This paper presents the design of local PI regulators to control voltage and active power of the Distributed Energy Resources (DERs) in grid-connected Active Distribution Networks (ADNs). The design is developed based on the proposed Multiple-Input Multiple-Output (MIMO) model of ADN. Firstly, the Relative Gain Array (RGA) matrix is used to address the problem of input–output pairing and to show that the voltage control loops are coupled whereas the active power control loops are decoupled. Subsequently the method of the Effective Open-Loop Transfer Function (EOTF) is used to decompose the multi-loop voltage control system into a set of equivalent Single-Input Single-Output (SISO) loops. Then, each PI regulator is independently designed to fulfill some control objectives dictated by the designer. The proposed design procedure is simple and straightforward. The fixed-parameters PI regulators facilitate the integration of DERs into traditional distribution networks which are usually operated without or with limited communication infrastructure. The simulation results presented for various scenarios of two different ADN confirm that performance objectives and regulation at the desired set-points are achieved in a robust sense.