Effects Of Modalities Research Articles

The Influence Mechanism of Screw Internal Fixation on the Biomechanics of Lateral Malleolus Oblique Fractures.

It remains inconclusive about the stability and optimal fixation scheme of screw internal fixation for lateral malleolus oblique fractures in clinical practice. In this study, the effects of different screw internal fixation methods on the biomechanics of lateral malleolus oblique fractures were investigated. These efforts are expected to lay a theoretical foundation for the selection of internal fixation methods and rehabilitation training regimens in the treatment of lateral malleolus fractures. A healthy ankle joint model and a lateral malleolus fracture internal fixation model were established based on CT data with the aid of some software. Besides, the effects of screw internal fixation modalities on the fracture displacement of fibula fractures, fibula Von Mises stress, and screw Von Mises stress under different physiological conditions and loading conditions were investigated using finite element methods (FEMs) and invitro physical experiments. The double screw vertical fibular axis internal fixation approach had the lowest fracture displacement of fibula fractures and screw Von Mises stress values; while the double screw vertical fracture line internal fixation approach had the lowest fibula Von Mises stress values. Under different physiological conditions, the magnitude of the peak Von Mises stress of the fibula and screw was ranked as plantarflexion 20° > plantarflexion 10° > neutral position > dorsiflexion 10° > dorsiflexion 20°; and the magnitude of the peak displacement of the fibula fracture breaks was ranked as plantarflexion 20° > plantarflexion 10° > neutral position > dorsiflexion 20° > dorsiflexion 10°. The results of invitro physical experiments and finite element analyses were in good agreement, which validated the validity of finite element analyses. The vertical fracture line screw implantation method displays a better load-sharing ability; while the vertical fibular axis screw implantation method exhibits a better ability to prevent axial shortening of the fibula and also reduces the risk of screw fatigue damage. Overall, the double screw achieves better therapeutic effects than the single screw. Given that the ankle joint has high stability in the dorsiflexion position, it is recommended to prioritize dorsiflexion rehabilitation training, rather than dorsiflexion and plantarflexion rehabilitation training with too large angles, in the treatment of lateral malleolus fractures.

Neutrophil but not lymphocyte response to matched interval and continuous running differs between protocols and sex.

When considering the acute effects of different modalities of endurance training on cellular immune components, the matching of duration and mean intensity and the consideration of sex-dependent differences have received less attention so far. The aim of the study was to compare the effects of interval running (IR) vs. continuous running (CR) on circulating immune cells and cellular immune inflammation markers. Additionally, we analyze sex-dependent differences in these effects. In a cross-over study design, 24 recreational runners completed a mean intensity and duration-matched session of IR and CR. Blood samples were taken immediately before, after, and 1h after exercise cessation for cell counts and cortisol level quantification. Neutrophil counts showed a sustained increase after both exercise modalities with significantly greater values after IR compared to CR at 1h after exercise and greater increases in females. Neutrophil-to-lymphocyte ratio and systemic immune-inflammation index increased 1h after exercise with significantly higher values after IR compared to CR with greater values in females. Platelet-to-lymphocyte ratio decreased in both immediately after IR and 1h after exercise in both sexes and modalities. The cortisol level shows a lower value immediately after CR compared to IR with no sex-dependent differences. The IR protocol induces greater immune cell mobilizations in comparison to CR, which is primarily based on a systemic increase in neutrophil counts. Neutrophil-to-lymphocyte ratio and systemic immune-inflammation index are suitable to distinguish this effect between training modalities. Sex-dependent differences confirm that biological sex influences the immune cells response to acute exercise. Protocol registration:German Clinical Trials Register,DRKS00017686,Date of registration: 11.02.2020.

