Effects Of Early Exercise Research Articles

EARLY MOTION AND DIRECTED EXERCISE (EMADE) VERSUS USUAL-CARE POST-ANKLE FRACTURE FIXATION: 12- AND 24-WEEK RESULTS FROM A PRAGMATIC RANDOMIZED CONTROLLED TRIAL

EARLY MOTION AND DIRECTED EXERCISE (EMADE) VERSUS USUAL-CARE POST-ANKLE FRACTURE FIXATION: 12- AND 24-WEEK RESULTS FROM A PRAGMATIC RANDOMIZED CONTROLLED TRIAL

Effects of early exercise on cardiac function and lipid metabolism pathway in heart failure.

We employed an early training exercise program, immediately after recovery from surgery, and before severe cardiac hypertrophy, to study the underlying mechanism involved with the amelioration of cardiac dysfunction in aortic stenosis (AS) rats. As ET induces angiogenesis and oxygen support, we aimed to verify the effect of exercise on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS and trained AS (AST). The exercise consisted of 5-week sessions of treadmill running for 16 weeks. Statistical analysis was conducted by anova or Kruskal-Wallis test and Goodman test. A global correlation between variables was also performed using a two-tailed Pearson's correlation test. AST rats displayed a higher functional capacity and a lower cardiac remodelling and dysfunction when compared to AS, as well as the myocardial capillary rarefaction was prevented. Regarding metabolic properties, immunoblotting and enzymatic assay raised beneficial effects of exercise on fatty acid transport and oxidation pathways. The correlation assessment indicated a positive correlation between variables of angiogenesis and FA utilisation, as well as between metabolism and echocardiographic parameters. In conclusion, early exercise improves exercise tolerance and attenuates cardiac structural and functional remodelling. In parallel, exercise attenuated myocardial capillary and lipid metabolism derangement in rats with aortic stenosis-induced heart failure.

Effect of Early Exercise on Limb Function Recovery in the Treatment of Hemiplegia

Effect of Early Exercise on Limb Function Recovery in the Treatment of Hemiplegia

The effect of early exercise on intracranial pressure in neurocritical patients: a systematic review

Background: Neurocritical patients commonly present with increased intracranial pressure and are regularly treated with physiotherapy through exercise early after admission to the intensive care unit. However, the effect of exercise on intracranial pressure is minimally investigated, and there appears to be no systematic reviews or meta-analyses addressing this topic in the published literature. This study aimed to determine the effect of exercise on the intracranial pressure of neurocritical patients.
 Methods: Through a systematic review, literature searches on PubMed, PEDro, and CENTRAL were conducted in January 2020. The keywords used were: “physical therapy”, “physiotherapy”, “exercise”, “range of motion”, “intracranial pressure”, and “ICP”, combined using Boolean operators “OR” and “AND”. Only studies published in the English and Indonesian language were considered.
 Results: A total of five studies involving 193 patients (mean age 41-56 years old) were included in this review. Most included studies reported that intracranial pressure did not change significantly after passive range of motion exercise, and some studies found that intracranial pressure actually decreased significantly during and after passive range of motion and active exercise. An additional finding was that isometric exercise significantly increased mean intracranial pressure in patients with normal intracranial pressure. All studies reported that exercise could be used safely in patients.
 Conclusion: Exercise, in particular passive range of motion, does not increase the intracranial pressure of neurocritical patients and does not lead to any adverse effects, as long as isometric or Valsalva-like maneuvers are avoided.

Effects of Early Exercise in Patients With Moderate to Severe Stroke.

Effects of Early Exercise in Patients With Moderate to Severe Stroke.

