Effect Of Chinese Herbal Formula Research Articles

Retracted: Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients.

[This retracts the article DOI: 10.1155/2022/5900024.].

Effects of Chinese Herbal Formula on Immune Function and Nutritional Status of Breast Cancer Patients.

Background Chinese herbal formulas have certain effects on patients with breast cancer (BC). This article discussed the effect of Buqi Yangxue decoction on the immune function and nutritional status of BC patients and provided an evidence for traditional Chinese medicine (TCM) to improve the quality of life and curative effect of BC patients. Methods 66 cases of BC patients were divided into control group (n =33) and Chinese herbal formula group (n =33). The control group was received with TE chemotherapy, and the Chinese herbal formula group was received with Buqi Yangxue decoction combined with TE chemotherapy. Nutritional status, immune function, TCM symptom quantitative score, and adverse reactions were compared between the two groups. Results There was no difference in all indexes between the two groups before intervention. After 4 weeks, the nutritional indexes ALB, PA, TRF, and TP in Chinese herbal formula group were higher than those in control group, except HGb. CD3+, CD4+, and CD4+/CD8+ in both groups were sharply higher than before treatment, while CD8+ was dramatically lower, and the changes in Chinese herbal formula group were more obvious than those in control group. In Chinese herbal formula group, the levels of IgG, IgA, and IgM were sharply increased compared with control group. The TCM syndrome scores in both groups were decreased significantly after treatment, especially in Chinese herbal formula group. In addition, nausea and vomiting, inappetence, liver function impairment, leukopenia, and thrombocytopenia occurred in both groups. There was no clear difference in the incidence of adverse reactions between Chinese herbal formula group and control group. Conclusion Buqi Yangxue decoction can effectively improve the nutritional status and immune function of BC patients, which has important clinical significance for the later comprehensive treatment.

Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions.

Atopic dermatitis (AD), also known as atopic eczema, is a chronic pruritic inflammatory skin disease. The available systemic therapies for atopic dermatitis are inadequate. Objective. This study aimed to evaluate the effects of the Chinese herbal formula Pei Tu Qing Xin (PTQX) on dermatitis severity and ear swelling, immunomodulation, and the infiltration of mast cells in a mouse model of 1-chloro-2,4-dinitrobenzene- (DNCB-) induced AD. Methods. AD-like symptoms were induced by DNCB in NC/Nga mice. Skin lesions, dermatitis, ear swelling, and scratching behaviour were evaluated. Changes in the T-helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) subtypes and immunoregulation in the spleen and lymph nodes were detected by flow cytometry. Results. Histopathological and immunohistochemical analyses demonstrated that PTQX decreased the DNCB-mediated induction of mast cells and infiltration of inflammatory cells in the ear and dorsal skin. PTQX also reduced the DNCB-induced increase in the serum immunoglobulin E level, pruritus, and dermatitis (red, flaky areas) on the dorsal skin. Furthermore, PTQX regulated the balance between the populations of Th1, Th2, Th17, and Treg cells (particularly the latter two) in the lymph nodes. Conclusions. Our results suggest that the Chinese herbal formula PTQX can alleviate symptoms of AD, such as epithelial damage, redness, swelling, and pruritus, and potentially be used to treat this condition.

Serum proteomics analysis based on label-free revealed the protective effect of Chinese herbal formula Gu-Ben-Fang-Xiao