Beyond conventional rehabilitation: an observational study on RYSEN body weight supported gait training in individuals after stroke and spinal cord injury

Purpose The RYSEN body weight support device enables multidirectional overground gait training and can be combined with augmented reality (RYSEN-AR). The aim of this study was to investigate differences in training goals, intensity and acceptance between RYSEN, RYSEN-AR and conventional gait training (CGT) during rehabilitation. Materials and Methods Eleven individuals after stroke (60.1 ± 13.4 years) and eleven individuals with SCI (66.5 ± 13.2 years) performed CGT, RYSEN and RYSEN-AR as part of their rehabilitation program. Heart rate and trunk accelerometry data were collected to assess training intensity. Patients rated their confidence in balance control, level of conscious movement processing and training experiences using questionnaires. Therapists reported their intended training goals. The (interaction) effects of modality and group on these outcomes were assessed using linear mixed-effects models. Results Training intensity in terms of heart rate and trunk accelerometry did not differ between modalities. Confidence in balance control was higher during RYSEN-AR than during CGT (p = 0.004). The level of conscious movement processing did not differ between modalities. Training goals did not considerably differ between modalities overall. RYSEN and RYSEN-AR training were well-accepted among patients and therapists. Conclusions In current practice, there is limited distinction in terms of training intensity and goals between RYSEN and RYSEN-AR training relative to CGT. Further research, guideline development and implementation strategies are needed to use the RYSEN to its full potential in rehabilitation practice.

Comparative Effects of GLP-1 Agonists, Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Diabetes Mellitus Outcomes.

The purpose of this review is to assess the effects of glucagon-like peptide-1 (GLP-1) agonists, sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus (T2DM) remission. This review explores the efficacy, safety, and durability of these surgical and medical modalities of diabetes management. Studies have shown that GLP-1 agonists achieve higher rates of T2DM remission compared to standard glucose-lowering medications and lifestyle changes. In addition to weight loss, bariatric surgery has been found to be highly effective in treating and inducing remission of T2DM. Studies suggest that post-surgical patients see enhanced glycemic control. Both surgical interventions and GLP1 agonists are effective in achieving T2DM remission. Long-term follow-up and randomized controlled trials comparing bariatric surgery and GLP-1 agonists are necessary to evaluate their relative effectiveness in T2DM control. Further research is also needed to assess the combined effects of these treatment modalities.

The effect of energy modality on tissue identification from surgical smoke by differential ion mobility spectrometry

Surgical smoke analysis offers a way to provide assisting information to the surgeon intraoperatively, which can be potentially used to assess cancer tumor margins in surgical oncology and alert the operator of accidental organ injuries caused by electrosurgical (ES) instruments. Surgical smoke content is affected by the energy instrument it is produced by. Classification of surgical smoke by differential ion mobility spectrometry (DMS) was evaluated with 6 porcine tissue types and 5 energy instruments. Instruments consisted of mono- and bipolar instruments, ultrasonic shears and a –blade. Machine learning was used to classify tissues by training binary classifier linear discriminant analysis (LDA) to distinguish a marked tissue class from the rest. The greatest binary classification accuracies were obtained with the monopolar instruments and the lowest with the bipolar instrument, 93.5 % and 77.5 % respectively. The analysis of surgical smoke with DMS is possible with a variety of energy instruments, however with varying performance. This implies that DMS based tissue identification is generalizable across different surgical instruments and surgical specialties.

Augmented reality safety warnings in roadway work zones: Evaluating the effect of modality on worker reaction times

