Effects Of Stress Reduction Research Articles

Autonomic modulation with mindfulness-based stress reduction in chronic kidney disease: a randomized controlled trial.

Chronic kidney disease (CKD) is characterized by overactivation of the sympathetic nervous system (SNS) that leads to increased risk of cardiovascular disease. This study was conducted to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) programme on SNS activity in CKD patients. Participants with CKD stages III-IV were randomized to the 8week MBSR programme or Health Enhancement Program (HEP; a structurally parallel, active control group). Intraneural measures of SNS activity directed to muscle [muscle sympathetic nerve activity (MSNA)] via microneurography was recorded at rest and during stress manoeuvres (mental arithmetic, handgrip exercise and cold pressor test). Data analyses were performed based on the intent-to-treat principle. In total, 29 participants (64±9years; 86% males) completed the intervention with 17 in the MBSR and 12 in the HEP groups. There was a significant Group (MBSR vs. HEP) by Time (baseline vs. post-intervention) interaction in MSNA reactivity to mental stress (P=0.029), with a significant reduction in the mean ∆MSNA over 3min of mental arithmetic at post-intervention (10.3±4.2-5.9±5.6 bursts/min, P<0.001; Hedges' g=-0.858, 95% confidence interval [-1.578, -0.167]), while no change was observed within the HEP group (P=0.818). Reduced ∆MSNA during handgrip exercise was also observed, while ∆MSNA during the cold pressor test and resting MSNA remained unchanged in both groups from baseline to post-intervention. In this randomized controlled trial, patients with CKD had a reduction of sympathetic reactivity during mental stress and static handgrip exercise following 8weeks of MBSR but not after HEP. Our findings demonstrate that mindfulness training is feasible and may have clinically beneficial effects on autonomic function in CKD. KEY POINTS: Question: Does the Mindfulness-Based Stress Reduction (MBSR) programme reduce sympathetic activity in patients with chronic kidney disease (CKD)? Finding: In this randomized controlled trial including 29 patients with CKD, 8weeks of MBSR decreased sympathetic reactivity to mental stress compared to the control Health Enhancement Program (HEP). Meaning: These finding suggest that mindfulness training may have clinically beneficial effects on autonomic function in CKD.

Effectiveness of Mindfulness-Based Stress Reduction on Anxiety Disorder: A Systematic Review

Anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder, and specific phobias, are significant public health concerns that affect millions worldwide and lead to substantial impairments in daily functioning and quality of life. Traditional treatments may not suit everyone, highlighting the need for alternatives like Mindfulness-Based Stress Reduction (MBSR), which emphasizes mindfulness meditation. This systematic review evaluates the effectiveness of MBSR in reducing anxiety symptoms across various anxiety disorders by synthesizing research findings from studies published between January 2013 and April 2024. A comprehensive search was conducted in electronic databases, including PubMed, Semantic Scholar, ScienceDirect, PsycINFO, and Web of Science, using keywords such as “Mindfulness-Based Stress Reduction,” “MBSR,” “anxiety disorder,” and “effectiveness.” Peer-reviewed studies assessing the efficacy of MBSR on anxiety disorders were included, with data extraction and quality assessment performed following PRISMA 2022 guidelines. The search identified 1095 articles, with 13 studies meeting the inclusion criteria for the final analysis, encompassing a total sample size of 751 participants. The studies varied in design, sample size, participant demographics, and targeted anxiety disorders. Findings consistently showed significant reductions in anxiety symptoms among participants receiving MBSR compared to control groups. For GAD, studies reported improvements in anxiety and stress measures such as the Beck Anxiety Inventory (BAI) and Hamilton Anxiety Rating Scale (HAM-A). For SAD, reductions in social anxiety symptoms were observed, with some studies showing comparable effectiveness to CBT. This review presents compelling evidence supporting the efficacy of MBSR in reducing symptoms associated with anxiety disorders. Future research should focus on the long-term effects, impact on diverse demographic groups, and specific mechanisms to improve its clinical applicability.

Comparison of Mindfulness Practices for Effectiveness of Stress and Burnout Reduction in Healthcare Staff.

Comparison of Mindfulness Practices for Effectiveness of Stress and Burnout Reduction in Healthcare Staff.

