Effects Of Acute Aerobic Exercise Research Articles

Acute effects of aerobic exercise on corticomotor plasticity in individuals with and without depression

BackgroundAlthough complex in nature, the pathophysiology of depression involves reduced or impaired neuroplastic capabilities. Restoring or enhancing neuroplasticity may serve as a treatment target for developing therapies for depression. Aerobic exercise (AEx) has antidepressant benefits and may enhance neuroplasticity in depression although the latter has yet to be substantiated. Therefore, we sought to examine the acute effect of AEx on neuroplasticity in depression. MethodsSixteen individuals with (DEP; 13 female; age = 28.5 ± 7.3; Montgomery-Äsberg Depression Rating Scale [MADRS] = 21.3 ± 5.2) and without depression (HC; 13 female; age 27.2 ± 7.5; MADRS = 0.8 ± 1.2) completed three experimental visits consisting of 15 min of low intensity AEx (LO) at 35% heart rate reserve (HRR), high intensity AEx (HI) at 70% HRR, or sitting (CON). Following AEx, excitatory paired associative stimulation (PAS25ms) was employed to probe neuroplasticity. Motor evoked potentials (MEP) were assessed via transcranial magnetic stimulation before and after PAS25ms to indicate acute changes in neuroplasticity. ResultsPAS25ms primed with HI AEx led to significant increases in MEP amplitude compared to LO and CON. HI AEx elicited enhanced PAS25ms-induced neuroplasticity for up to 1-h post-PAS. There were no significant between-group differences. ConclusionHI AEx enhances PAS measured neuroplasticity in individuals with and without depression. HI AEx may have a potent influence on the brain and serve as an effective primer, or adjunct, to therapies that seek to harness neuroplasticity.

Acute effect of aerobic exercise on brain-derived neurotrophic factor levels in patients with chronic heart failure

Acute effect of aerobic exercise on brain-derived neurotrophic factor levels in patients with chronic heart failure

The Benefits of Acute Exercise for Children's Cognition are Associated with Trait Anxiety.

Children's anxiety is associated with decreased cognitive performance. One well-established behavioral intervention to transiently improve cognitive performance in children is acute aerobic exercise (AAE). Thus far, however, it is unclear whether the benefits of AAE on cognition vary based on individual differences in children's anxiety level. Therefore, we investigated whether trait anxiety levels mediate the effects of AAE on cognitive outcomes in preadolescent children. Ninety-five preadolescent children (9-11 years, 41 females) underwent two experimental interventions in a random, crossover, and counterbalanced design: an exercise protocol (20 minutes of walking at 65-75% of HRpeak) and a non-exercise control (seated rest). Behavioral indices of cognitive performance (accuracy, reaction times, response time variability) were assessed before and after each intervention using a modified flanker task. The effects of each intervention on cognitive performance were calculated as pre- to post-intervention differences (effect scores). These scores were first correlated with children's personal characteristics: anxiety (STAIC), sex, age, BMI, IQ, and aerobic fitness. Significant correlations guided subsequent hierarchical regression models, which specifically tested for associations between the effects scores and anxiety levels while controlling for remaining relevant covariates. Regression analysis revealed that anxiety was a significant predictor of the effects that AAE and rest had on cognitive performance. Specifically, higher anxiety scores were associated with greater exercise-induced cognitive benefits (increased accuracy, decreased response time variability; p's < 0.05) and greater rest-induced cognitive impairments (decreased accuracy, increased response time variability; p's < 0.01). These findings suggest that children reporting higher trait anxiety might experience greater cognitive benefits from a single bout of AAE.

An investigation of the acute effects of aerobic exercise on executive function and cortical excitability in adolescents with attention deficit hyperactivity disorder (ADHD).

Previous studies have shown that aerobic exercise has beneficial effects on executive function in adolescents with attention-deficit hyperactivity disorder (ADHD). The underlying mechanisms could be partially due to aerobic exercise-induced cortical excitability modulation. The aim of this study was to explore the effects of acute aerobic exercise on executive functions and cortical excitability and the association between these phenomena in adolescents with ADHD. The study was conducted using a complete crossover design. Executive functions (inhibitory control, working memory, and planning) and cortical excitability were assessed in twenty-four drug-naïve adolescents with ADHD before and after acute aerobic exercise or a control intervention. Inhibitory control, working memory, and planning improved after acute aerobic exercise in adolescents with ADHD. Moreover, cortical excitability monitored by transcranial magnetic stimulation (TMS) decreased after intervention in this population. Additionally, improvements in inhibitory control and working memory performance were associated with enhanced cortical inhibition. The findings provide indirect preliminary evidence for the assumption that changes in cortical excitability induced by aerobic exercise partially contribute to improvements in executive function in adolescents with ADHD.