Given the aging highway infrastructure requiring extensive rebuilding and enhancements, and the consequent rise in the number of work zones, there is an urgent need to develop advanced safety systems to protect workers. While Augmented Reality (AR) holds significant potential for delivering warnings to workers, its integration into roadway work zones remains relatively unexplored. The primary objective of this study is to improve safety measures within roadway work zones by conducting an extensive analysis of how different combinations of multimodal Augmented Reality (AR) warnings influence the reaction times of workers. This paper addresses this gap through a series of experiments that aim to replicate the distinctive conditions of roadway work zones, both in real-world and virtual reality environments. Our approach comprises three key components: an advanced AR system prototype, a VR simulation of AR functionality within the work zone environment, and the Wizard of Oz technique to synchronize user experiences across experiments. To assess reaction times, we leverage both the simple reaction time (SRT) technique and an innovative vision-based metric that utilizes real-time pose estimation. By conducting five experiments in controlled outdoor work zones and indoor VR settings, our study provides valuable information on how various multimodal AR warnings impact workers reaction times. Furthermore, our findings reveal the disparities in reaction times between VR simulations and real-world scenarios, thereby gauging VR’s capability to mirror the dynamics of roadway work zones. Furthermore, our results substantiate the potential and reliability of vision-based reaction time measurements. These insights resonate well with those derived using the SRT technique, underscoring the viability of this approach for tangible real-world uses.

Long-Term Effects on Gonadal Function After Treatment of Colorectal Cancer: A Systematic Review and Meta-Analysis

Background: The incidence of colorectal cancer (CRC) is increasing in the population under 50 years of age, with more than 10% of cases occurring in young adults. Fertility preservation counseling has therefore received increased attention in this younger patient population. The treatment of CRC is often based on multimodal therapies, including surgery, radiotherapy, chemotherapy, and, more recently, immunotherapy, which makes it difficult to estimate the expected effect of treatment on fertility. We, therefore, systematically analyzed the published literature on the gonadotoxic effects of CRC treatments to better advise patients on the risk of infertility and the need for fertility preservation measures. This systematic review and meta-analysis are part of the FertiTOX project, which aims to reduce the data gap regarding the gonadotoxicity of oncological therapies. Objectives: The aim of this review and meta-analysis is to evaluate the potential impact of CRC therapies on gonadal function to allow more accurate counseling regarding the risk of clinically relevant gonadotoxicity and the need for fertility preservation measures before oncological treatment. Materials and Methods: A systematic literature search was conducted in Medline, Embase, the Cochrane database of systematic reviews, and CENTRAL in March 2024. A total of 22 out of 4420 studies were included in the review. Outcomes were defined as clinically relevant gonadotoxicity, indicated by elevated follicle-stimulating hormone (FSH) and/or undetectable anti-Müllerian hormone (AMH) levels and/or the need for hormone replacement therapy in women and azoo-/oligozoospermia and/or low inhibin B levels in men. Studies with fewer than nine patients were excluded from the meta-analysis. Results: The qualitative analysis included 22 studies with 1634 subjects (775 women, 859 men). Treatment consisted of active surveillance after surgery (37.7%), chemotherapy (12.7%), radiation (0.2%), or radiochemotherapy (53.9%). In 0.5%, the therapy was not clearly described. The meta-analysis included ten studies and showed an overall prevalence of clinically relevant gonadotoxicity of 23% (95% CI: 13–37%). In women, the prevalence was 27% (95% CI: 11–54%), and in men, 18% (95% CI: 13–26%). A subanalysis by type of CRC was only possible for rectal cancer, with a prevalence of relevant gonadotoxicity of 39% (95% CI: 20–64%). In patients undergoing chemotherapy exclusively, the prevalence was 4% (95% CI: 2–10%). In those receiving only radiotherapy, the prevalence was 23% (95% CI: 10–44%); in contrast, it reached 68% (95% CI: 40–87%) in patients who received radiochemotherapy. Conclusions: This first meta-analysis of the clinically relevant gonadotoxicity of CRC therapies provides a basis for counseling on the risk of infertility and the need for fertility preservation measures. Despite the low prevalence of gonadotoxicity in cases receiving chemotherapy alone, fertility preservation is still recommended due to the uncertainty of subsequent therapy and the lack of large longitudinal data on individual treatment effects. Further prospective studies are needed to investigate the impact of CRC treatment on gonadal function and estimate the effect of new treatment modalities, such as immunotherapies.

