Effects Of Childhood Physical Abuse Research Articles

Differential recall bias in estimating treatment effects in observational studies.

Observational studies are frequently used to estimate the effect of an exposure or treatment on an outcome. To obtain an unbiased estimate of the treatment effect, it is crucial to measure the exposure accurately. A common type of exposure misclassification is recall bias, which occurs in retrospective cohort studies when study subjects may inaccurately recall their past exposure. Particularly challenging is differential recall bias in the context of self-reported binary exposures, where the bias may be directional rather than random and its extent varies according to the outcomes experienced. This paper makes several contributions: (1) it establishes bounds for the average treatment effect even when a validation study is not available; (2) it proposes multiple estimation methods across various strategies predicated on different assumptions; and (3) it suggests a sensitivity analysis technique to assess the robustness of the causal conclusion, incorporating insights from prior research. The effectiveness of these methods is demonstrated through simulation studies that explore various model misspecification scenarios. These approaches are then applied to investigate the effect of childhood physical abuse on mental health in adulthood.

Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

BackgroundChildhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. AimTo study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. MethodIn seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. ResultsOf the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. ConclusionsChildhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe.

Disentangling possible effects of childhood physical abuse on gray matter changes in violent offenders with psychopathy

Violent offenders with psychopathy present a lifelong pattern of callousness and aggression and fail to benefit from rehabilitation programs. This study presents the first, albeit preliminary, evidence suggesting that some of the structural brain anomalies distinguishing violent offenders with psychopathy may result from physical abuse in childhood.

Childhood Abuse and Criminal Behavior

This article draws on general strain theory (GST) to develop and test a model of the childhood abuse-crime relationship. Using data from the National Longitudinal Study of Adolescent Health (Add Health),(1) we find that early childhood physical and sexual abuse are robust predictors of offending in adolescence, for the full sample and in equations disaggregated by gender. GST is partially supported in that the effects of childhood physical abuse on offending for both females and males are mediated by an index of depression symptoms, whereas the effect of sexual abuse among females appears to be mediated largely by closeness to mother. The effect of childhood sexual abuse among males, however, is more robust than among females and it persists despite controls for low self-control, ties to delinquent peers, school attachment, and closeness to mother. Theoretical implications of the findings are discussed.

Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression

The endocannabinoid system has been implicated in stress adaptation and the regulation of mood in rodent studies, but few human association studies have examined these links and replications are limited. To examine whether a synonymous polymorphism, rs1049353, in exon 4 of the gene encoding the human endocannabinoid receptor (CNR1) moderates the effect of self-reported childhood physical abuse on lifetime anhedonia and depression and to replicate this interaction in an independent sample. Genetic association study in 1041 young US women with replication in an independent Australian sample of 1428 heroin-dependent individuals as cases and 506 participants as neighborhood controls. Self-reported anhedonia and depression (with anhedonia). In both samples, individuals who experienced childhood physical abuse were considerably more likely to report lifetime anhedonia. However, in those with 1 or more copies of the minor allele of rs1049353, this pathogenic effect of childhood physical abuse was attenuated. Thus, in participants reporting childhood physical abuse, although 57.1% of those homozygous for the major allele reported anhedonia, only 28.6% of those who were carriers of the minor allele reported it (P=.01). The rs1049353 polymorphism also buffered the effects of childhood physical abuse on major depressive disorder; however, this influence was largely attributable to anhedonic depression. These effects were also noted in an independent sample, in which minor allele carriers were at decreased risk for anhedonia even when exposed to physical abuse. Consistent with preclinical findings, a synonymous CNR1 polymorphism, rs1049353, is linked to the effects of stress attributable to childhood physical abuse on anhedonia and anhedonic depression. This polymorphism reportedly resides in the neighborhood of an exon splice enhancer; hence, future studies should carefully examine its effect on expression and conformational variation in CNR1, particularly in relation to stress adaptation.

