Effective One-pot Synthesis Research Articles

Facile synthesis, corrosion inhibition, adsorption and DFT studies of 2-(4-(methylsulfanyl) phenyl) −4, 5-diphenyl-1H-imidazole for mild steel in acidic environment

A green, solvent-free, cost effective one-pot synthesis method is employed to produce the innovative corrosion-inhibiting compound 2-(4-(methylsulfanyl)phenyl)-4,5-diphenyl-1H-imidazole (MDPI). The molecular structure of MDPI can be identified using CHN analyses, FT-IR, 1H and 13C NMR spectra. Various electrochemical and gravimetric techniques are utilized to evaluate the anti-corrosion properties of MDPI. The results indicate that MDPI effectively inhibits the corrosion of mild steel under all tested conditions. At 306 K, MDPI achieved a maximum corrosion inhibition efficiency of 98.01 % at a concentration of 10 mM. MDPI exhibited strong adsorption and excellent anti-corrosion properties, forming a protective layer on the mild steel surface. The Langmuir adsorption isotherm, with a ΔGoads value of −39.55 kJ/M was found to be more suitable for this study, indicating that the process occurred by physisorption. Tafel curves indicated that MDPI functions as a mixed-type corrosion inhibitor. Surface characteristics were analyzed using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and atomic force microscopy (AFM). Quantum chemistry studies revealed a HOMO-LUMO energy gap of 3.926 eV, corroborating the anti-corrosion effectiveness of MDPI in hydrochloric acid solution. MDPI exhibited promising anti-corrosion activity due to its heterocyclic ring containing nitrogen heteroatoms as well as a methylsulfanyl functional group.

Gelucire®-mediated heterometallic AgAu nanohybrid engineering for femtomolar cysteine detection using smartphone-based plasmonics technology

Conventionally nanoparticles (NPs) are synthesized using reducing and capping agents that are often hazardous for the environment and are not economically viable. Consequently, there is a growing requirement of bio-friendly methodologies for nanosynthesis via the green chemistry approach. The present study discusses the frugal and cost effective one-pot synthesis of AgAu nanohybrid exploiting the UV-treatment without the use of environmentally hazardous chemicals. Biocompatible pharmaceutical carrier Gelucire® has been utilized for this purpose as both the reducing agent and stabilizer. The obtained nanohybrids displayed unique nano-geometries and generated regions of augmented electromagnetic (EM) intensity ‘hotspots’ while studied on metallic thin films in reverse Kretschmann (RK) configuration. In addition to being highly beneficial from the sustainable development standpoint, the synthesized nanohybrids showcased unprecedented surface plasmon-coupled emission (SPCE) enhancement of >1000-fold and a sharply directional, p-polarized dequenched emission, on account of high EM field intensity. Furthermore, the obtained augmented SPCE enhancement was utilized for attaining femtomolar sensitivity of biologically significant amino acid cysteine using a mobile phone based plasmonics platform. Excellent correlation has been observed between the results obtained using an expensive spectrophotometer and the user-friendly mobile phone-based detector.

Green chemistry approach for the synthesis of 2,4,5-triaryl-1H-imidazole derivatives using lemon juice as a bio-catalyst

The use of green chemistry is crucial for organic synthesis to protect the environment from hazardous and toxic substances. Lemon juice is a promising candidate for a green chemistry catalyst because it is widely available, inexpensive, biodegradable, and non-toxic. This study reports a simple and highly effective one-pot synthesis of 2,4,5-triaryl-1H-imidazole derivatives 4(a-l) using lemon juice as a biocatalyst. The method involves a three-component condensation reaction of benzil, aromatic aldehydes, and ammonium acetate in ethanol using lemon juice asa catalyst, and offers several benefits such as short reaction time, easy work-up, low-cost catalyst, and good yields. Additionally, in silico prediction of ADME properties suggests that the synthesized compounds 4(a-l) have the potential to exhibit favourable oral drug-like properties.

Cost effective one-pot synthesis approach for the formation of pure Cr2O3 nanocrystalline materials

A simple onepot synthesis method is used for the preparation of pure Cr2O3 nanomaterials by varying the fuel efficiency of hexamine as ɸe = 0, 1, 2, 3, 4, and 5. Powder XRD, TG / DTA, Raman, and FESEM-EDX are the characterization techniques used to examine the structural, microstructural, thermal, optical, and morphological features of obtained Cr2O3 nanomaterials. The XRD pattern confirms the as-prepared Cr2O3 nanomaterials are pure and it reveals the trigonal structure with the space group, R-3c h (167). The D values for the different Cr2O3 nanomaterials are in the range of 15.8–21.6 nm. The TGA shows the maximum weight loss of 15 % for the Cr2O3 nanomaterials obtained with ɸe = 0 and the minimum weight loss of 1.5 % with ɸe = 2. The fine agglomerated particles are seen for the combustion product (ɸe = 2) of Cr2O3 nanomaterials by FESEM images.

