted a parallel design randomized study. Participants were consenting adults randomly assigned to 0.9% WSMR and 0.2% chlorhexidine gel (administered twice daily post‐operatively) groups. All participants were followed up daily post‐operatively for one week. The primary outcome was an incidence of AO, assessed using Blum's criteria. Fischer's exact tests and regression models were used to investigate the effect of interventions on AO.ResultsOne hundred participants were enrolled in the study, with 50 participants in each group. A higher incidence of AO was observed in the WSMR group than the chlorhexidine group (16% vs. 2%, p = 0.01). However, after adjusting for duration of extraction (aOR: 0.18; 95% CI: 0.02, 1.71) and bone operating time (aOR: 0.16; 95% CI: 0.02, 1.47), the difference was not statistically significant.ConclusionsIn conclusion, the study demonstrates that the application of the 0.2% chlorhexidine gel was not significantly more effective in preventing AO compared with the use of WSMR following transalveolar IMTM extraction after controlling for operative factors.

Effect of Chlorhexidine Gel in Mentally Handicapped Children highly Infected with Streptococcus Mutans

Objective: To evaluate the effect of 1% chlorhexidine (CHX) gel on mentally handicapped children (n=11) highly infected with Streptococcus mutans (SM) and evaluate the re-colonization time of this bacterium after the treatment period.. Material and Methods: Before CHX treatment, saliva samples were collected to establish baseline saliva SM levels. CHX gel was daily applied for 5 min, for 7 consecutive days. Saliva samples were then collected after 7, 30, 60, 90 and 120 days to evaluate SM oral re-colonization. Data were analyzed by the Wilcoxon test (α=0.05). Results: When compared to baseline (5.7 / 3.0 x 105), the collection performed 7 days after CHX treatment (0.06 / 0.2 x 105) showed a significant reduction (P 0.05). Conclusion: Treatment with CHX gel for 7 days was effective in reducing the SM levels of mentally handicapped children and should be repeated after 60 days to control the risk of caries in these children.

Effect of chlorhexidine gel containing saccharin or aspartame in deaf children highly infected with mutans streptococci

Aim: Since deaf children are unable to comprehend or cooperate with dental treatment due to lack of communication, preventive measures may be an important way to control the high prevalence of dental caries in these patients. The aim of the this study was to evaluate the effect of an intensive treatment with chlorhexidine (CHX) gel, containing either saccharin or aspartame, in deaf children highly infected with mutans streptococci (MS). Methods: Eighteen children were randomly divided into two groups, according to the sweetener used to improve the CHX gel bitter taste: saccharin or aspartame. Before CHX treatment, saliva samples were collected to establish baseline microbial data for MS. CHX gel was applied on two consecutive days, four times the first day and three times the second day. Saliva samples were then taken after 7, 30, 60, 90 and 120 days to evaluate MS oral recolonization. Results: CHX gel containing saccharin was not effective on the reduction of MS levels, while the gel containing aspartame decreased significantly MS levels after treatment (P<.05). Conclusions: Although a new CHX application may be necessary after 60 days to control caries risk and MS levels, CHX treatment should be individually controlled because of variations in the response of subjects.

Antimicrobial Efficacy of Four Calcium Hydroxide Formulations and Chlorhexidine Gel using Agar Diffusion Model

Aim: We sought to assess, in vitro, the antimicrobial efficacy of four Calcium hydroxide formulations and chlorhexidine (CHX) gel against E.faecalis.Materials and Methods: The effect of CHX gel and Calcium hydroxide in combination with various vehicles was evaluated by using the agar diffusion test, to measure the zone of inhibition. Plates of BHO agar were inoculated with E.Faecalis. Each plate had six wells saturated with the medicaments and the center well without the medicament served as the control. The samples were incubated at 37 C for 24 hrs in an incubator. The largest diameter of the zones of microbial inhibition was measured and recorded. Statistical analysis was performed using One-way ANOVA followed by multiple Tukey HSD method.Results: In the agar diffusion test, 1% chlorhexidine Gluconate gel showed better antibacterial efficacy (p<.05) against E. faecalis. Vitapex paste with 30% Ca(OH)2 showed least inhibition of E. faecalis Conclusion: CHX is effective against E.faecalis in vitro. Further in vivo studies are needed to confirm the value of CHX in clinical treatment.

Effects of Chlorhexidine Gel in a Group of Maintenance Care Patients with Poor Oral Hygiene

An intraindividual double-blind crossover study was designed in order to see if a 1% chlorhexidine gel used twice a day could substitute for ordinary toothpaste in group of maintenance-care patients with poor oral hygiene. Twenty patients from a student clinic participated, each with a long history of maintenance-care problems. A 4-week test period with chlorhexidine gel or placebo gel was followed by an intermediate period with ordinary toothpaste, and then by another 4-week test period. Plaque-covered surfaces (%), bleeding sites (%) and extraneous staining (color slides) were recorded at each sitting. The results demonstrated that brushing with chlorhexidine gel significantly influenced both the oral hygiene level and the gingival inflammation. The only adverse effect observed was a marked increase in the amount of brown staining, especially on the facial surfaces of the nonsmokers. In this short-term study, the staining was not considered cosmetically unacceptable by the patients. The total amount of staining was always greater in smokers than in nonsmokers.

The effect of chlorhexidine gel on plaque and gingivitis in children

The effect of chlorhexidine gel on plaque and gingivitis in children