Adult Criminal Involvement: A Cross-Sectional Inquiry Into Correlates and Mechanisms Over the Life Course

In this paper, we examine the relative contribution of four domains of predictors that have been linked to adult criminal involvement: (1) socio-demographic characteristics, (2) family-of-origin factors, (3) proximal processes developed during adolescence, and (4) current lifestyle and situational factors. Cross-sectional data were collected through face-to-face interviews with 242 community-recruited adults. Data analysis involved negative binomial regression. Being male, family size, juvenile delinquency, aggression, living with someone involved in illegal activity and recent violent victimization were independently associated with non-violent criminal involvement. Aggression, association with deviant peers, and recent violent victimization were independently associated with violent criminal involvement. Juvenile delinquency and aggression mediated the affect of multiple family-of-origin characteristics on non-violent criminal involvement and aggression mediated the effect of childhood physical abuse on violent criminal involvement. The results emphasize the importance of investigating both antecedents and proximal risk factors predictive of different types of criminal involvement, which, in turn, will assist in developing risk-focused prevention and intervention programs.

Relationship of childhood physical abuse and internet addiction disorder in adolescence: the mediating role of self-esteem

To find out whether the effects of childhood physical abuse on internet addiction disorder in adolescence could be mediated by self-esteem. 3798 high school students selected from 76 classes in Grade One and Grade Two, were asked to fill in the anonymous questionnaire, which including the demographic characteristics of students, Young's Internet Addiction Scale, Parent-Child Conflict Tactics Scales and Rosenberg's Self-Esteem Scale. Childhood physical abuse could directly predict less self-esteem and internet addiction disorder (r = -0.108, P < 0.01, r = 0.057, P < 0.01) and had significant indirect effects on internet addiction disorder which could be mediated through self-esteem (a = -0.703, standardized b = -0.104, z = 5.052, P < 0.001). Self-esteem had mediated 22.5% of the childhood physical abuse cases on their internet addiction disorders during the period of adolescence. Self-esteem could partially mediate the relationship between childhood physical abuse and internet addiction disorder. The mediating roles of self-esteem suggested that salient leverage points could make a change through empowerment training, self-esteem group training on self-esteem enhancement in the stage of adolescence.

Association of childhood abuse with homeless women's social networks

ObjectiveChildhood abuse has been linked to negative sequelae for women later in life including drug and alcohol use and violence as victim or perpetrator and may also affect the development of women's social networks. Childhood abuse is prevalent among at-risk populations of women (such as the homeless) and thus may have a stronger impact on their social networks. We conducted a study to: (a) develop a typology of sheltered homeless women's social networks; (b) determine whether childhood abuse was associated with the social networks of sheltered homeless women; and (c) determine whether those associations remained after accounting for past-year substance abuse and recent intimate partner abuse. MethodsA probability sample of 428 homeless women from temporary shelter settings in Los Angeles County completed a personal network survey that provided respondent information as well as information about their network members’ demographics and level of interaction with each other. Cluster analyses identified groups of women who shared specific social network characteristics. Multinomial logistic regressions revealed variables associated with group membership. ResultsWe identified three groups of women with differing social network characteristics: low-risk networks, densely connected risky networks (dense, risky), and sparsely connected risky networks (sparse, risky). Multinomial logistic regressions indicated that membership in the sparse, risky network group, when compared to the low-risk group, was associated with history of childhood physical abuse (but not sexual or emotional abuse). Recent drug abuse was associated with membership in both risky network groups; however, the association of childhood physical abuse with sparse, risky network group membership remained. ConclusionsAlthough these findings support theories proposing that the experience of childhood abuse can shape women's social networks, they suggest that it may be childhood physical abuse that has the most impact among homeless women. Practical implicationsThe effects of childhood physical abuse should be more actively investigated in clinical settings, especially those frequented by homeless women, particularly with respect to the formation of social networks in social contexts that may expose these women to greater risks.