Synthesis and Mechanistic Insights of the Formation of 3-Hydroxyquinolin-2-ones including Viridicatin from 2-Chloro-N,3-diaryloxirane-2-carboxamides under Acid-Catalyzed Rearrangements.

N-Benzyl-2-chloro-N,3-diaryloxirane-2-carboxamides, easily obtained from aromatic aldehydes and anilides of dichloroacetic acid under Darzens condensation conditions, proved to be excellent starting compounds for the synthesis of 3-hydroxyindolin-2-ones, cyclohepto[b]pyrrole-2,3-diones, and 1-azaspiro[4.5]deca-3,6,9-triene-2-ones via the C(sp2)-C(sp2) bond formation in the first case and C(sp2)-C(sp3) bond formation in the second and third cases. Under optimized reaction conditions, 3-hydroxyindolin-2-ones are obtained in a one-pot process, which involves the treatment of N-benzyl-2-chloro-N,3-diaryloxirane-2-carboxamides with CF3CO2H or AcOH/H2SO4. In the case of intramolecular cyclization, the detailed reaction channels depend strongly on the substituents present in the anilide component and in the aromatic ring of the aldehyde component of N-benzyl-2-chloro-N,3-diaryloxirane-2-carboxamides, as well as the temperature and duration of the reaction. A combined experimental and DFT mechanistic study of the formation of 1-benzyl-3-hydroxy-4-arylquinolin-2(1H)-ones showed that there are three competing reaction channels: (a) ring-closure via the ipso site, (b) ring-closure via the 1,2-Cl shift, and (c) ring-closure via the ortho site. Such mechanistic insights enabled an effective one-pot gram-scale synthesis of viridicatin from benzaldehyde and 2,2-dichloro-N-(4-methoxybenzyl)-N-phenylacetamide.

Copper-catalyzed synthesis and anticancer activity evaluation of indolo[1,2-a]quinoline derivatives

A simple and effective one-pot synthesis of substituted indolo[1,2-a]quinolines has been developed. The desired products were obtained in up to 98% yield when substituted 2-methyindoles were treated with 2-iodobenzaldehyde in the presence of Cs2CO3, CuI and l-proline. Our mechanistic study confirmed that the reaction sequence involved an intermolecular Knoevenagel reaction followed by an intramolecular Ullmann-type coupling reaction. Moreover, some of the synthesized compounds were found to be active against human breast (MCF-7) and colorectal (HCT-116) cancer cells with IC50 values of 27.96 μM and in the range of 6.21–46.91 μM, respectively.

One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis.

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.

New One-Pot Synthesis of 1,3,5-Triazines: Three-Component Condensation, Dimroth Rearrangement, and Dehydrogenative Aromatization.

A new, effective one-pot synthesis of the 6, N2-diaryl-1,3,5-triazine-2,4-diamines under microwave irradiation was developed. The method involved an initial three-component condensation of cyanoguanidine, aromatic aldehydes, and arylamines in the presence of hydrochloric acid. Without isolation, the resulting 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines were treated with a base to initiate Dimroth rearrangement and spontaneous dehydrogenative aromatization, affording the desired compounds. The developed method was found to be sufficiently general in scope, tolerating various aromatic aldehydes and amines; by using their combinations in the first step, a representative library of 110 compounds was successfully prepared and screened for anticancer properties.

One-pot synthesis of 1,2,3-triazole derivatives of maleopimaric and dihydroquinopimaric acids

Effective one-pot synthesis of 1,2,3-triazole derivatives of maleopimaric and dihydroquinopimaric acids consists in the reaction of diterpene propargyl esters with organic azides generated in situ in the presence of СuI catalyst.

Effective one-pot synthesis of (E)-poly(vinyl arylenes) via trans-borylation/Suzuki coupling protocol

Abstract A new stereoselective method for the synthesis of (E)-poly(vinylarenes) on the basis of the Ru-H catalyzed trans-borylation reaction and sequential Suzuki coupling is described. Two different strategies of Pd-catalyzed polycondensation leading to unsaturated organic macromolecular compounds are discussed. Development of a one-pot procedure reduces costs and time, needed for the separation of intermediates, the amount of organic solvents used for purification and therefore has a positive influence on the process sustainability.