Influence of Exercise, Age, Body weight, and Growth on the Development of Tarsal Osteoarthritis in Young Mangalarga Marchador Horses

In this study, the effect of early exercise, age, body weight (BW), and growth on the articular cartilage and subchondral bones of the tarsocrural joints was evaluated in 40 young Mangalarga Marchador horses allowed free choice exercise in pasture. Twenty of the horses had additional controlled exercise 3 days per week from a mean age of 30 ± 20 days until 36 months. The training program consisted of an increasing number of 15-minute gallop sprints in an oval paddock with a concrete floor covered by a thick layer of sand. BW, withers height (WH), and neck circumference were measured and body condition scores, cresty neck scores, and obesity index were rated. For each tarsus and foal, 5 standard radiographic projections were evaluated. All evaluations were performed at time point 1 (18 months of age) and time point 2 (36 months of age). Radiographic changes suggestive of tarsal osteoarthritis were observed in two male foals of the trained group at time point 2 (10% of 20). No horses from the untrained group developed OA. Training of the foals did not result in alterations of the morphometric parameters evaluated. However, significant differences were found between time point 1 and 2 in trained and untrained animals. At time point 2, the animals presented greater weights and WHs than at time point 1. We conclude that specific levels of physical activity during initial development do not increase the prevalence of osteoarthritic injury in Mangalarga Marchador foals.

Horse owner understanding of equine gastric ulcer syndrome (EGUS)

In this study, the effect of early exercise, age, body weight (BW), and growth on the articular cartilage and subchondral bones of the tarsocrural joints was evaluated in 40 young Mangalarga Marchador horses allowed free choice exercise in pasture. Twenty of the horses had additional controlled exercise 3 days per week from a mean age of 30 ± 20 days until 36 months. The training program consisted of an increasing number of 15-minute gallop sprints in an oval paddock with a concrete floor covered by a thick layer of sand. BW, withers height (WH), and neck circumference were measured and body condition scores, cresty neck scores, and obesity index were rated. For each tarsus and foal, 5 standard radiographic projections were evaluated. All evaluations were performed at time point 1 (18 months of age) and time point 2 (36 months of age). Radiographic changes suggestive of tarsal osteoarthritis were observed in two male foals of the trained group at time point 2 (10% of 20). No horses from the untrained group developed OA. Training of the foals did not result in alterations of the morphometric parameters evaluated. However, significant differences were found between time point 1 and 2 in trained and untrained animals. At time point 2, the animals presented greater weights and WHs than at time point 1. We conclude that specific levels of physical activity during initial development do not increase the prevalence of osteoarthritic injury in Mangalarga Marchador foals.

PL-019 Effect of early exercise on autophagy of liver tumor in mice

Objective To investigate whether the liver autophagy level can be altered by pre exercise training in mice liver tumors.
 Methods 40 Male C57BL/6J mice aged 7 months were randomly divided into 2 groups: control group (YC) and exercise group (YE). YE were exercised on a treadmill for 12 weeks (12m/min). After12 weeks each group was randomly divided into two groups. The tumor model was constructed by injection of HEPA1- 6 mouse hepatoma cell into liver tissue.Then the groups were control group (YC), exercise group (YE), tumor group (YCT), exercise tumor group (YET).The experimental samples were prepared on the 13 day after the tumor model was constructed. the hematoxylin and eosin stain of the liver was observed.The expression of autophagy related protein BECLIN1, LC3-II and ATG5 in liver tissues of mice was detected by Western blot.
 Results Compared with YCT group,the boundary of inflammatory cells and tumor cells in YET group was clear with normal cells.Compared with YCT group, the expression levels of BECLIN1, LC3-II and ATG5 in liver tissue of YET group were significantly higher (p < 0.01, P < 0.01, P < 0.05).
 Conclusions Early exercise can help the 7 month old mice to resist the occurrence and development of the liver tumor. It's probably associated with increased level of autophagy in the liver by early exercise training.

The Effects of Early Exercise on Motor, Sense, and Memory Recovery in Rats With Stroke.

Exercise is an effective, inexpensive, home-based, and accessible intervention strategy for stroke treatment, and early exercise after stroke has attracted a great deal of attention in recent years. However, the effects of early exercise on comprehensive functional recovery remain poorly understood. The present study investigated the effect of early exercise on motor, sense, balance, and spatial memory recovery. Adult Sprague-Dawley rats were subjected to unilateral middle cerebral artery occlusion (MCAO) and were randomly divided into early exercise group (EE), non-exercise group (NE), and sham group. EE group received 2 weeks of exercise training initiated at 24 hours after operation. The recovery of motor, sense, and balance function was evaluated every 3 days after MCAO. Spatial memory recovery was detected from 21 to 25 days after MCAO. The results showed that early exercise significantly promoted the motor and spatial memory recovery with statistical differences. The rats in EE group have a better recovery in sense and balance function, but there is no statistically significant difference about these results. Our results showed that early moderate exercise can significantly promote motor and spatial memory recovery, but not the sense and balance functions.