Mindfulness-based stress reduction (MBSR) for improving hope and happiness in men with visual impairment

Hope and happiness are positive emotions that affect an individual’s thoughts, feelings, and behavior. These two variables also affect different aspects of an individual’s life such as physical health, lifespan, academic performance, socialization process, creative thinking, problem-solving ability, and mental health. This study seeks to examine the effectiveness of mindfulness-based stress reduction (MBSR) in improving hope and happiness in visually impaired people. Employing a quasi-experimental pre-test–post-test design with a control group, this study sought to examine the degree of the effectiveness of MBSR therapy in improving hope and happiness in visually impaired people. The participants were selected from all visually impaired men aged 20 and 40 living in Tehran in 2023, who were supported by the State Welfare Organization of Iran and were members of the White Cane Society. A total of 40 visually impaired people were selected as the participants and randomly assigned to intervention and control groups (each with 20 members). The data were collected using Snyder’s Adult Hope Scale (1991) and Oxford Happiness Questionnaire (OHQ; 1990). The participants in the intervention group attended eight 90-min MBSR intervention sessions once a week. One-way analysis of covariance (ANCOVA) was used to analyze the data. The mean hope scores in the pre-intervention and post-intervention stages were 20 ± 3.28 and 25.53 ± 3.138, respectively. The mean happiness scores in the pre-intervention and post-intervention stages were 66.86 ± 5.91 and 75.93 ± 4.47, respectively (mean difference = 75.93 – 66.86). The findings showed that MBSR was effective in improving hope ( F = 32.7; p = .01) and happiness ( F = 45.86; p &lt; .001) in men with visual impairment. As a result, MBSR can be considered an effective intervention to enhance happiness and hope while reducing the psychological complications associated with visual impairment in affected individuals.

The Effect of Mindfulness-Based Stress Reduction on Pediatric Oncology Nurses' Stress Level, and Pediatric Oncology Patients' Psychosocial Symptoms and Care Satisfaction: A Prospective Non-Randomized Trial.

Studies investigating the effects of relaxation practices on nurses and patient outcomes are limited. This study aimed to evaluate the impact of Mindfulness-Based Stress Reduction (MBSR) on pediatric oncology nurses' stress levels, as well as the psychosocial symptoms and care satisfaction of pediatric oncology patients. A non-randomized prospective study with a pretest-posttest design was conducted, involving 112 children and 8 pediatric oncology nurses between November 2021 and August 2022. The study was conducted in 3 stages. First, the children's nursing care satisfaction and psychosocial symptoms were evaluated during the first 3 months before the MBSR intervention. Second, the nurses participated in the MBSR program for 2 months. Third, the children's nursing care satisfaction and psychosocial symptoms were assessed again 3 months after the MBSR intervention. The results showed that children who received nursing care post-MBSR had lower scores in the Psychosocial, Hopelessness, and Communication Difficulty subscales compared to those who received care pre-MBSR. Additionally, these children had higher scores in Evaluation of Quality of Care from the Children's Point of View, Psychosocial, Physical, and Information subscales. There was a significant reduction in the stress levels of nurses between the pre-MBSR and post-MBSR assessments. MBSR is an effective method for reducing pediatric oncology nurses' perceived stress levels and should be utilized to support both pediatric oncology nurses and patients in enhancing their psychosocial functioning.

The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.

Genetics may influence symptoms experienced by breast cancer survivors (BCS) by moderating the effects of stress-reducing interventions, including the Mindfulness-Based Stress Reduction (MBSR(BC)) program, to reduce symptom severity. As part of a larger clinical trial, the aim of this study was to evaluate genetic variants as moderators of MBSR(BC) on improvements among BCS in cognitive functioning and symptoms. BCS (n = 128) were randomized to MBSR(BC) or the Breast Cancer Education Support Program. Objective neuropsychological and subjective measures of cognitive performance, and psychological and physical symptoms were collected at baseline, 6, 12, and 26 weeks. Linear mixed models were implemented to identify MBSR(BC)'s effects over time. A total of 22 single nucleotide polymorphisms (SNPs) from 20 genes known to be related to these symptoms were investigated using genomic DNA. These SNPs were tested as moderators of MBSR(BC) program effects. Results showed MBSR(BC) participants experienced significantly greater benefits in cognitive functioning, however, the level of benefit varied based on one's genetic profile. Effects sizes, consistency across similar measures were investigated. Among 22 candidate SNPs, rs4680 in COMT, rs1800497 in ANKK1, and rs6277 in DRD2 demonstrated the strongest, most consistent positive effects in moderating MBSR(BC)'s impact on cognitive outcomes. Although the effects were small, this translational research may potentially identify BCS with genotypes that would be most influenced by the MBSR(BC) program. These results may be used to develop personalized intervention programs tailored to the genetic profile of each breast cancer survivor who received chemotherapy or chemotherapy and radiation. ClinicalTrials.gov, https://www.ClinicalTrials.gov Registration Number: NCT02786797.

