Shot Effect Research Articles

Evolution of Technical-Tactical Performance Indicators in College Men’s Football Players (U.S. NCAA Division I)

Background: Players, through the different stages of their development, increase their performance due to their maturation process, training, and the increase in their experiences. The college competition in the US allows players to train and compete in a stable context over 4 years in their transition from U18 to senior level. Objective: The objective of the study was to analyse the evolution of game statistics as a function of the year of college of NCAA Division I men’s players. Methodology: The sample was 52,852 Division I National Collegiate Athletic Association (NCAA) players of the United States (2010-2021 seasons). The study design was retrospective non-experimental. The variables studied were games played, games as a starter, points, goals, assists, shot attempts, shots on goal, effectiveness of attempts, effectiveness of shots on goal, fouls, yellow cards, and red cards. To establish the evolution between players from top and bottom teams, one-way ANOVA was used. To analyse the differences according to the top and bottom teams, a T-test and discriminant analysis were performed. Results: The older, more experienced, and trained players were, the more they participated in the game, both in terms of games played and in terms of game actions (assists, shots, and goals). The increase in the effectiveness of shots and shots on goal shows that the evolution in training and experience leads to higher player skill. Conclusion: These findings highlight the importance of experience, training, and maturity in the performance of U-23 male football players.

Comparison of adverse events following the second/third dose of BNT162b2 in a medical institute in Japan

BackgroundVaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are crucial for ending the pandemic of coronavirus disease 2019 (COVID-19). Currently, the cumulative effect of booster shots of mRNA vaccines on adverse events is not sufficiently characterized. MethodsA survey-based study on vaccine adverse events was conducted in a Japanese medical institute after the third dose of Pfizer BNT162b2. Adverse events were grouped using network analysis, and a heteroscedastic probit model was built to analyse adverse events. ResultsThere were two main clusters of adverse events, systemic and local injection site-associated events. Subject background and the experience of previous vaccine-related adverse events were variably associated with the occurrence and intensity of adverse events following the third dose. Among adverse events, only lymphadenopathy increased prominently following the third dose, while the largest increase in other systemic adverse events occurred generally following the second dose. ConclusionsThe effect of repeated booster vaccines on the frequency and intensity of adverse events differs depending on the kind of adverse event.

Sensitivity evaluation of optical receiver mixers

In optical receivers for realisation of procedures of heterodyning of a signal, both at a stage of formation, and at reception, as a rule, diodes are used. At the same time diodes, being electronic devices, are characterised by internal noises, which limit the sensitivity of reception. The nature of internal noise of electronic devices is determined by thermal processes and shot effect, which in their turn are determined not only by the ambient background temperature, but also by the frequency of received radiations. To present the results of estimation of the threshold sensitivity of diode mixers in heterodyning paths of optical receivers. Results are presented on the development of an approach to sensitivity estimation of heterodyne receiver mixer estimation. Estimation expressions for calculating the internal noise level of an optical mixer are obtained. The approach of shot noise estimation characterising the threshold sensitivity from the position of noise temperature is proposed. Simplified expressions of dependence of threshold sensitivity as a function of radiation frequency at a given temperature are obtained. Noise values in terms of temperature for different frequencies are calculated. A practical method of measuring the noise temperature, which characterises the sensitivity of reception, based on measuring the output voltage when receiving signals from sources with known temperatures of emitters, is substantiated. The values of the signal-to-noise ratio of the threshold sensitivity for different frequency ranges are presented. The obtained analytical expressions allow us to conclude that the rational solution is the choice of the frequency range in the region of 0.1…1 THz, because it is characterised by a relatively low noise temperature, but at the same time it is able to provide a high speed of message transmission.

Residual stress and crystallite size analysis of SMAT on AA7075-T6

The study examines how SMAT influences the microstructure, dislocation density, and residual stress of AA7075-T6 alloy. SMAT involves the repeated impact of shots on a material surface within a vibration chamber, inducing severe plastic deformation and grain refinement. The study explores the interplay between vibration-induced shot effects and their impact on surface properties, emphasizing the importance of optimizing process parameters for improved material performance. Experimental analyses, including surface and subsurface microstructure examinations, X-ray diffraction (XRD) characterization, and residual stress evaluations, are conducted to elucidate the underlying mechanisms of SMAT. Results indicate that SMAT leads to significant plastic deformation, grain size reduction, increased dislocation density, and microstrain. The treatment produces a nanocrystallite layer, enhancing material properties. Residual stress measurements reveal a surface stress of −245 MPa, increasing to −360 MPa at 50 µm depth. The proposed multiple impact model accurately predicts deformation behavior, highlighting the deep pit regions formed during SMAT. This comprehensive investigation provides insights into the dynamic nature of SMAT and its potential for enhancing material properties. By integrating experimental findings with numerical modeling approaches, the study advances our understanding of SMAT-induced plastic deformation mechanisms and residual stress profiles.