Gubenfangxiao decoction (GBFXD) is a traditional Chinese medicine formula derived from Yupingfengsan, an ancient formula widely used to treat respiratory diseases. In recent years, GBFXD has been applied to efficaciously and safely treat asthma. However, the mechanism of GBFXD is still not fully elucidated. The aim of this study was to employ the label-free proteomic method to explore the protective mechanism of GBFXD in respiratory syncytial virus (RSV)-ovalbumin (OVA) induced chronic persistent asthmatic mice. After RSV-OVA challenge, mice were orally administered GBFXD at a dose of 36 g/kg accompanied with OVA nasal spray once every 3 days for 28 days. The label-free proteomics-based liquid chromatography-tandem mass spectrometry method was used to explore the differentially abundant proteins (DAPs) in the serum from model mice compared with that in control mice (M:C), and in GBFXD-treated mice compared with that in model mice (G:M). The mass spectrometry proteomics data have been deposited to the ProteomeXchange with identifier PXD013244. A total of 69 significant DAPs were identified including 39 in M:C, 46 in G:M, and 16 common differential proteins. Bioinformatics analysis revealed that the DAPs of M:C were mainly involved in inflammatory response and were related to lipid metabolism. However, the DAPs of G:M mostly participated in stress response, inflammatory response, and epithelial cell proliferation. Serum levels of Apoa-1, Apoc-1, Cfd, and Lrg1, EGFR and Lrg1 in the lungs were consistent with the results of proteomic analysis. Apoa-1 and Apoc-1 were closely related to cholesterol transport, lipid metabolism balance, and airway epithelial integrity; Cfd participated in immune response, affecting the occurrence and development of inflammation; EGFR and Lrg1 were involved in epithelial cell proliferation, influencing the process of airway remodeling.In summary, these results indicated that GBFXD may affect inflammatory and immune response of asthma by regulating cholesterol transport and complement factor activation. Furthermore, it could repair damaged airway epithelium and avoid airway remodeling to prevent and treat asthma.

The effect of Chinese herbal formula as adjuvant treatment for patients with ACS: study protocol for a prospective cohort study

The effect of Chinese herbal formula as adjuvant treatment for patients with ACS: study protocol for a prospective cohort study

Changes of brain activity during a functional magnetic resonance imaging stroop task study: Effect of Chinese herbal formula in Alzheimer’s disease

IntroductionThe functional magnetic resonance imaging (fMRI) Stroop task could be used to study brain activity changes during treatment for Alzheimer’s disease(AD). The aim was to observe the brain functional activity changes during the treatment for AD patients with Yishen Huazhuo Decoction (YHD) using an fMRI Stroop task. MethodsThirty-five mild AD patients were randomized into either a treatment group or a control group in order to observe the brain activity before and after the treatment. ResultsBefore the treatment, the activated regions were bilateral cerebellar hemispheres and bilateral frontal occipital lobe. After the treatment, the activated regions of bilateral cerebellar hemispheres and bilateral frontal occipital lobes decreased for patients in control group, but the activated regions were larger than that in treatment group, and there appeared deactivated regions in the bilateral prefrontal lobes, left orbitofrontal gyrus and right inferior parietal lobule; the activated state of bilateral anterior cingulate gyri, bilateral superior, middle, and medial frontal gyri, left middle-superior frontal gyrus, right middle-superior frontal gyrus, and bilateral posterior cingulate gyri significantly decreased after treatment compared with before treatment in control group.Regions of higher brain functional activity changes in YHD treatment group were observed in the control group were; left anterior central gyrus, left middle-inferior frontal gyrus, bilateral medial frontal gyri, left anterior cingulate gyrus, bilateral superior frontal gyri, left middle frontal gyrus, left superior-middle frontal gyrus. ConclusionsWe used an fMRI Stroop task to investigate the brain functional activity changes during the treatment of AD patients by YHD, and we found that YHD could improve brain activity of AD patients.

Bone protection effects of a novel Chinese herbal formula, taikong yangxin prescription, in hindlimb unloaded rats against bone deterioration.

To investigate the protective effects of a Chinese herbal formula, taikong yangxin prescription (TKYXP) against bone deterioration in a hindlimb unloaded (tail-suspension) rat model. Thirty-two male Sprague-Dawley rats were divided into 4 groups: tail-suspension group fed with 2.5 g•kg(-1)•day(-1) of TKYXP extract (high dose), tail-suspension group fed with 1.25 g•kg(-1)•day(-1) (low dose), tail-suspended group treated with water placebo (placebo control group) and non tail-suspended group. The effects of TKYXP on bone were assessed using peripheral quantitative computed tomography (pQCT), microcomputerized tomography (micro-CT) and three-point bending biomechanical test on the femur in vivo. TKYXP had a significant protective effect against bone loss induced by tail-suspension on day 28, as shown in the reduction in bone mineral density (BMD) loss, preservation of bone micro-architecture and biomechanical strength. The administration ofhigh dose TKYXP could significantly reduce the total BMD loss by 4.8% and 8.0% at the femur and tibia regions, respectively, compared with the placebo control group (P<0.01) on day 28. Its bone protective effect on the femur was further substantiated by the increases of the trabecular BMD (by 6.6%), bone volume fraction (by 20.9%), trabecular number (by 9.5%) and thickness (by 11.9%) as compared with the placebo control group. TKYXP may protect the bone under weightless influence from gradual structural deterioration in the tail-suspension model.