Effects of mindfulness-based stress reduction on cancer-related fatigue in patients with breast cancer: a meta-analysis of randomized controlled trials.

Mindfulness-based stress reduction (MBSR) has been widely used for improving psychological symptoms and sleep quality in breast cancer patients and has a positive impact on posttraumatic growth and immunology. Moreover, MBSR is increasingly being used in cancer-related fatigue (CRF) intervention studies for breast cancer patients, but conflicting results also exist. This study aimed to evaluate the effect of MBSR on CRF in patients with breast cancer. A comprehensive computer search of the Pubmed, Cochrane Library, Embase, Web of Science, China Biomedical Document Service System, China Knowledge Infrastructure Engineering, Wanfang Data Knowledge Service Platform, and VIP databases was performed. Randomized controlled trials (RCTs) published before April 10, 2023, were identified. The primary outcome was cancer-related fatigue associated with breast cancer. Two researchers independently screened the studies, extracted the data, and evaluated the methodological quality of the studies according to the inclusion and exclusion criteria. The Meta-analysis of the outcome indicators was performed using STATA 16.0 software. A total of 13 studies were included, including 1992 patients (997 patients in the MBSR group and 1015 patients in the control group). Compared with conventional care, MBSR significantly alleviated the symptoms of CRF in breast cancer patients (SMD=-0.32, 95% CI [-0.42, -0.22], z=6.54, p<.01). Under the supervision of experts, the 8-week MBSR had a great influence on CRF, especially in the Asian population. MBSR is effective in the treatment of CRF induced by breast cancer, and no obvious adverse effects occur; thus, MBSR can be recommended as a beneficial adjuvant therapy for treating CRF in breast cancer patients. https://www.crd.york.ac.uk/prospero/, identifier CRD42021245365.

Mindfulness-based stress reduction via mobile phone on female family caregivers' anxiety and sleep quality during COVID-19

PurposeThis study aims to determine the effect of Mindfulness-Based Stress Reduction (MBSR) via mobile phone on female family caregivers during COVID-19.Design/methodology/approachIn the experimental study, 81 female family caregivers were randomly divided into the experimental group (n = 40) and control group (n = 41). The experimental group received MBSR via mobile phone. Pittsburgh Sleep Quality Inventory and Generalized Anxiety Disorder Questionnaire - Seventh Edition were evaluated at the beginning of the study, week 3 and week 8, respectively.FindingsIn both groups, anxiety decreased over time, although the decrease in the experimental group was significantly higher than in the control group (F = 22.912 p < 0.001). Sleep quality improved slightly in both groups over time; this improvement in the experimental group was significantly more than in the control group (F = 3.751 p = 0.035).Originality/valueThe MBSR via mobile phone helps to reduce anxiety and improve sleep quality in women caring for isolated patients at home.

Correction to “The effects of mindfulness-based stress reduction on spiritual well-being and hope in patients with breast cancer: A randomized controlled trial” by Wang et al. (2024).

Correction to “The effects of mindfulness-based stress reduction on spiritual well-being and hope in patients with breast cancer: A randomized controlled trial” by Wang et al. (2024).

Mindfulness-based stress reduction for chronic pain: Enhancing psychological well-being without altering attentional biases towards pain faces.

This study examines the effects of a Mindfulness-Based Stress Reduction (MBSR) program on psychological measures and attentional patterns to pain stimuli, using eye-tracking methods, in individuals with chronic pain. Thirty-two participants with chronic pain and no prior mindfulness experience were randomly assigned to an experimental group or a waiting list group. Both groups completed self-report measures of symptoms, well-being, and an attentional disengagement task using emotional faces as stimuli. Assessments were conducted at two points: before and after the intervention for the experimental group, with the waiting list group serving as a control. Before the MBSR program, chronic pain participants exhibited significant attentional biases towards pain-related stimuli during early attentional stages. Following the program, significant improvements were observed in depression, anxiety, stress, pain acceptance, overall well-being, and life satisfaction. However, it had a limited impact on attentional patterns, with only a significant increase in gaze duration across all stimuli. Despite the MBSR program's success in reducing symptoms associated with chronic pain, the lack of broader attentional improvements raises questions about the mechanisms responsible for psychological improvements. This study pioneers the use of eye-tracking to examine how MBSR influences attention in chronic back pain. While the program improved psychological well-being, it did not generally alter attentional patterns, except for an increased ability to maintain attention across stimuli. We discuss whether this attentional change could be associated with the increased acceptance observed in the MBSR program.