Influences of vaccination and public health strategies on COVID-19 dynamics in the United States: Evaluating policy impacts, behavioral responses, and variant proliferation

Background and Aim: The United States (US) government implemented interventions against COVID-19, but their effects on variant-related risks remain inconclusive. We aimed to assess the causal effects of vaccination rates, booster uptakes, face mask mandates, and public area mobility (societal behavioral factor) on early-stage COVID-19 case and death growth rates and identify the most effective public health response for controlling COVID-19 in the US. Materials and Methods: We performed retrospective analyses using four standard correlated random effects models, analyzing a robust panel dataset that encompasses 16,700 records across all fifty US states. Models 1 and 3 analyzed COVID-19 case rates and death growth rates, respectively, from January 2021 to November 2021. In contrast, using the data from August 2021 to November 2021, Models 2 and 4 assessed the effect of Delta variants and booster shots on COVID-19 case and death growth rates, respectively. Results: We found that face mask mandate (p < 0.01) and workplace mobility (p < 0.05) led to lower COVID-19 case growth rates. COVID-19 vaccination uptake rate reduced COVID-19 death growth rates (p < 0.01). Furthermore, contrary to Epsilon variant (p < 0.01), which contributed to reduced COVID-19 case growth rates, Delta variant led to significant increases in COVID-19 cases (p < 0.001). Conclusion: This study suggests that immediate public health interventions, like mask mandates, are crucial for crisis mitigation, while long-term solutions like vaccination effectively address pandemics. The findings of this study not only sheds light on the recent pandemic but also equips policy-makers and health professionals with tools and knowledge to tackle future public health emergencies more effectively. Keywords: COVID-19, face mask mandate, public mobility, vaccination, variants.

Association between levels of receptor binding domain antibodies of SARS-CoV-2, receipt of booster and risk of breakthrough infections: LA pandemic surveillance cohort study

Prevention of COVID-19 with vaccine requires multiple doses and updated boosters to maintain protection; however currently there are no tests that can measure immunity and guide clinical decisions about timing of booster doses. This study examined the association between the risk of COVID-19 breakthrough infections and receptor binding domain (RBD) antibody levels and receipt of booster of COVID-19 vaccines. A community sample of Los Angeles County adults were surveyed between 2021 and 2022 to determine if they had a self-reported breakthrough infection. Predictors included RBD antibody levels, measured by binding antibody responses to the ancestral strain at baseline and self-reported booster shot during the study period. Of the 859 participants, 182 (21%) reported a breakthrough infection. Irrespective of the level of antibodies, the risk of breakthrough infection was similar, ranging from 19 to 23% (P = 0.78). The risk of breakthrough infections was lower among participants who had a booster shot (P = 0.004). The protective effect of a booster shot did not vary by antibody levels prior to receiving the booster. This study found no association between RBD antibody levels and risk of breakthrough infections, while the receipt of booster was associated with lower risk of breakthrough infections, which was independent of pre-booster antibody levels. Therefore, antibody levels might not be a useful guide for clinical decisions about timing of booster doses.

Exploring the structure of the shot effectiveness model for elite table tennis players

BackgroundCurrently, technical and tactical analysis has become an indispensable task for sport in many countries. Many studies analysed players’ specific technical and tactical factors, but it is rare to quantitatively analyse the importance of table tennis players’ shot effectiveness. This is the first study to propose the new concept of “shot effectiveness model”, and the purpose of this study is to explore the structure of the shot effectiveness model for elite table tennis, including the importance degree of shot effectiveness, and the relationship between them.Methods258 matches were selected between the top 50 players in the world from 2019 to 2021 as samples. Multiple regression analysis was used to obtain the standard regression coefficients and game simulation, and the total decision coefficient (TDC) was used to evaluate the importance degrees of shot effectiveness (SE) on match results.Results(1) There was little difference in the importance degree of each shot effectiveness between men and women players. (2) The importance degree of the first and third shots (SE1), the second and fourth shots (SE2), the fifth and after shots (SE3), and the sixth and after shots (SE4) for both men and women players account for approximately 25%, 35%, 22%, and 16% respectively. (3) There was little difference in the importance degree of each shot effectiveness between Chinese women players and women players from other countries and regions with the same importance order of SE2 > SE1 > SE3 > SE4. However, the structure of the shot effectiveness model for men players was quite different from that for women players. (4) There is a compensation effect between shot effectiveness of table tennis players, and the total evaluation score of 12 and 13 is the dividing line for success or failure in both men and women matches.ConclusionsTDC could well reflect the important degrees of each shot effectiveness in various ways on winning probability in table tennis matches. And this study compared the importance of several types of players’ performance on the probability of winning a match. In addition, we found that there is a compensation effect between shot effectiveness of table tennis players, and the magnitude of this effect will vary according to the type and level of shot effectiveness.

