This research evaluates the effectiveness of the Risk-Based Planning and Monitoring Information System (SIPPISKO) used by all units within the Ministry of Health. Using the Delone and McLean Information Systems Success Model, the study employs PLS-SEM analysis to assess six key dimensions: system quality, information quality, service quality, use, user satisfaction, and net benefits. Data were gathered from auditors and Ministry of Health units through questionnaires. The analysis reveals that system quality significantly impacts user satisfaction but not use, while information and service quality significantly influence both use and user satisfaction. Although use does not substantially affect user satisfaction, system use significantly impacts perceived net benefits. These findings suggest that enhancing the quality of SIPPISKO's system and services could improve user satisfaction and overall system effectiveness. The results offer strategic insights for the Ministry of Health to strengthen its information systems, leading to more effective risk management and oversight. Keywords: DeLone and McLean Information Systems Success Model, Evaluation of The Effectiveness, Information System, PLS Structural Equation Modeling analysis, SIPPISKO