Aerobic fitness as a moderator of acute aerobic exercise effects on executive function.

This study aimed to investigate the moderating role of aerobic fitness on the effect of acute exercise on improving executive function from both behavioral and cerebral aspects. Thirty-four young individuals with motor skills were divided into high- and low-fitness groups based on their maximal oxygen uptake. Both groups completed 30min of moderate-intensity aerobic exercise on a power bike. Executive function tests (Flanker, N-back, More-odd-shifting) were performed before and after exercise and functional near-infrared spectroscopy was used to monitor prefrontal cerebral blood flow changes during the tasks. The results indicated significant differences between the two groups regarding executive function. Participants with lower aerobic fitness performed better than their higher fitness counterparts in inhibitory control and working memory, but not in cognitive flexibility. This finding suggests that the aerobic fitness may moderate the extent of cognitive benefits gained from acute aerobic exercise. Furthermore, the neuroimaging data indicated negative activation in the frontopolar area and dorsolateral prefrontal cortex in response to three complex tasks. These findings underscore the importance of considering individual aerobic fitness when assessing the cognitive benefits of exercise and could have significant implications for tailoring fitness programs to enhance cognitive performance.

Effects of acute aerobic exercise with different intensities on cerebral dopamine/norepinephine/serotonin metabolites and executive-related oculomotor control in individuals with Parkinson's disease

The present study aimed to investigate the acute effects of aerobic exercise with different intensities on executive-related oculomotor control and cerebral dopamine/serotonin/norepinephrine metabolite concentrations in individuals with Parkinson's disease (PD). Twenty-eight PD individuals completed acute bouts of high-intensity interval exercise (HIIE), moderate-intensity continuous exercise (MICE), and REST sessions. The order of the three sessions was counterbalanced. We assessed the concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and methoxyhydroxyphenylglycol (MHPG), as well as neuropsychological and oculomotor performance indices in the saccade paradigm at baseline and following each session. The present study found that there was no significant effect of acute HIIE or MICE on the coefficient of variation of reaction time (RT) in individuals with PD. However, HIIE resulted in significantly shorter RTs in the antisaccade condition, and MICE achieved the same in both the prosaccade and antisaccade conditions. For oculomotor performance, we observed a change in saccade peak velocity only following MICE but not HIIE. Neither of the two aerobic exercise modes significantly affected saccade amplitude and latency. In addition, concentrations of HVA and MHPG, but not 5-HIAA, significantly increased following both MICE and HIIE in individuals with PD. Notably, MICE had a greater impact on HVA compared to HIIE. We also found significant correlations between the changes in MHPG concentration, but not HVA and 5-HIAA, and RTs before and after the two aerobic exercise interventions. These results suggest that although acute HIIE and MICE protocols could not improve oculomotor control, the two aerobic exercise modes induced distinct beneficial effects on executive function and cerebral neurotransmitter concentrations in individuals with PD.

Acute Bouts of Aerobic Exercise Do Not Modulate Task-Evoked Midfrontal Theta Oscillations in School-Age Children

While acute aerobic exercise has been found to have a facilitative effect on task components with varied cognitive control demands in school-age children, its effects on specific neural processes evoked by a cognitive control task remain underexplored. The objective of the current study was to examine the effects of acute aerobic exercise on task-evoked midfrontal theta event-related synchronization (ERS)—which plays a crucial role in supporting cognitive control. Thirty-three preadolescent children were recruited into this within-subjects, crossover study. Participants engaged in an aerobic exercise condition and a seated rest condition in a counterbalanced order. After both conditions, participants completed a flanker task, with concurrent EEG data collection. The results revealed no differences in midfrontal theta ERS following acute aerobic exercise as compared with following the control condition. However, midfrontal theta ERS was higher during congruent trials relative to incongruent trials following control condition but not following aerobic exercise. Collectively, acute bouts of aerobic exercise do not appear to modulate the control and behavioral monitoring processes indexed by midfrontal theta ERS during cognitive control in children.

Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals.

