Effects Of Bioactive Substances Research Articles

The effect of bioactive substances derived from gut bacteria on the development of allergic diseases

The effect of bioactive substances derived from gut bacteria on the development of allergic diseases

Bioactive Compounds for Skin Health: A Review.

Human skin is continually changing. The condition of the skin largely depends on the individual’s overall state of health. A balanced diet plays an important role in the proper functioning of the human body, including the skin. The present study draws attention to bioactive substances, i.e., vitamins, minerals, fatty acids, polyphenols, and carotenoids, with a particular focus on their effects on the condition of the skin. The aim of the study was to review the literature on the effects of bioactive substances on skin parameters such as elasticity, firmness, wrinkles, senile dryness, hydration and color, and to define their role in the process of skin ageing.

Фітогормональний статус і фотосинтетична активність рослин м'якої пшениці за дії біологічно активних речовин

Фітогормональний статус і фотосинтетична активність рослин м'якої пшениці за дії біологічно активних речовин

Preliminary studies on the eff ect of bioactive substances of Hypnea musciformis (Wulf.) Lamour. on the growth of seedlings in green gram, Vigna radiata L.

<p>The effect of seaweed liquid fertilizer (SLF) of Hypnea musciformis (wulf.) Lamour.was tested at different concentrations (1, 2, 3 and 4 g/ml) on seed germination and biochemical constituents of Vigna radiata L. The extracts promoted seed germination at lower levels of SLF application. The seeds treated with, 2 g/ ml concentration showed maximum seed germination, radicle length, hypocotyl length, seedling length, fresh weight, phytomass, productivity, phytotoxicity, and photosynthetic pigments like Chlorophyll A, B, and total chlorophyll. Moreover, the different extracts of seaweed were subjected to phytochemical screening. All the<br />tested compounds (tannins, alkaloids, saponins, glycosides, and steroids) were present in varied degrees in Hypnea. The result of the present study can help in the identification and selection of raw materials in agriculture and drug industry.</p>

Effects of Bioactive Substances from Citrus on the Central Nervous System and Utilization as Food Material

We have recently shown that 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) and auraptene (AUR) have neuroprotective effects on the central nervous system. HMF, a citrus flavonoid, altered NMDA-type glutamate receptor antagonist MK-801-induced memory dysfunction and schizophrenia-positive symptom-like behavior. HMF also showed a protective effect against ischemia-induced short-term memory dysfunction. In the ischemic brain, HMF induced the following protective effects against brain dysfunction: 1) rescue of neuronal cell death in the hippocampus; 2) increased production of brain-derived neurotrophic factor; 3) stimulation of neurogenesis in the dentate gyrus subgranular zone; 4) activation of the autophosphorylation of calcium-calmodulin-dependent protein kinase II; and 5) suppression of microglial activation. On the other hand, AUR, a citrus coumarin, ameliorated lipopolysaccharide-induced inflammation in the brain as shown by inhibition of microglial activation and inhibition of cyclooxygenase (COX)-2 expression in the hippocampus. AUR also showed antiinflammatory effects on the ischemic brain by inhibiting microglial activation, COX-2 expression, and neuronal cell death in the hippocampus. The peel of kawachibankan (Citrus kawachiensis), a noted citrus product of Ehime prefecture, Japan, contains AUR, HMF, naringin, and narirutin. The dried powder of both the peel and juice had antiinflammatory effects in the mouse hippocampus, suggesting that citrus compounds may be beneficial as neuroprotective agents in the treatment of neurological disorders.

Effects of bioactive substances from tall delphinium on the development of acute inflammation of different genesis

Effects of complex and individual bioactive substances extracted from tall delphinium on acute inflammation induced by carrageenin, acetic acid, serotonin, and histamine were studied. The studied plant substances produced a pronounced antiinflammatory effect comparable to that of nonsteroid antiinflammatory drugs.

Effects of bioactive substances in milk on mineral and trace element metabolism with special reference to casein phosphopeptides.

Bioactivity of phosphopeptides yielded after tryptic hydrolysis of casein (CPP) was reported more than 50 years ago when CPP were found to improve calcium balance in rachitic newborns. Several investigations have been carried out to study the effects of CPP mainly on calcium metabolism but also on other minerals like iron and zinc. Most of the experiments were in vitro studies or short-term experiments like the effects of CPP after single meals or their effect on mineral disappearance from intestinal everted sac or ligated loop. Investigations on calcium balance were also mainly short term, i.e. 3-4 weeks, and mainly done in rats. A few experiments have been carried out in minipigs, an animal model that is closer to the human than the rat. Studies in human were rare and short term. To date a variety of other peptides have been isolated after enzymatic hydrolysis, and some have been investigated for bioactivity, with equivocal findings. Bioactivity of phosphopeptides seemed to be more obvious when investigations were done in vitro or short term. Results were less clear in metabolic balance studies, especially under physiological conditions. The composition of the basal diet, i.e. content of calcium and phytate, or the protein source had a significant impact on the effect of phosphopeptides. It was concluded that phosphopeptides revealed positive effects on mineral solubility and absorbability, and bone mineralisation under certain experimental conditions. Accordingly they could have a beneficial effect on bone health for some groups of the population.

Use of cultured human fibroblasts for rapid evaluation of cytotoxic effects of bioactive substances.

A test system for detecting cytotoxic effects of bioactive substances based on human fibroblast culture is proposed. The effects of acrylamide, streptomycin, cycloheximide, sodium dodecyl sulfate, sanguiritrine, and ethanol were evaluated by organic stain binding. Typical dose-effect relationships were detected for all substances except cycloheximide. The proposed test system can be used for screening of bioactive substances in preclinical trials.

生理活性物質の中耳，耳管粘膜に対する影響について 第１報：血小板活性化因子ＰＡＦのモルモット耳管粘膜に対する影響:第1報: 血小板活性化因子PAFのモルモット耳管粘膜に対する影響

生理活性物質の中耳，耳管粘膜に対する影響について 第１報：血小板活性化因子ＰＡＦのモルモット耳管粘膜に対する影響:第1報: 血小板活性化因子PAFのモルモット耳管粘膜に対する影響