Management of cutaneous head and neck squamous cell carcinoma with trigeminal nerve involvement: a systematic review

Cutaneous head and neck squamous cell carcinoma (cHNSCC) is the second most common cancer worldwide, carrying a favorable prognosis. Perineural invasion/spread dramatically reduces survival outcomes. The trigeminal nerve (CNV) is most commonly affected, providing abundant opportunities for skull base and intracranial cavity invasion. Standard treatment includes surgery and radiotherapy (SRT). We intended to systematically review the literature on cHNSCC with CNV involvement and evaluate the effects of treatment modalities and pattern of CNV invasion/spread on outcomes. We performed a systematic review according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA). Kaplan-Meier curves were utilized to determine the impact of treatment and pattern of invasion/spread on disease-free survival (DFS) and overall survival (OS). Fifty-one studies were identified, generating a sample size of 172 patients with cHNSCC and CNV involvement. The most common treatment modality was SRT (n=90, 52.9%), and all three major CNV branches were affected with similar frequency (V1 33.7%, V2 33.7%, V3 32.6%). Cox proportional hazards regression models revealed significant differences in OS for V1 vs V2 involvement (HR 2.84 95% CI 1.02-7.89), skull base invasion (HR 3.90 95%CI 1.30-11.65), SRT vs RT alone (HR 5.77 95% CI 2.13-15.6), SRT vs other treatment (HR 6.21 95 CI 2.24-17.20). Only SRT and RT had a significant difference in DFS (HR of 3.90, 95%CI 1.30-11.65). In cHNSCC with CNV involvement, treatment modality and the pattern of CNV are crucial for locoregional control and mortality. V1 involvement and definitive RT are associated with significantly lower survival curves.

Comparison of different exercise modalities on fatigue and muscular fitness in patients with multiple sclerosis: a systematic review with network, and dose–response meta-analyses

BackgroundFatigue and muscular fitness are closely related to the quality of life in patients with multiple sclerosis (MS). However, the optimal exercise dosage to improve these outcomes remains unclear.ObjectiveWe evaluated the effects of different exercise modalities and dosages on fatigue levels and muscular fitness in patients with MS.MethodsA systematic search was conducted across five electronic databases, including randomized controlled trials involving exercise interventions for patients with MS. The data covered literature from the establishment of each database up to August 2024. Two independent reviewers assessed the quality of the studies. Network and dose–response meta-analyses were performed using a random-effects model to evaluate the impact of exercise.ResultsA total of 84 papers were included, involving 3,786 participants. The network meta-analysis revealed that mind–body exercise (MBE) had the most significant effect on reducing fatigue (SMD = −0.94; 95% CrI: −1.3 to −0.6), followed by resistance training (RT) (SMD = −0.86; 95% CrI: −1.2 to −0.58), combined exercise (COM) (SMD = −0.70; 95% CrI: −1.2 to −0.22), and high-intensity interval training (HIIT) (SMD = −0.50; 95% CrI: −1.1 to 0.14). Additionally, HIIT were found to be the most effective in improving muscular fitness (SMD = −0.86; 95% CrI: −1.5 to −0.27), followed by COM (SMD = −0.81; 95% CrI: −1.2 to −0.41), MBE (SMD = −0.64; 95% CrI: −1.1 to −0.16), and RT (SMD = −0.62; 95% CrI: −0.89 to −0.16). Moreover, a dose as low as 240 METs-min/week was sufficient to improve fatigue, while a dose of 430 METs-min/week was required to enhance muscular fitness. The optimal dose for reducing fatigue was 650 METs-min/week, and the best dose for improving muscular fitness was 530 METs-min/week.ConclusionExercise is an effective method for improving fatigue and muscular fitness in patients with MS. While MBE and COM rank relatively higher compared to other exercise modalities. The optimal exercise dosage for reducing fatigue and improving muscular fitness ranges between approximately 530 to 860 MET-minutes per week.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD42024577643.

Comparison of the Effects of Long-term Hemodialysis and Peritoneal Dialysis Modalities on Left Ventricular Functions.

Hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) affect left ventricular hemodynamics. This study compared the effect of two treatment modalities, CAPD and HD, on left ventricular systolic and diastolic functions in maintenance dialysis patients. A total of 47 patients (24 CAPD and 23 HD) undergoing long-term dialysis were included in the study. Left ventricular functions, left ventricular hypertrophy, and left ventricular geometry were evaluated using echocardiography. The mean age of the patients was 58.6 ± 11.2 years. The mean dialysis time was 125.1 ± 35.2 months. When echocardiographic parameters were examined, left ventricular muscle mass, mass index, E/e' ratios, and global longitudinal strain were significantly higher in the CAPD group. The rates of diastolic dysfunction (66.7% vs. 26.1%) and left ventricular hypertrophy (91.7% vs. 60.9%) were higher in the CAPD group than in the HD group. Dialysis modality CAPD, abnormal global longitudinal strain (GLS), and increased serum calcium were associated with an increased risk of diastolic dysfunction. The study results demonstrated that left ventricle (LV) diastolic dysfunction and deterioration in left ventricular geometry were significantly higher in patients receiving long-term CAPD treatment than for long-term HD treatment.

Effect of different pooled qc samples on data quality during an inter-batch experiment in untargeted UHPLC-HRMS analysis on two different MS platforms.

Quality control (QC) samples are commonly used in metabolomics approaches for three main reasons: (i) the initial conditioning of the column; (ii) the correction of analytical drift especially between batches; and (iii) the evaluation of measurement precision. In practice, there are several ways to prepare and conserve QC samples. The most common in untargeted metabolomics is to pool samples after or before extraction, in order to obtain pooled QC samples accounting, respectively, for analytical variance or for both analytical and sample preparation variances. In this study, focusing on untargeted analysis of tea (Camellia sinensis) leaves, we compared three ways of preparing pooled QC samples (two usual and one unusual QC sample preparations) and their efficiency to improve data quality in terms of inter-batch correction, measurement precision, and VIP candidates selection on datasets obtained using two mass spectrometry (MS) technologies (Orbitrap and time of flight (QToF)). We also investigated the effect of data processing modalities, based on the different QC preparations, on data loss and on the global structure of the datasets. Generally, our results show that usual QC sample preparation leads to comparable datasets quality in terms of precision and dispersion on both MS instruments. They also show that QC preparation is crucial for VIP selection; in fact, up to 54% of biomarkers candidates were specific of the QC preparation type used for data processing.

Effect of different training modalities on lipid metabolism in patients with type ii diabetes mellitus: a network meta-analysis

Background/Aims This study to evaluate the effects of different training modalities on blood lipids in type II diabetic patients by Network Meta-analysis, and provide a relevant basis for patients to develop exercise prescriptions to regulate blood lipids. Methods Randomized controlled trials (RCTs) were retrieved from Zhiwang, Wanfang, Wipu, PubMed, EBSCO, Cochrane Library, and Web of Science that were published from the establishment to February 2023. Relevant statistical analyses were performed using Stata 17.0 software and Revman 5.4. Results A total of 35 randomized controlled trials with 2771 patients with type II diabetes were finally included. The results of Network Meta-analysis showed that, compared with the control group, Chinese traditional fitness exercise (CTF), resistance training (RT), and aerobic training (AT) could reduce total cholesterol (TC) levels; CTF, RT, whole body vibration training (WBV), and AT could reduce triacylglycerol (TG) levels; CTF, WBV and AT could increase High-density lipoprotein cholesterol (HDL) levels; CTF, RT and AT could reduce Low-density lipoprotein cholesterol (LDL) levels. SUCRA probability ranking results showed that CTF was the most effective in reducing TC[SMD= −0.57, 95% CI (−0.83, −0.31), p < 0.001], TG[SMD= −0.24, 95% CI (−0.36, −0.12), p < 0.001], LDL[SMD= −0.52, 95% CI (−0.70, −0.35), p < 0.001]; RT was the most effective in increasing HDL[SMD = 0.14, 95% CI (0.03, 0.26), p < 0.05]. Conclusions CTF is more effective in improving TC, TG and LDL levels, while RT is most effective in improving HDL levels.