Choline Chloride Catalyzed Eco-Friend and Effective One-Pot Synthesis of 9-Arylacridine-1,8-dione and Hexahydroquinoline via Hantzsch Type Reaction

Choline Chloride Catalyzed Eco-Friend and Effective One-Pot Synthesis of 9-Arylacridine-1,8-dione and Hexahydroquinoline via Hantzsch Type Reaction

Effective one-pot synthesis of 2,3-dialkyl-1,4-dicyclopropyl-butane-1,4-diones catalyzed by Cp2TiCl2

2,3-Dialkyl-l,4-dicyclopropylbutane-1,4-diones were prepared in one pot from symmetrical acetylenes, ethylaluminum dichloride and methyl cyclopropanecarboxylate in the presence of magnesium metal and Cp 2 TiCl 2 (10 mol%) as a catalyst in 62–66% yield. Comparison of 1,4-dicyclopropylbutane-1,4-diones with other analogues to form furans in the course of the Paal–Knorr reaction was made by quantum chemical DFT calculations.

A Nitrogen-Assisted One-Pot Heteroaryl Ketone Synthesis from Carboxylic Acids and Heteroaryl Halides.

A practical and highly effective one-pot synthesis of versatile heteroaryl ketones directly from carboxylic acids and heteroaryl halides under mild conditions is reported. This method does not require derivatization of carboxylic acids (preparation of acid chlorides, Weinreb amides, etc.) or the use of any additives/catalysts. A wide substrate scope of carboxylic acids with high functional group tolerance has also been demonstrated. The results reveal that the presence of an α-nitrogen on the halide substrate greatly improves the desired ketone formation.

One-pot four-enzyme synthesis of thymidinediphosphate-l-rhamnose.

A new, robust one-pot four-enzyme synthetic method was developed for thymidinediphosphate-l-rhamnose starting from d-glucose-1-phosphate. The enzymes, Glc-1-P thymidylyltransferase, dTDP-Glc-4,6-dehydratase, dTDP-4-keto-6-deoxy-Glc-3,5-epimerase and dTDP-4-keto-Rha reductase were derived from Streptococcus pneumonia serotype 23F, expressed in Escherichia coli, and studied in detail to provide the first direct evidence for their functions.

Green and Effective One-Pot Synthesis of 5-Oxo-pyrazolidine and 5-Amino-2,3-dihydro-1H-Pyrazole Derivatives through Ball Milling Under Catalyst-Free and Solvent-Free Conditions

Green and Effective One-Pot Synthesis of 5-Oxo-pyrazolidine and 5-Amino-2,3-dihydro-1H-Pyrazole Derivatives through Ball Milling Under Catalyst-Free and Solvent-Free Conditions

ChemInform Abstract: Synthesis of Functionalized Benzene Using Diels—Alder Reaction of Activated Acetylenes with Synthesized Phosphoryl‐2‐oxo‐2H‐pyran.

An effective one-pot synthesis of benzene derivatives using a Diels–Alder reaction of activated acetylenes with phosphoryl-2-oxo-2H-pyrans is described. The latter compounds were synthesized in good yield via the reaction of dialkyl acetylenedicarboxylates and alkyl bromides in the presence of trialkyl phosphites under solvent-free conditions at 50 ᵒC.

Base-catalyzed one-pot tandem reaction: an effective strategy for the synthesis of pyrazolo[3,4-d]pyrimidinone derivatives

An effective one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidinone derivatives through the tandem heterocyclization of hydrazine, methylenemalononitrile and aldehyde has been developed. This highly effective method includes nucleophilic addition, heterocyclization, substitution, intramolecular Pinner, Dimroth rearrangement and dehydroaromatization.

3,7-Diarylpyrazolo[1,5-α]pyrimidines의 개선된 One-pot Regioselective 합성과 CB1R 활성

This study demonstrates an effective one-pot regioselective synthesis of 3,7-diarylpyrazolo [1,5-α]pyrimidines. Moreover, the derivatives obtained were effective CB1R antagonists. These pyrazolo [1,5-α]pyrimidines with diaryl groups at the 3,7-positions are potential pharmacophores for CB1R candidates.

1, 3-Disulfonic acid imidazolium hydrogen sulphate as an efficient and reusable ionic liquid for the multicomponent synthesis of polyhydroquinoline derivatives under solvent-free conditions

A facile and highly effective one-pot synthesis of polyhydroquinoline derivatives is reported via Hantzsch condensation of aldehydes, 1,3-dicarbonyl compounds, ethyl acetoacetate, and ammonium acetate in the presence of 1,3-disulfonic acid imidazolium hydrogen sulfate as an efficient and recyclable ionic liquid under solvent-free conditions. This methodology offers several advantages such as short reaction times, high yields, environmentally benign, mild reaction conditions, simple work-up procedure, and reusability of the ionic liquid.

Synthesis of functionalized benzene using Diels–Alder reaction of activated acetylenes with synthesized phosphoryl-2-oxo-2H-pyran

Abstract An effective one-pot synthesis of benzene derivatives using a Diels–Alder reaction of activated acetylenes with phosphoryl-2-oxo-2H-pyrans is described. The latter compounds were synthesized in good yield via the reaction of dialkyl acetylenedicarboxylates and alkyl bromides in the presence of trialkyl phosphites under solvent-free conditions at 50 oC.