Effect of childhood physical abuse on cortisol stress response

Abuse and neglect are highly prevalent in children and have enduring neurobiological effects. Stressful early life environments perturb the hypothalamic-pituitary-adrenal (HPA) axis, which in turn may predispose to psychiatric disorders in adulthood. However, studies of childhood maltreatment and adult HPA function have not yet rigorously investigated the differential effects of maltreatment subtypes, including physical abuse. In this study, we sought to replicate our previous finding that childhood maltreatment was associated with attenuated cortisol responses to stress and determine whether the type of maltreatment was a determinant of the stress response. Salivary cortisol response to the Trier Social Stress Test (TSST) was examined in a non-clinical sample of women (n = 110). Subjects had no acute medical problems and were not seeking psychiatric treatment. Effects of five maltreatment types, as measured by the Childhood Trauma Questionnaire, on cortisol response to the TSST were investigated. To further examine the significant (p < 0.005) effect of one maltreatment type, women with childhood physical abuse (PA) (n = 20) were compared to those without past PA (n = 90). Women reporting childhood PA displayed a significantly blunted cortisol response to the TSST compared with subjects without PA, after controlling for estrogen use, age, other forms of maltreatment, and other potential confounds. There were no differences between PA and control groups with regard to physiological arousal during the stress challenge. In a non-clinical sample of women with minimal or no current psychopathology, physical abuse is associated with a blunted cortisol response to a psychosocial stress task.

The impact of childhood abuse and combat‐related trauma on postdeployment adjustment

This retrospective study examined the effects of childhood physical abuse (CPA) and combat-related trauma on postdeployment psychiatric symptoms in an outpatient clinical sample of 1,045 U.S. service members. The authors conducted hierarchical multiple regression analyses to examine the impact of CPA and combat-related trauma on alcohol use, anxiety, depression, and posttraumatic stress disorder (PTSD) symptoms. Analyses revealed significant main effects for CPA and combat-related trauma on anxiety, depression, and PTSD. In contrast, no interactive effects were observed. Findings support and expand current knowledge about the roles that CPA and combat trauma play in the development of psychiatric symptoms and suggest a more complex etiology for postdeployment symptomatology. Clinical implications and future research opportunities are discussed.

Effects of childhood physical abuse on depression, problem drinking and perceived poor health status in adolescents living in rural Taiwan

The aim of the present study was to investigate the magnitude and independence of the effects of childhood physical abuse on adolescent depression, problem drinking and perceived poor mental health in Taiwanese indigenous and non-indigenous adolescents living in rural areas controlling for individual and familial characteristics. A sample of adolescents was randomly selected from junior high schools in the rural areas of southern Taiwan. The associations between childhood physical abuse and adolescent depression, problem drinking and perceived poor health status were examined on univariate and multivariate logistic regression. Of the 1684 adolescents who completed the questionnaires, 374 (22.2%) reported that they had experienced physical abuse in childhood. Controlling for individual and familial factors, childhood physical abuse significantly increased the risk of depression, problem drinking and perceived poor health status in the present sample of adolescents on multivariate logistic regression. History of childhood physical abuse should be elicited from adolescents in treatment for depression, alcohol abuse or physical discomfort of unknown etiology. This finding may be of clinical benefit in terms of the design and implementation of intervention.

Gender Differences in the Connections Between Violence Experienced as a Child and Perpetration of Intimate Partner Violence in Young Adulthood