Effects of different exercise modalities on pediatric and adolescent populations with developmental disorders: a network meta-analysis of randomized controlled trials.

Combat sports, ball sports, neurodevelopmental motor training, and aquatic exercise may be effective exercise modalities for improving symptoms in children and adolescents with developmental disorders. However, the degree of improvement can vary among individuals with specific developmental disorders. Therefore, precise assessment of the individual symptoms of children or adolescents is crucial before selecting specific exercise interventions. PROSPERO (CRD42024545673). • Many studies indicate that exercise as an intervention can have positive effects on individuals with developmental disorders, such as ADHD and autism. However, reported effects vary, and there is no clear consensus on the optimal exercise intervention method yet. • Through a comprehensive network meta-analysis, various exercise interventions for children and adolescents with developmental disorders were compared to determine the optimal approach. The study found that combat sports, ball sports, neurodevelopmental motor training, and aquatic exercise could potentially be effective modalities for improving symptoms in this population.

Controlling harmful milling vibration for robotic milling system based on the optimization of milling posture and spindle speed

Harmful machining vibration including milling chatter and resonance are easily generated during robotic milling process, and it seriously restrict the machining ability of the robot. To address this problem, a harmful machining vibration-controlled method based on the combined optimization of milling posture and spindle speed is proposed for robotic milling system in this paper. With this context, firstly, the robot stiffness model is established based on the theory of the multi-body with small-deformation, and the stiffness ellipsoid at the tool cutting point is used to optimize the milling posture, so that the structure stiffness of the robot can be enhanced; Then, the robot chatter stability model is constructed considering the modal coupling effect, and the spindle speed is optimized to restrain the milling chatter and resonance. Finally, with the optimized milling posture and spindle speed, the milling process is planned and performed with a Staubli TX-200 robot, and two experiments for workpiece with steel and aluminum are implemented to verify the proposed method. The experiment results demonstrate that the comprehensive optimization of milling posture and spindle speed can efficiently control the harmful machining vibration for the robotic milling system, thus, the machining quality of the workpiece can be improved.

Similar adaptive responses in the upper body physical performance of table tennis players following the traditional and cluster set resistance and plyometric training

Numerous studies have investigated the impact of resistance training (RT) and plyometric training (PT) set configurations (cluster sets [CS] and traditional sets [TS]) on lower body performance adaptations. However, the effects of these training modalities on upper body physical performance, particularly among Table Tennis (TT) players, remain unclear. Therefore, this study aimed to examine the effects of an 8-week RT and PT using CS and TS configurations on the physical performance attributes of male TT players. Forty young male players were recruited from a local academy and after determining their dominant hand, divided into CS-PT, TS-PT, CS-RT, TS-RT, and active control (CON) groups, each of eight. Pre- and post-interventions, the upper body muscular power (medicine ball throw), maximal strength (bench press), reaction time, and arm crank anaerobic power test were measured. Following the intervention, the CON group exhibited no changes; however, the CS-PT, TS-PT, CS-RT, and TS-RT groups displayed significant (p = 0.001) improvements in muscular power (effect size [ES] = 1.21 [large], 1.02 [medium], 0.81 [medium], 0.64 [medium]), strength (ES = 0.40 [small], 0.43 [small], 0.62 [medium], 0.63 [medium]), reaction time (ES = − 0.71 [medium], − 0.68 [medium], − 0.83 [medium], − 0.61 [medium]), peak power (ES = 1.83 [large], 1.66 [large], 0.90 [medium], 0.67 [medium]), and mean power (ES = 0.89 [medium], 0.89 [medium], 0.57 [small], 0.59 [small]), respectively. The PT groups indicated significantly greater changes than the RT groups in both muscular (CS, p = 0.021; TS, p = 0.018) and anaerobic power (peak power: CS, p = 0.017; TS, p = 0.011; mean power: CS, p = 0.024; TS, p = 0.042) performance, while the RT groups showed greater adaptive responses than the PT groups in maximal strength (CS, p = 0.033; TS, p = 0.048). In conclusion, PT is recommended for enhancing power performance, while RT is preferred for increasing strength. When various set configurations were incorporated, no further effects were noted.