BMI-matched normal- (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m2 ) and abnormal-glucose-tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m2 ) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO2 max. Participants also completed a treadmill walking test at 65% VO2 max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p < 0.05) body fat % (+24%), fasting plasma glucose (+37%), OGTT AUC (+59%), and HOMA-IR (+55%) and lower (p < 0.05) VO2 max (-24%). sTLR2 was 33% lower in AGT than NGT (main effect, p = 0.034). However, sTLR2 did not change (p > 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main effect, p = 0.096) and did not change following AE (p > 0.05). Total sRAGE and isoforms were similar (p > 0.05) between groups and did not change following AE (p > 0.05). sTLR2 was correlated with (p < 0.05) basal BG (r = -0.505) and OGTT AUC (r = -0.687). sTLR4 was correlated with basal BG (p < 0.10, r = -0.374) and OGTT AUC (p < 0.05, r = -0.402). Linear regressions were predictive of sTLRs in the basal state (sTLR2: R2 = 0.641, p = 0.01; sTLR4: R2 = 0.566, p = 0.037) and after acute exercise state (sTLR2: R2 = 0.681, p = 0.004, sTLR4: R2 = 0.568, p = 0.036).These findings show circulating sTLR profiles are disrupted in AGT and acute AE minimally modulates their levels.

Effects of acute aerobic exercise on arterial stiffness in transgender men.

Testosterone replacement therapy (TRT) in transgender men (TM) results in side effects such as elevated triglycerides and increased arterial stiffness. Exercise may be useful to ameliorate such effects, but no studies have examined the effects of acute aerobic exercise in TM. This study aimed to investigate the effects of acute aerobic exercise on arterial stiffness in TM. Thirty-six participants were included, comprising 12TM (duration of TRT: 57.4 ± 30.3 months), 12 males and 12 females. All participants performed acute aerobic exercise on a treadmill at 50% heart rate reserve for 30min. Arterial stiffness as measured by brachial-ankle pulse wave velocity (baPWV) was measured before exercise (Pre), 30min after exercise (Post30), and 60min after exercise (Post60). Serum sex hormone levels, and serum lipid profile were determined only before exercise. Serum low-density lipoprotein cholesterol (LDL-C) levels before exercise were significantly higher in TM than in males or females (males: p < 0.01; females: p < 0.05). At all points, baPWV in TM was significantly higher than in females (p < 0.05) and significantly lower than in males (p < 0.05). However, when comparing changes in baPWV over time in each group, significant decreases in Post30 and Post60 were seen in males compared to Pre (both p < 0.05), but no significant change after aerobic exercise was seen in TM or females. These results suggest that acute aerobic exercise yield different effects in TM than in males, but is unlikely to reduce arterial stiffness in TM receiving TRT.

The Effect of Acute Aerobic Exercise on Measures of Stress and Inflammation in Healthy Young Adults

Introduction: While the effects of long-term measures of inflammation and stress are well studied, less is known about the effects of an acute exercise challenge on exercise in young healthy individuals. Methods: This was a randomized crossover design (mean age = 19.25, SD = 1.45) that measured biomarkers of stress (cortisol and salivary alpha amylase, sAA) and inflammation (IL-1β, CRP) in an exercise and control condition. In the exercise condition, participants walked or ran on a treadmill at 75-85% of their maximum heart rate for 40 minutes. Under the control condition, participants stood for 40 minutes to control for orthostatic effects. Biomarkers were quantified from saliva collected before, 1 minute after, and 45 minutes after the exercise and control condition. Results: The change in biomarkers from baseline values (+1 min and + 45 min) between exercise and control conditions showed that compared to the control condition, the acute exercise bout significantly increased sAA CRP at +1min at +45 min and in IL-1β +45 min. Cortisol levels significantly decreased at both time points in the control condition Conclusions: Ultimately, the results of this study show how small and realistically achievable amounts of exercise can acutely strengthen the body’s physiological responses to immune challenges.

Acute effects of different exercise forms on executive function and the mechanism of cerebral hemodynamics in hospitalized T2DM patients: a within-subject study.