Effects of Mindfulness-Based Stress Reduction on Emotional Intelligence and Job Development in Saudi Educators

Effects of Mindfulness-Based Stress Reduction on Emotional Intelligence and Job Development in Saudi Educators

Effects of Hormonal Replacement Therapy and Mindfulness-Based Stress Reduction on Climacteric Symptoms Following Risk-Reducing Salpingo-Oophorectomy.

Breast Cancer Associated Susceptibility Proteins Type 1/2 (BRCA1/2) promote cellular functioning by modulating NRF2-mediated antioxidant signaling. Redox failure in women with BRCA1/2 insufficiency increases the risk for breast/ovarian/uterine cancers. Risk-reducing salpingo-oophorectomy (RRSO) is a prophylactic surgery of the reproductive organs, which is frequently conducted by the age of 40 to lower the occurrence of cancer in women with BRCA1/2 mutations. However, abrupt estrogen decline following RRSO causes ovarian failure, which implicates various cellular physiological processes, resulting in the increased release of free radicals and subsequent severe onset of menopausal symptoms. Comfort measures (e.g., hormonal replacement therapy (HRT) and mindfulness-based stress reduction (MBSR)) may improve chronological menopause-related quality of life, but their specific effects are not clear in women with gene mutations. Aiming to fill the gap, this study used path analysis to examine the effects of HRT and MBSR on menopausal symptoms among RRSO patients (N = 199, mean age = 50.5 ± 6.7 years). HRT directly alleviated the levels of urogenital symptoms (β = -0.195, p = 0.005), which mediated its indirect significant effects on the somatic-vegetative and psychological symptoms of menopause (β = -0.046, -0.067; both p values = 0.004, respectively), especially in BRCA2 carriers and in women who were currently physically active, premenopausal at the time of RRSO, had a high BMI, and had no history of breast cancer. It increased the severity of urogenital symptoms in women with a history of cancer. MBSR, on the other hand, was associated with indirect increases in the intensity of the somatic-vegetative and psychological symptoms of menopause (β = 0.108, 0.029; p = 0.003, 0.033, respectively). It exerted positive direct effects on different menopausal symptoms in multigroup analysis. The results suggest that young women undergoing recent RRSO may benefit from HRT at an individual level, while their need for extensive measures to optimize their psychological wellbeing is ongoing. The adverse effects of MBSR, which are captured in the present study, imply that MBSR may interfere with redox sensitivity associated with estradiol fluctuations in BRCA1/2 carriers. Investigations are needed to test this hypothesis and elaborate on the underlying mechanisms in these women.

The effect of mindfulness-based stress reduction on caregiving in romantic relationships of overweight women: A quasi-experimental design

The effect of mindfulness-based stress reduction on caregiving in romantic relationships of overweight women: A quasi-experimental design

Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction during Pregnancy on Fetal Brain Development Detected by Neurosonography: A Secondary Analysis of a Randomized Clinical Trial (IMPACT BCN).

We investigated whether structured maternal lifestyle interventions based on Mediterranean diet or stress reduction influence fetal-infant neurodevelopment detected by detailed fetal neurosonography and Ages and Stages Questionnaires 3rd edition (ASQ) at 12 months old. This was a secondary analysis of a randomized clinical trial (2017-2020), including 1,221 singleton pregnancies at high risk for small-for-gestational age. Participants were randomized into three groups at 19-23 weeks' gestation: Mediterranean diet intervention, stress reduction program, or usual care. A detailed neurosonography was performed on 881 participants at mean (SD) 33.4 (1.1) weeks' gestation. Neurosonographic measurements were done offline. ASQ was performed on 276 infants at 1 year of corrected age. Biparietal diameter was similar among study groups. Mediterranean diet group fetuses had deeper insula (26.80 [1.68] versus 26.63 [1.75], mm, p = 0.02) and longer corpus callosum (42.98 [2.44] versus 42.62 [2.27], mm, p = 0.04), with a lower rate of suboptimal score infants in ASQ problem-solving domain (6.2 vs. 16.3%, p = 0.03). Stress reduction group fetuses had deeper insula (26.90 [1.75] versus 26.63 [1.75], mm, p = 0.04) and lower rates of suboptimal score infants in ASQ fine motor domain (4.3 vs. 12.8%, p = 0.04), compared to usual care group fetuses. Maternal structured intervention during pregnancy of the trial has the potential to modify offspring's neurodevelopment.

Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion: A subanalysis of the IMPACT BCN randomized clinical trial.

The IMPACT BCN trial-a parallel-group randomized clinical trial where 1221 pregnant women at high risk for small-for-gestational age (SGA) newborns were randomly allocated at 19- to 23-week gestation into three groups: Mediterranean diet, Mindfulness-based Stress reduction or non-intervention-has demonstrated a positive effect of Mediterranean diet and Stress reduction in the prevention of SGA. However, the mechanism of action of these interventions remains still unclear. The aim of this study is to investigate the effect of Mediterranean diet and Stress reduction on placental volume and perfusion. Participants in the Mediterranean diet group received monthly individual and group educational sessions, and free provision of extra-virgin olive oil and walnuts. Women in the Stress reduction group underwent an 8-week Stress reduction program adapted for pregnancy, consisting of weekly 2.5-h and one full-day sessions. Non-intervention group was based on usual care. Placental volume and perfusion were assessed in a subgroup of randomly selected women (n = 165) using magnetic resonance (MR) at 36-week gestation. Small placental volume was defined as MR estimated volume <10th centile. Perfusion was assessed by intravoxel incoherent motion. While mean MR placental volume was similar among the study groups, both interventions were associated with a lower prevalence of small placental volume (3.9% Mediterranean diet and 5% stress reduction vs. 17% non-intervention; p = 0.03 and p = 0.04, respectively). Logistic regression showed that small placental volume was significantly associated with higher risk of SGA in both study groups (OR 7.48 [1.99-28.09] in Mediterranean diet and 20.44 [5.13-81.4] in Stress reduction). Mediation analysis showed that the effect of Mediterranean diet on SGA can be decomposed by a direct effect and an indirect effect (56.6%) mediated by a small placental volume. Similarly, the effect of Stress reduction on SGA is partially mediated (45.3%) by a small placental volume. Results on placental intravoxel incoherent motion perfusion fraction and diffusion coefficient were similar among the study groups. Structured interventions during pregnancy based on Mediterranean diet or Stress reduction are associated with a lower proportion of small placentas, which is consistent with the previously observed beneficial effects of these interventions on fetal growth.

Exploring the Interpersonal Outcomes of Mindfulness-Based Stress Reduction Training Among Police Employees

Police employees have an essential role in sustaining safety and harmony within communities, and they need to stay well as individuals in order to achieve this. Yet, their stressful work environment does not always afford optimal interpersonal interactions. In collaboration with the Dutch police force, the present project explored the effects of a mindfulness-based stress reduction (MBSR) training on the fostering of constructive interpersonal responses as well as individual well-being among employees of the Dutch police. In total, 133 police employees participated in a non-randomized waitlist controlled MBSR intervention. Participants filled out four online questionnaires spread evenly over a period of six months on constructive interpersonal responses and individual well-being. Linear mixed-effects analyses showed increases on various indicators of constructive interpersonal responding and individual well-being from pre-to post-training. These results were largely maintained at two-month follow-up. Interestingly, the positive effects of mindfulness intervention did not generalize across all measures of constructive interpersonal responding. Moreover, more frequent home practice predicted training benefits. We discuss the theoretical and practical implications of these findings.