This paper uses longitudinal and nationally representative survey data to investigate the direct relationship between three forms of child maltreatment (neglect, physical abuse, and sexual abuse), and future intimate partner violence (IPV) perpetration in the USA. We further examine the indirect effect that child maltreatment has on future IPV perpetration through the presence of youth violence perpetration, and the roles of socioeconomic factors on committing youth violence and IPV. Analyses indicate that gender differences exist for the developmental relationship between child maltreatment and young adult IPV perpetration, and the effects of socioeconomic factors on youth violence and IPV perpetration. For males, the direct effects of being neglected/physically abused as a child on IPV perpetration are not significant. However, the indirect effects of being neglected/physically abused on IPV perpetration through the presence of youth violence perpetration are significant. For females, the direct effects of being neglected/physically abused on IPV perpetration are significant. The indirect effect of being neglected on IPV perpetration is significant, while the indirect effect of childhood physical abuse is not significant. Childhood sexual abuse is not significantly directly associated with IPV perpetration for females; however, for males, it is the strongest (i.e., largest effect size) direct predictor of IPV perpetration. The indirect effects of childhood sexual abuse on IPV perpetration are not significant for both females and males.

The Effects of Childhood Physical Abuse or Childhood Sexual Abuse in Battered Women's Coping Mechanisms: Obsessive-Compulsive Tendencies and Severe Depression

What role does childhood abuse have on the coping choices made by a battered woman? Ancillary to a depression study (Bailey, 1996) in 79 battered women from a Houston area women's shelter were compared for past abuse experiences and how the women were coping with abuse in adulthood. This study compared coping styles between two groups of battered women: those who experienced childhood physically abuse (CPA) (n=35), and those who did not experience childhood physically abuse (NCPA) in childhood (n=44). All of the women filled out a battery of questionnaires including The Brief Symptom Inventory (BSI), and a scale for learned helplessness. A t-test conducted on obsessive-compulsive tendencies (OCT) scale of the BSI found that women who were NPPA had significantly lower BSI-OCT scores t(77)=−2.05, p < .05 than women who were PPA. No statistically significant differences were found between groups for learned helplessness. Out of the 35 battered women who reported physical abuse in childhood were more likely to report sexual abuse as girls than battered women who were not physically abused, t(77)=−3.40, p < .001. Battered women who had been physically and sexually abused in childhood were more severely depressed. Battered women who were not abused in childhood had more obsessive compulsive tendencies. The ramifications of these findings for therapeutic treatment are discussed.

Effects of childhood physical abuse on course and severity of substance abuse.

The present study sought to assess the course and severity of Substance Related Disorder (SRD) in relation to childhood physical abuse (CPA) using retrospective data on CPA and current indices of substance use, abuse, and related morbidity. A total of 642 patients were assessed, of whom 195 (30.4%) experienced CPA, were assessed in two university medical centers with Alcohol-Drug Programs located within departments of psychiatry. A research assistant obtained demographic data, family history of substance abuse, problems related to substance abuse, and treatment of substance abuse. Data on severity included two measures of SRD-associated problems (one patient-rated and one psychiatrist-rated), substance abuse vs. dependence, self-help activities, and previous treatment. The study found that patients with CPA were more likely to be women, have lower socioeconomic status, and have more extended family members with substance abuse. Their substance abuse was more severe on five out of six severity measures. Patients with CPA showed more lifetime treatment on three out of four measures. Physical abuse during childhood resulted in a more morbid course of substance abuse later in adulthood. Although female gender and lower SES were both associated with CPA, the relationships were separate (i.e., women did not have lower SES).

Reconstructions of family relationships: Parent–child alliances, personal distress, and self-esteem.

The aim of this study was to operationalize the structure of family relationships and examine how women's reconstructions of various family patterns during childhood and adulthood relate to their levels of depression, anxiety, and self-esteem. Using a sample of 93 women, ages 19 to 22, two family patterns emerged: (a) father-daughter alliance (FDA), whereby fathers seek intimacy and affection from their daughters instead of their wives and have emotionally distant marriages; and (b) mother-daughter triangulation (MDT), characterized by conflicted marriages whereby daughters are caught between their battling parents and mothers seek intimacy from their daughters instead of their husbands. Regression estimates suggest that childhood FDA significantly contributes to depression, anxiety, and low self-esteem even after controlling for the effects of childhood physical abuse and current FDA. Current MDT contributes to anxiety.