This study aimed to investigate the acute effects of aerobic exercise (AE), resistance exercise (RE), and integrated concurrent exercise (ICE; i.e., AE plus RE) on executive function among hospitalized type 2 diabetes mellitus (T2DM) inpatients, and the mechanism of cerebral hemodynamics. A within-subject design was applied in 30 hospitalized patients with T2DM aged between 45 and 70 years in the Jiangsu Geriatric Hospital, China. The participants were asked to take AE, RE, and ICE for 3 days at 48-h intervals. Three executive function (EF) tests, namely, Stroop, More-odd shifting, and 2-back tests, were applied at baseline and after each exercise. The functional near-infrared spectroscopy brain function imaging system was used to collect cerebral hemodynamic data. The one-way repeated measurement ANOVA was used to explore training effects on each test indicator. Compared with the baseline data, the EF indicators have been improved after both ICE and RE (p < 0.05). Compared with the AE group, the ICE and RE groups have demonstrated significant improvements in inhibition (ICE: MD = - 162.92 ms; RE: MD = -106.86 ms) and conversion functions (ICE: MD = -111.79 ms; RE: MD = -86.95 ms). Based on the cerebral hemodynamic data, the beta values of brain activation in executive function related brain regions increased after three kinds of exercise, the EF improvements after the ICE showed synchronous activation of blood flow in the dorsolateral prefrontal cortex (DLPFC), the frontal polar (FPA) and orbitofrontal cortex (OFC), the improvement of inhibitory function after RE displayed synchronous activation of DLPFC and FPA, and AE mainly activates DLPFC. The HbO2 concentration in the pars triangularis Broca's area increased significantly after AE, but the EF did not improve significantly. The ICE is preferred for the improvements of executive function in T2DM patients, while AE is more conducive to the improvements of refresh function. Moreover, a synergistic mechanism exists between cognitive function and blood flow activation in specific brain regions.

Effects of acute aerobic exercise with self-selected music on working memory and alpha oscillation

ABSTRACT This study investigated the effects of exercise while listening to music on behavioural performance and electroencephalogram of working memory (WM). The within-subjects crossover posttest comparison design was used, and 37 participants were recruited to perform the following three sessions in a counterbalanced order: 30-minute bout of exercise while listening to music (Ms), exercise without music (Ex), and control condition (Cn). Exercise intensity was defined as within 40–60% of maximal heart rate and a tempo of 125–140 bpm was used as the qualification for selecting music. After each session, lower and upper alpha event-related desynchronisation (ERD) was measured during auditory WM. Affective response analysis showed that Ms and Ex induced positive mood in participants compared to Cn. Ms had lower rate of perceive exertion compared to Ex and only Ex had lower tranquility from post-exercise to pre-exercise, indicating relatively more effort and less calm following Ex. behavioural analysis showed that Ms had shorter reaction time compared to Cn, indicating better WM performance following Ms. Upper Alpha ERD analysis showed a task effect on Cn instead of Ms or Ex. Generally, exercise with self-selected music can make exercising more enjoyable and effortless, while reaping the additional benefits of enhanced WM to efficiently retain and manipulate information from daily tasks.

The Effect of Acute Aerobic Exercise on Working Memory Among Female Students of Bingham University, Nigeria

Researches have showed that participation in a physical activity is associated with increased performance across a variety of tasks involving attention, cognition, and memory. The present study aimed at investigating the effects of aerobic exercise on working memory in non-athletic female students of Bingham University. A total of 53 participants who completed the physical activity readiness questionnaire (PAR-Q) were considered for this study. The study was conducted in three days, with day 1 being the baseline testing. Participants completed an N-back working memory task before the start of aerobic exercise. They were then required to perform an aerobic exercise on the treadmill for 10 min; and after which, were made to perform the N-back working memory task again. The same procedure was carried out on days 2 and 3. All data were analysed using analysis of variance at p&lt;0.05. A significant (p&lt;0.001) increase in total false alarm was observed in subjects after exercise and on days 2 and 3 compared to the first day before exercise. There was significant decrease in reaction time after the exercise, and on days 2 and 3 of the study as compared to the first day at p&lt;0.001. This study has shown that acute aerobic exercise improved working memory in the female students’ population

Effects of acute aerobic exercise on the motor inhibitory process in the go/no-go task in humans: a functional near-infrared spectroscopy study.

While many studies have reported the relationship between human cognitive functions and exercise, only a few have investigated the effect of mild-intensity exercise on the human motor inhibitory process. We employed the go/no-go task as a useful paradigm for studying the neural mechanisms involved in response execution and inhibition. Using functional near-infrared spectroscopy, we observed 17 subjects performing go/no-go tasks under a control condition and an exercise condition. Under the control condition, the subjects performed a go/no-go session before and after a 15 min rest. Under the exercise condition, the subjects performed a go/no-go session before and after a 10 min ergometer cycling session followed by a 5 min rest. We set the exercise intensity individually for each subject at 30% of their maximum heart rate as calculated by Karvonen's formula. We recorded an increase oxygenated hemoglobin (oxy-Hb) in the go/no-go blocks compared to those in the go blocks and found that mild exercise significantly enhanced the peak amplitude of oxy-Hb. On the other hand, we observed no significant changes under the control condition. This result suggests that mild exercise could trigger enhanced activation in the right frontal area, and cause a stronger inhibitory effect related to go/no-go tasks.