The Feeling of Pleasure for Overweight Children during Different Types of Physical Activity.

The feeling of pleasure during physical education (PE) could increase with physical activity participation and adherence for overweight children. While traditional games are known to have positive benefits on motor skill development, especially for children with poorer motor skills, and on the body mass of children, little is known about overweight children's feelings of enjoyment when playing these games. To identify a program of physical activity appreciated by overweight children, we tested the effect of different activities, namely soccer (SO), shot put (SP), and traditional motor games (TMGs), on the feelings of pleasure for 28 overweight male children (aged 12.11 ± 0.63 years, BMI 26.89 ± 0.15 kg·m-2) participating in a 3-month cross-over study. To measure affective responses to exercises, we applied a validated feeling scale. The data were collected during eight PE lessons, which were organized for each cycle taught. Post hoc pairwise comparisons revealed a significant difference (Z = -3.195, p < 0.01) between the mean feeling score reported after the SO cycle (2.48 ± 0.41) and that after the TMGs (3.04 ± 0.32). A similar significant difference (Z = -3.304, p < 0.01) was found between the mean feeling scores reported after the SP cycle (2.27 ± 0.32) and the TMGs (3.04 ± 0.32). There was no significant difference between the mean feeling scores reported after the SO (2.48 ± 0.41) and SP cycles (2.27 ± 0.32). In conclusion, the findings of the present study suggest that TMGs may have beneficial effects on the feelings of pleasure for overweight children. Therefore, TMGs might potentially be considered as an alternative to conventional physical activities.

Inactivated SARS-CoV-2 booster vaccine enhanced immune responses in patients with chronic liver diseases

Chronic liver disease (CLD) entails elevated risk of COVID-19 severity and mortality. The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear. Therefore, we conducted a cross-sectional study involving 237 adult CLD patients and 170 healthy controls (HC) to analyze neutralizing antibodies (NAbs) against SARS-CoV-2 prototype and BA.4/5 variant, anti-receptor binding domain (RBD) IgG, and total anti-SARS-CoV-2 antibodies. Serum levels of the total anti-SARS-CoV-2 antibodies, anti-RBD IgG and inhibition efficacy of NAbs were significantly elevated in CLD patients after the booster dose compared with the pre-booster dose, but were relatively lower than those of HCs. Induced humoral responses decreased over time after booster vaccination. The neutralization efficiency of the serum against BA.4/5 increased but remained below the inhibition threshold. All four SARS-CoV-2 antibodies, including total anti-SARS-CoV-2 antibodies, anti-RBD IgG and NAbs against prototype and BA.4/5, were lower in patients with severe CLD than those with non-severe CLD. After booster shot, age and time after the last vaccine were the risk factors for seropositivity of NAb against BA.4/5 in CLD patients. Additionally, white blood cell counts and hepatitis B core antibodies were the protective factors, and severe liver disease was the risk factor associated with seropositivity of total anti-SARS-CoV-2 antibodies. Overall, our data uncovered that antibody responses were improved in CLD patients and peaked at 120 days after the booster vaccines. All antibodies excepting total anti-SARS-CoV-2 antibodies declined after peak. CLD patients exhibited impaired immunologic responses to vaccination and weakened NAbs against BA.4/5, which hindered the protective effect of the booster shot against Omicron prevalence. Cellular immune responses should be further evaluated to determine the optimal vaccine regimen for CLD patients.