Effect of diet combined with exercise intervention on tumor necrosis factor α in overweight or obese groups: Based on the exercise dose-response relationship

Background: Chronic low-grade systemic inflammation, often linked to obesity or being overweight, is associated with various complications and an increased risk of disease development. Tumor necrosis factor α (TNF-α) is a key inflammatory factor that significantly impacts various body functions. Objective: 1) To assess whether combined interventions are more effective than single interventions in combining diet and exercise. 2) To assess the effectiveness of exercise dose in different interventions on tumor necrosis factor (TNF-α) levels in obese or overweight patients. Methods: A thorough search was conducted across four electronic databases of randomized controlled trials that focus on exercise or dietary interventions for patients with obesity or overweight. This comprehensive review encompasses data collected up to August 2024. Two independent researchers conducted a thorough evaluation of the literature's quality. Network and dose-response analyses were performed using random effects models to examine the impact of diverse interventions on TNF-α. Results: A total of 19 randomized controlled trials with 1479 patients with obesity or overweight were included. The meta-analysis showed that the hypocaloric diet combined with aerobic training (HDAT) possessed the highest ranking (SMD= -1.00,95%CI -1.51 to -0.49), followed by the hypocaloric diet (HD) (SMD= -0.40,95%CI -0.89 to 0.09), hypocaloric diet combined with resistance training (HDRT) (SMD= -0.48,95%CI- 1.43 to 0.48), and aerobic training combined with resistance training (ART) (SMD= -0.18,95%CI -0.92 to 0.57). Additionally, a notable improvement in TNF-α levels was observed in individuals adhering to a hypocaloric diet in conjunction with exercise when the cumulative exercise volume reached 150 metabolic equivalent of task minutes per week. Conclusion: Based on the GRADE rating guidelines, moderate-quality research evidence indicates that a hypocaloric diet combined with aerobic training (HDAT) is the most effective intervention for enhancing tumor TNF-α levels in individuals with obesity or overweight. Additionally, the dose-response relationship was observed between the total exercise dose and TNF-α levels. Future research should investigate the specific effects of various aerobic exercise modalities on TNF-α levels in obese or overweight patients to develop a more personalized approach to exercise prescription.

EXPRESS: Distinct Components of Stroop Interference and Facilitation: The role of phonology and response modality.

Multi-stage accounts of Stroop effects suggest that Stroop effects result from different conflict and facilitation components. Consistent with these accounts, Augustinova et al. (2019) reported evidence for task, semantic and response components in Stroop effects. They also investigated how vocal and manual responses impacted the magnitude of each of the conflict and facilitation components. However, the role of phonological components in Stroop effects was not investigated in their study. The impact of phonology on Stroop effects has been observed in several studies (Besner & Stolz, 1998; Parris et al., 2019; Spinks et al., 2000). However, these studies did not investigate the role of different conflict/facilitation components in Stroop effects. To investigate the impact of phonological components as well as task, semantic, and response components on Stroop effects, a vocal and manual Stroop task was for the first time conducted with Chinese speakers using a design similar to that of Augustinova et al. (2019). The data revealed only in the vocal Stroop task phonological conflict and facilitation, whereas semantic and response conflicts were found with vocal and manual responses. Implications of the findings for response modality effects and the measures of facilitation/conflict components are discussed.

Beneficial effects of non-pharmacological interventions for post-stroke pain: A meta-analysis.