Effects of Acute Aerobic Exercise, Mindfulness Training and Combined Mindfulness and Exercise on Cognitive Performance

Physical activity (PA) and mindfulness are independently associated with improved cognitive function; however, the effects of their combination on cognitive function are unknown. The purpose of this study was to examine the effects of an acute bout of PA, mindfulness training, and combined PA and mindfulness training on changes in cognitive function and perceived cognitive ability. Using a repeated measures within-subjects design, adults (N = 29, Mage = 28.6) completed three 20-minute counterbalanced conditions: a) mindfulness training (MIND); b) moderate-intensity walking (PA), and c) moderate-intensity walking while listening to PA-specific mindfulness training (PAMIND). Participants completed the NIH Toolbox Cognitive Battery and PROMIS Applied Cognition Short Form before and after each condition. Within-subjects repeated measures ANOVAs revealed inhibitory control, working memory, task shifting, processing speed and the fluid composite score ( P &lt; .01 for all) improved from pre-to post-condition for all conditions. Perceived cognitive ability declined across all conditions pre- to post-condition ( P &lt; .001); decreases were largest in the MIND condition. Cognitive performance improved following acute bouts of general mindfulness, PA, and the combination of the two, but perceived cognitive ability declined. Future work is warranted to examine effects in other populations and as a result of different PA and mindfulness doses and interventions.

The effect of acute aerobic exercise on arterial stiffness in individuals with different body fat percentages: A cross-sectional study.

Body fat percentage were positively correlated with arterial stiffness, but the acute change in arterial stiffness after aerobic exercise in individuals with different body fat percentages remains unclear. This study was aimed to determine the effect of acute aerobic exercise on arterial stiffness in individuals with different body fat percentages. Individuals who both participated in the seventh survey of the Kailuan study and the fifth iteration of National Physical Fitness Monitoring were enrolled in our study. All participants underwent measurement of brachial-ankle pulse wave velocity, blood pressure, and heart rate before and after a two-stage load test on cycle ergometry. Additionally, the generalized linear model was established to analyse between-group differences of the change in brachial-ankle pulse wave velocity before and after exercise for individuals with different body fat percentages. The participants (N = 940, 36.8 ± 7.7years old, all male) were divided into: Q1 10.0-19.3%, Q2 19.3-23.3%, Q3 23.3-27.1% and Q4 27.1-37.7% by body fat percentage quartile. Overall, after exercise, brachial-ankle pulse wave velocity decreased significantly (before, 1,375.1 ± 209.1; after, 1,341.5 ± 208.0cm/s; p < 0.01). After adjusting for confounding factors, the generalized linear model showed that the β values and 95% confidence interval (CI) of Q1, Q2 and Q3 groups were -38.1 (95% CI: -57.3, -19.0), -8.5 (95% CI: -25.8, 3.7),-3.7 (95% CI: -20.5, 13.0), respectively, when compared with Q4. For an increase in body fat percentage by one standard deviation (5.8%), β = 14.5 (95% CI: 7.3, 21.6). Similar results were obtained in sensitivity analyses. Acute aerobic exercise had a positive effect on the arterial stiffness of adults with different body fat percentages. Compared with individuals with high body fat percentages, the arterial stiffness of people with low body fat percentages had significant reduction after exercise.

The Effect of Acute Aerobic Exercise on Biomarkers of Renal Health and Filtration in Moderate-CKD

ABSTRACT Purpose: Efficacy of exercise to improve renal health and filtration remains understudied in adults with moderate-stages (stages G3a-b) of chronic kidney disease (CKD). Acute exercise may contribute clinically relevant information for exercise-related augmentation of renal health and filtration in CKD. Urine epidermal growth factor (uEGF) and cystatin C (CyC) are proposed to be more direct biomarkers of renal health and filtration. This study aimed to determine the influence of continuous moderate-intensity exercise (CMIE) and high-intensity interval exercise (HIIE) on traditional and novel biomarkers of renal health and filtration in moderate-stages of CKD. Methods: Twenty CKD participants completed 30 minutes of both CMIE and HIIE. Blood and urine samples were obtained pre, 1-hour, and 24-hours post-exercise. Traditional—serum creatinine (sCr) urine creatinine, novel—uEGF, uEGF ratio (uEGFr), and CyC. Estimates of glomerular filtration rate (eGFR)—modification of diet in renal disease (MDRD) and the CKD-Epidemiology (CKD-EPI)—responses were compared pre, 1 hr, and 24 hr post-exercise. Results: Relative to pre-exercise measures, uEGF remained unchanged in both exercise conditions. However, uEGFr was 5.4% greater 24-hours after HIIE (P = .05), while uEGFr remained unchanged with CMIE. sCr decreased 6 to 19% 1-hour post-exercise in both conditions (P = .009). On average renal filtration increased in eGFR-MDRD (7.2 ± 2.0 ml/min/1.73 m2) (P = .007) and eGFR-CKD-EPI (8.6 ± 2.3 ml/min/1.73 m2) 1-hour post-exercise (P = .009). Conclusion: By clinical estimates, renal filtration in CKD was not normalized but transiently improved regardless of exercise condition, with HIIE eliciting transient improvements in renal health.