The Effectiveness of Mindfulness-Based Stress Reduction (MBSR) to Increase the Academic Resilience of New Class X High School Students: Literature Review

The Effectiveness of Mindfulness-Based Stress Reduction (MBSR) to Increase the Academic Resilience of New Class X High School Students: Literature Review

The Effectiveness of Mindfulness-Based Stress Reduction on Quality of Life, Emotional Distress, and Pain Intensity among Women with Breast Cancer

Background: The purpose of this study was to investigate the effectiveness of mindfulness-based stress reduction training on improving quality of life, emotional distress, and pain intensity among women with breast cancer. Methods: In this semi-experimental research, a pretest-post-test design with a control group (unequal) was used. Its statistical population included all women with breast cancer in Sirjan city in 2021. Forty women with breast cancer in Sirjan city in 2021 were selected using the convenience sampling method and randomly assigned to either the experimental or control group. At first, a pre-test was taken from both groups. Then, mindfulness-based stress reduction training was implemented for the experimental group, and no intervention was performed for the control group. To collect data, the quality-of-life questionnaire of the World Health Organization and the emotional distress questionnaire were used. The research data were analyzed using covariance analysis. Results: The quality-of-life scores in the experimental group increased from 20.54 in the pre-test phase to 85.97 in the post-test phase and decreased from 48.85 to 39.05 in the control group. The emotional distress score in the experimental group decreased from 100.05 in the pre-test to 51.40 in the post-test stage. In the control group, the emotional distress decreased from 107.1 in the pretest to 103.7 in the post-test stage. Also, in the experimental group, the pain intensity scores decreased from 8.60 in the pre-test to 4.35 in the post-test. In the control group, the pain intensity decreased from 7.20 in the pre-test to 7.80 in the post-test. Conclusion: Stress reduction methods based on mindfulness can be effective in the quality of life, emotional distress, and pain intensity in women with breast cancer. According to the results, it seems necessary for nurses, doctors, and patients to cooperate with psychologists to carry out interventions.

The mental health of nursing students during the COVID-19 pandemic: Beneficial effects of mindfulness-based stress reduction

BackgroundFollowing the COVID-19 global emergency, health students were faced with increased workloads, university closures, study interruptions, loss of peer support networks, and the challenges of volunteer work in hospitals. These factors caused health students to experience significant stress and anxiety, highlighting the necessity of psychological interventions for this group. Several studies have reported that a mindfulness-based stress reduction (MBSR) protocol offers valuable coping skills for traumatic events. This study aimed to investigate the impact of Mindfulness-Based Stress Reduction (MBSR) on stress, anxiety, and depression among nursing students at Qom University of Medical Sciences during the COVID-19 pandemic. MethodThis experimental study was conducted on 72 nursing students from the nursing faculty of Qom University of Medical Sciences in 2020. The sampling was conducted using stratified sampling, and the allocation method employed was simple randomization. MBSR intervention based on social networks was implemented for the experimental group. The Stress-Anxiety-Depression Assessment Questionnaire (DASS-21) was completed by both groups before the study commenced, immediately after, and 2 months post-intervention. Data were analyzed in SPSS-16 using t-test, chi-square, and repeated measures analysis. ResultsAnalysis of variance with repeated measures showed that in the experimental group, the effect of time on the average score of stress, anxiety, and depression is significant (p < 0.001). The t-test showed significant differences between the two groups in terms of stress, anxiety, and depression scores immediately after the intervention (p < 0.001) and in the follow-up phase (p < 0.001). ConclusionsMBSR based on social networks is effective and applicable in reducing stress, anxiety, and depression among nursing students during the COVID-19 pandemic. It is suggested that MBSR should be included in the curriculum of nursing students so that they can have the necessary mental preparation to face acute critical conditions such as COVID-19.

Impact of ‘web-based mindfulness based stress reduction combined with solution-focused intervention on dementia caregivers’ negative affect

Objective: This study aims to explore the effects of web-based mindfulness-based stress reduction (MBSR) combined with focused solution mode on alleviating negative emotions in dementia caregivers. Methods: Sixty dementia caregivers were randomly assigned to either a control group receiving conventional guidance or an intervention group receiving MBSR combined with focused solution mode in addition to conventional guidance. The intervention lasted for 8 weeks. Changes in depression-anxiety-stress scale 21 (DASS-21) and Zarit caregiver burden inventory (ZBI) scores were compared between the two groups before and after the intervention. Results: After 8 weeks of intervention, caregivers in the intervention group showed significant decreases in depression, anxiety, stress, and total DASS-21 scores as well as total ZBI score (P&lt;0.001), all of which were lower than those of the control group (P&lt;0.001). Conclusion: MBSR combined with focused solution mode can effectively improve negative emotions and reduce burden levels in dementia caregivers, and is worth promoting and applying in clinical settings.