Effect of early exercise nursing after the operation on pain and gastrointestinal function in abdominal operation patients

Objective To investigate the application effect of early exercise nursing after the operation on in abdominal operation patients.Methods A total of 100 abdominal operation patients were randomly divided into the observation group and the control group.The control group was given conventional nursing during operation period and the observation group was given early exercise nursing based on the control group.Postoperative recovery was compared between two groups.Results Eating time,recovery time of bowel sound,defecation time and ambulation time in the observation group were significantly shorter than those in the control group (P ＜ 0.05),postoperative complications,hospital stay in observation group were significantly less than those in the control group,postoperative pain score was significantly lower than that in the control group,nursing satisfaction was significantly higher than that in the control group (P ＜ 0.05).Conclusions The early postoperative exercise nursing could promote recovery of gastrointestinal functions in abdominal operation patients,decrease pain and complications. Key words: Early exercise nursing after the operation; Abdominal operation; Gastrointestinal function; Postoperative pain

Associations between yearling exercise and interruptions during race training in Thoroughbred racehorses

To investigate the effect of exercise during yearling sales preparation on the risk of interruptions during training in Thoroughbred racehorses. 114 Thoroughbred racehorses. Information regarding the daily exercise of yearlings during sales preparation was obtained prospectively from a convenience sample of stud farms. Yearlings were followed to entry into race training, and subsequently, daily training information was recorded until the end of the racing season. Competing-risks survival analysis was used to model time from entry into race training to voluntary training interruption (no known condition or disease identified) and time from entry into race training to involuntary training interruption (due to presence of a condition or disease) occurring before the first trial (practice race for education). Total hand walking time and mechanical walker time accumulated during sales preparation were the main exposures of interest. 82 of 114 (71.9%) horses had an interruption before the first trial; 65 (79%) interruptions were voluntary, and 17 (21%) interruptions were involuntary. Increased total hand walking time was significantly associated with decreased risk of voluntary interruptions, whereas longer cumulative distances at a canter were significantly associated with decreased risk of involuntary interruptions. Results identified an association between early exercise during sales preparation and decreased risk of voluntary interruption and increased risk of involuntary interruption during training of 2-year-old Thoroughbred racehorses. Further investigation into the effects of early exercise on racing performance is needed, but results have indicated that there may be an opportunity to modify early exercise programs.

Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood

We have previously shown that 4 wk of exercise training early in life normalizes the otherwise greatly reduced pancreatic β-cell mass in adult male rats born small. The aim of the current study was to determine whether a similar normalization in adulthood of reduced skeletal muscle mitochondrial biogenesis markers and alterations in skeletal muscle lipids of growth-restricted male rats occurs following early exercise training. Bilateral uterine vessel ligation performed on day 18 of gestation resulted in Restricted offspring born small (P < 0.05) compared with both sham-operated Controls and a sham-operated Reduced litter group. Offspring remained sedentary or underwent treadmill running from 5-9 (early exercise) or 20-24 (later exercise) wk of age. At 24 wk of age, Restricted and Reduced litter offspring had lower (P < 0.05) skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) protein expression compared with Control offspring. Early exercise training had the expected effect of increasing skeletal muscle markers of mitochondrial biogenesis, but, at this early age (9 wk), there was no deficit in Restricted and Reduced litter skeletal muscle mitochondrial biogenesis. Unlike our previous observations in pancreatic β-cell mass, there was no "reprogramming" effect of early exercise on adult skeletal muscle such that PGC-1α was lower in adult Restricted and Reduced litter offspring irrespective of exercise training. Later exercise training increased mitochondrial biogenesis in all groups. In conclusion, although the response to exercise training remains intact, early exercise training in rats born small does not have a reprogramming effect to prevent deficits in skeletal muscle markers of mitochondrial biogenesis in adulthood.