Analgesic effect of Chinese herbal formula Hua-Jian-Ba-Du ointment on visceral pain in mice induced by acetic acid.

Visceral pain is one of the most important pains caused by cancer or other diseases, and most of the medications may lead to tolerance, addiction, and toxic side effects. Hua-Jian-Ba-Du Ointment (HJBDO), which is a commonly used conjugate based on traditional Chinese medicine theory, has been effective against visceral pain. Here, we verify the efficacy and underlying mechanism of HJBDO in an acetic-acid induced visceral pain model. Mice were subjected to acetic acid with or without HJBDO. Hua-Jian-Ba-Du Ointment at low (7.5 mL/kg•d), moderate (15 mL/kg•d), and high (30 mL/kg•d) dosages was applied on the abdomen, 3 times per day for 3 days. The acetic acid writhing test was used to evaluate antinociception. Interleukin-2 (IL-2) in serum, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) in peritoneal fluid were detected by ELISA. 5-hydroxytryptamine (5-HT), norepinephrine (NE), dopamine (DA), and β-endorphin (β-EP) were examined by high performance liquid chromatography and radioimmunoassay, respectively. N-methyl-D-aspartic acid receptor (NMDAR1) and c-fos expressions in both rostral ventromedial medulla (RVM) and spinal dorsal horn were determined by western blot. Hua-Jian-Ba-Du Ointment at 3 dosage levels produced dose-dependent antinociception and shortened the latent time. Hua-Jian-Ba-Du Ointment at high or moderate dosage inhibited the release of TNF-α, IL-6, and PGE2, as well as increased the release of IL-2. Hua-Jian-Ba-Du Ointment could also increase NE and 5-HT contents and decrease the NE content. No effect of HJBDO at 3 dosages on the DA system was detected. Furthermore, HJBDO could suppress the expressions of NMDAR and c-fos in both RVM and spinal dorsal horn. Our results exhibited the analgesic effect of HJBDO on visceral pain in mice, and this effect might be mediated by the regulation of inflammation and neurotransmitters.

Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate

Background/Aims: Hyperuricemia is an independent risk factor for chronic kidney disease and cardiovascular disease. Here, we examined the combined protective effects of Chinese herbal formula Si-Wu-Tang and Er-Miao-San on hyperuricemia and renal impairment in rats. Methods: Rats were randomly divided into normal rats, hyperuricemic rats, and hyperuricemic rats orally administrated with benzbromarone (4.5 mg·kg^-1·d^-1), Si-Wu-Tang (3.78 g·kg^-1·d^-1) and Si-Wu-Tang plus Er-Miao-San (6.48 g·kg^-1·d^-1) for 4 weeks. Hyperuricemic rats were orally gavaged with adenine (0.1 g·kg^-1·d^-1) and potassium oxonate (1.5 g·kg^-1·d^-1) daily for 4 weeks. Serum uric acid, creatinine, total cholesterol (TCH), triglyceride and blood urea nitrogen (BUN) concentrations, as well as urinary uric acid and microalbuminuria were measured weekly. Serum xanthine oxidase (XOD) activity and renal histopathology were also evaluated. The renal expression of organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) was detected by western blot. Results: Si-Wu-Tang plus Er-Miao-San lowered serum uric acid, creatinine, triglyceride and BUN levels to a greater degree than did Si-Wu-Tang alone. Si-Wu-Tang plus Er-Miao-San ameliorated microalbuminuria and renal histopathology, as well as decreased serum TCH concentration and XOD activity in hyperuricemic rats. Combination of Si-Wu-Tang and Er-Miao-San also led to a greater increase in OAT1 and OAT3 expression than did Siwutang alone. Conclusion: Si-Wu-Tang and Er-Miao-San synergistically ameliorated hyperuricemia and renal impairment in rats through upregulation of OAT1 and OAT3.