EFFECT OF SHOT BLASTING PARAMETERS ON THE WATER CONTACT ANGLE ON THE SURFACE OF ADDITIVELY MANUFACTURED AlSi10Mg ALUMINUM ALLOY

In this paper, the effect of shot blasting parameters such as time, pressure, and grit size were studied over the water contact angle of additively manufactured aluminum alloy (AlSi10Mg) surfaces. The Taguchi L9 orthogonal array was implied to set the correlations and interactions between the shot blasting parameters and water contact angle as output parameters. The analysis of variance establishes a good agreement with the results, revealing the time as the most significant parameter with a 41.98% contribution, followed by the pressure (41.57%) and grit size (16.43%). Further, the roughness measurements and scanning electron microscopy analysis of the shot-blasted surfaces validate the variations in the water contact angle.

The effectiveness of the program for improving tactical actions in the attack of student teams in 3x3 basketball

The purpose of the study is to find out the change in the tactical indicators of the competitive activity of student teams in 3x3 basketball under the influence of the program for improving tactical preparedness. Research organization. The pedagogical experiment was conducted with the involvement of qualified teams of 3x3 basketball players of the experimental group (n=12) and the control group (n=12). At the beginning of the experiment, we analyzed 64 games for the experimental and control groups with the determination of quantitative and qualitative data of the indicated indicators of competitive activity in 3x3 basketball. At the end of the experiment, 56 games were analyzed for the experimental group and 62 games for the control group according to the indicated indicators of competitive activity. The following indicators were determined: general group (number of points scored per game, total and "net" playing time), adjacent group (total number of rebounds, number of rebounds on the "own" and "alien" boards, the number of ball losses and the number of made and interceptions), shooting group (number of attacks and throws, number of one-point, two-point and free throws, their effectiveness and efficiency), technical-tactical group (number of individual and group tactical actions, their effectiveness and efficiency, number of group tactical actions of different duration with differentiation by the cost of the throw). Research results. At the end of the pedagogical experiment in the control group, there were significant changes in 13 of the 59 indicators that were studied. In the experimental group, probable changes were recorded in 35 out of 59 indicators of competitive activity of qualified teams in 3x3 basketball. These include more points scored, overall attack efficiency, better two-point shooting efficiency, etc. Intergroup differences at the end of the pedagogical experiment were established in 36 out of 59 indicators, namely in the time characteristics of the game, overall efficiency, effectiveness of two-point shots, effectiveness and efficiency of group offensive actions. Conclusions. As a result of the study, it was established that in the experimental group, the indicators of the number of points scored on average per game increased by 1.5 points (p&lt;0.01), the total and "net" time of the game decreased, which indicates an increase in the intensity of the game. In the experimental group, a smaller number of ball pickups on the "alien" shield and the number of ball losses were recorded. According to the results of the pedagogical experiment, a significant decrease in the quantitative performance of individual tactical actions and an increase in the number of group tactical actions in the experimental group were recorded.

Multi-impact response of CR4 mild steel: characterising the transition from absorption to failure

Single impact perforation shots are well understood for various target materials and different shaped projectiles. Although considered a rare case, localised multi-impacts are not well understood as they involve both perforating and non-perforating impacts on the target. The lack of understanding of non-perforating impact on metallic materials makes it tough to predict the change in the material’s mechanical performance. Given the widespread use of metallic materials for protective applications, it is important to understand the material response when subject to multiple impacts. To determine the effect of a non-perforating shot on CR4 mild steel and establish a minimum energy impact that will define the transition point whereby the metal can no longer absorb energy a series of impact experiments were conducted. Results show a subsequent perforation event occurs at a lower than the experimentally determined perforation velocity. Results suggest that there could be a direct correlation between the material thickness and the critical crater depth (the depth of crater required to affect the materials ability to absorb energy, the measure of materials performance). As the crater depth increased from 3 mm to 8.5 mm for the first shot, the energy absorption of the steel plate reduced by 25%. This allowed the residual performance for CR4 mild steel to be quantified for a known impact crater, giving a 7% performance loss for every millimetre the critical crater depth grows beyond 3 mm until the point of failure.

The interactions between incoming shot flow and structural target in a Flap Shot Peening process

A novel numerical modeling approach capable of computing and simulating the Flap Shot Peening (FSP) dynamic process of industrial interest was proposed by the coupling of the Discrete Element Method (DEM) and Finite Element Method (FEM). During the process of shots impacting the metallic target, the shot flow and the target were respectively modeled by DEM and FEM, and the interaction between the shots and structure was efficiently evaluated by DEM-FEM. This approach can be employed to rationally control and regulate the FSP multiple parameters, which would induce an appropriate distribution of Compressive Residual Stress (CRS) within the target to provide additional resistance to the treated component. In this paper, a benchmark was first performed to verify the computational method successfully. Further, the influence of variant mass flow rates on the target was also investigated. The result shows that low mass flow rates can be replaced by a higher mass flow rate in case both were able to generate a similar shot effect.