Effects of Early Exercise on the Development of Lymphedema in Patients With Breast Cancer Treated With Axillary Lymph Node Dissection

Despite advances in the treatment of breast cancer, there is little research examining the prevention of lymphedema after breast and/or axillary surgery. Currently, there are no national guidelines for activity restrictions; however, many medical providers recommend restricting activity of the surgically affected arm, which can create quality-of-life issues as well as future medical issues for patients with breast cancer. A literature review of several current research articles was performed. This report reviews four studies evaluating the effects of restricted activity versus progressive exercise and stretching activities on development of lymphedema. The results show that there is no difference in the risk of developing lymphedema when following activity guidelines. All four of the studies reviewed report results of either a decrease in the development of lymphedema or no increased risk of development of lymphedema when early exercise regimens are incorporated into postoperative care. The four research articles show promising results that support future change in practice guidelines. However, none of the studies report follow-up results beyond 2 years. Additionl evaluation to monitor long-term effects is warranted.

The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats

AimExercise can be used to enhance neuroplasticity and facilitate motor recovery after a stroke in rats. We investigated whether treadmill running could reduce brain damage and enhance the expression of midkine (MK) and nerve growth factor (NGF), increase angiogenesis and decrease the expression of caspase-3.MethodsSeventy-seven Wistar rats were split into three experimental groups (ischaemia-control: 36, ischaemia-exercise: 36, sham-exercise: 5). Stroke was induced by 90-min left middle cerebral artery occlusion using an intraluminal filament. Beginning on the following day, the rats were made to run on a treadmill for 20 min once a day for a maximum of 28 consecutive days. Functional recovery after ischaemia was assessed using the beam-walking test and a neurological evaluation scale in all rats. Infarct volume, and the expression of MK, NGF, anti-platelet-endothelial cell adhesion molecule (PECAM-1), and caspase-3 were evaluated at 1, 3, 5, 7, 14 and 28 days after the induction of ischaemia.ResultsOver time motor coordination and neurological deficits improved more in the exercised group than in the non-exercised group. The infarct volume in the exercised group (12.4 ± 0.8%) subjected to treadmill running for 28 days was significantly decreased compared with that in the control group (19.8 ± 4.2%, P < 0.01). The cellular expression levels of MK, NGF and PECAM-1 were significantly increased while that of caspase-3 was decreased in the peri-infarct area of the exercised rats.ConclusionsOur findings show that treadmill exercise improves motor behaviour and reduces neurological deficits and infarct volume, suggesting that it may aid recovery from central nervous system injury.

The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats.

Exercise can be used to enhance neuroplasticity and facilitate motor recovery after a stroke in rats. We investigated whether treadmill running could reduce brain damage and enhance the expression of midkine (MK) and nerve growth factor (NGF), increase angiogenesis and decrease the expression of caspase-3. Seventy-seven Wistar rats were split into three experimental groups (ischaemia-control: 36, ischaemia-exercise: 36, sham-exercise: 5). Stroke was induced by 90-min left middle cerebral artery occlusion using an intraluminal filament. Beginning on the following day, the rats were made to run on a treadmill for 20 min once a day for a maximum of 28 consecutive days. Functional recovery after ischaemia was assessed using the beamwalking test and a neurological evaluation scale in all rats. Infarct volume, and the expression of MK, NGF, anti-platelet-endothelial cell adhesion molecule (PECAM-1), and caspase-3 were evaluated at 1, 3, 5, 7, 14 and 28 days after the induction of ischaemia. Over time motor coordination and neurological deficits improved more in the exercised group than in the non-exercised group. The infarct volume in the exercised group (12.4 ± 0.8%) subjected to treadmill running for 28 days was significantly decreased compared with that in the control group (19.8 ± 4.2%, P < 0.01). The cellular expression levels of MK, NGF and PECAM-1 were significantly increased while that of caspase-3 was decreased in the peri-infarct area of the exercised rats. Our findings show that treadmill exercise improves motor behaviour and reduces neurological deficits and infarct volume, suggesting that it may aid recovery from central nervous system injury.