Effects of Chinese herbal formula “Kangshu I” on the blood heat shock protein (HSP70) and levels of some hormones in heat-stressed cows

In order to investigate the effects of the Chinese herbal formula “Kangshu = 1 \* ROMAN I” on the mechanism in dairy cows, 10 Holstein dairy cows which had similar weight, age, parity, milk yield were selected, and the experiments were conducted in three stages: the room temperature stage (negative control group), heat stress stage (positive control group) and heat stress stage with drug treatment (drug treatment group). The results indicated that the dairy cows sera heat shock protein (HSP70) concentration in the positive control group increased significantly than those in the negative control group (P 0.05). After usage of Chinese herbal formula “Kangshu I”, HSP70 levels in drug treatment group increased non-significantly than those in the positive control group (P>0.05). The plasma ALD concentrations, sera COR and T4 concentrations were significantly higher than those in the positive control group (P 0.05). Key words: Dairy cow, heat stress, Chinese herbal formula, heat shock protein (HSP70), hormone.

Effects of Chinese herbal formula Maxing Shigan powder on IgA secreting cells in chicken bronchus

In this paper the effects of a Chinese formula Maxing Shigan powder were investigated on IgA-secreting cells of chicken bronchus. The herbal powder was dissolved in water at three dosages, 0.5, 1 and 1.5 g/L. Each dosage was given to 15-day-old chickens which were challenged with infectious bronchitis virus (IBV) by artificial infection for 3 days. Then thetherapeutic effects were detected. The chickens were sacrificed at 18, 21, 24, 27 and 30 days old. The changes of IgA-secreting cells per unit area of bronchus were measured by immunohistochemistry. The IBV antibody titers in serum were determined by ELISA. The results of the therapeutic effects showed that Maxing Shigan powder can significantly reduce the mortality and enhance the recovery rate. Positive expression rate of bronchial IgA-secreting cells and higher IBV antibody titers were observed in the herbal treated groups. The results suggest that Maxing Shigan powder can protect the mucosa of IBV chickens, promote IgA secreting cells recruitment in the mucosa and secretion of the IBV antibody so as to lower the mortality and elevate the recovery rate of the IBV infected chickens. Key words: Maxing Shigan powder, infectious bronchitis virus, IgA secreting cells, antibody.In this paper the effects of a Chinese formula Maxing Shigan powder were investigated on IgA-secreting cells of chicken bronchus. The herbal powder was dissolved in water at three dosages, 0.5, 1 and 1.5 g/L. Each dosage was given to 15-day-old chickens which were challenged with infectious bronchitis virus (IBV) by artificial infection for 3 days. Then thetherapeutic effects were detected. The chickens were sacrificed at 18, 21, 24, 27 and 30 days old. The changes of IgA-secreting cells per unit area of bronchus were measured by immunohistochemistry. The IBV antibody titers in serum were determined by ELISA. The results of the therapeutic effects showed that Maxing Shigan powder can significantly reduce the mortality and enhance the recovery rate. Positive expression rate of bronchial IgA-secreting cells and higher IBV antibody titers were observed in the herbal treated groups. The results suggest that Maxing Shigan powder can protect the mucosa of IBV chickens, promote IgA secreting cells recruitment in the mucosa and secretion of the IBV antibody so as to lower the mortality and elevate the recovery rate of the IBV infected chickens. Key words: Maxing Shigan powder, infectious bronchitis virus, IgA secreting cells, antibody.