Handball Offensive Analysis: Comparative Evolution of Linear Tendency Lines between Finalist Teams in the EHF CL

(1) Background: This study aims to analyze the evolution of the finalist teams in five years of the EHF Champions League and compare winning teams with defeated teams, presenting their evolution along the competition from the quarterfinals to the final; (2) Methods: A total of 35 games were analyzed, corresponding to four games per team over five seasons. Tendency lines were created according to the 13 offensive indicators of winning teams, divided into three macro categories: game actions, goals, and effectiveness of shots; (3) Results: The results indicated 21 linear tendency lines valid for the study. Winning teams presented five increasing lines (ascending line) and 16 decreasing lines (negative slope) during the competition. Assists, goals from the 6 m, and effectiveness at 6 m shots presented an increasing tendency line for winning teams, and the effectiveness of shots, the effectiveness of the organized attack, and the effectiveness of shots from 9–6 m presented a decreasing tendency line; (4) Conclusions: winning teams have more constancy during the competition. Due to the expected increased difficulty in successive matches, tendency lines tend to present decreasing slopes as teams advance toward the final. Nevertheless, winning teams need to adapt to the increasing challenge, describing growth in some key indicators, and being more regular than other teams.

Datumetine Preferentially Upregulates N-methyl-D-aspartate Receptor Signalling Pathways in Different Brain Regions of Mice.

We previously reported that datumetine possesses binding affinity with N-methyl-D-aspartate receptor (NMDAR) and that 14-day exposure to datumetine altered NMDAR signaling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. 30 male adult BALB/c mice were used for the study. The mice were randomly divided into three groups of ten mice each with an intraperitoneal injection of 0.1 mL of 10% DMSO for the Vehicle group, Datumetine group were administered 0.1 mg/kg body weight (bw) of datumetine and MK-801+Datumetine group were administered 0.5 mg/kg bw of MK-801 (to block NMDAR) followed by 0.1 mg/kg bw of datumetine after 30 minutes. 24 hours after administration, mice were euthanized in an isoflurane chamber followed by perfusion with 1X PBS. Brains were excised and stored at -20°C till further processing. Mice designated for IHC were further perfused with 4% PFA and brain excised and stored in 4% PFA till further processing. NMDAR signalling molecules expression was evaluated in frozen brain samples and the fixed brain samples were stained for neuron, vGlut and NMDAR subtypes. Relative to vehicle (Veh), datumetine downregulate calcium calmodulin kinase II alpha (CamKIIα) expression in the hippocampus and prefrontal cortex (PFC) but not in the cerebellum, cyclic AMP response element binding protein (CREB) was also upregulated only in the PFC but phosphorylated CREB (pCREB) was also upregulated in three brain regions observed, while brain-derived neurotrophic factor (BDNF) was only upregulated in hippocampus and PFC of Datumetine relative to vehicle (Veh). On the other hand, dizocilpine (MK-801) reversed some of the effects of datumetine in the observed brain regions. No major histological alterations were observed in the different brain regions immunohistochemically. We conclude that a low dose of datumetine moderately enhances NMDAR activity. This showed the neuroprotective potentials of low datumetine exposure.

Breakthrough infections, hospital admissions, and mortality after major COVID-19 vaccination profiles: A prospective cohort study.

Several COVID-19 vaccination rollout strategies are implemented. Real-world data from the large-scale, government-mandated Central Vaccination Center (CVC), Thailand, could be used for comparing the breakthrough infection, across all available COVID-19 vaccination profiles. This prospective cohort study combined the vaccine profiles from the CVC registry with three nationally validated outcome datasets to assess the breakthrough COVID-19 infection, hospitalization, and death among Thais individuals who received at least one dose of the COVID-19 vaccine. The outcomes were analyzed by comparing vaccine profiles to investigate the shot effect and homologous effect. Of 2,407,315 Thais who had at least one dose of COVID-19 vaccine, 63,469 (2.75%) had breakthrough infection, 42,001 (1.79%) had been hospitalized, and 431 (0.02%) died. Per one vaccination shot added, there was an 18% risk reduction of breakthrough infection (adjusted hazard ratio [HR] 0.82, 95% confidence interval [CI] 0.80-0.82), a 25% risk reduction of hospitalization (HR 0.75, 95% CI 0.73-0.76), and a 96% risk reduction of mortality (HR 0.04, 95% CI 0.03-0.06). The heterologous two-shot vaccine profiles had a higher protective effect against infection, hospitalization, and mortality compared to the homologous counterparts. COVID-19 breakthrough infection, hospitalization, and death differ across vaccination profiles that had a different number of shots and types of vaccines. This study did not involve any funding.

