The purpose of the article is to analyze contemporary problems of cultural and educational activity in museums of the artistic profile, to determine the role and effectiveness of psychological methods, in the context of working with visitors of different ages. Research methodology . An interdisciplinary approach has been applied, using analysis, synthesis and generalizations methods. The scientific novelty of the research is that this article launches an analysis of cultural and educational activities of art museums from the standpoint of museum psychology in Ukrainian museums. Conclusions . Today, the problems of using psychological methods in the cultural and educational work of domestic art museums are not sufficiently studied. In Ukraine museum psychology is developing as part of cultural and educational work and museum pedagogy. The effectiveness of the museum information perception by museum visitors depends on many factors, among which the study of needs and interests of museum visitors, the interpretation of expositions taking into account the principles of developmental psychology and sensory perception are important. At the beginning of the 21st century, the development of trends in differentiated and multisensory approaches to the interpretation of museum displays is observed. In the cultural and educational activities with modern visitors, innovative, art-therapeutic, sensory, multimedia and virtual technologies are used. These funds, taking into account the principle of museum psychology, diversify the processes of transmitting cultural experience in domestic museums, and bring cultural and educational activities to a qualitatively new level of development.