Control effect of Chinese herbal formula on grass carp hepatobiliary syndrome

Taking grass carp(Ctenopharyngodon idellus)fingerling with hepatobiliary syndrome as sample and Chinese herbal formula as test drug,we designed 3 poison bait groups mixed with 0.50%,0.75% and 1.00% concentration of Chinese herbal formula,one common feed group without Chinese herbal formula and one green feed group to feed the sick fish for 4 weeks,so as to study the control effect of Chinese herbal formula on grass carp hepatobiliary syndrome by histopathology method.The result shows that the liver-lesion tissue of the test fish has many self-soluble necroses and is destroyed dispersively;the liver nuclei moves,accompanying with vacuolar and hydropic degenerations;the survival of the 3 experimental groups and 2 control ones(green feed group and common feed group without Chinese herbal formula) is 60.0%,80.0%,96.7%,36.7% and 16.7%,respectively;the hepatobiliary syndrome of the test fish has obviously ameliorated in experimental groups than in the control;the body color,body surface slime,and the shape,color and texture of liver return to normal;the dorsal fin,caudal fin and edges turn white;the blood extravasation and congestion in gill disappear;the slime on gill decreases obviously.For the experimental group with 1.00% concentration,the hepatic lobule and hepatocytes of grass carp′s liver have clear boundaries;nuclear membrane and nucleolus of hepatocytes are easily recognized;the nucleolus have moved to the middle of hepatocytes which return to normal gradually.

Inhibitory effects of Chinese herbal formula &lt;I&gt;Bingdeling&lt;/I&gt; on four common bacteria &lt;I&gt;in vitro&lt;/I&gt;

Inhibitory effects of Chinese herbal formula &lt;I&gt;Bingdeling&lt;/I&gt; on four common bacteria &lt;I&gt;in vitro&lt;/I&gt;

Effects of Chinese herbal formula Heat-stress-releasing on antioxidant function in dairy cows

In order to investigate the effects of a Chinese herbal formula Heat-stress-releasing on the antioxidant function in dairy cows, ten dairy cows were randomly divided into the control group and the experimental group, with five cows in each group. All the cows were fed with a basal diet. The animals in the experimental group were given with 220 g of herbs per day in addition to the basal diet. The trial was conducted for 14 days. Blood samples were taken from the vena cava at day 0, day 7, and day 15, respectively. The antioxidant statuses were examined. The results are as follows. (1) Heat-Stress-releasing formula can significantly increase the milk yield of dairy cows under heat stress. Compared with the control group, the milk yield of the herb-treated group increased by 14.01% (P<0.05), 14.32% (P<0.05) and 15.01% (P<0.05) in prophase, metaphase and anaphase of the test, respectively. (2) Heat-Stress-releasing formula can increase significantly the antioxidant status of the heat stressed dairy cows. Compared with the control group, the superoxide dismutase (SOD) activity increased by 45.93% (P<0.01) at day 7 and by 54.40% (P<0.01) at day 15. The Glutathioneperoxidase (GSH-PX) activity of the test group increased by 17.99% (P<0.05) at day 7 and 25.98% (P<0.01) at day 15. The total antioxidant capacity (T-AOC) of the test group increased by 43.64% (P<0.01) at day 7 and 46.35% (P<0.01) at day 15. The malondaldehyd (MDA) content of test group declined by 23.88% (P<0.01) at day 7 and 25.32% (P<0.01) at day 15.

The Anti-inflammatory and Anti-hyperuricemic Effects of Chinese Herbal Formula Danggui-Nian-Tong-Tang on Acute Gouty Arthritis: A Comparative Study with Indomethacin and Allopurinol

The traditional Chinese antirheumatic herb Danggui-Nian-Tong-Tang (DGNTT) was studied comparatively with indomethacin and allopurinol to evaluate its anti-inflammatory and antihyperuricemic effects in patients with gout. Results in this study did not show any significant improvement in reducing the total number of painful and swollen joints, articular index and pain score (P > 0.05) by treatment with DGNTT. Unlike allopurinol, DGNTT did not lower the high serum level of uric acid. In vitro study in rats showed that DGNTT significantly inhibits the activity of beta-glucuronidase (P < 0.05) and lysozyme release (P < 0.01) from neutrophils. In conclusion, despite the effect of inhibition on enzyme release from neutrophils, DGNTT is not effective in treating acute arthritis or hyperuricemia.