This paper presents the findings of a research program that was undertaken to evaluate the static and fatigue characteristics of an innovative 3-D glass fiber reinforced polymer (GFRP) sandwich panel proposed for civil infrastructure and transportation applications. The research consists of analytical modeling verified by experimental results. A rational analytical model is presented and used to evaluate the effective elastic modulus, shear modulus and degree of composite interaction of the panels to resist one-way bending. The experimental program was conducted in two phases to study the static and fatigue behavior of the panels. In the first phase a total of 730 sandwich beams were tested to evaluate the effect of different parameters on the fundamental behavior of the panel. The parameters considered include the pattern and density of through-thickness fiber insertions, the overall thickness of the panels, and the number of FRP plies in the face skins. The study indicates that the shear behavior and degree of composite interaction of the panels is sensitive to the configuration of the panel core. The second phase of the experimental program included testing of 24 additional sandwich panels to evaluate the fatigue behavior. The results of the experimental program indicate that the panels with stiffer cores generally exhibited a higher degree of degradation than panels with more flexible cores. The findings of this study indicate that the proposed panels represent a versatile construction system which can be configured to achieve the specific design demands for civil engineering infrastructure applications.