Pain is a frequent post-stroke health concern, and several non-pharmacological interventions are commonly employed to manage it. However, few reviews have examined the effectiveness of such interventions, making it difficult to draw conclusions about their usefulness. Furthermore, subgroup analysis based on post-stroke pain level or intervention characteristics is rarely performed. This study aimed to investigate the effectiveness of non-pharmacological interventions and evaluate the significant factors associated with post-stroke pain through subgroup analysis. Systematic review and meta-analysis. Relevant studies were obtained from seven databases, from their commencement up to March 2024, as well as from the gray literature. The PICOS approach was used to evaluate the eligibility criteria of the studies. The RoB-2 tool was used to determine the risk of bias in each randomized trial. Pooled estimations of standardized mean difference and heterogeneity (quantified with I2) were obtained using a random-effects model. The stability of the pooled result was then assessed using the leave-one-out approach. STATA 17.0 was used to run the meta-analysis. Non-pharmacological interventions were effective in reducing pain immediately after intervention (pooled SMDs: -0.79; 95% confidence interval [CI]: -1.06 to -0.53; p < 0.001). The approach involving acupuncture, aquatic therapy, or laser therapy and rehabilitation training was effective for post-stroke hemiplegic shoulder pain. A pooled analysis of non-pharmacological interventions showed that both less than 4 weeks and more than 4 weeks of interventions were effective in alleviating pain in stroke patients. Non-pharmacological approaches appear to be beneficial for reducing post-stroke pain. The outcomes based on the modalities merit further research. Further studies are needed to determine the effects of different modalities on pain intensity following a stroke. Furthermore, to avoid overestimation of intervention efficacy, future randomized trials should consider blinding approaches to the interventions delivered.

Systematic review and network meta-analysis of non-invasive respiratory support in paediatric patients with acute hypoxaemic respiratory failure: a protocol

IntroductionAcute hypoxic respiratory failure (AHRF) is one of the most common causes of admission to paediatric intensive care units (PICUs) around the world, posing a serious health concern for the...

The Current Role of Imaging in the Diagnosis of Inflammatory Bowel Disease and Detection of Its Complications: A Systematic Review.

Inflammatory bowel disease (IBD) encompasses complex gastrointestinal (GI) conditions, primarily Crohn's disease (CD) and ulcerative colitis (UC), requiring precise imaging for effective diagnosis and management of complications. This systematic review aimed to evaluatethe current role of imaging modalities in diagnosing IBD and detecting related complications. Thereview adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We performed a literature search using text words and controlled vocabulary applying Boolean operators "AND," "OR," with various combinations on databases such as PubMed, Embase, and Cochrane Library. The search targeted open-access articles involving humans, with full-text available, and published in the English Language from 2005 to 2024. The quality of the included studies was assessed using the Cochrane Risk-of-Bias (RoB) checklist. Our search process identified 127 recordsfrom Cochrane (39), Embase (29), and PubMed (59). After removing 98 irrelevant records, 29 underwent further screening. Five were excluded as they involved irrelevant problems or outcomes, leaving us with 24 reports with full text, all of which were accessible. Following the eligibility assessment, two more reports were excluded due to inaccessibility, and 22 studies were included in the final analysis. The risk of bias and methodological quality assessment revealed that out of 22 studies analyzed, five (23%) had a high risk of bias, while 13 (59%) were classified as moderate risk, and four (18%) showed low risk. This distribution highlights a predominance of moderate-risk studies in research on imaging in IBD, emphasizing the need for enhanced study designs in future investigations. Our findings revealed the varying effectiveness of imaging modalities in diagnosing complications of CD and UC. Magnetic resonance enterography (MRE) stands out as the preferred method for CD due to its high sensitivity and noninvasive nature. In contrast, colonoscopy remains the gold standard for UC, providing direct visualization of mucosal lesions. While techniques like ultrasound and capsule endoscopy offer valuable insights, they havelimitations that may affect their utility in certain cases.