Effects of early exercise on metacarpophalangeal joints in horses

Effects of early exercise on metacarpophalangeal joints in horses

Effects of early exercise on metacarpophalangeal joints in horses

To determine the effects of exercise at an early age on tissues in the metacarpophalangeal joints of horses. Twelve 18-month-old horses. All horses were pasture reared, but 6 horses had additional exercise starting at 3 weeks of age until 18 months of age. At that time, computed tomography, articular cartilage metabolism evaluation, and histologic assessments of synovial membrane, articular cartilage, and subchondral bone were performed. Exercised horses had fewer gross lesions, less articular cartilage matrix staining in the dorsal aspect of the condyle, greater bone fraction in the dorsolateral aspect of the condyle, and higher bone formation rate, compared with nonexercised horses. Exercise at a young age may be protective to joints, although more research is needed to characterize changes in articular cartilage matrix. Results suggested that exercise can be safely imposed at an early age.

The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats

The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats

Exercise After Myocardial Infarction Improves Contractility and Decreases Myofilament Ca 2+ Sensitivity

See related article, pages 1079–1088 While myocardial infarction (MI) is the major cause of heart failure, there are conflicting data over the roles of abnormal calcium handling and myofilament function. The acute injury leads to the activation of neurohormones and cytokines, subsequent myocardial remodelling, further decline in heart function, and finally overt heart failure. Depressed myocyte contractility in the remodelled myocardium can largely be explained by Ca2+ handling abnormalities.1 Abnormalities in myofilament function are less well understood. A seminal study in pigs demonstrated that impaired pump function three weeks after MI can also be attributed to decreased maximal isometric tension in skinned cardiomyocytes in areas remote from the ischemic border zone.2 Somewhat paradoxically, the impairment occurred in the context of increased Ca2+ sensitivity of the myofilaments. The authors attributed the increased Ca2+ sensitivity following MI to reduced protein kinase A-mediated troponin I (TnI) phosphorylation.2 Increased myofilament Ca2+ sensitivity has also been reported for end-stage human heart failure, apparently largely because of a reduction of TnI phosphorylation.3 One of the most effective and least expensive therapies for cardiovascular disease is exercise. Clinical studies generally show a benefit of exercise training and a reduction of cardiac mortality after MI by 26%.4 The question remains of how soon to start exercising, especially after a large MI. In several clinical5 and animal6,7 studies, there were detrimental consequences when exercise began immediately after an MI. In the current issue of Circulation Research , de Waard et al8 present remarkable data addressing the question of exercise training early post MI. After a large MI, mice were subjected to 8 weeks of “voluntary” exercise training. Exercise had no detrimental effects on mortality and minimal effects on myocardial hypertrophy and left ventricular remodelling. Furthermore, there …

The effect of early exercise on myocardial infarct scar formation

The purpose of this study was to determine if exercise undertaken during the phase of incomplete healing after myocardial infarction influences scar formation. Eighteen ether-anesthetized rats underwent coronary artery occlusion (CAO) and were paired by matching ECG infarct size as assessed by QRS morphology. One member of each pair was randomized to a nonswimming group (NoS) or a graded swimming (S) protocol group (up to 40 minutes of swimming per day) beginning 7 days after CAO. Twenty-one days after CAO, rats were reanesthetized, hearts were excised and examined under magnification, and were then sectioned for histology. Transmural scar thickness (mm) measured on gross pathologic specimens was thinner in the S rats (1.0 ± 0.2, p < 0.05) than in the NoS rats (1.4 ± 0.3, p < 0.05), while noninfarcted septal wall thickness (mm) was similar in the two groups (2.2 ± 0.1 versus 2.1 ± 0.1, respectively). The thinnest portion of the scar in S rats measured only 0.6 ± 0.2 mm compared to that of NoS rats (1.1 ± 0.3 mm, p < 0.05). In this experiment exercise during the healing phase of acute myocardial infarction (AMI) caused thinning of the transmural scar.