Comparative effectiveness of playing golf to Nordic walking and walking on acute physiological effects on cardiometabolic markers in healthy older adults: a randomised cross-over study

ObjectivesThe acute effects of aerobic exercise on cardiometabolic markers are well documented in younger healthy individuals, but the same effects in older adults have not been elucidated. As such, this...

Responses of complement C1q/tumor necrosis factor-related proteins to acute aerobic exercise.

Aerobic exercise is an effective therapeutic strategy to manage metabolic disorders. However, the mechanisms of aerobic exercise-induced improvements in metabolic diseases are not completely understood. Complement C1q/tumor necrosis factor-related protein (CTRP) 1, CTRP3, CTRP5, and CTRP9 have important roles in improving metabolic disorders via the adenosine monophosphate-activated protein kinase signaling pathway. In this study, we investigated the effects of acute aerobic exercise on circulating CTRP1, CTRP3, CTRP5, and CTRP9 levels in human participants. Eight healthy males with an age of 20.4±0.2years, height 173.1±1.7cm, body mass 68.0±1.8kg, body mass index 22.7±0.7kg/m2, and maximal oxygen uptake (VO2max) 51.3±2.5mL/kg/min performed acute aerobic cycling exercise at 75% of their VO2max for 30min (data are mean±standard error). Blood samples were obtained before; immediately after; and 30, 60, and 120min after exercising. Serum concentrations of CTRP1, CTRP3, CTRP5, CTRP9, tumor necrosis factor-α (TNF-α), and insulin were measured. The CTRP1 concentration significantly increased immediately after exercising and remained elevated for up to 120min (p<0.01). The CTRP3 concentration significantly increased at 60min after exercise (p<0.05), and the increasing trend continued until at least 120min after exercise (p<0.01). The CTRP5, CTRP9, TNF-α, and insulin concentrations significantly increased immediately after exercise (p<0.05, p<0.01, p<0.05, and p<0.05, respectively) and decreased thereafter. A significant correlation was observed between the peak post-exercise concentrations of CTRP1 and TNF-α (p<0.05); however, no correlation was observed between the peak post-exercise concentrations of CTRP3 and insulin. The results of this study indicate that acute aerobic exercise may enhance the secretion of CTRP1, CTRP3, CTRP5, and CTRP9 in healthy adults.

Effects of acute aerobic exercise on brain-derived neurotrophic factor level in rheumatoid arthritis patients.

The study aimed to investigate the variation of brain-derived neurotrophic factor (BDNF) levels following acute exercise in patients with rheumatoid arthritis (RA). This cross-sectional study was conducted with 88 participants (25 males, 63 females; mean age: 45.1±8.3 years; range, 18 to 65 years) between July 2020 and May 2021. Of the participants, 44 were RA patients, and 44 were age-and sex-matched healthy controls. Aerobic exercise was utilized in all participants for a single session. Depression and anxiety levels were evaluated with the Beck Depression Inventory and Hospital Anxiety and Depression Scale. Blood samples were collected from all subjects before and immediately after the intervention. Serum BDNF levels (both baseline and after exercise) were similar in the RA and control groups. Although serum BDNF levels significantly decreased in both groups after aerobic exercise (Wilcoxon rank p<0.05), ΔBDNF levels were significantly higher in the RA group than in the control group (p=0.047). Additionally, ΔBDNF levels were significantly correlated with the Hospital Anxiety and Depression Scale scores in the RA group (p<0.05) but not in the control group. A single bout of exercise may effectively decrease serum BDNF levels in patients with RA and healthy subjects. The long-term effect of exercise on BDNF levels should be investigated in prospective studies.