Показники змагальної діяльності команд різної кваліфікації у баскетболі 3х3

The purpose of the study was to determine the qualification differences in the structure and content of the competitive activity of teams of different qualifications in 3x3 basketball. Materials and methods. Indicators of competitive activity of highly qualified teams in 22 games of the 2018 World Cup and indicators of competitive activity of qualified teams in 38 games were analyzed. Quantitative indicators of execution and implementation of technical and tactical actions were identified and their effectiveness was calculated in five groups of indicators. Results and discussion. The average indicators of the duration of the game of teams of high qualification are smaller both in the total time of the game and in the indicators of "net" time. The number of executions and the effectiveness of one-point shots are higher in skilled teams, but the efficiency of the specified component is higher in highly skilled teams. The performance of two-point shots (number of shots, effectiveness and efficiency) is higher in highly skilled teams. In the indicators of the adjacent group, significant differences were recorded only in the total number of losses per game, which confirms the high intensity of the game in the competitions of highly qualified teams. The study of the differences in the indicators of the tactical group revealed that the skilled teams reliably prevail in the number of offensive actions with the help of individual actions. However, at the same time, the efficiency indicators are better in highly qualified teams. A study of the indicators of conducting attacks with the help of group tactical actions showed that the advantage in almost all indicators is on the side of highly skilled teams, except for the number of one-point shots and the efficiency of the implementation of two-point shots. Differentiation of group tactical actions by duration (number of passes) showed that highly skilled teams prefer longer attacking actions in order to bring the player to a comfortable position for a shot. Conclusion. Characteristic features of the structure and content of the competitive activity of teams of different qualifications are a shorter duration of the game, a smaller number of attacks and throws by highly qualified teams, higher indicators of the effectiveness and efficiency of throws by highly qualified teams, and the absence of differences in the effectiveness of free throws. Qualified teams have significantly more turnovers. The overall quantitative indicators of execution and effectiveness, indicators of execution and effectiveness of one-point shots during the use of individual tactical actions by players of highly qualified teams are significantly lower (p &lt;0.01) than the mentioned indicators of qualified teams. It was found that the group tactical actions of highly qualified teams are aimed at completing attacks with a two-point shot, which in most cases is confirmed by a significant advantage (р &lt;0.01) over the indicators of quantitative performance and performance of qualified teams. However, at the same time, the indicators of the performance of two-point shots are not significant (p &gt;0.05), but better in qualified teams

"Investigation of the effect of shot blasting on the surface properties of the HA coatings processed by the EPD method "

"Investigation of the effect of shot blasting on the surface properties of the HA coatings processed by the EPD method "

"Investigation of the effect of shot blasting on the surface properties of the HA coatings processed by the EPD method "

"Investigation of the effect of shot blasting on the surface properties of the HA coatings processed by the EPD method "

Cost-Effectiveness of COVID-19 Sequential Vaccination Strategies in Inactivated Vaccinated Individuals in China.

To effectively prevent and control the COVID-19 pandemic, countries have adopted a booster vaccination strategy. This study aimed to estimate the cost-effectiveness of sequential booster COVID-19 vaccination compared to two-dose inactivated vaccination in China from a societal perspective. A Markov model was developed to estimate the cost-effectiveness of sequential vaccination, including two doses of an inactivated vaccine followed by a booster shot of an inactivated vaccine, adenovirus vectored vaccine, protein subunit vaccine, or mRNA vaccine. The incremental effects of a booster shot with an inactivated vaccine, protein subunit vaccine, adenovirus vectored vaccine, and mRNA vaccine were 0.0075, 0.0110, 0.0208, and 0.0249 QALYs and saved costs of US$163.96, US$261.73, US$583.21, and US$724.49, respectively. Under the Omicron virus pandemic, the sequential vaccination among adults and the elderly (aged 60–69, 70–79, over 80) was consistently cost-saving, and a booster shot of the mRNA vaccine was more cost-saving. The results indicate that the sequential vaccination strategy is cost-effective in addressing the COVID-19 pandemic, and improving vaccination coverage among the elderly is of great importance in avoiding severe cases and deaths.